Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E（1 and 2）,together with three known analogs.The structures of...Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E（1 and 2）,together with three known analogs.The structures of the new compounds were established by extensive analysis of 1Dand 2DNMR spectra,as well as MS data.Their absolute configurations were determined by CD spectra.All compounds showed moderate inhibitory effects on A431,A549,BGC-823,HL-60,HT-29,and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 μM.展开更多
Two new sesquiterpene esters, 3b, 6b, 8a-triacetyl-4b, 5a-epoxy -1- oxogermacr- 10(14)-ene (1) and 3b, 6b, 8a-triacetyl-4b, 5a-epoxygermacr-1(10)-ene (2) were isolated from the whole plant of Salvia roborowskii Maxim....Two new sesquiterpene esters, 3b, 6b, 8a-triacetyl-4b, 5a-epoxy -1- oxogermacr- 10(14)-ene (1) and 3b, 6b, 8a-triacetyl-4b, 5a-epoxygermacr-1(10)-ene (2) were isolated from the whole plant of Salvia roborowskii Maxim. Their structures were elucidated by means of spectral data (2DNMR and HRMS).展开更多
A new sesquiterpene with a unusual modified germacrane skeleton was isolated from the ethanol extracts of the roots of Biondia hemsleyana and its structure was elucidated as 3β-hydroxy- 4,14-cyclogermacra-11-en-9-one...A new sesquiterpene with a unusual modified germacrane skeleton was isolated from the ethanol extracts of the roots of Biondia hemsleyana and its structure was elucidated as 3β-hydroxy- 4,14-cyclogermacra-11-en-9-one by the spectroscopic methods and X-ray crystallography.展开更多
Two new germacranes, chrysanthemumins C （1） and D （2）, and five eudesmanes, chrysanthemumols I-K （3- 5） as new ones, eudesm-4（14）-ene-3a,11-diol （6） and canusesnol E （7）, were isolated from the ethyl aceta...Two new germacranes, chrysanthemumins C （1） and D （2）, and five eudesmanes, chrysanthemumols I-K （3- 5） as new ones, eudesm-4（14）-ene-3a,11-diol （6） and canusesnol E （7）, were isolated from the ethyl acetate soluble fraction of 95% EtOH extract of the flowers of Chrysanthemum indicum. The structures of isolated sesquiterpe- noids were elucidated on basis of extensive spectroscopic evidences.展开更多
基金Financial support from the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"(Nos.2012ZX09301001-001,2015ZX09103002)the National Natural Science Funds of China(Nos.81302657,81573305,81473112)+3 种基金Youth Innovation Promotion Association CAS,the Ministry of Science and Technology(No.2010DFA30980)the Chinese Academy of Sciences(No.KSZD-EW-Z-004-01)the Shanghai Commission of Science and Technology(No.11DZ1970700,12JC1410300)the Research Fund of University of Macao(MYRG2014-00020-ICMS-QRCM and MYRG2015-00153ICMS-QRCM)
文摘Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E（1 and 2）,together with three known analogs.The structures of the new compounds were established by extensive analysis of 1Dand 2DNMR spectra,as well as MS data.Their absolute configurations were determined by CD spectra.All compounds showed moderate inhibitory effects on A431,A549,BGC-823,HL-60,HT-29,and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 μM.
基金the Natural Science Foundation of Gansu Province(No.25001-A25-001-2)
文摘Two new sesquiterpene esters, 3b, 6b, 8a-triacetyl-4b, 5a-epoxy -1- oxogermacr- 10(14)-ene (1) and 3b, 6b, 8a-triacetyl-4b, 5a-epoxygermacr-1(10)-ene (2) were isolated from the whole plant of Salvia roborowskii Maxim. Their structures were elucidated by means of spectral data (2DNMR and HRMS).
文摘A new sesquiterpene with a unusual modified germacrane skeleton was isolated from the ethanol extracts of the roots of Biondia hemsleyana and its structure was elucidated as 3β-hydroxy- 4,14-cyclogermacra-11-en-9-one by the spectroscopic methods and X-ray crystallography.
文摘Two new germacranes, chrysanthemumins C （1） and D （2）, and five eudesmanes, chrysanthemumols I-K （3- 5） as new ones, eudesm-4（14）-ene-3a,11-diol （6） and canusesnol E （7）, were isolated from the ethyl acetate soluble fraction of 95% EtOH extract of the flowers of Chrysanthemum indicum. The structures of isolated sesquiterpe- noids were elucidated on basis of extensive spectroscopic evidences.
