In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be ...In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be deleted.The correct sentence is as below.展开更多
Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^(...Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.展开更多
Integrator processes with long delay are difficult to control. Nonlinear characteristics of actuators make the control problem more challenging. A technique is proposed in this paper for global satisfactory control (...Integrator processes with long delay are difficult to control. Nonlinear characteristics of actuators make the control problem more challenging. A technique is proposed in this paper for global satisfactory control (GSC) of such processes with relay-type nonlinearity. An oscillatory control signal is injected into the nonlinear process; the amplitude and frequency of the oscillatory signal are designed to linearise the nonlinear process in the sense of harmonic analysis; and a state feedback controller is configured to implement GSC over the linearised process. An illustrative example is given to demonstrate the effectiveness of展开更多
The reaction heat effect analysis for the aromatization process of Liquefied Petroleum Gas (LPG) was completed in this paper. In order to characterize this complex reaction system, one set of independent reactions was...The reaction heat effect analysis for the aromatization process of Liquefied Petroleum Gas (LPG) was completed in this paper. In order to characterize this complex reaction system, one set of independent reactions was determined by means of atomic coefficient matrix method. Based on reaction thermodynamic and stoichiometric knowledge, the heat effect, Gibbs free energy change and equilibrium constant for each independent reaction was calculated for the specified conditions. Under these conditions, based on the initial and final composition data from LPG aromatization experiments, the actual extent of reaction for each independent reaction was determined. Furthermore, the global reaction heat and adiabatic temperature rise of LPG aromatization reaction system could be estimated. This work would provide a theoretical guidance for the design and scale-up of reactor for LPG aromatization process, as well as for the selection of proper operating conditions.展开更多
The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstl...The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstly prove the existence of local and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Secondly we show, by the construction of appropriate Lyapunov functions, that the uninfected equilibrium and the unique infected equilibrium of the mathematical model of HCV are globally asymptotically stable respectively when the threshold number and when .展开更多
Objective: A global-local processing task was adapted to be used in an event- related potential paradigm in order to examine the effects of positive emotion on
The results of the spectral-correlation analysis of the fluid-dynamic (radon and hydrogen) data monitoring obtained in the seismically active region—on Kamchatka and in conditions of Russian platform where compared t...The results of the spectral-correlation analysis of the fluid-dynamic (radon and hydrogen) data monitoring obtained in the seismically active region—on Kamchatka and in conditions of Russian platform where compared to the results of the laser-deformometer measurements obtained on Caucasus. It allowed identify spectral components of the measured parameters, first of all, in the area of the lunar-solar tides. This identification have demonstrated the identical reaction of the mountain and platform regions to the global geodeformation processes of the tidal level and have shown the possibility of the measuring parameters response to the catastrophic events preparation processes. Really the prognostic effects in the investigated fields where indicated in periods of preparation and realization of the catastrophic earthquakes in Indian Ocean on December, 26, 2004 and on March, 28, 2005.展开更多
In this paper, the author intends to illustrate cultural materialism behind cultural diffusion process. The author first argues that despite the two opposing paradigms of cultural views (differentialism vs. universal...In this paper, the author intends to illustrate cultural materialism behind cultural diffusion process. The author first argues that despite the two opposing paradigms of cultural views (differentialism vs. universalism) what is really happening and winning is the third paradigm of mixing cultural perspective as presented in Jan Nederveen Pieterse's book Globalization and culture-global Mdlange. Then the author takes Marvin Harris' cultural materialism theory as the basis and gives specific evidence from China to illustrate the formation and eventual spread of any "new cultural scripts", which is done through the transformation process from territorial culture to translocal culture with economic motive behind as the driving force. These Chinese cases of global mixing, in turn, form a further support to Marvin Harris's cultural materialism theory.展开更多
We present (on the 13<sup>th</sup> International Conference on Geology and Geophysics) the convincing evidence that the strongest earthquakes (according to the U.S. Geological Survey) of the Earth (during ...We present (on the 13<sup>th</sup> International Conference on Geology and Geophysics) the convincing evidence that the strongest earthquakes (according to the U.S. Geological Survey) of the Earth (during the range 2020 - 2023 AD) occurred near the predicted (calculated in advance based on the global prediction thermohydrogravidynamic principles determining the maximal temporal intensifications of the global seismotectonic, volcanic, climatic and magnetic processes of the Earth) dates 2020.016666667 AD (Simonenko, 2020), 2021.1 AD (Simonenko, 2019, 2020), 2022.18333333 AD (Simonenko, 2021), 2023.26666666 AD (Simonenko, 2022) and 2020.55 AD, 2021.65 AD (Simonenko, 2019, 2021), 2022.716666666 AD (Simonenko, 2022), respectively, corresponding to the local maximal and to the local minimal, respectively, combined planetary and solar integral energy gravitational influences on the internal rigid core of the Earth. We present the short-term thermohydrogravidynamic technology (based on the generalized differential formulation of the first law of thermodynamics and the first global prediction thermohydrogravidynamic principle) for evaluation of the maximal magnitude of the strongest (during the March, 2023 AD) earthquake of the Earth occurred on March 16, 2023 AD (according to the U.S. Geological Survey). .展开更多
This paper discusses the problems we confront in the study of magnetospheric substorms. This includes the global processes of magnetospheric substorms, the origin of the southern-northern component of interplanetary m...This paper discusses the problems we confront in the study of magnetospheric substorms. This includes the global processes of magnetospheric substorms, the origin of the southern-northern component of interplanetary magnetic field, quantitative effects of the interplanetary conditions, driving processes of the solar wind, location of the triggering of the expansion phase, and relationship between magnetospheric storms and substorms. Moreover, the research directions in the future have also been discussed.展开更多
Silicon is a necessary nutrient for diatoms, silicon uptake in diatom reproduction decreased sea- water silicon content. This paper clarified the characteristics of silicon transferring in the sea, which plays an impo...Silicon is a necessary nutrient for diatoms, silicon uptake in diatom reproduction decreased sea- water silicon content. This paper clarified the characteristics of silicon transferring in the sea, which plays an important role in phytoplankton growth, zooplankton graze and marine ecosystem. Analysis revealed that silicate is supplied by terrestrial sources, through plankton uptake, death, and eventually deposits to the sea bottom, and cannot diffuse upward. This is a general silicon deficit process. Many global marine waters showed the same silicon transfer route: land→silicon biogeochemical process→sea bottom. River flow brings abundant silicate into marine waters, silicate concentration in the waters decreased in the distance away from the river estuaries. In discussion of silicon characteristics and its transfer route, it was considered that the main factor controlling the mechanism of diatom and non-diatom red tides occurrence is silicon, and the changes in silicon source. Human activities, such as sea-route cutting by building embankment and dam, and silicon supplement by the sea, such as sandstorm, rainstorm and storm tide, have largely impaired the earth ecosystem and hugely threatened the human existence. It is suggested in this paper that man should resume the original face of the Si input into the sea to keep natural ecosystem in sustainable pattern.展开更多
Due to large deserts on Earth surface a thorough understanding of climate change, landscape evolution and geomorphological processes having occurred in deserts is crucial for Earth System Science. The landscapes in de...Due to large deserts on Earth surface a thorough understanding of climate change, landscape evolution and geomorphological processes having occurred in deserts is crucial for Earth System Science. The landscapes in deserts are, however, diverse and different over the globe with regard to their geomorphological nature, human activities and geological histories. In the last decades a great number of efforts have been put to the investigation of the initial timing of the occurrence of arid climate, e. g. in northwestern China. Silty sediments in the downwind directions have been used to deduce the histories of deserts. In general, there is a lack of knowledge about processes and landscapes in Chinese drylands between the initial Miocene silt sedimentation at desert margins and the late Quaternary multiple occurrences of wetter climate with assumed large lakes in many of the deserts in northern China. The geomorphological concept of three primary triggering factors, i.e., the sediment supply, sediment availability and transport capacity of wind, and additionally the underground geology need to be fully considered for a better understanding of the environmental histories of sand seas which should not be viewed as equivalent for deserts because sand seas cover between 〈 1% and ca. 45% of the desert areas in various continents dependent on a complex interaction between various processes of both exogenous and endogenous origins.展开更多
In the globalized market environment, increasingly significant economic and environmental factors withincomplex industrial plants impose importance on the optimization of global production indices; such opti-mization ...In the globalized market environment, increasingly significant economic and environmental factors withincomplex industrial plants impose importance on the optimization of global production indices; such opti-mization includes improvements in production efficiency, product quality, and yield, along with reductionsof energy and resource usage. This paper briefly overviews recent progress in data-driven hybrid intelli-gence optimization methods and technologies in improving the performance of global production indicesin mineral processing. First, we provide the problem description. Next, we summarize recent progress indata-based optimization for mineral processing plants. This optimization consists of four layers: optimiza-tion of the target values for monthly global production indices, optimization of the target values for dailyglobal production indices, optimization of the target values for operational indices, and automation systemsfor unit processes. We briefly overview recent progress in each of the different layers. Finally, we point outopportunities for future works in data-based optimization for mineral processing plants.展开更多
Many studies revealed unconscious effects on conscious processing. However, in this study, we tried to investigate whether unconscious processes could interact with each other by using simultaneously presented face pi...Many studies revealed unconscious effects on conscious processing. However, in this study, we tried to investigate whether unconscious processes could interact with each other by using simultaneously presented face pictures with the same or a different unconscious valence (SUV versus DUV). In the first event-related potential (ERP) study, DUV elicited a smaller N2 as compared with SUV. In the second functional magnetic resonance imaging (fMRI) experiment, the left middle frontal gyrus (MFG) was activated under DUV condition in comparison to SUV condition. These results support the idea of interactions between unconscious processes (unconscious mismatch detection). The theoretical implications are discussed in the light of the global neuronal workspace theory.展开更多
In this paper, we develop a new theoretical framework by means of the absorbing Markov process theory for analyzing some stochastic global optimization algorithms. Applying the framework to the pure random search, we ...In this paper, we develop a new theoretical framework by means of the absorbing Markov process theory for analyzing some stochastic global optimization algorithms. Applying the framework to the pure random search, we prove that the pure random search converges to the global minimum in probability and its time has geometry distribution. We also analyze the pure adaptive search by this framework and turn out that the pure adaptive search converges to the global minimum in probability and its time has Poisson distribution.展开更多
This paper considers a dynamic optimization problem(DOP)of 1,3-propanediol fermentation process(1,3-PFP).Our main contributions are as follows.Firstly,the DOP of 1,3-PFP is modeled as an optimal control problem of swi...This paper considers a dynamic optimization problem(DOP)of 1,3-propanediol fermentation process(1,3-PFP).Our main contributions are as follows.Firstly,the DOP of 1,3-PFP is modeled as an optimal control problem of switched dynamical systems.Unlike the existing switched dynamical system optimal control problem,the state-dependent switching method is applied to design the switching rule.Then,in order to obtain the numerical solution,by introducing a discrete-valued function and using a relaxation technique,this problem is transformed into a nonlinear parameter optimization problem(NPOP).Although the gradient-based algorithm is very efficient for solving NPOPs,the existing algorithm is always trapped in a local minimum for such problems with multiple local minima.Next,in order to overcome this challenge,a gradient-based random search algorithm(GRSA)is proposed based on an improved gradient-based algorithm(IGA)and a novel random search algorithm(NRSA),which cannot usually be trapped in a local minimum.The convergence results are also established,and show that the GRSA is globally convergent.Finally,a DOP of 1,3-PFP is provided to illustrate the effectiveness of the GRSA proposed by this paper.展开更多
Complex processes often work with multiple operation regions, it is critical to develop effective monitoring approaches to ensure the safety of chemical processes. In this work, a discriminant local consistency Gaussi...Complex processes often work with multiple operation regions, it is critical to develop effective monitoring approaches to ensure the safety of chemical processes. In this work, a discriminant local consistency Gaussian mixture model(DLCGMM) for multimode process monitoring is proposed for multimode process monitoring by integrating LCGMM with modified local Fisher discriminant analysis(MLFDA). Different from Fisher discriminant analysis(FDA) that aims to discover the global optimal discriminant directions, MLFDA is capable of uncovering multimodality and local structure of the data by exploiting the posterior probabilities of observations within clusters calculated from the results of LCGMM. This may enable MLFDA to capture more meaningful discriminant information hidden in the high-dimensional multimode observations comparing to FDA. Contrary to most existing multimode process monitoring approaches, DLCGMM performs LCGMM and MFLDA iteratively, and the optimal subspaces with multi-Gaussianity and the optimal discriminant projection vectors are simultaneously achieved in the framework of supervised and unsupervised learning. Furthermore, monitoring statistics are established on each cluster that represents a specific operation condition and two global Bayesian inference-based fault monitoring indexes are established by combining with all the monitoring results of all clusters. The efficiency and effectiveness of the proposed method are evaluated through UCI datasets, a simulated multimode model and the Tennessee Eastman benchmark process.展开更多
文摘In the published version of our article(Shaji et al.,2024),in the last paragraph of the article,Hong Kong should be corrected to Hong Kong(China)and the repetition of Spain and Ireland in the same sentence need to be deleted.The correct sentence is as below.
文摘Overweight and obesity has been a major public health problem globally.It was estimated that more than 2.1 billion adults were affected by overweight or obese in 2021 worldwide,about one fifth of whom lived in China^([1]).By 2050,the country is forecast to remain the one with the largest population of overweight and obese globally^([1]),if no effective strategies were applied on overweight/obesity control.
文摘Integrator processes with long delay are difficult to control. Nonlinear characteristics of actuators make the control problem more challenging. A technique is proposed in this paper for global satisfactory control (GSC) of such processes with relay-type nonlinearity. An oscillatory control signal is injected into the nonlinear process; the amplitude and frequency of the oscillatory signal are designed to linearise the nonlinear process in the sense of harmonic analysis; and a state feedback controller is configured to implement GSC over the linearised process. An illustrative example is given to demonstrate the effectiveness of
文摘The reaction heat effect analysis for the aromatization process of Liquefied Petroleum Gas (LPG) was completed in this paper. In order to characterize this complex reaction system, one set of independent reactions was determined by means of atomic coefficient matrix method. Based on reaction thermodynamic and stoichiometric knowledge, the heat effect, Gibbs free energy change and equilibrium constant for each independent reaction was calculated for the specified conditions. Under these conditions, based on the initial and final composition data from LPG aromatization experiments, the actual extent of reaction for each independent reaction was determined. Furthermore, the global reaction heat and adiabatic temperature rise of LPG aromatization reaction system could be estimated. This work would provide a theoretical guidance for the design and scale-up of reactor for LPG aromatization process, as well as for the selection of proper operating conditions.
文摘The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstly prove the existence of local and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Secondly we show, by the construction of appropriate Lyapunov functions, that the uninfected equilibrium and the unique infected equilibrium of the mathematical model of HCV are globally asymptotically stable respectively when the threshold number and when .
文摘Objective: A global-local processing task was adapted to be used in an event- related potential paradigm in order to examine the effects of positive emotion on
文摘The results of the spectral-correlation analysis of the fluid-dynamic (radon and hydrogen) data monitoring obtained in the seismically active region—on Kamchatka and in conditions of Russian platform where compared to the results of the laser-deformometer measurements obtained on Caucasus. It allowed identify spectral components of the measured parameters, first of all, in the area of the lunar-solar tides. This identification have demonstrated the identical reaction of the mountain and platform regions to the global geodeformation processes of the tidal level and have shown the possibility of the measuring parameters response to the catastrophic events preparation processes. Really the prognostic effects in the investigated fields where indicated in periods of preparation and realization of the catastrophic earthquakes in Indian Ocean on December, 26, 2004 and on March, 28, 2005.
文摘In this paper, the author intends to illustrate cultural materialism behind cultural diffusion process. The author first argues that despite the two opposing paradigms of cultural views (differentialism vs. universalism) what is really happening and winning is the third paradigm of mixing cultural perspective as presented in Jan Nederveen Pieterse's book Globalization and culture-global Mdlange. Then the author takes Marvin Harris' cultural materialism theory as the basis and gives specific evidence from China to illustrate the formation and eventual spread of any "new cultural scripts", which is done through the transformation process from territorial culture to translocal culture with economic motive behind as the driving force. These Chinese cases of global mixing, in turn, form a further support to Marvin Harris's cultural materialism theory.
文摘We present (on the 13<sup>th</sup> International Conference on Geology and Geophysics) the convincing evidence that the strongest earthquakes (according to the U.S. Geological Survey) of the Earth (during the range 2020 - 2023 AD) occurred near the predicted (calculated in advance based on the global prediction thermohydrogravidynamic principles determining the maximal temporal intensifications of the global seismotectonic, volcanic, climatic and magnetic processes of the Earth) dates 2020.016666667 AD (Simonenko, 2020), 2021.1 AD (Simonenko, 2019, 2020), 2022.18333333 AD (Simonenko, 2021), 2023.26666666 AD (Simonenko, 2022) and 2020.55 AD, 2021.65 AD (Simonenko, 2019, 2021), 2022.716666666 AD (Simonenko, 2022), respectively, corresponding to the local maximal and to the local minimal, respectively, combined planetary and solar integral energy gravitational influences on the internal rigid core of the Earth. We present the short-term thermohydrogravidynamic technology (based on the generalized differential formulation of the first law of thermodynamics and the first global prediction thermohydrogravidynamic principle) for evaluation of the maximal magnitude of the strongest (during the March, 2023 AD) earthquake of the Earth occurred on March 16, 2023 AD (according to the U.S. Geological Survey). .
文摘This paper discusses the problems we confront in the study of magnetospheric substorms. This includes the global processes of magnetospheric substorms, the origin of the southern-northern component of interplanetary magnetic field, quantitative effects of the interplanetary conditions, driving processes of the solar wind, location of the triggering of the expansion phase, and relationship between magnetospheric storms and substorms. Moreover, the research directions in the future have also been discussed.
基金This study was funded by the key subject development of Shanghai Education Council (04SC12), the Director’s Foundation of the Beihai Monitoring Center and the State Oceanic Administration and Chinese Academy of Science (KZCX 2-207).
文摘Silicon is a necessary nutrient for diatoms, silicon uptake in diatom reproduction decreased sea- water silicon content. This paper clarified the characteristics of silicon transferring in the sea, which plays an important role in phytoplankton growth, zooplankton graze and marine ecosystem. Analysis revealed that silicate is supplied by terrestrial sources, through plankton uptake, death, and eventually deposits to the sea bottom, and cannot diffuse upward. This is a general silicon deficit process. Many global marine waters showed the same silicon transfer route: land→silicon biogeochemical process→sea bottom. River flow brings abundant silicate into marine waters, silicate concentration in the waters decreased in the distance away from the river estuaries. In discussion of silicon characteristics and its transfer route, it was considered that the main factor controlling the mechanism of diatom and non-diatom red tides occurrence is silicon, and the changes in silicon source. Human activities, such as sea-route cutting by building embankment and dam, and silicon supplement by the sea, such as sandstorm, rainstorm and storm tide, have largely impaired the earth ecosystem and hugely threatened the human existence. It is suggested in this paper that man should resume the original face of the Si input into the sea to keep natural ecosystem in sustainable pattern.
基金the National Natural Science Foundation of China(grant no.:41430532)the Alexander von Humboldt Stiftung/Foundation,Germany for support
文摘Due to large deserts on Earth surface a thorough understanding of climate change, landscape evolution and geomorphological processes having occurred in deserts is crucial for Earth System Science. The landscapes in deserts are, however, diverse and different over the globe with regard to their geomorphological nature, human activities and geological histories. In the last decades a great number of efforts have been put to the investigation of the initial timing of the occurrence of arid climate, e. g. in northwestern China. Silty sediments in the downwind directions have been used to deduce the histories of deserts. In general, there is a lack of knowledge about processes and landscapes in Chinese drylands between the initial Miocene silt sedimentation at desert margins and the late Quaternary multiple occurrences of wetter climate with assumed large lakes in many of the deserts in northern China. The geomorphological concept of three primary triggering factors, i.e., the sediment supply, sediment availability and transport capacity of wind, and additionally the underground geology need to be fully considered for a better understanding of the environmental histories of sand seas which should not be viewed as equivalent for deserts because sand seas cover between 〈 1% and ca. 45% of the desert areas in various continents dependent on a complex interaction between various processes of both exogenous and endogenous origins.
文摘In the globalized market environment, increasingly significant economic and environmental factors withincomplex industrial plants impose importance on the optimization of global production indices; such opti-mization includes improvements in production efficiency, product quality, and yield, along with reductionsof energy and resource usage. This paper briefly overviews recent progress in data-driven hybrid intelli-gence optimization methods and technologies in improving the performance of global production indicesin mineral processing. First, we provide the problem description. Next, we summarize recent progress indata-based optimization for mineral processing plants. This optimization consists of four layers: optimiza-tion of the target values for monthly global production indices, optimization of the target values for dailyglobal production indices, optimization of the target values for operational indices, and automation systemsfor unit processes. We briefly overview recent progress in each of the different layers. Finally, we point outopportunities for future works in data-based optimization for mineral processing plants.
文摘Many studies revealed unconscious effects on conscious processing. However, in this study, we tried to investigate whether unconscious processes could interact with each other by using simultaneously presented face pictures with the same or a different unconscious valence (SUV versus DUV). In the first event-related potential (ERP) study, DUV elicited a smaller N2 as compared with SUV. In the second functional magnetic resonance imaging (fMRI) experiment, the left middle frontal gyrus (MFG) was activated under DUV condition in comparison to SUV condition. These results support the idea of interactions between unconscious processes (unconscious mismatch detection). The theoretical implications are discussed in the light of the global neuronal workspace theory.
文摘In this paper, we develop a new theoretical framework by means of the absorbing Markov process theory for analyzing some stochastic global optimization algorithms. Applying the framework to the pure random search, we prove that the pure random search converges to the global minimum in probability and its time has geometry distribution. We also analyze the pure adaptive search by this framework and turn out that the pure adaptive search converges to the global minimum in probability and its time has Poisson distribution.
基金the National Natural Science Foundation of China(61963010 and 61563011)the special project for cultivation of new academic talent and innovation exploration of Guizhou Normal University in 2019(11904-0520077)。
文摘This paper considers a dynamic optimization problem(DOP)of 1,3-propanediol fermentation process(1,3-PFP).Our main contributions are as follows.Firstly,the DOP of 1,3-PFP is modeled as an optimal control problem of switched dynamical systems.Unlike the existing switched dynamical system optimal control problem,the state-dependent switching method is applied to design the switching rule.Then,in order to obtain the numerical solution,by introducing a discrete-valued function and using a relaxation technique,this problem is transformed into a nonlinear parameter optimization problem(NPOP).Although the gradient-based algorithm is very efficient for solving NPOPs,the existing algorithm is always trapped in a local minimum for such problems with multiple local minima.Next,in order to overcome this challenge,a gradient-based random search algorithm(GRSA)is proposed based on an improved gradient-based algorithm(IGA)and a novel random search algorithm(NRSA),which cannot usually be trapped in a local minimum.The convergence results are also established,and show that the GRSA is globally convergent.Finally,a DOP of 1,3-PFP is provided to illustrate the effectiveness of the GRSA proposed by this paper.
基金Supported by the National Natural Science Foundation of China(61273167)
文摘Complex processes often work with multiple operation regions, it is critical to develop effective monitoring approaches to ensure the safety of chemical processes. In this work, a discriminant local consistency Gaussian mixture model(DLCGMM) for multimode process monitoring is proposed for multimode process monitoring by integrating LCGMM with modified local Fisher discriminant analysis(MLFDA). Different from Fisher discriminant analysis(FDA) that aims to discover the global optimal discriminant directions, MLFDA is capable of uncovering multimodality and local structure of the data by exploiting the posterior probabilities of observations within clusters calculated from the results of LCGMM. This may enable MLFDA to capture more meaningful discriminant information hidden in the high-dimensional multimode observations comparing to FDA. Contrary to most existing multimode process monitoring approaches, DLCGMM performs LCGMM and MFLDA iteratively, and the optimal subspaces with multi-Gaussianity and the optimal discriminant projection vectors are simultaneously achieved in the framework of supervised and unsupervised learning. Furthermore, monitoring statistics are established on each cluster that represents a specific operation condition and two global Bayesian inference-based fault monitoring indexes are established by combining with all the monitoring results of all clusters. The efficiency and effectiveness of the proposed method are evaluated through UCI datasets, a simulated multimode model and the Tennessee Eastman benchmark process.