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Knowledge graph-enhanced long-tail learning approach for traditional Chinese medicine syndrome differentiation
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作者 Weikang Kong Chuanbiao Wen Yue Luo 《Digital Chinese Medicine》 2026年第1期57-67,共11页
Objective To address the dual challenges of long-tail distribution and feature sparsity in traditional Chinese medicine(TCM)syndrome differentiation within real clinical settings,we propose a data-efficient learning f... Objective To address the dual challenges of long-tail distribution and feature sparsity in traditional Chinese medicine(TCM)syndrome differentiation within real clinical settings,we propose a data-efficient learning framework enhanced by knowledge graphs.Methods We developed Agent-GNN,a three-stage decoupled learning framework,and validated it on the Traditional Chinese Medicine Syndrome Diagnosis(TCM-SD)dataset containing 54152 clinical records across 148 syndrome categories.First,we constructed a comprehensive medical knowledge graph encoding the complete TCM reasoning system.Second,we proposed a Functional Patient Profiling(FPP)method that utilizes large language models(LLMs)combined with Graph Retrieval-Augmented Generation(RAG)to extract structured symptom-etiology-pathogenesis subgraphs from medical records.Third,we employed heterogeneous graph neural networks to learn structured combination patterns explicitly.We compared our method against multiple baselines including BERT,ZY-BERT,ZY-BERT+Know,GAT,and GPT-4 Few-shot,using macro-F1 score as the primary evaluation metric.Additionally,ablation experiments were conducted to validate the contribution of each key component to model performance.Results Agent-GNN achieved an overall macro-F1 score of 72.4%,representing an 8.7 percentage points improvement over ZY-BERT+Know(63.7%),the strongest baseline among traditional methods.For long-tail syndromes with fewer than 10 samples,Agent-GNN reached a macro-F1 score of 58.6%,compared with 39.3%for ZY-BERT+Know and 41.2%for GPT-4 Few-shot,representing relative improvements of 49.2%and 42.2%,respectively.Ablation experiments confirmed that the explicit modeling of etiology-pathogenesis nodes contributed 12.4 percentage points to this enhanced long-tail syndrome performance.Conclusion This study proposes Agent-GNN,a knowledge graph-enhanced framework that effectively addresses the long-tail distribution challenge in TCM syndrome differentiation.By explicitly modeling manifestation-mechanism-essence patterns through structured knowledge graphs,our approach achieves superior performance in data-scarce scenarios while providing interpretable reasoning paths for TCM intelligent diagnosis. 展开更多
关键词 Syndrome differentiation Medical knowledge graph graph neural networks Long-tail learning Data-efficient learning
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Interdisciplinary Arts and Sciences Education:An Exploration on Knowledge Graph-aided I Ching Learning
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作者 Yinuo Liu Wendong Li +3 位作者 Wenxuan Ouyang Gaojie Wang Li Pan Shijun Liu 《计算机教育》 2026年第3期130-138,共9页
To integrate traditional culture and modern technology,Shandong University’s School of Software has promoted an interdisciplinary teaching project called IYAN&ITAN,the I Ching Knowledge Graph.The project,driven b... To integrate traditional culture and modern technology,Shandong University’s School of Software has promoted an interdisciplinary teaching project called IYAN&ITAN,the I Ching Knowledge Graph.The project,driven by I Ching texts,guides students to practice natural language processing(NLP)and knowledge graph technology in a task-oriented curriculum,based on constructivism,situated learning,and inquiry-based pedagogy,with a progressive and task-oriented teaching model.The platform established enables the retrieval of knowledge,parsing of text,symbolic-numeric analysis,and historical commentary integration,making possible multidimensional,structured representation of I Ching knowledge,and offering an extensible reference for interdisciplinary learning in the context of New Engineering Education. 展开更多
关键词 Interdisciplinary teaching Knowledge graph CONSTRUCTIVISM Situated learning Inquiry-based learning
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Predicting the synthesizability of inorganic crystals by bridging crystal graphs and phonon dynamics
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作者 Mei Ma Wei Ma +2 位作者 Le Gao Zong-Guo Wang Hao Liu 《Chinese Physics B》 2026年第1期35-44,共10页
Accurately predicting the synthesizability of inorganic crystal materials serves as a pivotal tool for the efficient screening of viable candidates,substantially reducing the costs associated with extensive experiment... Accurately predicting the synthesizability of inorganic crystal materials serves as a pivotal tool for the efficient screening of viable candidates,substantially reducing the costs associated with extensive experimental trial-and-error processes.However,existing methods,limited by static structural descriptors such as chemical composition and lattice parameters,fail to account for atomic vibrations,which may introduce spurious correlations and undermine predictive reliability.Here,we propose a deep learning model termed integrating graph and dynamical stability(IGDS)for predicting the synthesizability of inorganic crystals.IGDS employs graph representation learning to construct crystal graphs that precisely capture the static structures of crystals and integrates phonon spectral features extracted from pre-trained machine learning interatomic potentials to represent their dynamic properties.Our model exhibits outstanding performance in predicting the synthesizability of low-energy unsynthesizable crystals across 41 material systems,achieving precision and recall values of 0.916/0.863 for ternary compounds.By capturing both static structural descriptors and dynamic features,IGDS provides a physics-informed method for predicting the synthesizability of inorganic crystals.This approach bridges the gap between theoretical design concepts and their practical implementation,thereby streamlining the development cycle of new materials and enhancing overall research efficiency. 展开更多
关键词 crystal synthesizability prediction deep learning graph learning AI for science
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GFL-SAR: Graph Federated Collaborative Learning Framework Based on Structural Amplification and Attention Refinement
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作者 Hefei Wang Ruichun Gu +2 位作者 Jingyu Wang Xiaolin Zhang Hui Wei 《Computers, Materials & Continua》 2026年第1期1683-1702,共20页
Graph Federated Learning(GFL)has shown great potential in privacy protection and distributed intelligence through distributed collaborative training of graph-structured data without sharing raw information.However,exi... Graph Federated Learning(GFL)has shown great potential in privacy protection and distributed intelligence through distributed collaborative training of graph-structured data without sharing raw information.However,existing GFL approaches often lack the capability for comprehensive feature extraction and adaptive optimization,particularly in non-independent and identically distributed(NON-IID)scenarios where balancing global structural understanding and local node-level detail remains a challenge.To this end,this paper proposes a novel framework called GFL-SAR(Graph Federated Collaborative Learning Framework Based on Structural Amplification and Attention Refinement),which enhances the representation learning capability of graph data through a dual-branch collaborative design.Specifically,we propose the Structural Insight Amplifier(SIA),which utilizes an improved Graph Convolutional Network(GCN)to strengthen structural awareness and improve modeling of topological patterns.In parallel,we propose the Attentive Relational Refiner(ARR),which employs an enhanced Graph Attention Network(GAT)to perform fine-grained modeling of node relationships and neighborhood features,thereby improving the expressiveness of local interactions and preserving critical contextual information.GFL-SAR effectively integrates multi-scale features from every branch via feature fusion and federated optimization,thereby addressing existing GFL limitations in structural modeling and feature representation.Experiments on standard benchmark datasets including Cora,Citeseer,Polblogs,and Cora_ML demonstrate that GFL-SAR achieves superior performance in classification accuracy,convergence speed,and robustness compared to existing methods,confirming its effectiveness and generalizability in GFL tasks. 展开更多
关键词 graph federated learning GCN GNNs attention mechanism
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A knowledge graph-based reinforcement learning approach for cooperative caching in MEC-enabled heterogeneous networks
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作者 Dan Wang Yalu Bai Bin Song 《Digital Communications and Networks》 2025年第4期1236-1244,共9页
Existing wireless networks are flooded with video data transmissions,and the demand for high-speed and low-latency video services continues to surge.This has brought with it challenges to networks in the form of conge... Existing wireless networks are flooded with video data transmissions,and the demand for high-speed and low-latency video services continues to surge.This has brought with it challenges to networks in the form of congestion as well as the need for more resources and more dedicated caching schemes.Recently,Multi-access Edge Computing(MEC)-enabled heterogeneous networks,which leverage edge caches for proximity delivery,have emerged as a promising solution to all of these problems.Designing an effective edge caching scheme is critical to its success,however,in the face of limited resources.We propose a novel Knowledge Graph(KG)-based Dueling Deep Q-Network(KG-DDQN)for cooperative caching in MEC-enabled heterogeneous networks.The KGDDQN scheme leverages a KG to uncover video relations,providing valuable insights into user preferences for the caching scheme.Specifically,the KG guides the selection of related videos as caching candidates(i.e.,actions in the DDQN),thus providing a rich reference for implementing a personalized caching scheme while also improving the decision efficiency of the DDQN.Extensive simulation results validate the convergence effectiveness of the KG-DDQN,and it also outperforms baselines regarding cache hit rate and service delay. 展开更多
关键词 Multi-access edge computing Cooperative caching Resource allocation Knowledge graph Reinforcement learning
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Container cluster placement in edge computing based on reinforcement learning incorporating graph convolutional networks scheme
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作者 Zhuo Chen Bowen Zhu Chuan Zhou 《Digital Communications and Networks》 2025年第1期60-70,共11页
Container-based virtualization technology has been more widely used in edge computing environments recently due to its advantages of lighter resource occupation, faster startup capability, and better resource utilizat... Container-based virtualization technology has been more widely used in edge computing environments recently due to its advantages of lighter resource occupation, faster startup capability, and better resource utilization efficiency. To meet the diverse needs of tasks, it usually needs to instantiate multiple network functions in the form of containers interconnect various generated containers to build a Container Cluster(CC). Then CCs will be deployed on edge service nodes with relatively limited resources. However, the increasingly complex and timevarying nature of tasks brings great challenges to optimal placement of CC. This paper regards the charges for various resources occupied by providing services as revenue, the service efficiency and energy consumption as cost, thus formulates a Mixed Integer Programming(MIP) model to describe the optimal placement of CC on edge service nodes. Furthermore, an Actor-Critic based Deep Reinforcement Learning(DRL) incorporating Graph Convolutional Networks(GCN) framework named as RL-GCN is proposed to solve the optimization problem. The framework obtains an optimal placement strategy through self-learning according to the requirements and objectives of the placement of CC. Particularly, through the introduction of GCN, the features of the association relationship between multiple containers in CCs can be effectively extracted to improve the quality of placement.The experiment results show that under different scales of service nodes and task requests, the proposed method can obtain the improved system performance in terms of placement error ratio, time efficiency of solution output and cumulative system revenue compared with other representative baseline methods. 展开更多
关键词 Edge computing Network virtualization Container cluster Deep reinforcement learning graph convolutional network
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Fault Detection in Wind Turbine Bearings by Coupling Knowledge Graph and Machine Learning Approach
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作者 Paras Garg Arvind Keprate +2 位作者 Gunjan Soni A.P.S.Rathore O.P.Yadav 《Journal of Dynamics, Monitoring and Diagnostics》 2025年第4期250-263,共14页
Fault sensing in wind turbine(WT)generator bearings is essential for ensuring reliability and holding down maintenance costs.Feeding raw sensor data to machine learning(ML)model often overlooks the enveloping interdep... Fault sensing in wind turbine(WT)generator bearings is essential for ensuring reliability and holding down maintenance costs.Feeding raw sensor data to machine learning(ML)model often overlooks the enveloping interdependencies between system elements.This study proposes a new hybrid method that combines the domain knowledge via knowledge graphs(KGs)and the traditional feature-based data.Incorporation of contextual relationships through construction of graph embedding methods,such as Node2Vec,can capture meaningful information,such as the relationships among key parameters(e.g.wind speed,rotor Revolutions Per Minute(RPM),and temperature)in the enriched feature representations.These node embeddings,when augmented with the original data,can be used to allow the model to learn and generalize better.As shown in results achieved on experimental data,the augmented ML model(with KG)is much better at predicting with the help of accuracy and error measure compared to traditional ML methods.Paired t-test analysis proves the statistical validity of this improvement.Moreover,graph-based feature importance increases the interpretability of the model and helps to uncover the structurally significant variables that are otherwise ignored by the common methods.The approach provides an excellent,knowledge-guided manner through which intelligent fault detection can be executed on WT systems. 展开更多
关键词 anomaly detection knowledge graph embedding machine learning wind turbine fault detection
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Adaptive multi-view learning method for enhanced drug repurposing using chemical-induced transcriptional profiles, knowledge graphs, and large language models
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作者 Yudong Yan Yinqi Yang +9 位作者 Zhuohao Tong Yu Wang Fan Yang Zupeng Pan Chuan Liu Mingze Bai Yongfang Xie Yuefei Li Kunxian Shu Yinghong Li 《Journal of Pharmaceutical Analysis》 2025年第6期1354-1369,共16页
Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches ofte... Drug repurposing offers a promising alternative to traditional drug development and significantly re-duces costs and timelines by identifying new therapeutic uses for existing drugs.However,the current approaches often rely on limited data sources and simplistic hypotheses,which restrict their ability to capture the multi-faceted nature of biological systems.This study introduces adaptive multi-view learning(AMVL),a novel methodology that integrates chemical-induced transcriptional profiles(CTPs),knowledge graph(KG)embeddings,and large language model(LLM)representations,to enhance drug repurposing predictions.AMVL incorporates an innovative similarity matrix expansion strategy and leverages multi-view learning(MVL),matrix factorization,and ensemble optimization techniques to integrate heterogeneous multi-source data.Comprehensive evaluations on benchmark datasets(Fdata-set,Cdataset,and Ydataset)and the large-scale iDrug dataset demonstrate that AMVL outperforms state-of-the-art(SOTA)methods,achieving superior accuracy in predicting drug-disease associations across multiple metrics.Literature-based validation further confirmed the model's predictive capabilities,with seven out of the top ten predictions corroborated by post-2011 evidence.To promote transparency and reproducibility,all data and codes used in this study were open-sourced,providing resources for pro-cessing CTPs,KG,and LLM-based similarity calculations,along with the complete AMVL algorithm and benchmarking procedures.By unifying diverse data modalities,AMVL offers a robust and scalable so-lution for accelerating drug discovery,fostering advancements in translational medicine and integrating multi-omics data.We aim to inspire further innovations in multi-source data integration and support the development of more precise and efficient strategies for advancing drug discovery and translational medicine. 展开更多
关键词 Drug repurposing Multi-view learning Chemical-induced transcriptional profile Knowledge graph Large language model Heterogeneous network
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Denoising graph neural network based on zero-shot learning for Gibbs phenomenon in high-order DG applications
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作者 Wei AN Jiawen LIU +3 位作者 Wenxuan OUYANG Haoyu RU Xuejun LIU Hongqiang LYU 《Chinese Journal of Aeronautics》 2025年第3期234-248,共15页
With the availability of high-performance computing technology and the development of advanced numerical simulation methods, Computational Fluid Dynamics (CFD) is becoming more and more practical and efficient in engi... With the availability of high-performance computing technology and the development of advanced numerical simulation methods, Computational Fluid Dynamics (CFD) is becoming more and more practical and efficient in engineering. As one of the high-precision representative algorithms, the high-order Discontinuous Galerkin Method (DGM) has not only attracted widespread attention from scholars in the CFD research community, but also received strong development. However, when DGM is extended to high-speed aerodynamic flow field calculations, non-physical numerical Gibbs oscillations near shock waves often significantly affect the numerical accuracy and even cause calculation failure. Data driven approaches based on machine learning techniques can be used to learn the characteristics of Gibbs noise, which motivates us to use it in high-speed DG applications. To achieve this goal, labeled data need to be generated in order to train the machine learning models. This paper proposes a new method for denoising modeling of Gibbs phenomenon using a machine learning technique, the zero-shot learning strategy, to eliminate acquiring large amounts of CFD data. The model adopts a graph convolutional network combined with graph attention mechanism to learn the denoising paradigm from synthetic Gibbs noise data and generalize to DGM numerical simulation data. Numerical simulation results show that the Gibbs denoising model proposed in this paper can suppress the numerical oscillation near shock waves in the high-order DGM. Our work automates the extension of DGM to high-speed aerodynamic flow field calculations with higher generalization and lower cost. 展开更多
关键词 Computational fluid dynamics High-order discon tinuous Galerkin method Gibbs phenomenon graph neural networks Zero-shot learning
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Graph-based multi-agent reinforcement learning for collaborative search and tracking of multiple UAVs 被引量:2
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作者 Bocheng ZHAO Mingying HUO +4 位作者 Zheng LI Wenyu FENG Ze YU Naiming QI Shaohai WANG 《Chinese Journal of Aeronautics》 2025年第3期109-123,共15页
This paper investigates the challenges associated with Unmanned Aerial Vehicle (UAV) collaborative search and target tracking in dynamic and unknown environments characterized by limited field of view. The primary obj... This paper investigates the challenges associated with Unmanned Aerial Vehicle (UAV) collaborative search and target tracking in dynamic and unknown environments characterized by limited field of view. The primary objective is to explore the unknown environments to locate and track targets effectively. To address this problem, we propose a novel Multi-Agent Reinforcement Learning (MARL) method based on Graph Neural Network (GNN). Firstly, a method is introduced for encoding continuous-space multi-UAV problem data into spatial graphs which establish essential relationships among agents, obstacles, and targets. Secondly, a Graph AttenTion network (GAT) model is presented, which focuses exclusively on adjacent nodes, learns attention weights adaptively and allows agents to better process information in dynamic environments. Reward functions are specifically designed to tackle exploration challenges in environments with sparse rewards. By introducing a framework that integrates centralized training and distributed execution, the advancement of models is facilitated. Simulation results show that the proposed method outperforms the existing MARL method in search rate and tracking performance with less collisions. The experiments show that the proposed method can be extended to applications with a larger number of agents, which provides a potential solution to the challenging problem of multi-UAV autonomous tracking in dynamic unknown environments. 展开更多
关键词 Unmanned aerial vehicle(UAV) Multi-agent reinforcement learning(MARL) graph attention network(GAT) Tracking Dynamic and unknown environment
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Joint learning based on multi-shaped filters for knowledge graph completion 被引量:2
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作者 Li Shaojie Chen Shudong +1 位作者 Ouyang Xiaoye Gong Lichen 《High Technology Letters》 EI CAS 2021年第1期43-52,共10页
To solve the problem of missing many valid triples in knowledge graphs(KGs),a novel model based on a convolutional neural network(CNN)called ConvKG is proposed,which employs a joint learning strategy for knowledge gra... To solve the problem of missing many valid triples in knowledge graphs(KGs),a novel model based on a convolutional neural network(CNN)called ConvKG is proposed,which employs a joint learning strategy for knowledge graph completion(KGC).Related research work has shown the superiority of convolutional neural networks(CNNs)in extracting semantic features of triple embeddings.However,these researches use only one single-shaped filter and fail to extract semantic features of different granularity.To solve this problem,ConvKG exploits multi-shaped filters to co-convolute on the triple embeddings,joint learning semantic features of different granularity.Different shaped filters cover different sizes on the triple embeddings and capture pairwise interactions of different granularity among triple elements.Experimental results confirm the strength of joint learning,and compared with state-of-the-art CNN-based KGC models,ConvKG achieves the better mean rank(MR)and Hits@10 metrics on dataset WN18 RR,and the better MR on dataset FB15k-237. 展开更多
关键词 knowledge graph embedding(KGE) knowledge graph completion(KGC) convolutional neural network(CNN) joint learning multi-shaped filter
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Graph CA: Learning From Graph Counterfactual Augmentation for Knowledge Tracing 被引量:1
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作者 Xinhua Wang Shasha Zhao +3 位作者 Lei Guo Lei Zhu Chaoran Cui Liancheng Xu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第11期2108-2123,共16页
With the popularity of online learning in educational settings, knowledge tracing(KT) plays an increasingly significant role. The task of KT is to help students learn more effectively by predicting their next mastery ... With the popularity of online learning in educational settings, knowledge tracing(KT) plays an increasingly significant role. The task of KT is to help students learn more effectively by predicting their next mastery of knowledge based on their historical exercise sequences. Nowadays, many related works have emerged in this field, such as Bayesian knowledge tracing and deep knowledge tracing methods. Despite the progress that has been made in KT, existing techniques still have the following limitations: 1) Previous studies address KT by only exploring the observational sparsity data distribution, and the counterfactual data distribution has been largely ignored. 2) Current works designed for KT only consider either the entity relationships between questions and concepts, or the relations between two concepts, and none of them investigates the relations among students, questions, and concepts, simultaneously, leading to inaccurate student modeling. To address the above limitations,we propose a graph counterfactual augmentation method for knowledge tracing. Concretely, to consider the multiple relationships among different entities, we first uniform students, questions, and concepts in graphs, and then leverage a heterogeneous graph convolutional network to conduct representation learning.To model the counterfactual world, we conduct counterfactual transformations on students’ learning graphs by changing the corresponding treatments and then exploit the counterfactual outcomes in a contrastive learning framework. We conduct extensive experiments on three real-world datasets, and the experimental results demonstrate the superiority of our proposed Graph CA method compared with several state-of-the-art baselines. 展开更多
关键词 Contrastive learning counterfactual representation graph neural network knowledge tracing
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Reliable knowledge graph fact prediction via reinforcement learning 被引量:1
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作者 Fangfang Zhou Jiapeng Mi +5 位作者 Beiwen Zhang Jingcheng Shi Ran Zhang Xiaohui Chen Ying Zhao Jian Zhang 《Visual Computing for Industry,Biomedicine,and Art》 EI 2023年第1期304-317,共14页
Knowledge graph(KG)fact prediction aims to complete a KG by determining the truthfulness of predicted triples.Reinforcement learning(RL)-based approaches have been widely used for fact prediction.However,the existing ... Knowledge graph(KG)fact prediction aims to complete a KG by determining the truthfulness of predicted triples.Reinforcement learning(RL)-based approaches have been widely used for fact prediction.However,the existing approaches largely suffer from unreliable calculations on rule confidences owing to a limited number of obtained reasoning paths,thereby resulting in unreliable decisions on prediction triples.Hence,we propose a new RL-based approach named EvoPath in this study.EvoPath features a new reward mechanism based on entity heterogeneity,facilitating an agent to obtain effective reasoning paths during random walks.EvoPath also incorporates a new postwalking mechanism to leverage easily overlooked but valuable reasoning paths during RL.Both mechanisms provide sufficient reasoning paths to facilitate the reliable calculations of rule confidences,enabling EvoPath to make precise judgments about the truthfulness of prediction triples.Experiments demonstrate that EvoPath can achieve more accurate fact predictions than existing approaches. 展开更多
关键词 Knowledge graph Fact prediction Reinforcement learning Entity heterogeneity Postwalking mechanism
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Personalized Learning Path Recommendations for Software Testing Courses Based on Knowledge Graphs 被引量:1
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作者 Wei Zheng Ruonan Gu +2 位作者 Xiaoxue Wu Lipeng Gao Han Li 《计算机教育》 2023年第12期63-70,共8页
Software testing courses are characterized by strong practicality,comprehensiveness,and diversity.Due to the differences among students and the needs to design personalized solutions for their specific requirements,th... Software testing courses are characterized by strong practicality,comprehensiveness,and diversity.Due to the differences among students and the needs to design personalized solutions for their specific requirements,the design of the existing software testing courses fails to meet the demands for personalized learning.Knowledge graphs,with their rich semantics and good visualization effects,have a wide range of applications in the field of education.In response to the current problem of software testing courses which fails to meet the needs for personalized learning,this paper offers a learning path recommendation based on knowledge graphs to provide personalized learning paths for students. 展开更多
关键词 Knowledge graphs Software testing learning path Personalized education
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Decentralized Federated Graph Learning via Surrogate Model
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作者 Bolin Zhang Ruichun Gu Haiying Liu 《Computers, Materials & Continua》 2025年第2期2521-2535,共15页
Federated Graph Learning (FGL) enables model training without requiring each client to share local graph data, effectively breaking data silos by aggregating the training parameters from each terminal while safeguardi... Federated Graph Learning (FGL) enables model training without requiring each client to share local graph data, effectively breaking data silos by aggregating the training parameters from each terminal while safeguarding data privacy. Traditional FGL relies on a centralized server for model aggregation;however, this central server presents challenges such as a single point of failure and high communication overhead. Additionally, efficiently training a robust personalized local model for each client remains a significant objective in federated graph learning. To address these issues, we propose a decentralized Federated Graph Learning framework with efficient communication, termed Decentralized Federated Graph Learning via Surrogate Model (SD_FGL). In SD_FGL, each client is required to maintain two models: a private model and a surrogate model. The surrogate model is publicly shared and can exchange and update information directly with any client, eliminating the need for a central server and reducing communication overhead. The private model is independently trained by each client, allowing it to calculate similarity with other clients based on local data as well as information shared through the surrogate model. This enables the private model to better adjust its training strategy and selectively update its parameters. Additionally, local differential privacy is incorporated into the surrogate model training process to enhance privacy protection. Testing on three real-world graph datasets demonstrates that the proposed framework improves accuracy while achieving decentralized Federated Graph Learning with lower communication overhead and stronger privacy safeguards. 展开更多
关键词 Federated learning federated graph learning DECENTRALIZED graph neural network privacy preservation
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An inductive learning-based method for predicting drug-gene interactions using a multi-relational drug-disease-gene graph
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作者 Jian He Yanling Wu +4 位作者 Linxi Yuan Jiangguo Qiu Menglong Li Xuemei Pu Yanzhi Guo 《Journal of Pharmaceutical Analysis》 2025年第8期1902-1915,共14页
Computational analysis can accurately detect drug-gene interactions(DGIs)cost-effectively.However,transductive learning models are the hotspot to reveal the promising performance for unknown DGIs(both drugs and genes ... Computational analysis can accurately detect drug-gene interactions(DGIs)cost-effectively.However,transductive learning models are the hotspot to reveal the promising performance for unknown DGIs(both drugs and genes are present in the training model),without special attention to the unseen DGIs(both drugs and genes are absent in the training model).In view of this,this study,for the first time,proposed an inductive learning-based model for the precise identification of unseen DGIs.In our study,by integrating disease nodes to avoid data sparsity,a multi-relational drug-disease-gene(DDG)graph was constructed to achieve effective fusion of data on DDG intro-relationships and inter-actions.Following the extraction of graph features by utilizing graph embedding algorithms,our next step was the retrieval of the attributes of individual gene and drug nodes.In this way,a hybrid feature characterization was represented by integrating graph features and node attributes.Machine learning(ML)models were built,enabling the fulfillment of transductive predictions of unknown DGIs.To realize inductive learning,this study generated an innovative idea of transforming known node vectors derived from the DDG graph into representations of unseen nodes using node similarities as weights,enabling inductive predictions for the unseen DGIs.Consequently,the final model was superior to existing models,with significant improvement in predicting both external unknown and unseen DGIs.The practical feasibility of our model was further confirmed through case study and molecular docking.In summary,this study establishes an efficient data-driven approach through the proposed modeling,suggesting its value as a promising tool for accelerating drug discovery and repurposing. 展开更多
关键词 Drug-gene interactions Inductive learning Multi-relational drug-disease-gene graph graph embedding Node attributes Machine learning
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Graph Similarity Learning Based on Learnable Augmentation and Multi-Level Contrastive Learning
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作者 Jian Feng Yifan Guo Cailing Du 《Computers, Materials & Continua》 2025年第3期5135-5151,共17页
Graph similarity learning aims to calculate the similarity between pairs of graphs.Existing unsupervised graph similarity learning methods based on contrastive learning encounter challenges related to random graph aug... Graph similarity learning aims to calculate the similarity between pairs of graphs.Existing unsupervised graph similarity learning methods based on contrastive learning encounter challenges related to random graph augmentation strategies,which can harm the semantic and structural information of graphs and overlook the rich structural information present in subgraphs.To address these issues,we propose a graph similarity learning model based on learnable augmentation and multi-level contrastive learning.First,to tackle the problem of random augmentation disrupting the semantics and structure of the graph,we design a learnable augmentation method to selectively choose nodes and edges within the graph.To enhance contrastive levels,we employ a biased random walk method to generate corresponding subgraphs,enriching the contrastive hierarchy.Second,to solve the issue of previous work not considering multi-level contrastive learning,we utilize graph convolutional networks to learn node representations of augmented views and the original graph and calculate the interaction information between the attribute-augmented and structure-augmented views and the original graph.The goal is to maximize node consistency between different views and learn node matching between different graphs,resulting in node-level representations for each graph.Subgraph representations are then obtained through pooling operations,and we conduct contrastive learning utilizing both node and subgraph representations.Finally,the graph similarity score is computed according to different downstream tasks.We conducted three sets of experiments across eight datasets,and the results demonstrate that the proposed model effectively mitigates the issues of random augmentation damaging the original graph’s semantics and structure,as well as the insufficiency of contrastive levels.Additionally,the model achieves the best overall performance. 展开更多
关键词 graph similarity learning contrastive learning attributes STRUCTURE
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Cyclical Training Framework with Graph Feature Optimization for Knowledge Graph Reasoning
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作者 Xiaotong Han Yunqi Jiang +1 位作者 Haitao Wang Yuan Tian 《Computers, Materials & Continua》 2025年第5期1951-1971,共21页
Knowledge graphs(KGs),which organize real-world knowledge in triples,often suffer from issues of incompleteness.To address this,multi-hop knowledge graph reasoning(KGR)methods have been proposed for interpretable know... Knowledge graphs(KGs),which organize real-world knowledge in triples,often suffer from issues of incompleteness.To address this,multi-hop knowledge graph reasoning(KGR)methods have been proposed for interpretable knowledge graph completion.The primary approaches to KGR can be broadly classified into two categories:reinforcement learning(RL)-based methods and sequence-to-sequence(seq2seq)-based methods.While each method has its own distinct advantages,they also come with inherent limitations.To leverage the strengths of each method while addressing their weaknesses,we propose a cyclical training method that alternates for several loops between the seq2seq training phase and the policy-based RL training phase using a transformer architecture.Additionally,a multimodal data encoding(MDE)module is introduced to improve the representation of entities and relations in KGs.TheMDE module treats entities and relations as distinct modalities,processing each with a dedicated network specialized for its respective modality.It then combines the representations of entities and relations in a dynamic and fine-grained manner using a gating mechanism.The experimental results from the knowledge graph completion task highlight the effectiveness of the proposed framework.Across five benchmark datasets,our framework achieves an average improvement of 1.7%in the Hits@1 metric and a 0.8%average increase in the Mean Reciprocal Rank(MRR)compared to other strong baseline methods.Notably,the maximum improvement in Hits@1 exceeds 4%,further demonstrating the effectiveness of the proposed approach. 展开更多
关键词 Knowledge graph reinforcement learning TRANSFORMER
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Subgraph Matching on Multi-Attributed Graphs Based on Contrastive Learning
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作者 LIU Bozhi FANG Xiu +1 位作者 SUN Guohao LU Jinhu 《Journal of Donghua University(English Edition)》 2025年第5期523-533,共11页
Graphs have been widely used in fields ranging from chemical informatics to social network analysis.Graph-related problems become increasingly significant,with subgraph matching standing out as one of the most challen... Graphs have been widely used in fields ranging from chemical informatics to social network analysis.Graph-related problems become increasingly significant,with subgraph matching standing out as one of the most challenging tasks.The goal of subgraph matching is to find all subgraphs in the data graph that are isomorphic to the query graph.Traditional methods mostly rely on search strategies with high computational complexity and are hard to apply to large-scale real datasets.With the advent of graph neural networks(GNNs),researchers have turned to GNNs to address subgraph matching problems.However,the multi-attributed features on nodes and edges are overlooked during the learning of graphs,which causes inaccurate results in real-world scenarios.To tackle this problem,we propose a novel model called subgraph matching on multi-attributed graph network(SGMAN).SGMAN first utilizes improved line graphs to capture node and edge features.Then,SGMAN integrates GNN and contrastive learning(CL)to derive graph representation embeddings and calculate the matching matrix to represent the matching results.We conduct experiments on public datasets,and the results affirm the superior performance of our model. 展开更多
关键词 subgraph matching graph neural network(GNN) multi-attributed graph contrastive learning(CL)
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A Knowledge-Enhanced Disease Diagnosis Method Based on Prompt Learning and BERT Integration
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作者 Zheng Zhang Hengyang Wu Na Wang 《Journal on Artificial Intelligence》 2025年第1期17-37,共21页
This paper proposes a knowledge-enhanced disease diagnosis method based on a prompt learning framework.Addressing challenges such as the complexity ofmedical terminology,the difficulty of constructingmedical knowledge... This paper proposes a knowledge-enhanced disease diagnosis method based on a prompt learning framework.Addressing challenges such as the complexity ofmedical terminology,the difficulty of constructingmedical knowledge graphs,and the scarcity of medical data,the method retrieves structured knowledge from clinical cases via external knowledge graphs.The method retrieves structured knowledge from external knowledge graphs related to clinical cases,encodes it,and injects it into the prompt templates to enhance the language model’s understanding and reasoning capabilities for the task.We conducted experiments on three public datasets:CHIP-CTC,IMCS-V2-NER,and KUAKE-QTR.The results indicate that the proposedmethod significantly outperforms existing models acrossmultiple evaluation metrics.Additionally,ablation studies confirmed the critical role of the knowledge injection module,as the removal of this module resulted in a significant drop in F1 score.The experimental results demonstrate that the proposed method not only effectively improves the accuracy of disease diagnosis but also enhances the interpretability of the predictions,providing more reliable support and evidence for clinical diagnosis. 展开更多
关键词 Knowledge enhancement disease diagnosis prompt learning BERT knowledge graph
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