Because the physiological characteristics and melanin regulation mechanism of zebrafish are highly similar with those of humans,it is of high reference value to use zebrafish model in the evaluation of cosmetic whiten...Because the physiological characteristics and melanin regulation mechanism of zebrafish are highly similar with those of humans,it is of high reference value to use zebrafish model in the evaluation of cosmetic whitening efficacy.In this study,zebrafish embryos are used as biological models to evaluate the whitening efficacy of six kinds of cosmetics raw materials,such as antioxidant,preservative and essence,and the formula of facial cleanser and facial mask products,and the limitations of the zebrafish melanin production grayscale detection method in practical application are discussed.The results show that the selection of different types of components can also reduce the production of melanin and show whitening effect.It can be seen that the gray scale method of melanin production in zebrafish is suitable for the evaluation of the efficacy of raw materials.In practical application,due to the complexity of the formula,the toxic effects of different types of ingredients may interfere with the melanin generation of zebrafish,affecting the judgment and evaluation of whitening efficacy.For the detection of whitening efficacy of products,a comprehensive evaluation system should be built together with other methods to accurately evaluate the whitening efficacy.展开更多
文摘Because the physiological characteristics and melanin regulation mechanism of zebrafish are highly similar with those of humans,it is of high reference value to use zebrafish model in the evaluation of cosmetic whitening efficacy.In this study,zebrafish embryos are used as biological models to evaluate the whitening efficacy of six kinds of cosmetics raw materials,such as antioxidant,preservative and essence,and the formula of facial cleanser and facial mask products,and the limitations of the zebrafish melanin production grayscale detection method in practical application are discussed.The results show that the selection of different types of components can also reduce the production of melanin and show whitening effect.It can be seen that the gray scale method of melanin production in zebrafish is suitable for the evaluation of the efficacy of raw materials.In practical application,due to the complexity of the formula,the toxic effects of different types of ingredients may interfere with the melanin generation of zebrafish,affecting the judgment and evaluation of whitening efficacy.For the detection of whitening efficacy of products,a comprehensive evaluation system should be built together with other methods to accurately evaluate the whitening efficacy.
