目的比较老年营养风险指数(GNRI)与营养风险筛查2002(NRS2002)在糖尿病肾病(DKD)患者中的应用价值。方法选取DKD患者218例,采用GNRI及NRS2002分别对其进行营养风险筛查。收集患者相关营养及肾功能指标,对两种筛查工具评分与上述生化指...目的比较老年营养风险指数(GNRI)与营养风险筛查2002(NRS2002)在糖尿病肾病(DKD)患者中的应用价值。方法选取DKD患者218例,采用GNRI及NRS2002分别对其进行营养风险筛查。收集患者相关营养及肾功能指标,对两种筛查工具评分与上述生化指标进行相关性分析。结果218例患者中GNRI评分<92分的有91例(41.7%),NRS2002评分≥3分的有51例(23.4%),二者营养风险筛查结果的一致性不理想。两种筛查工具得分与营养指标体质指数(BMI)、血清白蛋白(Alb)、血清前白蛋白(PA)、血红蛋白(HGB)均具有相关性(P<0.01)。GNRI得分与肾功能指标(尿微量白蛋白/尿肌酐)ACR、肾小球滤过虑(eGFR)、随机尿蛋白/随机尿肌酐(Up/Ucr)、24 h尿蛋白(24 h UP)、肌酐(Cr)、尿素(BUN)具有相关性(P<0.01),NRS2002得分与肾功能指标无相关性(P>0.05)。结论相比NRS2002,GNRI能更好地反映DKD患者营养及肾功能状况,适宜在临床推广应用,为DKD患者的精准营养支持提供科学依据。展开更多
BACKGROUND The correlation between geriatric nutritional risk index(GNRI)and the prognosis of patients with osteoporosis or osteopenia has not been studied.This study aims to explore the relationship between GNRI and ...BACKGROUND The correlation between geriatric nutritional risk index(GNRI)and the prognosis of patients with osteoporosis or osteopenia has not been studied.This study aims to explore the relationship between GNRI and the cardiovascular disease(CVD)and all-cause mortality rates in elderly patients with osteoporosis or osteopenia.METHODS This study included 4756 patients with osteoporosis and osteopenia from five cycles of the National Health and Nutrition Examination Survey(NHANES).We used multivariable Cox regression and subgroup analyses to investigate the correlation between GNRI and mortality rates.The restricted cubic spline analysis was used to assess the dose-response relationship between GNRI and mortality risk.Mediation analysis was conducted to examine the mediating effect of chronic kidney disease on the relationship between nutritional risk and mortality.RESULTS During a median follow-up period of 114 months,a total of 1241 deaths(26.09%)occurred,including 300 deaths due to CVD(6.31%).In the fully adjusted Model 3,compared to the no-risk group,the risk group showed significantly increased all-cause mortality risk(HR=2.05,95%CI:1.74–2.40)and CVD mortality risk(HR=1.88,95%CI:1.30–2.71).The restricted cubic spline analysis indicated a non-linear association between GNRI and all-cause mortality risk as well as CVD mortality risk.The mediation analysis results indicated that chronic kidney disease mediates 16.9%of the effect of nutritional risk on all-cause mortality and 25.3%on CVD mortality risk.CONCLUSIONS GNRI can serve as a predictive factor for all-cause and CVD mortality rates in elderly patients with osteoporosis or osteopenia.展开更多
Background: The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been shown to be a pre...Background: The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been shown to be a predictor of cardiovascular (CV) outcomes in the general population. Objectives: The aim of this study was to determine whether the combination of GNRI and TG/HDL-C ratio is a predictor of all-cause mortality and CV deaths in maintenance hemodialysis (MHD) patients. Methods: We performed a retrospective, observational cohort study in which we enrolled 341 MHD patients from a single center in Japan who had been followed up for a mean of 48.0 ± 12.7 months. The outcomes were defined as the occurrence of all-cause mortality and CV deaths during the follow-up period. Baseline GNRI and TG/HDL-C ratios were investigated for associations with outcomes by using Cox proportion hazards models adjusted for demographic parameters. Results: Overall, 101 of the subjects had died, of whom 52 died due to CV events during the mean follow-up period of 48.0 ± 12.7 months. The patients were grouped into four categories according to a median GNRI Conclusion: The combination of GNRI and TG/HDL-C ratio is an easily accessible marker for predicting all-cause mortality and CV deaths in MHD patients.展开更多
文摘目的比较老年营养风险指数(GNRI)与营养风险筛查2002(NRS2002)在糖尿病肾病(DKD)患者中的应用价值。方法选取DKD患者218例,采用GNRI及NRS2002分别对其进行营养风险筛查。收集患者相关营养及肾功能指标,对两种筛查工具评分与上述生化指标进行相关性分析。结果218例患者中GNRI评分<92分的有91例(41.7%),NRS2002评分≥3分的有51例(23.4%),二者营养风险筛查结果的一致性不理想。两种筛查工具得分与营养指标体质指数(BMI)、血清白蛋白(Alb)、血清前白蛋白(PA)、血红蛋白(HGB)均具有相关性(P<0.01)。GNRI得分与肾功能指标(尿微量白蛋白/尿肌酐)ACR、肾小球滤过虑(eGFR)、随机尿蛋白/随机尿肌酐(Up/Ucr)、24 h尿蛋白(24 h UP)、肌酐(Cr)、尿素(BUN)具有相关性(P<0.01),NRS2002得分与肾功能指标无相关性(P>0.05)。结论相比NRS2002,GNRI能更好地反映DKD患者营养及肾功能状况,适宜在临床推广应用,为DKD患者的精准营养支持提供科学依据。
文摘BACKGROUND The correlation between geriatric nutritional risk index(GNRI)and the prognosis of patients with osteoporosis or osteopenia has not been studied.This study aims to explore the relationship between GNRI and the cardiovascular disease(CVD)and all-cause mortality rates in elderly patients with osteoporosis or osteopenia.METHODS This study included 4756 patients with osteoporosis and osteopenia from five cycles of the National Health and Nutrition Examination Survey(NHANES).We used multivariable Cox regression and subgroup analyses to investigate the correlation between GNRI and mortality rates.The restricted cubic spline analysis was used to assess the dose-response relationship between GNRI and mortality risk.Mediation analysis was conducted to examine the mediating effect of chronic kidney disease on the relationship between nutritional risk and mortality.RESULTS During a median follow-up period of 114 months,a total of 1241 deaths(26.09%)occurred,including 300 deaths due to CVD(6.31%).In the fully adjusted Model 3,compared to the no-risk group,the risk group showed significantly increased all-cause mortality risk(HR=2.05,95%CI:1.74–2.40)and CVD mortality risk(HR=1.88,95%CI:1.30–2.71).The restricted cubic spline analysis indicated a non-linear association between GNRI and all-cause mortality risk as well as CVD mortality risk.The mediation analysis results indicated that chronic kidney disease mediates 16.9%of the effect of nutritional risk on all-cause mortality and 25.3%on CVD mortality risk.CONCLUSIONS GNRI can serve as a predictive factor for all-cause and CVD mortality rates in elderly patients with osteoporosis or osteopenia.
文摘Background: The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been shown to be a predictor of cardiovascular (CV) outcomes in the general population. Objectives: The aim of this study was to determine whether the combination of GNRI and TG/HDL-C ratio is a predictor of all-cause mortality and CV deaths in maintenance hemodialysis (MHD) patients. Methods: We performed a retrospective, observational cohort study in which we enrolled 341 MHD patients from a single center in Japan who had been followed up for a mean of 48.0 ± 12.7 months. The outcomes were defined as the occurrence of all-cause mortality and CV deaths during the follow-up period. Baseline GNRI and TG/HDL-C ratios were investigated for associations with outcomes by using Cox proportion hazards models adjusted for demographic parameters. Results: Overall, 101 of the subjects had died, of whom 52 died due to CV events during the mean follow-up period of 48.0 ± 12.7 months. The patients were grouped into four categories according to a median GNRI Conclusion: The combination of GNRI and TG/HDL-C ratio is an easily accessible marker for predicting all-cause mortality and CV deaths in MHD patients.
