Traditional Chinese medicine(TCM)exerts integrative effects on complex diseases owing to the characteristics of multiple components with multiple targets.However,the syndrome-based system of diagnosis and treatment in...Traditional Chinese medicine(TCM)exerts integrative effects on complex diseases owing to the characteristics of multiple components with multiple targets.However,the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians,which has been a major challenge in the global acceptance and application of TCM.Therefore,a standardized TCM prescription system needs to be explored to promote its clinical application.In this study,we first developed a gradient weighted disease-target-herbal ingredient-herb network to aid TCM formulation.We tested its efficacy against intracerebral hemorrhage(ICH).First,the top 100 ICH targets in the GeneCards database were screened according to their relevance scores.Then,SymMap and Traditional Chinese Medicine Systems Pharmacology(TCMSP)databases were applied to find out the target-related ingredients and ingredient-containing herbs,respectively.The relevance of the resulting ingredients and herbs to ICH was determined by adding the relevance scores of the corresponding targets.The top five ICH therapeutic herbs were combined to form a tailored TCM prescriptions.The absorbed components in the serum were detected.In a mouse model of ICH,the new prescription exerted multifaceted effects,including improved neurological function,as well as attenuated neuronal damage,cell apoptosis,vascular leakage,and neuroinflammation.These effects matched well with the core pathological changes in ICH.The multi-targets-directed gradient-weighting strategy presents a promising avenue for tailoring precise,multipronged,unbiased,and standardized TCM prescriptions for complex diseases.This study provides a paradigm for advanced achievements-driven modern innovation in TCM concepts.展开更多
Compared with traditional gravity measurement data,gravity gradient tensor data contain more high frequency information,which can be used to understand the earth's interior structure,mineral resources distribution...Compared with traditional gravity measurement data,gravity gradient tensor data contain more high frequency information,which can be used to understand the earth's interior structure,mineral resources distribution etc. In this study,the authors present an algorithm for inverting gravity gradiometer data to recover the three-dimensional( 3-D) distributions of density. Spatial gradient weighting was used to constrain the extent of the body horizontally and vertically. A more accurate inversion result can be obtained by combining the prior information into the weighting function and applying it in inversion. This method was tested on synthetic models and the inverted results showed that the resolution was significantly improved. Moreover,the algorithm was applied to the inversion of empirical data from a salt dome located in Texas,USA,which demonstrated the validity of the proposed method.展开更多
Let （M,g, e^-fdv） be a smooth metric measure space. In this paper, we con- sider two nonlinear weighted p-heat equations. Firstly, we derive a Li-Yau type gradient estimates for the positive solutions to the followi...Let （M,g, e^-fdv） be a smooth metric measure space. In this paper, we con- sider two nonlinear weighted p-heat equations. Firstly, we derive a Li-Yau type gradient estimates for the positive solutions to the following nonlinear weighted p-heat equationand f is a smooth function on M under the assumptionthat the m-dimensional nonnegative Bakry-Emery Ricci curvature. Secondly, we show an entropy monotonicity formula with nonnegative m-dimensional Bakry-Emery Ricci curva- ture which is a generalization to the results of Kotschwar and Ni [9], Li [7].展开更多
In this paper, we consider gradient estimates for positive solutions to the following weighted nonlinear parabolic equations on a complete smooth metric measure space with only Bakry-Émery Ricci tensor bounded be...In this paper, we consider gradient estimates for positive solutions to the following weighted nonlinear parabolic equations on a complete smooth metric measure space with only Bakry-Émery Ricci tensor bounded below: One is $${u_t} = {\Delta _f}u + au\log u + bu$$ with a, b two real constants, and another is $${u_t} = {\Delta _f}u + \lambda {u^\alpha }$$ with λ, α two real constants. We obtain local Hamilton-Souplet-Zhang type gradient estimates for the above two nonlinear parabolic equations. In particular, our estimates do not depend on any assumption on f.展开更多
Let M be an n-dimensional complete noncompact Riemannian manifold with sectional curvature bounded from below, dμ = e^h（x） dV（x） the weighted measure and △μ,p the weighted p-Laplacian. In this paper we consider...Let M be an n-dimensional complete noncompact Riemannian manifold with sectional curvature bounded from below, dμ = e^h（x） dV（x） the weighted measure and △μ,p the weighted p-Laplacian. In this paper we consider the non-linear elliptic equation △μ,pu=-λμ,p｜u｜^p-2ufor p ∈ （1, 2）. We derive a sharp gradient estimate for positive smooth solutions of this equation. As applications, we get a Harnack inequality and a Liouville type theorem..展开更多
This paper explores a highly accurate identification modeling approach for the ship maneuvering motion with fullscale trial. A multi-innovation gradient iterative(MIGI) approach is proposed to optimize the distance me...This paper explores a highly accurate identification modeling approach for the ship maneuvering motion with fullscale trial. A multi-innovation gradient iterative(MIGI) approach is proposed to optimize the distance metric of locally weighted learning(LWL), and a novel non-parametric modeling technique is developed for a nonlinear ship maneuvering system. This proposed method’s advantages are as follows: first, it can avoid the unmodeled dynamics and multicollinearity inherent to the conventional parametric model; second, it eliminates the over-learning or underlearning and obtains the optimal distance metric; and third, the MIGI is not sensitive to the initial parameter value and requires less time during the training phase. These advantages result in a highly accurate mathematical modeling technique that can be conveniently implemented in applications. To verify the characteristics of this mathematical model, two examples are used as the model platforms to study the ship maneuvering.展开更多
The economic benefits of transport infrastructure investment have been widely accepted.However,the varying influence of road transport development across vertical space has rarely been discussed.Taking Sichuan provinc...The economic benefits of transport infrastructure investment have been widely accepted.However,the varying influence of road transport development across vertical space has rarely been discussed.Taking Sichuan province in China as case study area where the landform is diverse and complex,administrative counties were categorized into 4 main types:plain counties,hill counties,mountain counties,and plateau counties.Using statistical data during 2006-2014,theperformanceofeconomic development and transport construction level in the four types of counties are discussed.Subsequently,the heterogeneous effect of each grade road on economy was calculated by local regression model(GWR).The results indicate that plain counties largely surpassed the other geomorphic counties in economic development level,while the gradient gap among them was on the decline.Similarly,distribution of transport infrastructure presented a decreasing trend from the low plain counties to high plateau counties.Regional imbalances were mainly reflected in the County road and Village road.Regarding the changes of regional gaps,National&Provincial roads and County roads were constantly expanding,whereas the disparity of Village road was slowly narrowing over time.Particularly noteworthy was the non-stationary economic influence of traffic factors across vertical gradients.On average,National&Provincial roads generated higher benefits in the high elevation regions than the lowlands.In contrast,County road and Village road were found to be more effective in promoting economic development in plains.With regard to local estimates of traffic factors,coefficients in mountain counties exhibited larger fluctuation ranges than other geomorphic units.The conclusions provide a basis for government decisionmaking in a more reasonable construction arrangement of road facilities and sustainable economic development.展开更多
A patch-based method for detecting vehicle logos using prior knowledge is proposed.By representing the coarse region of the logo with the weight matrix of patch intensity and position,the proposed method is robust to ...A patch-based method for detecting vehicle logos using prior knowledge is proposed.By representing the coarse region of the logo with the weight matrix of patch intensity and position,the proposed method is robust to bad and complex environmental conditions.The bounding-box of the logo is extracted by a thershloding approach.Experimental results show that 93.58% location accuracy is achieved with 1100 images under various environmental conditions,indicating that the proposed method is effective and suitable for the location of vehicle logo in practical applications.展开更多
In this paper,we consider generalized Christo®el-Minkowski problems as followsσ_(k)(u_(ij)+uδ_(ij))/σ_(l)(u_(ij)+uδ_(ij))=|u^(p-1)f(x),x∈S^(n),where 0≤l≤k≤n,p-1>0 and f is positive,and we establish the...In this paper,we consider generalized Christo®el-Minkowski problems as followsσ_(k)(u_(ij)+uδ_(ij))/σ_(l)(u_(ij)+uδ_(ij))=|u^(p-1)f(x),x∈S^(n),where 0≤l≤k≤n,p-1>0 and f is positive,and we establish the weighted gradient estimate and uniform C^(0)estimate for the positive convex even solutions,which is a generalization of Guan-Xia[1]and Guan[2].展开更多
In this article, we consider existence and nonexistence of solutions to problem {-△pu＋g（x,u）｜↓△｜^p=f in -Ω,u=0 on Ω with 1〈p〈∞ where f is a positive measurable function which is bounded away from 0 in Ω,...In this article, we consider existence and nonexistence of solutions to problem {-△pu＋g（x,u）｜↓△｜^p=f in -Ω,u=0 on Ω with 1〈p〈∞ where f is a positive measurable function which is bounded away from 0 in Ω, and the domain Ω is a smooth bounded open set in R^N（N≥2）. Especially, under the condition that g（x, s） = 1/｜s｜^α （α〉0） is singular at s = 0, we obtain that α 〈 p is necessary and sufficient for the existence of solutions in W0^1,p（Ω） to problem （0.1） when f is sufficiently regular.展开更多
Let(M,g) be a smooth compact Riemannian manifold of dimension n.Denote△f=△-▽f.▽ the weighted Laplacian operator,where f is a smooth real valued function on M.When N is finite and the N-Bakry-Emery Ricci tensor is ...Let(M,g) be a smooth compact Riemannian manifold of dimension n.Denote△f=△-▽f.▽ the weighted Laplacian operator,where f is a smooth real valued function on M.When N is finite and the N-Bakry-Emery Ricci tensor is bounded from below by a constant,we establish local gradient estimates for positive solutions of the following simple Lichnerowicz equation△fu+cu^(-α)=0 on a compact Riemannian manifold,where α is a positive constant and c is a smooth function.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.:82174259 and 82304997)China Postdoctoral Followship Program of CPSF(Grant No.:GZC20233202)+4 种基金China Postdoctoral Science Foundation(Grant No.:2024M753698)the Key Research and Development Program of Hunan Province of China(Grant Nos.:2023SK2021 and 2022SK2015)the Natural Science Foundation of Hunan Province,China(Grant Nos.:2024JJ6632,2022JJ40853,and 2021JJ31117)the Hunan Traditional Chinese Medicine Scientific Research Program,China(Grant Nos.:B2024113,B2024114,and 2021032)the Fundamental Research Funds for the Central Universities of Central South University,China(Grant No.:1053320232786).
文摘Traditional Chinese medicine(TCM)exerts integrative effects on complex diseases owing to the characteristics of multiple components with multiple targets.However,the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians,which has been a major challenge in the global acceptance and application of TCM.Therefore,a standardized TCM prescription system needs to be explored to promote its clinical application.In this study,we first developed a gradient weighted disease-target-herbal ingredient-herb network to aid TCM formulation.We tested its efficacy against intracerebral hemorrhage(ICH).First,the top 100 ICH targets in the GeneCards database were screened according to their relevance scores.Then,SymMap and Traditional Chinese Medicine Systems Pharmacology(TCMSP)databases were applied to find out the target-related ingredients and ingredient-containing herbs,respectively.The relevance of the resulting ingredients and herbs to ICH was determined by adding the relevance scores of the corresponding targets.The top five ICH therapeutic herbs were combined to form a tailored TCM prescriptions.The absorbed components in the serum were detected.In a mouse model of ICH,the new prescription exerted multifaceted effects,including improved neurological function,as well as attenuated neuronal damage,cell apoptosis,vascular leakage,and neuroinflammation.These effects matched well with the core pathological changes in ICH.The multi-targets-directed gradient-weighting strategy presents a promising avenue for tailoring precise,multipronged,unbiased,and standardized TCM prescriptions for complex diseases.This study provides a paradigm for advanced achievements-driven modern innovation in TCM concepts.
基金Supported by Project of Natural Science Fund of Jilin Province(No.20180101312JC)
文摘Compared with traditional gravity measurement data,gravity gradient tensor data contain more high frequency information,which can be used to understand the earth's interior structure,mineral resources distribution etc. In this study,the authors present an algorithm for inverting gravity gradiometer data to recover the three-dimensional( 3-D) distributions of density. Spatial gradient weighting was used to constrain the extent of the body horizontally and vertically. A more accurate inversion result can be obtained by combining the prior information into the weighting function and applying it in inversion. This method was tested on synthetic models and the inverted results showed that the resolution was significantly improved. Moreover,the algorithm was applied to the inversion of empirical data from a salt dome located in Texas,USA,which demonstrated the validity of the proposed method.
基金supported by the Fundamental Research Fund for the Central Universities
文摘Let （M,g, e^-fdv） be a smooth metric measure space. In this paper, we con- sider two nonlinear weighted p-heat equations. Firstly, we derive a Li-Yau type gradient estimates for the positive solutions to the following nonlinear weighted p-heat equationand f is a smooth function on M under the assumptionthat the m-dimensional nonnegative Bakry-Emery Ricci curvature. Secondly, we show an entropy monotonicity formula with nonnegative m-dimensional Bakry-Emery Ricci curva- ture which is a generalization to the results of Kotschwar and Ni [9], Li [7].
文摘In this paper, we consider gradient estimates for positive solutions to the following weighted nonlinear parabolic equations on a complete smooth metric measure space with only Bakry-Émery Ricci tensor bounded below: One is $${u_t} = {\Delta _f}u + au\log u + bu$$ with a, b two real constants, and another is $${u_t} = {\Delta _f}u + \lambda {u^\alpha }$$ with λ, α two real constants. We obtain local Hamilton-Souplet-Zhang type gradient estimates for the above two nonlinear parabolic equations. In particular, our estimates do not depend on any assumption on f.
基金Supported by the National Natural Science Foundation of China (11171254, 11271209)
文摘Let M be an n-dimensional complete noncompact Riemannian manifold with sectional curvature bounded from below, dμ = e^h（x） dV（x） the weighted measure and △μ,p the weighted p-Laplacian. In this paper we consider the non-linear elliptic equation △μ,pu=-λμ,p｜u｜^p-2ufor p ∈ （1, 2）. We derive a sharp gradient estimate for positive smooth solutions of this equation. As applications, we get a Harnack inequality and a Liouville type theorem..
基金financially supported in part by the National High Technology Research and Development Program of China(863Program,Grant No.2015AA016404)the National Natural Science Foundation of China(Grant Nos.51109020,51179019 and 51779029)the Fundamental Research Program for Key Laboratory of the Education Department of Liaoning Province(Grant No.LZ2015006)
文摘This paper explores a highly accurate identification modeling approach for the ship maneuvering motion with fullscale trial. A multi-innovation gradient iterative(MIGI) approach is proposed to optimize the distance metric of locally weighted learning(LWL), and a novel non-parametric modeling technique is developed for a nonlinear ship maneuvering system. This proposed method’s advantages are as follows: first, it can avoid the unmodeled dynamics and multicollinearity inherent to the conventional parametric model; second, it eliminates the over-learning or underlearning and obtains the optimal distance metric; and third, the MIGI is not sensitive to the initial parameter value and requires less time during the training phase. These advantages result in a highly accurate mathematical modeling technique that can be conveniently implemented in applications. To verify the characteristics of this mathematical model, two examples are used as the model platforms to study the ship maneuvering.
基金supported by the National Natural Science Foundation of China (Grants No. 41571523 and 41661144038)the National Basic Research Program of China (973 Program) (Grant No. 2013CBA01808)the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (Grant No. 2014BAC05B01)
文摘The economic benefits of transport infrastructure investment have been widely accepted.However,the varying influence of road transport development across vertical space has rarely been discussed.Taking Sichuan province in China as case study area where the landform is diverse and complex,administrative counties were categorized into 4 main types:plain counties,hill counties,mountain counties,and plateau counties.Using statistical data during 2006-2014,theperformanceofeconomic development and transport construction level in the four types of counties are discussed.Subsequently,the heterogeneous effect of each grade road on economy was calculated by local regression model(GWR).The results indicate that plain counties largely surpassed the other geomorphic counties in economic development level,while the gradient gap among them was on the decline.Similarly,distribution of transport infrastructure presented a decreasing trend from the low plain counties to high plateau counties.Regional imbalances were mainly reflected in the County road and Village road.Regarding the changes of regional gaps,National&Provincial roads and County roads were constantly expanding,whereas the disparity of Village road was slowly narrowing over time.Particularly noteworthy was the non-stationary economic influence of traffic factors across vertical gradients.On average,National&Provincial roads generated higher benefits in the high elevation regions than the lowlands.In contrast,County road and Village road were found to be more effective in promoting economic development in plains.With regard to local estimates of traffic factors,coefficients in mountain counties exhibited larger fluctuation ranges than other geomorphic units.The conclusions provide a basis for government decisionmaking in a more reasonable construction arrangement of road facilities and sustainable economic development.
文摘A patch-based method for detecting vehicle logos using prior knowledge is proposed.By representing the coarse region of the logo with the weight matrix of patch intensity and position,the proposed method is robust to bad and complex environmental conditions.The bounding-box of the logo is extracted by a thershloding approach.Experimental results show that 93.58% location accuracy is achieved with 1100 images under various environmental conditions,indicating that the proposed method is effective and suitable for the location of vehicle logo in practical applications.
基金Supported by National Natural Science Foundation of China(12171260).
文摘In this paper,we consider generalized Christo®el-Minkowski problems as followsσ_(k)(u_(ij)+uδ_(ij))/σ_(l)(u_(ij)+uδ_(ij))=|u^(p-1)f(x),x∈S^(n),where 0≤l≤k≤n,p-1>0 and f is positive,and we establish the weighted gradient estimate and uniform C^(0)estimate for the positive convex even solutions,which is a generalization of Guan-Xia[1]and Guan[2].
基金supported by the Natural Science Foundation of Henan Province(15A110050)
文摘In this article, we consider existence and nonexistence of solutions to problem {-△pu＋g（x,u）｜↓△｜^p=f in -Ω,u=0 on Ω with 1〈p〈∞ where f is a positive measurable function which is bounded away from 0 in Ω, and the domain Ω is a smooth bounded open set in R^N（N≥2）. Especially, under the condition that g（x, s） = 1/｜s｜^α （α〉0） is singular at s = 0, we obtain that α 〈 p is necessary and sufficient for the existence of solutions in W0^1,p（Ω） to problem （0.1） when f is sufficiently regular.
文摘Let(M,g) be a smooth compact Riemannian manifold of dimension n.Denote△f=△-▽f.▽ the weighted Laplacian operator,where f is a smooth real valued function on M.When N is finite and the N-Bakry-Emery Ricci tensor is bounded from below by a constant,we establish local gradient estimates for positive solutions of the following simple Lichnerowicz equation△fu+cu^(-α)=0 on a compact Riemannian manifold,where α is a positive constant and c is a smooth function.
