On July 17,2024,Chinese electric vehicle manufacturer GAC International opened a smart factory in Rayong Province,Thailand.The next day,then Prime Minister of Thailand Saita Thawaixin met with a delegation led by Zeng...On July 17,2024,Chinese electric vehicle manufacturer GAC International opened a smart factory in Rayong Province,Thailand.The next day,then Prime Minister of Thailand Saita Thawaixin met with a delegation led by Zeng Qinghong,chairman of GAC Group.He encouraged GAC to purchase various spare parts in Thailand to enhance Thailand’s position in the global electric vehicle industry supply chain.“Thailand has a favorable business environment,”Zeng responded.“As the location of GAC’s first wholly-owned overseas facility,it was our premier choice.”展开更多
Kinematics has evolved with and contributed significantly to human demands. For example, slider-crank mechanisms have been widely used in engines since the industrial revolution. Additionally, constant-velocity shaft ...Kinematics has evolved with and contributed significantly to human demands. For example, slider-crank mechanisms have been widely used in engines since the industrial revolution. Additionally, constant-velocity shaft couplings have been developed to meet the needs of the automobile industry since the 1920＇s. With the development of robots, robot kinematics has been one of the research focuses in Kinematics since the 1970＇s.展开更多
BMW China R&D Center officially opened its facility in Beijing’s Shunyi District on May 15, 2018. The center is by far the biggest presence of BMW R&D outside Germany, among those in the U.S., Japan, South Ko...BMW China R&D Center officially opened its facility in Beijing’s Shunyi District on May 15, 2018. The center is by far the biggest presence of BMW R&D outside Germany, among those in the U.S., Japan, South Korea, and China, and its size far exceeds the company’s R&D center in Silicon Valley, northern California, U.S.A.展开更多
Fortune magazine has released China 100 in its September issue. This is the second consecutive year Fortune has released China 100. The ranking is made according to the business income of the country's major compa...Fortune magazine has released China 100 in its September issue. This is the second consecutive year Fortune has released China 100. The ranking is made according to the business income of the country's major companies in 2001.展开更多
Two recent bond offerings by China National Offshore Oil Corporation(CNOOC)and China Petrochemical Corporation(Sinopce)offer strong evidence of Chinese ascendancy to the world stage of finance,says veteran banker,Ther...Two recent bond offerings by China National Offshore Oil Corporation(CNOOC)and China Petrochemical Corporation(Sinopce)offer strong evidence of Chinese ascendancy to the world stage of finance,says veteran banker,Therese Esperdy,who heads Banking for Asia Pacific Corporate&Investment Bank at JP Morgan.The bond offering issued by CNOOC and Sinopec in the autumn of 2013 will set China in the global arena with full benefit rights as a prime player on world financial markets.展开更多
The forum brings together leaders from the Fortune 500 companies so that they may discuss matters on world economic development, Like the Fortune 500 list, forum findings are highly regarded by entrepreneurs and compa...The forum brings together leaders from the Fortune 500 companies so that they may discuss matters on world economic development, Like the Fortune 500 list, forum findings are highly regarded by entrepreneurs and company leaders. me upcoming forum will give world business leaders the Opportunity to learn more about China and to observe Chinese markets. At the same time, the forum will give Chinese entrepreneurs the opportunity to solicit direct investment from transnationals.展开更多
Chinese oil giants are eyeing an expanded presence in Brazil, winning holdings in three blocks awarded in Brazil＇s deepwater oil auction in a historic opening of the pre-salt play to foreign operators. Consortiums co...Chinese oil giants are eyeing an expanded presence in Brazil, winning holdings in three blocks awarded in Brazil＇s deepwater oil auction in a historic opening of the pre-salt play to foreign operators. Consortiums comprising China＇s three major oil giants, China National Petroleum Corp, China Petroleum ＆ Chemical Corp and China National Offshore Oil Corp, have respectively won three blocks recently, deepening the energy cooperation between the two countries. China has the technology,展开更多
AS a Chinese proverb goes, if two brothers are of the same mind, their sharpness can cut through metal. China CNR Corp. （CNR） and China CSR Corp. （CSR）, the world＇s two largest railway transportation equipment ma...AS a Chinese proverb goes, if two brothers are of the same mind, their sharpness can cut through metal. China CNR Corp. （CNR） and China CSR Corp. （CSR）, the world＇s two largest railway transportation equipment manufacturers, have decided to merge to compete in the global arena.展开更多
"I came to Chengdu for the giant pandas,and I stayed for the people and the sports," says Lamia Arab,from London,the United Kingdom.She moved to Chengdu,capital of Southwest China,s Sichuan Province,in 2017...."I came to Chengdu for the giant pandas,and I stayed for the people and the sports," says Lamia Arab,from London,the United Kingdom.She moved to Chengdu,capital of Southwest China,s Sichuan Province,in 2017.She is now a lecturer at Chengdu University.展开更多
Background:Giant cell arteritis(GCA),the most common systemic vasculitis affecting elderly individuals,currently lacks specific therapies.This study aimed to systematically identify therapeutic targets for GCA through...Background:Giant cell arteritis(GCA),the most common systemic vasculitis affecting elderly individuals,currently lacks specific therapies.This study aimed to systematically identify therapeutic targets for GCA through integration of large-scale multi-omics datasets.Methods:We constructed a multi-stage analytical framework encompassing 32 proteomic datasets(covering 2914 unique plasma proteins)and 6 transcriptomic datasets.Multi-omics integration strategies,including two-sample Mendelian randomization,colocalization analysis,and functional enrichment analysis,were employed to identify and validate causal relationships between candidate targets and GCA risk across 4 independent European-ancestry GCA cohorts.Single-cell RNA sequencing analysis of peripheral blood mononuclear cells from untreated GCA patients was performed to characterize hub gene-immune cell relationships.Results:We identified 43 plasma proteins causally associated with GCA[false discovery rate(FDR)<0.05],with 17 representing novel therapeutic targets.Through dual validation using proteome-wide association studies and transcriptome-wide association studies,we identified 13 high-confidence candidate targets with distinct tissue-specific expression patterns.Unc-51 like kinase 3(ULK3)emerged as the strongest protective factor(odds ratio=0.47,95%confidence interval:0.37–0.71)through autophagy regulation,while SLAMF7 represents an immediate drug repositioning opportunity as the target of food and drug administration-approved elotuzumab.Five targets have existing approved drugs(SLAMF7,ICAM1,IL18,IL6ST,CTSS).Single-cell analysis revealed profound disruption of hub gene-immune cell relationships in untreated GCA patients,with cell-type-specific alterations in inflammatory gene expression,and TYMP as the most critical hub gene.Conclusions:This study provides a clinically-actionable atlas of 43 potential therapeutic targets in GCA,identifying novel mechanisms including autophagy modulation and metabolic reprogramming,with immediate drug repositioning opportunities and precision medicine strategies based on tissue-specific and cell-type-specific expression patterns.These findings require experimental validation before clinical translation.展开更多
The accumulation and circulation of carbon and hydrogen contribute to the chemical evolution of ice giant planets.Species separation and diamond precipitation have been reported in carbon-hydrogen systems and have bee...The accumulation and circulation of carbon and hydrogen contribute to the chemical evolution of ice giant planets.Species separation and diamond precipitation have been reported in carbon-hydrogen systems and have been verified by static and shock compression experiments.Nevertheless,the dynamic formation processes underlying these phenomena remain insufficiently understood.In combination with a deep learning model,we demonstrate that diamonds form through a three-step process involving dissociation,species separation,and nucleation processes.Under shock conditions of 125 GPa and 4590 K,hydrocarbons decompose to give hydrogen and low-molecular-weight alkanes(CH_(4) and C_(2)H_(6)),which escape from the carbon chains,resulting in C/H species separation.The remaining carbon atoms without C-H bonds accumulate and nucleate to form diamond crystals.The process of diamond growth is associated with a critical nucleus size at which the dynamic energy barrier plays a key role.These dynamic processes of diamond formation provide insight into the establishment of a model for the evolution of ice giant planets.展开更多
At the core of current China-U.S. relations are post-Cold War experiences and major differences when it comes to politics, economy and security. But despite these issues and the rhetoric that surrounds them, the poten...At the core of current China-U.S. relations are post-Cold War experiences and major differences when it comes to politics, economy and security. But despite these issues and the rhetoric that surrounds them, the potential for cooperation remains great In an article published by Global Times, Wu Xinbo, Deputy Principal of the International Relations and Public Affairs College of Shanghai Fudan University, shares his analysis of bilateral ties. Excerpts follow:展开更多
On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged s...On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged salt lake resources,the proved lithium resources reserve here accounts for over 1/3 of the global resources reserve and over展开更多
文摘On July 17,2024,Chinese electric vehicle manufacturer GAC International opened a smart factory in Rayong Province,Thailand.The next day,then Prime Minister of Thailand Saita Thawaixin met with a delegation led by Zeng Qinghong,chairman of GAC Group.He encouraged GAC to purchase various spare parts in Thailand to enhance Thailand’s position in the global electric vehicle industry supply chain.“Thailand has a favorable business environment,”Zeng responded.“As the location of GAC’s first wholly-owned overseas facility,it was our premier choice.”
文摘Kinematics has evolved with and contributed significantly to human demands. For example, slider-crank mechanisms have been widely used in engines since the industrial revolution. Additionally, constant-velocity shaft couplings have been developed to meet the needs of the automobile industry since the 1920＇s. With the development of robots, robot kinematics has been one of the research focuses in Kinematics since the 1970＇s.
文摘BMW China R&D Center officially opened its facility in Beijing’s Shunyi District on May 15, 2018. The center is by far the biggest presence of BMW R&D outside Germany, among those in the U.S., Japan, South Korea, and China, and its size far exceeds the company’s R&D center in Silicon Valley, northern California, U.S.A.
文摘Fortune magazine has released China 100 in its September issue. This is the second consecutive year Fortune has released China 100. The ranking is made according to the business income of the country's major companies in 2001.
文摘Two recent bond offerings by China National Offshore Oil Corporation(CNOOC)and China Petrochemical Corporation(Sinopce)offer strong evidence of Chinese ascendancy to the world stage of finance,says veteran banker,Therese Esperdy,who heads Banking for Asia Pacific Corporate&Investment Bank at JP Morgan.The bond offering issued by CNOOC and Sinopec in the autumn of 2013 will set China in the global arena with full benefit rights as a prime player on world financial markets.
文摘The forum brings together leaders from the Fortune 500 companies so that they may discuss matters on world economic development, Like the Fortune 500 list, forum findings are highly regarded by entrepreneurs and company leaders. me upcoming forum will give world business leaders the Opportunity to learn more about China and to observe Chinese markets. At the same time, the forum will give Chinese entrepreneurs the opportunity to solicit direct investment from transnationals.
文摘Chinese oil giants are eyeing an expanded presence in Brazil, winning holdings in three blocks awarded in Brazil＇s deepwater oil auction in a historic opening of the pre-salt play to foreign operators. Consortiums comprising China＇s three major oil giants, China National Petroleum Corp, China Petroleum ＆ Chemical Corp and China National Offshore Oil Corp, have respectively won three blocks recently, deepening the energy cooperation between the two countries. China has the technology,
文摘AS a Chinese proverb goes, if two brothers are of the same mind, their sharpness can cut through metal. China CNR Corp. （CNR） and China CSR Corp. （CSR）, the world＇s two largest railway transportation equipment manufacturers, have decided to merge to compete in the global arena.
文摘"I came to Chengdu for the giant pandas,and I stayed for the people and the sports," says Lamia Arab,from London,the United Kingdom.She moved to Chengdu,capital of Southwest China,s Sichuan Province,in 2017.She is now a lecturer at Chengdu University.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2025ZFJH03)the Central Guidance Fund for Local Science and Technology Development(No.2024ZY01054)the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-045).
文摘Background:Giant cell arteritis(GCA),the most common systemic vasculitis affecting elderly individuals,currently lacks specific therapies.This study aimed to systematically identify therapeutic targets for GCA through integration of large-scale multi-omics datasets.Methods:We constructed a multi-stage analytical framework encompassing 32 proteomic datasets(covering 2914 unique plasma proteins)and 6 transcriptomic datasets.Multi-omics integration strategies,including two-sample Mendelian randomization,colocalization analysis,and functional enrichment analysis,were employed to identify and validate causal relationships between candidate targets and GCA risk across 4 independent European-ancestry GCA cohorts.Single-cell RNA sequencing analysis of peripheral blood mononuclear cells from untreated GCA patients was performed to characterize hub gene-immune cell relationships.Results:We identified 43 plasma proteins causally associated with GCA[false discovery rate(FDR)<0.05],with 17 representing novel therapeutic targets.Through dual validation using proteome-wide association studies and transcriptome-wide association studies,we identified 13 high-confidence candidate targets with distinct tissue-specific expression patterns.Unc-51 like kinase 3(ULK3)emerged as the strongest protective factor(odds ratio=0.47,95%confidence interval:0.37–0.71)through autophagy regulation,while SLAMF7 represents an immediate drug repositioning opportunity as the target of food and drug administration-approved elotuzumab.Five targets have existing approved drugs(SLAMF7,ICAM1,IL18,IL6ST,CTSS).Single-cell analysis revealed profound disruption of hub gene-immune cell relationships in untreated GCA patients,with cell-type-specific alterations in inflammatory gene expression,and TYMP as the most critical hub gene.Conclusions:This study provides a clinically-actionable atlas of 43 potential therapeutic targets in GCA,identifying novel mechanisms including autophagy modulation and metabolic reprogramming,with immediate drug repositioning opportunities and precision medicine strategies based on tissue-specific and cell-type-specific expression patterns.These findings require experimental validation before clinical translation.
基金supported by the National Natural Science Foundation of China(Grant Nos.12534013,12047561,and 12104507)the Science and Technology Innovation Program of Hunan Province(Grant Nos.2025ZYJ001 and 2021RC4026)the National University of Defense Technology Research Fund Project.
文摘The accumulation and circulation of carbon and hydrogen contribute to the chemical evolution of ice giant planets.Species separation and diamond precipitation have been reported in carbon-hydrogen systems and have been verified by static and shock compression experiments.Nevertheless,the dynamic formation processes underlying these phenomena remain insufficiently understood.In combination with a deep learning model,we demonstrate that diamonds form through a three-step process involving dissociation,species separation,and nucleation processes.Under shock conditions of 125 GPa and 4590 K,hydrocarbons decompose to give hydrogen and low-molecular-weight alkanes(CH_(4) and C_(2)H_(6)),which escape from the carbon chains,resulting in C/H species separation.The remaining carbon atoms without C-H bonds accumulate and nucleate to form diamond crystals.The process of diamond growth is associated with a critical nucleus size at which the dynamic energy barrier plays a key role.These dynamic processes of diamond formation provide insight into the establishment of a model for the evolution of ice giant planets.
文摘At the core of current China-U.S. relations are post-Cold War experiences and major differences when it comes to politics, economy and security. But despite these issues and the rhetoric that surrounds them, the potential for cooperation remains great In an article published by Global Times, Wu Xinbo, Deputy Principal of the International Relations and Public Affairs College of Shanghai Fudan University, shares his analysis of bilateral ties. Excerpts follow:
文摘On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged salt lake resources,the proved lithium resources reserve here accounts for over 1/3 of the global resources reserve and over
