Objective To investigate the correlation between the clinical features and endoscopic ultrasound-guided portal pressure gradient(EUS-PPG)in patients with cirrhosis.Methods A total of 148 patients with cirrhosis and po...Objective To investigate the correlation between the clinical features and endoscopic ultrasound-guided portal pressure gradient(EUS-PPG)in patients with cirrhosis.Methods A total of 148 patients with cirrhosis and portal hypertension who underwent EUS-PPG measurement at the Third Xiangya Hospital of Central South University from March 15,2022 to June 20,2023 were selected.The clinical data of patients collected before EUS-PPG measurement were analyzed.Variations in the EUS-PPG across different clinical data subgroups were analyzed.Multivariate linear regression analysis was used to explore the independent factors influencing EUS-PPG.Results The EUS-PPG was significantly elevated in patients exhibiting red signs(16.62±5.33 mmHg VS 13.44±5.34 mmHg,t=3.616,P<0.001),gastroesophageal varices(15.78±5.30 mmHg VS 9.70±4.77 mmHg,t=4.247,P<0.001),hepatic encephalopathy(20.83±7.52 mmHg VS 14.92±5.35 mmHg,t=2.606,P=0.010),thrombocytopenia(15.66±5.39 mmHg VS 13.29±5.83mmHg,t=2.136,P=0.034),hypoproteinemia(16.13±5.86 mmHg VS 14.12±5.03 mmHg,t=2.230,P=0.027),and an increased international normalized ratio(16.25±6.00 mmHg VS 14.40±5.11mmHg,t=2.022,P=0.045).Conversely,the EUS-PPG was significantly reduced in patients with a history of splenectomy and devascularization(13.17±5.88mmHgVS15.73±5.34mmHg,t=-2.379,P=0.019).The EUS-PPG in patients with varying degrees of ascites(no VS slight VS moderate or severe:13.40±5.48 mmHg VS 15.90±5.49 mmHg VS 16.69±5.17 mmHg,F=5.188,P=0.007)and different Child-Pugh classifications(A VS B VS C:14.07±5.05 mmHg VS 15.69±5.74 mmHg VS 17.64±5.99 mmHg,F=3.066,P=0.049)increased gradually.Multivariable linear regression analysis showed that red signs(β=2.44,t=2.732,P=0.007),gastroesophageal varices(β=4.45,t=2.990,P=0.003),ascites(β=1.75,t=2.368,P=0.019),and hepatic encephalopathy(β=5.82,t=2.644,P=0.009)were independentftactors fortheelevated1EUS-PPG.Conclusion There is a significant correlation between EUS-PPG and the clinical features related to the severity of cirrhotic portal hypertension,which indicates the feasibility of EUS-PPG in evaluating cirrhotic portal hypertension.展开更多
文摘Objective To investigate the correlation between the clinical features and endoscopic ultrasound-guided portal pressure gradient(EUS-PPG)in patients with cirrhosis.Methods A total of 148 patients with cirrhosis and portal hypertension who underwent EUS-PPG measurement at the Third Xiangya Hospital of Central South University from March 15,2022 to June 20,2023 were selected.The clinical data of patients collected before EUS-PPG measurement were analyzed.Variations in the EUS-PPG across different clinical data subgroups were analyzed.Multivariate linear regression analysis was used to explore the independent factors influencing EUS-PPG.Results The EUS-PPG was significantly elevated in patients exhibiting red signs(16.62±5.33 mmHg VS 13.44±5.34 mmHg,t=3.616,P<0.001),gastroesophageal varices(15.78±5.30 mmHg VS 9.70±4.77 mmHg,t=4.247,P<0.001),hepatic encephalopathy(20.83±7.52 mmHg VS 14.92±5.35 mmHg,t=2.606,P=0.010),thrombocytopenia(15.66±5.39 mmHg VS 13.29±5.83mmHg,t=2.136,P=0.034),hypoproteinemia(16.13±5.86 mmHg VS 14.12±5.03 mmHg,t=2.230,P=0.027),and an increased international normalized ratio(16.25±6.00 mmHg VS 14.40±5.11mmHg,t=2.022,P=0.045).Conversely,the EUS-PPG was significantly reduced in patients with a history of splenectomy and devascularization(13.17±5.88mmHgVS15.73±5.34mmHg,t=-2.379,P=0.019).The EUS-PPG in patients with varying degrees of ascites(no VS slight VS moderate or severe:13.40±5.48 mmHg VS 15.90±5.49 mmHg VS 16.69±5.17 mmHg,F=5.188,P=0.007)and different Child-Pugh classifications(A VS B VS C:14.07±5.05 mmHg VS 15.69±5.74 mmHg VS 17.64±5.99 mmHg,F=3.066,P=0.049)increased gradually.Multivariable linear regression analysis showed that red signs(β=2.44,t=2.732,P=0.007),gastroesophageal varices(β=4.45,t=2.990,P=0.003),ascites(β=1.75,t=2.368,P=0.019),and hepatic encephalopathy(β=5.82,t=2.644,P=0.009)were independentftactors fortheelevated1EUS-PPG.Conclusion There is a significant correlation between EUS-PPG and the clinical features related to the severity of cirrhotic portal hypertension,which indicates the feasibility of EUS-PPG in evaluating cirrhotic portal hypertension.
