The Linglong gold ore field is situated in the northwestern region of the Jiaodong gold province,China,with over 1000 tons of gold resources.Although the metallogenic mechanism and fluid sources of the Linglong gold d...The Linglong gold ore field is situated in the northwestern region of the Jiaodong gold province,China,with over 1000 tons of gold resources.Although the metallogenic mechanism and fluid sources of the Linglong gold deposit have been the subject of extensive discussion and analyzed by numerous scholars,a definitive conclusion remains elusive.The Jiuqu Au deposit is a significant metallogenic area in the eastern part of the Linglong gold ore field,characterized as a quartz vein-type gold deposit.Gold mineralization in the Jiuqu gold deposit is classified into four stages,primarily occurring within the Late Jurassic Linglong granite and Early Cretaceous Guojialing granodiorite.Pyrite,the primary gold-bearing mineral at the Jiuqu Gold Mine,has been present throughout the metallogenic period,is rich in a variety of trace elements and is closely related to the formation of gold ore.This study focused on evaluating pyrite from the essential metallogenic stages(Stages Ⅰ-Ⅲ)of the Jiuqu gold deposit using scanning electron microscopy(SEM),electron microprobe analysis(EMPA),laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and laser ablation multi-collector inductively coupled plasma mass spectrometry(LA-MC-ICP-MS) sulfur isotope analysis and detection.The work aimed to reconstruct the origin of metallogenic materials and the evolution of ore-forming fluids and to restrict the genesis of the deposit.Pyrite exhibits discernible alterations in both shape and crystal structure as it progresses through its ore-forming stages.The aforementioned stages can be delineated as follows:type 1 pyrite(PyⅠ),developed in the initial ore stage,is characterized by coarse-to-medium-grained euhedral pyrite in Stage Ⅰ;type 2 pyrite(PyⅡ),developed in the second ore stage,appears during the middle stage of mineralization and is characterized by subhedral or anhedral pyrite;type 3 pyrite(PyⅢ),developed in the third ore stage,primarily occurred in the late-middle stages of mineralization.It is fragmented and coexists with various metal sulfides,including chalcopyrite,sphalerite and galena.The in situ major and elemental compositions of pyrites at Jiuqu indicate that Au,in the form of visible gold,exists in pyrites with low Au and Ag contents throughout all stages.PyⅠ had lower Pb,Bi,Co and Ni contents than those of PyⅡ.PyⅢ displayed decreased Pb,Bi,Co and Ni levels compared with PyⅡ.The δ34S values of the PyⅠ,PyⅡ and PyⅢ pyrite stages ranged from 7.19% to 8.71%,6.24% to 7.68% and 7.66% to 8.07%,respectively.According to the structural and geochemical analysis of pyrite,the ore-forming fluid of the Jiuqu gold deposit was derived from a magmatic-hydrothermal formation created by enriched lithospheric mantle-derived magma,mixing S from Precambrian metamorphic rocks.Previous studies on the H-O isotopes of quartz in the region's ores have indicated the presence of primary magma water.Additionally,studies concerning the C-O isotopes of carbonate minerals in ores have suggested that C may have originated from the mantle.Fluid migration and water-rock interaction resulted in sulfide and gold precipitation.In the Late Meosozoic,lithospheric thinning of eastern North China Craton led to up welling of astheno spheric mantle and partial melting of lithospheric mantle in the Jiaodong area.Under tectonic changes,magmatic-hydro thermal fluid migrated upward along fault structures to form a gold province.展开更多
In the Fatira(Abu Zawal)mine area,located in the northern Eastern Desert of Egypt,fieldwork and mineralogical analysis,integrated with machine learning techniques applied to Landsat-8 OLI,ASTER,and Sentinel-2 multi-sp...In the Fatira(Abu Zawal)mine area,located in the northern Eastern Desert of Egypt,fieldwork and mineralogical analysis,integrated with machine learning techniques applied to Landsat-8 OLI,ASTER,and Sentinel-2 multi-spectral imagery(MSI)data delineate gold-sulfide mineralization in altered rocks.Gold(Au)anomalies in hydrothermal breccias and quartz veins are associated with NE-oriented felsite dykes and silicified granitic rocks.Two main alteration types are identified:a pyrite-sericite-quartz and a sulfide-chlorite-carbonate assemblage,locally with dispersed free-milling Au specks.Dimensionality reduction techniques,including principal component analysis(PCA)and independent component analysis(ICA),enabled mapping of alteration types.Sentinel-2 PC125 composite images offered efficient lithological differentiation,while supervised classifications,i.e.,the support vector machine(SVM)of Landsat-8 yielded an accuracy of 88.55%and a Kappa value of 0.86.ASTER mineral indices contributed to map hydrothermal alteration mineral phases,including sericite,muscovite,kaolinite,and iron oxides.Results indicate that post-magmatic epigenetic hydrothermal activity significantly contributed to the Au-sulfide mineralization in the Fatira area,distinguishing it from the more prevalent orogenic gold deposits in the region.展开更多
In October 2024,the Ministry of Natural Resources of PRC released the 2024 China Mineral Resources Report,which focuses on new progress since 2023 in the geological and mineral survey and evaluation,mineral resource e...In October 2024,the Ministry of Natural Resources of PRC released the 2024 China Mineral Resources Report,which focuses on new progress since 2023 in the geological and mineral survey and evaluation,mineral resource exploration and development,mine ecological restoration,green mine construction,new changes in mineral resource policies and regulations,new measures in mineral resource management,new situations in scientific and technological innovation,as well as the new achievements of the international geological and mineral cooperation.展开更多
Enhancing the mining speed of a working face has become the primary approach to achieve high production and efficiency in coal mines,thereby further improving the production capacity.However,the problem of rock bursts...Enhancing the mining speed of a working face has become the primary approach to achieve high production and efficiency in coal mines,thereby further improving the production capacity.However,the problem of rock bursts resulting from this approach has become increasingly serious.Therefore,to implement coal mine safety and efficient extraction,the impact of deformation pressure caused by different mining speeds should be considered,and a reasonable mining speed of the working face should be determined.The influence of mining speed on overlying rock breaking in the stope is analyzed by establishing a key layer block rotation and subsidence model.Results show that with the increasing mining speed,the compression amount of gangue in the goaf decreases,and the rotation and subsidence amount of rock block B above goaf decreases,forcing the rotation and subsidence amount of rock block A above roadway to increase.Consequently,the contact mode between rock block A and rock block B changes from line contact to point contact,and the horizontal thrust and shear force between blocks increase.The increase in rotation and subsidence of rock block A intensifies the compression degree of coal and rock mass below the key layer,thereby increasing the stress concentration degree of coal and rock mass as well as the total energy accumulation.In addition,due to the insufficient compression of gangue in the goaf,the bending and subsidence space of the far-field key layer are limited,the length of the suspended roof increases,and the influence range of mining stress and the energy accumulation range expand.Numerical test results and underground microseismic monitoring results verify the correlation between mining speed and stope energy,and high-energy events generally appear 1-2 d after the change in mining speed.On this basis,the statistical principle confirms that the maximum mining speed of the working face at 6 m/d is reasonable.展开更多
In the context of increasing demand for coal mine resources in China’s current socio-economic development,traditional mining methods have been difficult to effectively meet the requirements of safety production and e...In the context of increasing demand for coal mine resources in China’s current socio-economic development,traditional mining methods have been difficult to effectively meet the requirements of safety production and environmental protection.As a result,coal mine filling mining technology has emerged,which can effectively achieve the goal of controlling surface subsidence in practical applications,while also significantly improving the recovery rate of coal resources.Based on this,this study will first elaborate on the characteristics of filling mining technology,and then analyze the key points of the application of supporting technology for mechanical and electrical equipment in the corresponding working face based on actual cases,in order to provide support for improving the efficiency of coal mining.展开更多
Spectral analysis technology can identify minerals and their compositions based on spectral absorption characteristics.With hyperspectral remote sensing data,alteration minerals mapping in the wild range could be used...Spectral analysis technology can identify minerals and their compositions based on spectral absorption characteristics.With hyperspectral remote sensing data,alteration minerals mapping in the wild range could be used for mineral pro specting.However,whether hyperspectral data with low spatial resolution can be used in the exploration of small-scale deposits is worth discussing.The Bijia Mountain deposit is a small-scale epithermal gold deposit located in the Daha-nanhu island arc belt in northern China,which has great potential for porphyry and epithermal gold-copper deposit prospecting.The alteration minerals distri-bution on surface and core samples was analyzed with hyperspectral data(GF-5 and EMIT)and a spectrometer.The alteration minerals,as well as the com position of sericite and chlorite,were identified using a tool developed with Python programming based on the Tetracorder algorithm.The mapping re-sult showed the alteration zones:advanced argillic alteration(alunite+pyro-phyllite+kaolinite)in the core of the mine,argillic alteration(sericite+mont-morillonite),and propylitization alteration(chlorite+calcite).The composition of sericite and chlorite and the connections between mineralization and altera-tion minerals were discussed with high-sulfur epithermal metallogenic theory in this paper.展开更多
Processes supported by process-aware information systems are subject to continuous and often subtle changes due to evolving operational,organizational,or regulatory factors.These changes,referred to as incremental con...Processes supported by process-aware information systems are subject to continuous and often subtle changes due to evolving operational,organizational,or regulatory factors.These changes,referred to as incremental concept drift,gradually alter the behavior or structure of processes,making their detection and localization a challenging task.Traditional process mining techniques frequently assume process stationarity and are limited in their ability to detect such drift,particularly from a control-flow perspective.The objective of this research is to develop an interpretable and robust framework capable of detecting and localizing incremental concept drift in event logs,with a specific emphasis on the structural evolution of control-flow semantics in processes.We propose DriftXMiner,a control-flow-aware hybrid framework that combines statistical,machine learning,and process model analysis techniques.The approach comprises three key components:(1)Cumulative Drift Scanner that tracks directional statistical deviations to detect early drift signals;(2)a Temporal Clustering and Drift-Aware Forest Ensemble(DAFE)to capture distributional and classification-level changes in process behavior;and(3)Petri net-based process model reconstruction,which enables the precise localization of structural drift using transition deviation metrics and replay fitness scores.Experimental validation on the BPI Challenge 2017 event log demonstrates that DriftXMiner effectively identifies and localizes gradual and incremental process drift over time.The framework achieves a detection accuracy of 92.5%,a localization precision of 90.3%,and an F1-score of 0.91,outperforming competitive baselines such as CUSUM+Histograms and ADWIN+Alpha Miner.Visual analyses further confirm that identified drift points align with transitions in control-flow models and behavioral cluster structures.DriftXMiner offers a novel and interpretable solution for incremental concept drift detection and localization in dynamic,process-aware systems.By integrating statistical signal accumulation,temporal behavior profiling,and structural process mining,the framework enables finegrained drift explanation and supports adaptive process intelligence in evolving environments.Its modular architecture supports extension to streaming data and real-time monitoring contexts.展开更多
Up to now,“Turn-on”fluorescence sensor exhibits promising potential toward the detection of heavy metal ions,anions,drugs,organic dyes,DNA,pesticides,and other amino acids due to their simple,quick detection,and hig...Up to now,“Turn-on”fluorescence sensor exhibits promising potential toward the detection of heavy metal ions,anions,drugs,organic dyes,DNA,pesticides,and other amino acids due to their simple,quick detection,and high sensitivity and selectivity.Herein,a novel fluorescence method of detecting Cr^(3+)in an aqueous solution was described based on the fluorescence resonance energy transfer between rhodamine B(Rh B)and gold nanoparticles(Au NPs).The fluorescence of Rh B solution could be obviously quenched(“off”state)with the presence of citrate-stabilized Au NPs.However,upon addition of Cr^(3+)to Au NPs@Rh B system,the fluorescence of Au NPs was recovered owing to the strong interaction between Cr^(3+)and the specific groups on the surface of citrate-stabilized Au NPs,which will lead to the aggregation of Au NPs(“on”state).At this point,the color of the reaction solution turned to black.Under optimal conditions,the limit of detection(LOD)for Cr^(3+)was 0.95 n M(signal-to-noise ratio,S/N=3)with a linear range of 0.164 n M to 3.270μM.Furthermore,the proposed method exhibits excellent performances,such as rapid analysis,high sensitivity,extraordinary selectivity,easy preparation,switch-on fluorescence response,and non-time consuming.展开更多
Coal mine underground reservoir(CMUR) technology mitigates water scarcity in China's coal-rich western regions but lacks tailored solutions for steeply inclined coal seams.This study develops a novel framework of ...Coal mine underground reservoir(CMUR) technology mitigates water scarcity in China's coal-rich western regions but lacks tailored solutions for steeply inclined coal seams.This study develops a novel framework of steeply inclined coal mine underground reservoirs(SICMUR),which is a paradigm shift from conventional CMUR that the coal seam itself serves as the reservoir floor,challenging conventional designs due to depth-dependent permeability and mechanical constraints.Triaxial mechanical-seepage tests on Xinjiang Wudong coal samples(100,200,300 m depths) revealed a 3.5 MPa triaxial strength increase per 100 m depth and a 58-fold post-peak permeability surge at 300 versus 100 m.Similar model simulations revealed mining-induced stress redistribution and significant deformation effects,particularly subsidence and water-conducting fractures during lower coal seam mining.Results indicate a minimum 40 m safety distance between reservoirs and lower coal seams.Critical construction parameters were investigated for Wudong mine SICMUR as collapse zone heights(9.9–12.31 m) and waterconducting fracture zone heights(31.96–37.40 m).This work systematically bridges SICMUR concepts to field implementation,offering a framework for water preservation in steeply inclined mining while addressing safety concerns,providing a new approach for water reservation in steeply inclined coal mining.展开更多
The Boulon Djounga eastern perimeter is part of the Tiawa operating permit of the Société des Mines du Liptako (SML), located in the central southwestern part of Liptako (Niger). In this study, we used field...The Boulon Djounga eastern perimeter is part of the Tiawa operating permit of the Société des Mines du Liptako (SML), located in the central southwestern part of Liptako (Niger). In this study, we used field data, Reverse Circulation (RC) surveys and chemical analyzes of gold to determine the characteristics of gold and its mineralization style. The eastern perimeter of Boulon Djounga is represented by a succession of metabasalts and metasediments both intersected by intrusions of quartz and dolerite dykes, and covered by sandstone and clayey rocks. Gold is present in low contents (0.00 - 0.30 ppm) in the sedimentary cover and in medium (0.30 - 1.00 ppm) or high contents (1.00 - 4.534 ppm) in the metasediments, and in the gray quartz veins and locally in the volcanics. It exists in a disseminated state or in a concentrated state in the surrounding areas in the form of discrete grains associated with sulphurous minerals (pyrite: FeS<sub>2</sub>, chalcopyrite: CuFeS<sub>2</sub> or arsenopyrite: FeAsS). The presence of gold in the quartz veins, and the NE-SW and NW-SE orientations of the ore bodies suggest that the eastern Boulon Djounga gold mineralization would be established during a late magmatic extensive phase.展开更多
The Taishang-Shuiwangzhuang gold deposit is located in the southeastern margin of Linglong gold field in the northern part of the Zhaoping Fault metallogenic belt of the Jiaodong gold province-the world’s third-large...The Taishang-Shuiwangzhuang gold deposit is located in the southeastern margin of Linglong gold field in the northern part of the Zhaoping Fault metallogenic belt of the Jiaodong gold province-the world’s third-largest gold metallogenic area.Major prospecting breakthroughs have been made at the depth of 600‒2500 m in recent years,with cumulative proven gold resources exceeding 700 t.Based on a large number of exploration data,the main characteristics of the deposit are described in detail,and the spatial coupling relationship between ore-controlling fault and main orebodies is discussed.The main orebodies occur as regular large veins,exhibiting branching and combination,expansion and contraction,and pinch-out and reoccurrence.They extend in a gentle wave pattern along their strikes and dip directions and generally have a pitch direction of NEE and a plunge direction of NEE.As the ore-controlling fault,the Zhaoping Fault has the characteristics of wave-like fluctuation,with its dip angle presenting three steps of steep-slow transition within the depth range of 2500 m.The gold mineralization enrichment area is mainly distributed in the step parts where the fault plane changes from steeply to gently.The ore-forming age,ore-forming fluid and ore-forming material sources and the genesis of the ore deposit are analyzed based on the research results of ore deposit geochemistry.The ore-forming fluids were H_(2)O-CO_(2)-NaCl-type hydrothermal solutions with a medium-low temperature and medium-low salinity.The H-O isotopic characteristics indicate that the fluids in the early ore-forming stage were possibly formed by degassing of basic magma and that meteoric water gradually entered the ore-forming fluids in the late ore-forming stage.The S and Pb isotopes indicate that the ore-forming materials mainly originate from the lower crust and contain a small quantity of mantle-derived components.The comprehensive analysis shows that the Taishang-shuiwangzhuang gold deposit was a typical“Jiaodong type”gold deposit.The strong crust-mantle interactions,large-scale magmatism,and the material exchange arising from the transformation from the ancient lower crust to the juvenile lower crust during the Early Cretaceous provided abundant fluids and material sources for mineralization.Moreover,the detachment faults formed by the rapid magmatic uplift and the extensional tectonism created favorable temperature and pressure conditions and space for fluid accumulation and gold precipitation and mineralization.展开更多
Since the first discovery of gold deposits on the northeastern margin of the Jiaolai Basin in Shandong Province at the end of the 20^(th) century,seven medium-sized to large/super-large gold deposits have been identif...Since the first discovery of gold deposits on the northeastern margin of the Jiaolai Basin in Shandong Province at the end of the 20^(th) century,seven medium-sized to large/super-large gold deposits have been identified in this region,with cumulative proven gold resources of 223 t.This study reviewed the metallogenic and geochemical characteristics of various gold deposits in this region,examined the sources of their ore-forming fluids and materials,as well as their gold metallogenic epochs and processes,and developed a gold metallogenic model.The gold deposits in this region are governed by both dense fractures and detachment structural systems along basin margins,primarily categorized into the altered rock type and the pyrite-bearing carbonate vein type.The latter type,a recently discovered mineralization type in the Jiaodong Peninsula,enjoys high gold grade,a large scale,and high gold mineral fineness,suggesting considerable prospecting potential.Both types of gold deposits show metallogenic epochs ranging from 116 Ma to 119 Ma.Their ore-forming fluids are identified as a CO_(2)-NaCl-H_(2)O fluid system characterized by moderate to low temperatures,moderate to low salinity,and low density,with the pyrite-bearing carbonate vein-type gold deposits manifesting slightly higher salinity.The C-H-O,S,and Pb isotopes of hydrothermal minerals reveal that the ore-forming fluids and materials are characteristic of crust-mantle mixing.Specifically,they were derived from mantle fluids in the early stages,mixed with stratum water and meteoric water in the later stages for mineralization.The gold metallogenic process is identified as follows:During the Early Cretaceous,the subduction of the Pacific Plate and the destruction of the North China Craton led to asthenospheric upwelling.The resulting fluids,after metasomatizing the enriched mantle,differentiated and evolved into C-H-O ore-bearing fluids,which were then mixed with crustal fluids.The mixed fluids migrated to the shallow crust,where they mingled with stratum water and meteoric water.Then,the fluids underwent unloading and final mineralization in detachment fault tectonic systems on basin margins.Due to differences in mixed crustal materials or the surrounding rocks involved in water-rock interactions,altered rock-and pyrite-bearing carbonate vein-type gold deposits were formed in acidic and alkaline fluid environments,respectively.展开更多
Mining-induced surface deformation disrupts ecological balance and impedes economic progress.This study employs SBAS-InSAR with 107-view of ascending and descending SAR data from Sentinel-1,spanning February 2017 to S...Mining-induced surface deformation disrupts ecological balance and impedes economic progress.This study employs SBAS-InSAR with 107-view of ascending and descending SAR data from Sentinel-1,spanning February 2017 to September 2020,to monitor surface deformation in the Fa’er Coal Mine,Guizhou Province.Analysis on the surface deformation time series reveals the relationship between underground mining and surface shifts.Considering geological conditions,mining activities,duration,and ranges,the study determines surface movement parameters for the coal mine.It asserts that mining depth significantly influences surface movement parameters in mountainous mining areas.Increasing mining depth elevates the strike movement angle on the deeper side of the burial depth by 22.84°,while decreasing by 7.74°on the shallower side.Uphill movement angles decrease by 4.06°,while downhill movement angles increase by 15.71°.This emphasizes the technology's suitability for local mining design,which lays the groundwork for resource development,disaster prevention,and ecological protection in analogous contexts.展开更多
The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and ...The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of "pre-splitting cutting roof + NPR anchor cable"(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway.展开更多
The exploration of undersea resources becomes popular as land resources decrease. Researches were conducted with emphasis on the safety and efficiency of undersea mining of the large gold deposit in Xinli District of ...The exploration of undersea resources becomes popular as land resources decrease. Researches were conducted with emphasis on the safety and efficiency of undersea mining of the large gold deposit in Xinli District of Sanshandao Gold Mine. A series of tests for the physical and mechanical characteristics of rock mass were carried out, and the three-dimensional geo-stress distribution was tested in the mining area. Further, a similar experimental simulation platform, which revealed the mechanism of water inrush and ascertained the reason- able thickness of the safety isolate layer, was established for the undersea mining. Meanwhile, the feasibility of cancelling the ore pillars and the safety conditions was checked by numerical simulation. The simulation results show that it is safe to exploit the ore body below the -85 m level （presently, the exploitation level is below -160 m in Xinli District）, and the ore pillars can be cancelled below the -560 m level. Fur- thermore, a novel backfill method was designed to reduce the rock strata disturbance and settlement, and the settlement of roof strata was monitored during the mining process. Engineering practice shows that the settlement of roof strata was small and that no disaster happened. This indicates that the undersea safety mining technology of the large gold deposit is achieved in Xinli District.展开更多
Metal mineral resources play an indispensable role in the development of the national economy.Dynamic disasters in underground metal mines seriously threaten mining safety,which are major scientific and technological ...Metal mineral resources play an indispensable role in the development of the national economy.Dynamic disasters in underground metal mines seriously threaten mining safety,which are major scientific and technological problems to be solved urgently.In this article,the occurrence status and grand challenges of some typical dynamic disasters involving roof falling,spalling,collapse,large deformation,rockburst,surface subsidence,and water inrush in metal mines in China are systematically presented,the characteristics of mining-induced dynamic disasters are analyzed,the examples of dynamic disasters occurring in some metal mines in China are summarized,the occurrence mechanism,monitoring and early warning methods,and prevention and control techniques of these disasters are highlighted,and some new opinions,suggestions,and solutions are proposed simultaneously.Moreover,some shortcomings in current disaster research are pointed out,and the direction of efforts to improve the prevention and control level of dynamic disasters in China’s metal mines in the future is prospected.The integration of forward-looking key innovative theories and technologies in the abovementioned aspects will greatly enhance the cognitive level of disaster prevention and mitigation in China’s metal mining industry and achieve a significant shift from passive disaster relief to active disaster prevention.展开更多
Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and mortality.Even after maximum tumor resection assistance with a radiotherapy and chemotherapy combination,the r...Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and mortality.Even after maximum tumor resection assistance with a radiotherapy and chemotherapy combination,the recurrence of non-small cell lung cancer is still inevitable.In addition,low targeting efficiency and poor permeability of drug delivery systems strongly affect the therapeutic efficiency of anti-cancer drugs on non-small cell lung cancer.Here we designed a gemcitabine(GEM)loaded arginineglycine-aspartic acid-cysteine(RGDc)-modified gold mineralization“hybrid nanozyme bomb”(RGTG)to overcome those obstacles.RGDc modification improved the active targeting of liposomes to the tumor tissues with the second near-infrared(NIR-Ⅱ)-triggered gold-shell disruption and GEM release.The collapsed gold-shell particles with a smaller size could penetrate the tumor solid barrier and act as photothermal therapy(PTT)agents to improve PTT therapy and starvation therapy via generating gluconic acid and reactive oxygen species(ROS).Moreover,the resting reversal effect of gold particles on tumor fibroblasts can achieve accelerating tumor penetration of gold particles and GEM.Compared to monotherapy,RGTG showed significant improvement in tumor inhibition,with a tumor volume reduction of 83%compared to the control group,which provides a promising tumor treatment platform for non-small cell lung cancer(NSCLC).展开更多
To predict rock burst in deep mining excavation in Linglong gold mine, systematical laboratory tests of mechanical properties of rock, in situ stress measurement and 3-D FEM analysis on energy distribution in rock mas...To predict rock burst in deep mining excavation in Linglong gold mine, systematical laboratory tests of mechanical properties of rock, in situ stress measurement and 3-D FEM analysis on energy distribution in rock mass surrounding deep mining rooms were carried out. According to various prediction criteria of rock burst, it is concluded that rock burst is liable to occur during deep mining excavation in the mine.展开更多
基金supported by the National Natural Science Foundation of China(42273063)the Young Elite Scientists Sponsorship(YESS)Program of the China Association for Science and Technology(YESS20220661)+1 种基金Fundamental Research Funds for Central Universities(FRF-IDRY-23-004)the Natural Science Foundation of Shandong Province,China(ZR2022QD050).
文摘The Linglong gold ore field is situated in the northwestern region of the Jiaodong gold province,China,with over 1000 tons of gold resources.Although the metallogenic mechanism and fluid sources of the Linglong gold deposit have been the subject of extensive discussion and analyzed by numerous scholars,a definitive conclusion remains elusive.The Jiuqu Au deposit is a significant metallogenic area in the eastern part of the Linglong gold ore field,characterized as a quartz vein-type gold deposit.Gold mineralization in the Jiuqu gold deposit is classified into four stages,primarily occurring within the Late Jurassic Linglong granite and Early Cretaceous Guojialing granodiorite.Pyrite,the primary gold-bearing mineral at the Jiuqu Gold Mine,has been present throughout the metallogenic period,is rich in a variety of trace elements and is closely related to the formation of gold ore.This study focused on evaluating pyrite from the essential metallogenic stages(Stages Ⅰ-Ⅲ)of the Jiuqu gold deposit using scanning electron microscopy(SEM),electron microprobe analysis(EMPA),laser ablation inductively coupled plasma mass spectrometry(LA-ICP-MS) and laser ablation multi-collector inductively coupled plasma mass spectrometry(LA-MC-ICP-MS) sulfur isotope analysis and detection.The work aimed to reconstruct the origin of metallogenic materials and the evolution of ore-forming fluids and to restrict the genesis of the deposit.Pyrite exhibits discernible alterations in both shape and crystal structure as it progresses through its ore-forming stages.The aforementioned stages can be delineated as follows:type 1 pyrite(PyⅠ),developed in the initial ore stage,is characterized by coarse-to-medium-grained euhedral pyrite in Stage Ⅰ;type 2 pyrite(PyⅡ),developed in the second ore stage,appears during the middle stage of mineralization and is characterized by subhedral or anhedral pyrite;type 3 pyrite(PyⅢ),developed in the third ore stage,primarily occurred in the late-middle stages of mineralization.It is fragmented and coexists with various metal sulfides,including chalcopyrite,sphalerite and galena.The in situ major and elemental compositions of pyrites at Jiuqu indicate that Au,in the form of visible gold,exists in pyrites with low Au and Ag contents throughout all stages.PyⅠ had lower Pb,Bi,Co and Ni contents than those of PyⅡ.PyⅢ displayed decreased Pb,Bi,Co and Ni levels compared with PyⅡ.The δ34S values of the PyⅠ,PyⅡ and PyⅢ pyrite stages ranged from 7.19% to 8.71%,6.24% to 7.68% and 7.66% to 8.07%,respectively.According to the structural and geochemical analysis of pyrite,the ore-forming fluid of the Jiuqu gold deposit was derived from a magmatic-hydrothermal formation created by enriched lithospheric mantle-derived magma,mixing S from Precambrian metamorphic rocks.Previous studies on the H-O isotopes of quartz in the region's ores have indicated the presence of primary magma water.Additionally,studies concerning the C-O isotopes of carbonate minerals in ores have suggested that C may have originated from the mantle.Fluid migration and water-rock interaction resulted in sulfide and gold precipitation.In the Late Meosozoic,lithospheric thinning of eastern North China Craton led to up welling of astheno spheric mantle and partial melting of lithospheric mantle in the Jiaodong area.Under tectonic changes,magmatic-hydro thermal fluid migrated upward along fault structures to form a gold province.
基金the National Science Foundation of China (Grant No. NSFC: 92162213)the Geology Department Faculty of Science of Al-Azhar University (Assiut Branch)+2 种基金the China Scholarship CouncilChang'an UniversityIstanbul Technical University's Scientific Research Project (BAP Project ID: 45396, code: FHD-2024-45396)
文摘In the Fatira(Abu Zawal)mine area,located in the northern Eastern Desert of Egypt,fieldwork and mineralogical analysis,integrated with machine learning techniques applied to Landsat-8 OLI,ASTER,and Sentinel-2 multi-spectral imagery(MSI)data delineate gold-sulfide mineralization in altered rocks.Gold(Au)anomalies in hydrothermal breccias and quartz veins are associated with NE-oriented felsite dykes and silicified granitic rocks.Two main alteration types are identified:a pyrite-sericite-quartz and a sulfide-chlorite-carbonate assemblage,locally with dispersed free-milling Au specks.Dimensionality reduction techniques,including principal component analysis(PCA)and independent component analysis(ICA),enabled mapping of alteration types.Sentinel-2 PC125 composite images offered efficient lithological differentiation,while supervised classifications,i.e.,the support vector machine(SVM)of Landsat-8 yielded an accuracy of 88.55%and a Kappa value of 0.86.ASTER mineral indices contributed to map hydrothermal alteration mineral phases,including sericite,muscovite,kaolinite,and iron oxides.Results indicate that post-magmatic epigenetic hydrothermal activity significantly contributed to the Au-sulfide mineralization in the Fatira area,distinguishing it from the more prevalent orogenic gold deposits in the region.
文摘In October 2024,the Ministry of Natural Resources of PRC released the 2024 China Mineral Resources Report,which focuses on new progress since 2023 in the geological and mineral survey and evaluation,mineral resource exploration and development,mine ecological restoration,green mine construction,new changes in mineral resource policies and regulations,new measures in mineral resource management,new situations in scientific and technological innovation,as well as the new achievements of the international geological and mineral cooperation.
基金supported by Technology Innovation Fund of China Coal Research Institute(2022CX-I-04)Science and Technology Innovation Venture Capital Project of China Coal Technology Engineering Group(2020-2-TD-CXY005)。
文摘Enhancing the mining speed of a working face has become the primary approach to achieve high production and efficiency in coal mines,thereby further improving the production capacity.However,the problem of rock bursts resulting from this approach has become increasingly serious.Therefore,to implement coal mine safety and efficient extraction,the impact of deformation pressure caused by different mining speeds should be considered,and a reasonable mining speed of the working face should be determined.The influence of mining speed on overlying rock breaking in the stope is analyzed by establishing a key layer block rotation and subsidence model.Results show that with the increasing mining speed,the compression amount of gangue in the goaf decreases,and the rotation and subsidence amount of rock block B above goaf decreases,forcing the rotation and subsidence amount of rock block A above roadway to increase.Consequently,the contact mode between rock block A and rock block B changes from line contact to point contact,and the horizontal thrust and shear force between blocks increase.The increase in rotation and subsidence of rock block A intensifies the compression degree of coal and rock mass below the key layer,thereby increasing the stress concentration degree of coal and rock mass as well as the total energy accumulation.In addition,due to the insufficient compression of gangue in the goaf,the bending and subsidence space of the far-field key layer are limited,the length of the suspended roof increases,and the influence range of mining stress and the energy accumulation range expand.Numerical test results and underground microseismic monitoring results verify the correlation between mining speed and stope energy,and high-energy events generally appear 1-2 d after the change in mining speed.On this basis,the statistical principle confirms that the maximum mining speed of the working face at 6 m/d is reasonable.
文摘In the context of increasing demand for coal mine resources in China’s current socio-economic development,traditional mining methods have been difficult to effectively meet the requirements of safety production and environmental protection.As a result,coal mine filling mining technology has emerged,which can effectively achieve the goal of controlling surface subsidence in practical applications,while also significantly improving the recovery rate of coal resources.Based on this,this study will first elaborate on the characteristics of filling mining technology,and then analyze the key points of the application of supporting technology for mechanical and electrical equipment in the corresponding working face based on actual cases,in order to provide support for improving the efficiency of coal mining.
基金funded by“Study on Kiwifruit Monitoring Model in the West-ern Guanzhong Basin Based on Hyperspectral Remote Sensing Technology(No.2024JC-YBQN-0318)”“Science and Technology Innovation Foundation of Comprehensive Survey&Command Center for Natural Resources(Program No.KC20240009)”.
文摘Spectral analysis technology can identify minerals and their compositions based on spectral absorption characteristics.With hyperspectral remote sensing data,alteration minerals mapping in the wild range could be used for mineral pro specting.However,whether hyperspectral data with low spatial resolution can be used in the exploration of small-scale deposits is worth discussing.The Bijia Mountain deposit is a small-scale epithermal gold deposit located in the Daha-nanhu island arc belt in northern China,which has great potential for porphyry and epithermal gold-copper deposit prospecting.The alteration minerals distri-bution on surface and core samples was analyzed with hyperspectral data(GF-5 and EMIT)and a spectrometer.The alteration minerals,as well as the com position of sericite and chlorite,were identified using a tool developed with Python programming based on the Tetracorder algorithm.The mapping re-sult showed the alteration zones:advanced argillic alteration(alunite+pyro-phyllite+kaolinite)in the core of the mine,argillic alteration(sericite+mont-morillonite),and propylitization alteration(chlorite+calcite).The composition of sericite and chlorite and the connections between mineralization and altera-tion minerals were discussed with high-sulfur epithermal metallogenic theory in this paper.
文摘Processes supported by process-aware information systems are subject to continuous and often subtle changes due to evolving operational,organizational,or regulatory factors.These changes,referred to as incremental concept drift,gradually alter the behavior or structure of processes,making their detection and localization a challenging task.Traditional process mining techniques frequently assume process stationarity and are limited in their ability to detect such drift,particularly from a control-flow perspective.The objective of this research is to develop an interpretable and robust framework capable of detecting and localizing incremental concept drift in event logs,with a specific emphasis on the structural evolution of control-flow semantics in processes.We propose DriftXMiner,a control-flow-aware hybrid framework that combines statistical,machine learning,and process model analysis techniques.The approach comprises three key components:(1)Cumulative Drift Scanner that tracks directional statistical deviations to detect early drift signals;(2)a Temporal Clustering and Drift-Aware Forest Ensemble(DAFE)to capture distributional and classification-level changes in process behavior;and(3)Petri net-based process model reconstruction,which enables the precise localization of structural drift using transition deviation metrics and replay fitness scores.Experimental validation on the BPI Challenge 2017 event log demonstrates that DriftXMiner effectively identifies and localizes gradual and incremental process drift over time.The framework achieves a detection accuracy of 92.5%,a localization precision of 90.3%,and an F1-score of 0.91,outperforming competitive baselines such as CUSUM+Histograms and ADWIN+Alpha Miner.Visual analyses further confirm that identified drift points align with transitions in control-flow models and behavioral cluster structures.DriftXMiner offers a novel and interpretable solution for incremental concept drift detection and localization in dynamic,process-aware systems.By integrating statistical signal accumulation,temporal behavior profiling,and structural process mining,the framework enables finegrained drift explanation and supports adaptive process intelligence in evolving environments.Its modular architecture supports extension to streaming data and real-time monitoring contexts.
基金supported by the Natural Science Foundation of Qinghai Province in China(No.2019-ZJ-944Q)the University-level Planning Project of Qinghai Minzu University of Qinghai Province in China(Nos.2022GH11 and 2022GH13)。
文摘Up to now,“Turn-on”fluorescence sensor exhibits promising potential toward the detection of heavy metal ions,anions,drugs,organic dyes,DNA,pesticides,and other amino acids due to their simple,quick detection,and high sensitivity and selectivity.Herein,a novel fluorescence method of detecting Cr^(3+)in an aqueous solution was described based on the fluorescence resonance energy transfer between rhodamine B(Rh B)and gold nanoparticles(Au NPs).The fluorescence of Rh B solution could be obviously quenched(“off”state)with the presence of citrate-stabilized Au NPs.However,upon addition of Cr^(3+)to Au NPs@Rh B system,the fluorescence of Au NPs was recovered owing to the strong interaction between Cr^(3+)and the specific groups on the surface of citrate-stabilized Au NPs,which will lead to the aggregation of Au NPs(“on”state).At this point,the color of the reaction solution turned to black.Under optimal conditions,the limit of detection(LOD)for Cr^(3+)was 0.95 n M(signal-to-noise ratio,S/N=3)with a linear range of 0.164 n M to 3.270μM.Furthermore,the proposed method exhibits excellent performances,such as rapid analysis,high sensitivity,extraordinary selectivity,easy preparation,switch-on fluorescence response,and non-time consuming.
基金supported by Beijing Natural Science Foundation (No.8254049)the National Natural Science Foundation of China (No.52374139)the Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project (No.2024ZD1004505)。
文摘Coal mine underground reservoir(CMUR) technology mitigates water scarcity in China's coal-rich western regions but lacks tailored solutions for steeply inclined coal seams.This study develops a novel framework of steeply inclined coal mine underground reservoirs(SICMUR),which is a paradigm shift from conventional CMUR that the coal seam itself serves as the reservoir floor,challenging conventional designs due to depth-dependent permeability and mechanical constraints.Triaxial mechanical-seepage tests on Xinjiang Wudong coal samples(100,200,300 m depths) revealed a 3.5 MPa triaxial strength increase per 100 m depth and a 58-fold post-peak permeability surge at 300 versus 100 m.Similar model simulations revealed mining-induced stress redistribution and significant deformation effects,particularly subsidence and water-conducting fractures during lower coal seam mining.Results indicate a minimum 40 m safety distance between reservoirs and lower coal seams.Critical construction parameters were investigated for Wudong mine SICMUR as collapse zone heights(9.9–12.31 m) and waterconducting fracture zone heights(31.96–37.40 m).This work systematically bridges SICMUR concepts to field implementation,offering a framework for water preservation in steeply inclined mining while addressing safety concerns,providing a new approach for water reservation in steeply inclined coal mining.
文摘The Boulon Djounga eastern perimeter is part of the Tiawa operating permit of the Société des Mines du Liptako (SML), located in the central southwestern part of Liptako (Niger). In this study, we used field data, Reverse Circulation (RC) surveys and chemical analyzes of gold to determine the characteristics of gold and its mineralization style. The eastern perimeter of Boulon Djounga is represented by a succession of metabasalts and metasediments both intersected by intrusions of quartz and dolerite dykes, and covered by sandstone and clayey rocks. Gold is present in low contents (0.00 - 0.30 ppm) in the sedimentary cover and in medium (0.30 - 1.00 ppm) or high contents (1.00 - 4.534 ppm) in the metasediments, and in the gray quartz veins and locally in the volcanics. It exists in a disseminated state or in a concentrated state in the surrounding areas in the form of discrete grains associated with sulphurous minerals (pyrite: FeS<sub>2</sub>, chalcopyrite: CuFeS<sub>2</sub> or arsenopyrite: FeAsS). The presence of gold in the quartz veins, and the NE-SW and NW-SE orientations of the ore bodies suggest that the eastern Boulon Djounga gold mineralization would be established during a late magmatic extensive phase.
基金financially supported by the National Key Research and Development Program of China(Grant No.2023YFC2906900)Key Research and Development Program of Shandong Province(Grant No.2023CXGC011001)+2 种基金The Taishan Scholars Talent Project(TSTP 20240847)The Open Project of Technology Innovation Center for Deep Gold Resources Exploration and Mining,Ministry of Natural Resources(Grant No.SDK202211,SDK202214)Science and Technology Project of Shandong Bureau of Geology and Mineral Exploration and Development(Grant No.KY202208)。
文摘The Taishang-Shuiwangzhuang gold deposit is located in the southeastern margin of Linglong gold field in the northern part of the Zhaoping Fault metallogenic belt of the Jiaodong gold province-the world’s third-largest gold metallogenic area.Major prospecting breakthroughs have been made at the depth of 600‒2500 m in recent years,with cumulative proven gold resources exceeding 700 t.Based on a large number of exploration data,the main characteristics of the deposit are described in detail,and the spatial coupling relationship between ore-controlling fault and main orebodies is discussed.The main orebodies occur as regular large veins,exhibiting branching and combination,expansion and contraction,and pinch-out and reoccurrence.They extend in a gentle wave pattern along their strikes and dip directions and generally have a pitch direction of NEE and a plunge direction of NEE.As the ore-controlling fault,the Zhaoping Fault has the characteristics of wave-like fluctuation,with its dip angle presenting three steps of steep-slow transition within the depth range of 2500 m.The gold mineralization enrichment area is mainly distributed in the step parts where the fault plane changes from steeply to gently.The ore-forming age,ore-forming fluid and ore-forming material sources and the genesis of the ore deposit are analyzed based on the research results of ore deposit geochemistry.The ore-forming fluids were H_(2)O-CO_(2)-NaCl-type hydrothermal solutions with a medium-low temperature and medium-low salinity.The H-O isotopic characteristics indicate that the fluids in the early ore-forming stage were possibly formed by degassing of basic magma and that meteoric water gradually entered the ore-forming fluids in the late ore-forming stage.The S and Pb isotopes indicate that the ore-forming materials mainly originate from the lower crust and contain a small quantity of mantle-derived components.The comprehensive analysis shows that the Taishang-shuiwangzhuang gold deposit was a typical“Jiaodong type”gold deposit.The strong crust-mantle interactions,large-scale magmatism,and the material exchange arising from the transformation from the ancient lower crust to the juvenile lower crust during the Early Cretaceous provided abundant fluids and material sources for mineralization.Moreover,the detachment faults formed by the rapid magmatic uplift and the extensional tectonism created favorable temperature and pressure conditions and space for fluid accumulation and gold precipitation and mineralization.
基金supported by the Program of the National Natural Science Foundation of China(Nos.41973048,U2006201)the Open Project of State Key Laboratory of Geological Processes and Mineral Resources(No.GPMR202203)+1 种基金the Key R&D Program of Shandong Province(No.2023CXGC011001),the Taishan Scholars.Program(tstp20240847)the Open Project of Shandong Engineering Research Center of Application and Development of Big Data for Deep Gold Exploration(No.SDK202207)。
文摘Since the first discovery of gold deposits on the northeastern margin of the Jiaolai Basin in Shandong Province at the end of the 20^(th) century,seven medium-sized to large/super-large gold deposits have been identified in this region,with cumulative proven gold resources of 223 t.This study reviewed the metallogenic and geochemical characteristics of various gold deposits in this region,examined the sources of their ore-forming fluids and materials,as well as their gold metallogenic epochs and processes,and developed a gold metallogenic model.The gold deposits in this region are governed by both dense fractures and detachment structural systems along basin margins,primarily categorized into the altered rock type and the pyrite-bearing carbonate vein type.The latter type,a recently discovered mineralization type in the Jiaodong Peninsula,enjoys high gold grade,a large scale,and high gold mineral fineness,suggesting considerable prospecting potential.Both types of gold deposits show metallogenic epochs ranging from 116 Ma to 119 Ma.Their ore-forming fluids are identified as a CO_(2)-NaCl-H_(2)O fluid system characterized by moderate to low temperatures,moderate to low salinity,and low density,with the pyrite-bearing carbonate vein-type gold deposits manifesting slightly higher salinity.The C-H-O,S,and Pb isotopes of hydrothermal minerals reveal that the ore-forming fluids and materials are characteristic of crust-mantle mixing.Specifically,they were derived from mantle fluids in the early stages,mixed with stratum water and meteoric water in the later stages for mineralization.The gold metallogenic process is identified as follows:During the Early Cretaceous,the subduction of the Pacific Plate and the destruction of the North China Craton led to asthenospheric upwelling.The resulting fluids,after metasomatizing the enriched mantle,differentiated and evolved into C-H-O ore-bearing fluids,which were then mixed with crustal fluids.The mixed fluids migrated to the shallow crust,where they mingled with stratum water and meteoric water.Then,the fluids underwent unloading and final mineralization in detachment fault tectonic systems on basin margins.Due to differences in mixed crustal materials or the surrounding rocks involved in water-rock interactions,altered rock-and pyrite-bearing carbonate vein-type gold deposits were formed in acidic and alkaline fluid environments,respectively.
基金supported in part by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA28060201)the National Natural Science Foundation of China(Grant No.42067046)the Science and Technology Planning Project of Guiyang City(Grant No.ZKHT[2023]13-10).
文摘Mining-induced surface deformation disrupts ecological balance and impedes economic progress.This study employs SBAS-InSAR with 107-view of ascending and descending SAR data from Sentinel-1,spanning February 2017 to September 2020,to monitor surface deformation in the Fa’er Coal Mine,Guizhou Province.Analysis on the surface deformation time series reveals the relationship between underground mining and surface shifts.Considering geological conditions,mining activities,duration,and ranges,the study determines surface movement parameters for the coal mine.It asserts that mining depth significantly influences surface movement parameters in mountainous mining areas.Increasing mining depth elevates the strike movement angle on the deeper side of the burial depth by 22.84°,while decreasing by 7.74°on the shallower side.Uphill movement angles decrease by 4.06°,while downhill movement angles increase by 15.71°.This emphasizes the technology's suitability for local mining design,which lays the groundwork for resource development,disaster prevention,and ecological protection in analogous contexts.
基金funded by the National Natural Science Foundation of China (52174096, 52304110)the Fundamental Research Funds for the Central Universities (2022YJSSB03)the Scientific and Technological Projects of Henan Province (232102320238)。
文摘The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of "pre-splitting cutting roof + NPR anchor cable"(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway.
基金financially supported by the National Basic Research and Development Program of China (No. 2010CB732004)Joint Funding of the National Natural Science Foundation and Shanghai Baosteel Group Corporation (No. 51074177)
文摘The exploration of undersea resources becomes popular as land resources decrease. Researches were conducted with emphasis on the safety and efficiency of undersea mining of the large gold deposit in Xinli District of Sanshandao Gold Mine. A series of tests for the physical and mechanical characteristics of rock mass were carried out, and the three-dimensional geo-stress distribution was tested in the mining area. Further, a similar experimental simulation platform, which revealed the mechanism of water inrush and ascertained the reason- able thickness of the safety isolate layer, was established for the undersea mining. Meanwhile, the feasibility of cancelling the ore pillars and the safety conditions was checked by numerical simulation. The simulation results show that it is safe to exploit the ore body below the -85 m level （presently, the exploitation level is below -160 m in Xinli District）, and the ore pillars can be cancelled below the -560 m level. Fur- thermore, a novel backfill method was designed to reduce the rock strata disturbance and settlement, and the settlement of roof strata was monitored during the mining process. Engineering practice shows that the settlement of roof strata was small and that no disaster happened. This indicates that the undersea safety mining technology of the large gold deposit is achieved in Xinli District.
基金Project(52204084)supported by the National Natural Science Foundation of ChinaProject(FRF-IDRY-GD22-002)supported by the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities),China+2 种基金Project(QNXM20220009)supported by the Fundamental Research Funds for the Central Universities and the Youth Teacher International Exchange and Growth Program,ChinaProjects(2022YFC2905600,2022YFC3004601)supported by the National Key R&D Program of ChinaProject(2023XAGG0061)supported by the Science,Technology&Innovation Project of Xiongan New Area,China。
文摘Metal mineral resources play an indispensable role in the development of the national economy.Dynamic disasters in underground metal mines seriously threaten mining safety,which are major scientific and technological problems to be solved urgently.In this article,the occurrence status and grand challenges of some typical dynamic disasters involving roof falling,spalling,collapse,large deformation,rockburst,surface subsidence,and water inrush in metal mines in China are systematically presented,the characteristics of mining-induced dynamic disasters are analyzed,the examples of dynamic disasters occurring in some metal mines in China are summarized,the occurrence mechanism,monitoring and early warning methods,and prevention and control techniques of these disasters are highlighted,and some new opinions,suggestions,and solutions are proposed simultaneously.Moreover,some shortcomings in current disaster research are pointed out,and the direction of efforts to improve the prevention and control level of dynamic disasters in China’s metal mines in the future is prospected.The integration of forward-looking key innovative theories and technologies in the abovementioned aspects will greatly enhance the cognitive level of disaster prevention and mitigation in China’s metal mining industry and achieve a significant shift from passive disaster relief to active disaster prevention.
基金supported by the National Natural Science Foundation of China(No.81972892)。
文摘Lung cancer is one of the most common malignant tumors with the fastest increase in the incidence rate and mortality.Even after maximum tumor resection assistance with a radiotherapy and chemotherapy combination,the recurrence of non-small cell lung cancer is still inevitable.In addition,low targeting efficiency and poor permeability of drug delivery systems strongly affect the therapeutic efficiency of anti-cancer drugs on non-small cell lung cancer.Here we designed a gemcitabine(GEM)loaded arginineglycine-aspartic acid-cysteine(RGDc)-modified gold mineralization“hybrid nanozyme bomb”(RGTG)to overcome those obstacles.RGDc modification improved the active targeting of liposomes to the tumor tissues with the second near-infrared(NIR-Ⅱ)-triggered gold-shell disruption and GEM release.The collapsed gold-shell particles with a smaller size could penetrate the tumor solid barrier and act as photothermal therapy(PTT)agents to improve PTT therapy and starvation therapy via generating gluconic acid and reactive oxygen species(ROS).Moreover,the resting reversal effect of gold particles on tumor fibroblasts can achieve accelerating tumor penetration of gold particles and GEM.Compared to monotherapy,RGTG showed significant improvement in tumor inhibition,with a tumor volume reduction of 83%compared to the control group,which provides a promising tumor treatment platform for non-small cell lung cancer(NSCLC).
文摘To predict rock burst in deep mining excavation in Linglong gold mine, systematical laboratory tests of mechanical properties of rock, in situ stress measurement and 3-D FEM analysis on energy distribution in rock mass surrounding deep mining rooms were carried out. According to various prediction criteria of rock burst, it is concluded that rock burst is liable to occur during deep mining excavation in the mine.
