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Geometry-based BERT:An experimentally validated deep learning model for molecular property prediction in drug discovery
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作者 Xiang Zhang Chenliang Qian +5 位作者 Bochao Yang Hongwei Jin Song Wu Jie Xia Fan Yang Liangren Zhang 《Journal of Pharmaceutical Analysis》 2025年第12期2960-2974,共15页
Various deep learning based methods have significantlyimpacted the realm of drug discovery.The development of deep learning methods for identifying novel structural types of active compounds has become an urgent chall... Various deep learning based methods have significantlyimpacted the realm of drug discovery.The development of deep learning methods for identifying novel structural types of active compounds has become an urgent challenge.In this paper,we introduce a self-supervised representation learning framework,i.e.,Geometry-based Bidirectional Encoder Representations from Transformers(GEO-BERT).GEO-BERT considers the information of atoms and chemical bonds in chemical structures as the input,and integrates the positional information of the three-dimensional conformation of the molecule for training.Specifically,GEO-BERT enhances its ability to characterize molecular structures by introducing three different positional relationships:atom-atom,bond-bond,and atom-bond.By benchmarking study,GEO-BERT has demonstrated optimal performance on multiple benchmarks.We also performed prospective study to validate the GEO-BERT model,with screening for DYRK1A inhibitors as a case.Two potent and novel DYRK1A inhibitors(IC_(50):<1μM)were ultimately discovered.Taken together,we have developed an open-source GEO-BERT model for molecular property prediction(https://github.com/drug-designer/GEO-BERT)and proved its practical utility in early-stage drug discovery. 展开更多
关键词 Drug discovery Chemical pre-trained model Self-supervised learning BERT DYRK1A inhibitor
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3D Geometry-Based UAV-MIMO Channel Modeling and Simulation 被引量:15
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作者 Rubing Jia Yiran Li +1 位作者 Xiang Cheng Bo Ai 《China Communications》 SCIE CSCD 2018年第12期64-74,共11页
A more general narrowband regular-shaped geometry-based statistical model(RS-GBSM) combined with the line of sight(LoS) and single bounce(SB) rays for unmanned aerial vehicle(UAV) multiple-input multiple-output(MIMO) ... A more general narrowband regular-shaped geometry-based statistical model(RS-GBSM) combined with the line of sight(LoS) and single bounce(SB) rays for unmanned aerial vehicle(UAV) multiple-input multiple-output(MIMO) channel is proposed in this paper. The channel characteristics, including space-time correlation function(STCF), Doppler power spectral density(DPSD), level crossing rate(LCR) and average fade duration(AFD), are derived based on the single sphere reference model for a non-isotropic environment. The corresponding sum-of-sinusoids(SoS) simulation models including both the deterministic model and statistical model with finite scatterers are also proposed for practicable implementation. The simulation results illustrate that the simulation models well reproduce the channel characteristics of the single sphere reference model with sufficient simulation scatterers. And the statistical model has a better approximation of the reference model in comparison with the deterministic one when the simulation trials of the stochastic model are sufficient. The effects of the parameters such as flight height, moving direction and Rice factor on the characteristics are also studied. 展开更多
关键词 UAV-MIMO geometry-based model CHANNEL CHARACTERISTICS simulation model
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A 3D Geometry-Based Scattering Model for Vehicleto-Vehicle Wideband MIMO Relay-Based Cooperative Channels 被引量:1
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作者 Xiaolin Liang Xiongwen Zhao +2 位作者 Shu Li Qi Wang Wenbing Lu 《China Communications》 SCIE CSCD 2016年第10期1-10,共10页
In this paper, a three-dimensional(3D) geometry- based stochastic scattering model(GBSSM) for wideband multi-input multi-output(MIMO) vehicle-to-vehicle(V2V) relay-based cooperative fading channel based on geometrical... In this paper, a three-dimensional(3D) geometry- based stochastic scattering model(GBSSM) for wideband multi-input multi-output(MIMO) vehicle-to-vehicle(V2V) relay-based cooperative fading channel based on geometrical three-cylinder is proposed. Non-line-of-sight(NLOS) propagation condition is assumed in amplify-and-forward(AF) cooperative networks from the source mobile station(S) to the destination mobile station(D) via the mobile relay station(R). We extend the proposed narrowband model to wideband and also introduce the carrier frequency and bandwidth into the model. To avoid complicated procedure in deriving the analytical expressions of the channel parameters and functions, the channel is realized first. By using the realized channel matrix, the channel properties are further investigated. 展开更多
关键词 geometry-based scattering model MIMO relay-based cooperative communication vehicle-to-vehicle(V2V) WIDEBAND
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3D non-stationary geometry-based stochastic model for unmanned aerial vehicle air-to-ground multi-input multi-output channels
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作者 Yan Feng Zhou Tianxiang +4 位作者 Li Hao Pang Jingming Ding Kai Xia Weiwei Shen Lianfeng 《Journal of Southeast University(English Edition)》 EI CAS 2022年第4期323-331,共9页
A three-dimensional non-stationary geometry-based stochastic model for unmanned aerial vehicle(UAV)air-to-ground multi-input multi-output(MIMO)channels is proposed.The scatterers surrounding the UAV and ground station... A three-dimensional non-stationary geometry-based stochastic model for unmanned aerial vehicle(UAV)air-to-ground multi-input multi-output(MIMO)channels is proposed.The scatterers surrounding the UAV and ground station are assumed to be distributed on the surface of two cylinders in the proposed model.The impact of UAV rotations and accelerated motion is considered to describe channel non-stationarity.The computational methods of the corresponding time-variant parameters,such as UAV antenna array angles,time delays,and maximum Doppler frequencies,are theoretically deduced.The model is then used to derive channel statistical properties such as space-time correlation functions and Doppler power spectral density.Finally,numerical simulations are run to validate the channel s statistical properties.The simulation results show that increasing the UAV and ground station accelerations can reduce the time correlation function and increase channel non-stationarity in the time domain.Furthermore,the UAV s rotation significantly influences the spatial correlation function,with rolling having a greater influence than pitching.Similarly,the different directions of UAV movement significantly impact the Doppler power spectral density. 展开更多
关键词 unmanned aerial vehicles(UAVs) geometry-based stochastic model(GBSM) air-to-ground channels
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A Geometry-Based Non-Stationary MIMO Channel Model for Vehicular Communications 被引量:6
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作者 Yuanyuan Ma Lei Yang Xianghan Zheng 《China Communications》 SCIE CSCD 2018年第7期30-38,共9页
This paper derives a non-stationary multiple-input multiple-output(MIMO) from the one-ring scattering model. The proposed channel model characterizes vehicular radio propagation channels with considerations of moving ... This paper derives a non-stationary multiple-input multiple-output(MIMO) from the one-ring scattering model. The proposed channel model characterizes vehicular radio propagation channels with considerations of moving base and mobile stations, which makes the angle of arrivals(AOAs) along with the angle of departures(AODs) time-variant. We introduce the methodology of including the time-variant impacts when characterizing non-stationary radio propagation channels through the geometrical channel modelling approach. We analyze the statistical properties of the proposed channel model including the local time-variant autocorrelation function(ACF) and the space cross-correlation functions(CCFs). We show that the model developed in this paper for non-stationary scenarios includes the existing one-ring wide-sense stationary channel model as its special case. 展开更多
关键词 vehicular communications mobile fading channels non-stationary channels multiple antennas geometrical channel modeling one-ring scattering model
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UAV-to-Ground Channel Modeling:(Quasi-)Closed-Form Channel Statistics and Manual Parameter Estimation
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作者 Zeng Linzhou Liao Xuewen +3 位作者 Xie Wenwu Ma Zhangfeng Xiong Baiping Jiang Hao 《China Communications》 2026年第1期47-66,共20页
(Quasi-)closed-form results for the statistical properties of unmanned aerial vehicle(UAV)airto-ground channels are derived for the first time using a novel spatial-vector-based method from a threedimensional(3-D)arbi... (Quasi-)closed-form results for the statistical properties of unmanned aerial vehicle(UAV)airto-ground channels are derived for the first time using a novel spatial-vector-based method from a threedimensional(3-D)arbitrary-elevation one-cylinder model.The derived results include a closed-form expression for the space-time correlation function and some quasi-closed-form ones for the space-Doppler power spectrum density,the level crossing rate,and the average fading duration,which are shown to be the generalizations of those previously obtained from the two-dimensional(2-D)one-ring model and the 3-D low-elevation one-cylinder model for terrestrial mobile-to-mobile channels.The close agreements between the theoretical results and the simulations as well as the measurements validate the utility of the derived channel statistics.Based on the derived expressions,the impacts of some parameters on the channel characteristics are investigated in an effective,efficient,and explicable way,which leads to a general guideline on the manual parameter estimation from the measurement description. 展开更多
关键词 channel characteristics geometry-based stochastic model manual parameter estimation UAV channel modeling
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Polarization Projection for 3D Geometry-Based Stochastic Channel Model
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作者 PANG Lihua ZHANG Yang +5 位作者 GONG Fengkui WANG Anyi XIAO Liyuan LIANG Xiao WANG Qiaofeng LI Jiandong 《China Communications》 SCIE CSCD 2015年第10期52-63,共12页
Comprehensive radiation characteristics of polarized antenna are crucial in creating practical channel coefficients for next generation wireless communication system designs.Being currently supported within3 D geometr... Comprehensive radiation characteristics of polarized antenna are crucial in creating practical channel coefficients for next generation wireless communication system designs.Being currently supported within3 D geometry-based stochastic channel models(GSCM),field patterns are technically obtained by chamber measurement(or by its best fitting).However,in some channel related performance analysis scenarios,design insight can be crystallized better by starting the derivations with theoretical co-polarization and cross-polarization components.Specifically,these two components are mathematically linked with field patterns through the proposed polarization projection algorithm.In this manuscript,we focus on revealing the transformation criterion of polarization states between the antenna plane and the propagation plane.In practice,it makes retrieving the field patterns by electromagnetic computation possible.Meanwhile,the impact imposed by distinct antenna orientations is geometrically illustrated and consequently incorporated into the proposed algorithm.This will further facilitate flexible performance evaluation of related radio transmission technologies.Our conclusions are verified by the closed-form expression of the dipole field pattern(via an analytical approach) and by chamber measurement results.Moreover,we find that its 2D degenerative case is aligned with the definitions in 3^(rd) generation partnership project(3GPP)technical report 25.996.The most obvious benefit of the proposed algorithm is to significantly reduce the cost on generating channel coefficients in GSCM simulation. 展开更多
关键词 polarization 3D geometry-based stochastic channel model antenna orientation radiation characteristics dipole chamber measurement channel simulation
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A decision framework for rural domestic sewage treatment models and process:Evidence from Inner Mongolia Autonomous Region,China 被引量:1
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作者 Ying Yan Pengyu Li +5 位作者 Zixuan Wang Yubo Tan Tianlong Zheng Jianguo Liu Xiaoxia Yang Junxin Liu 《Journal of Environmental Sciences》 2026年第1期302-311,共10页
Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making sys... Rural domestic sewage treatment is critical for environmental protection.This study defines the spatial pattern of villages from the perspective of rural sewage treatment and develops an integrated decision-making system to propose a sewage treatment mode and scheme suitable for local conditions.By considering the village spatial layout and terrain factors,a decision tree model of residential density and terrain type was constructed with accuracies of 76.47%and 96.00%,respectively.Combined with binary classification probability unit regression,an appropriate sewage treatment mode for the village was determined with 87.00%accuracy.The Analytic Hierarchy Process(AHP),combined with the Technique for Order Preference(TOPSIS)by Similarity to an Ideal Solution model,formed the basis for optimal treatment process selection under different emission standards.Verification was conducted in 542 villages across three counties of the Inner Mongolia Autonomous Region,focusing on the standard effluent effect(0.3773),low investment cost(0.3196),and high standard effluent effect(0.5115)to determine the best treatment process for the same emission standard under different needs.The annual environmental and carbon emission benefits of sewage treatment in these villages were estimated.This model matches village density,geographic feature,and social development level,and provides scientific support and a theoretical basis for rural sewage treatment decision-making. 展开更多
关键词 Rural domestic sewage Sewage treatment model DECISION-MAKING Environmental-economic benefits Inner Mongolia
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Description and Evaluation of the Emission and Atmospheric Processes Integrated and Coupled Community(EPICC)Model Version 1.0 被引量:1
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作者 EPICC Model Working Group 《Advances in Atmospheric Sciences》 2026年第4期671-694,I0001-I0006,共30页
We present a comprehensive description and benchmark evaluation of the global–regional chemical transport model called the Emission and Atmospheric Processes Integrated and Coupled Community(EPICC)model.The framework... We present a comprehensive description and benchmark evaluation of the global–regional chemical transport model called the Emission and Atmospheric Processes Integrated and Coupled Community(EPICC)model.The framework incorporates(1)grid configuration,(2)transport dynamics,(3)chemical mechanisms,(4)aerosol processes,(5)wet/dry deposition parameterizations,and(6)heterogeneous chemistry treatments associated with sulfate,nitrous acid(HONO)chemistry,and aerosol/cloud–photolysis interactions(APIs/CPIs).Openly shared with the atmospheric research community,the model facilitates integration of advanced physicochemical schemes to enhance simulation accuracy.Globally,the model demonstrates realistic representations of ozone(O_(3))and aerosol optical depth.The EPICC model generally demonstrates robust performance in simulating regional concentrations of O_(3) and PM_(2.5)(and its components)in China.It successfully captures vertical profiles of both global and regional O_(3).Notably,the model mitigates frequently reported sulfate underestimations in highly industrialized regions of China.The model accurately captures two regional severe pollution episodes observed in eastern China(January/June 2021).Sensitivity experiments highlight the critical roles of heterogeneous chemical mechanisms associated with sulfate,HONO chemistry,APIs,and CPIs in capturing PM_(2.5) and O_(3) concentrations in China.Improved sulfate mechanisms result in an increase of approximately 32.4%(2.8μg m^(−3))in simulated winter sulfate concentrations when observations exceed 10μg m^(−3).Enhanced HONO elevates winter O_(3) and PM_(2.5) by≤20 and≤10μg m^(−3),respectively.Overall,CPIs dominate over APIs in improving O_(3) and PM_(2.5) simulations across China.Locally,APIs mitigate PM_(2.5) and O_(3) discrepancies in the Sichuan Basin.Seasonal cloud–chemistry coupling explains the weaker impact of PM_(2.5) in summer. 展开更多
关键词 EPICC model PM_(2.5) O_(3) sulfate nitrous acid aerosol/cloud-photolysis interactions
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Agri-Eval:Multi-level Large Language Model Valuation Benchmark for Agriculture
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作者 WANG Yaojun GE Mingliang +2 位作者 XU Guowei ZHANG Qiyu BIE Yuhui 《农业机械学报》 北大核心 2026年第1期290-299,共10页
Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLM... Model evaluation using benchmark datasets is an important method to measure the capability of large language models(LLMs)in specific domains,and it is mainly used to assess the knowledge and reasoning abilities of LLMs.Therefore,in order to better assess the capability of LLMs in the agricultural domain,Agri-Eval was proposed as a benchmark for assessing the knowledge and reasoning ability of LLMs in agriculture.The assessment dataset used in Agri-Eval covered seven major disciplines in the agricultural domain:crop science,horticulture,plant protection,animal husbandry,forest science,aquaculture science,and grass science,and contained a total of 2283 questions.Among domestic general-purpose LLMs,DeepSeek R1 performed best with an accuracy rate of 75.49%.In the realm of international general-purpose LLMs,Gemini 2.0 pro exp 0205 standed out as the top performer,achieving an accuracy rate of 74.28%.As an LLMs in agriculture vertical,Shennong V2.0 outperformed all the LLMs in China,and the answer accuracy rate of agricultural knowledge exceeded that of all the existing general-purpose LLMs.The launch of Agri-Eval helped the LLM developers to comprehensively evaluate the model's capability in the field of agriculture through a variety of tasks and tests to promote the development of the LLMs in the field of agriculture. 展开更多
关键词 large language models assessment systems agricultural knowledge agricultural datasets
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Ecological Dynamics of a Logistic Population Model with Impulsive Age-selective Harvesting
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作者 DAI Xiangjun JIAO Jianjun 《应用数学》 北大核心 2026年第1期72-79,共8页
In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asy... In this paper,we establish and study a single-species logistic model with impulsive age-selective harvesting.First,we prove the ultimate boundedness of the solutions of the system.Then,we obtain conditions for the asymptotic stability of the trivial solution and the positive periodic solution.Finally,numerical simulations are presented to validate our results.Our results show that age-selective harvesting is more conducive to sustainable population survival than non-age-selective harvesting. 展开更多
关键词 The logistic population model Selective harvesting Asymptotic stability EXTINCTION
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Special Issue“Recent Developments in Dimension Reduction and Model Checking”——In Honor of Professor Lixing Zhu's Outstanding Contributions in Statistics
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作者 ZHU Liping XU Wangli LI Yingxing 《Journal of Systems Science & Complexity》 2026年第1期1-2,共2页
The proliferation of high-dimensional data and the widespread use of complex models present central challenges in contemporary statistics and data science.Dimension reduction and model checking,as two foundational pil... The proliferation of high-dimensional data and the widespread use of complex models present central challenges in contemporary statistics and data science.Dimension reduction and model checking,as two foundational pillars supporting scientific inference and data-driven decisionmaking,have evolved through the collective wisdom of generations of statisticians.This special issue,titled"Recent Developments in Dimension Reduction and Model Checking for regressions",not only aims to showcase cutting-edge advances in the field but also carries a distinct sense of academic homage to honor the groundbreaking and enduring contributions of Professor Lixing Zhu,a leading scholar whose work has profoundly shaped both areas. 展开更多
关键词 scientific inference model checking model checkingas complex models dimension reduction high dimensional data
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Ecosystem service models are indeed being validated:A response to Pereira et al.(2025)
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作者 James M.Bullock Danny A.P.Hooftman +1 位作者 John W.Redhead Simon Willcock 《Geography and Sustainability》 2026年第1期247-248,共2页
In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation ... In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade. 展开更多
关键词 evaluation MAPPING modeling es model ecosystem services VALIDATION
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Efficient Model Reduction of Linear Time-varying Systems via Shifted Legendre Polynomial Approximations
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作者 XIAO Zhihua TANG Man ZHU Zhihui 《应用数学》 北大核心 2026年第2期481-493,共13页
This paper presents an efficient model reduction technique for linear time-varying systems based on shifted Legendre polynomials.The approach constructs approximate low-rank decomposition factors of finite-time Gramia... This paper presents an efficient model reduction technique for linear time-varying systems based on shifted Legendre polynomials.The approach constructs approximate low-rank decomposition factors of finite-time Gramians directly from the expansion coefficients of impulse responses.Leveraging these factors,we develop two model reduction algorithms that integrate the low-rank square root method with dominant subspace projection.Our method is computationally efficient and flexible,requiring only a few matrix-vector operations and a singular value decomposition of a low-dimensional matrix,thereby avoiding the need to solve differential Lyapunov equations.Numerical experiments confirm the effectiveness of the proposed approach. 展开更多
关键词 model reduction Time-varying systems Low-rank Gramians Balanced truncation Shifted Legendre polynomials
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Modeling of Precipitation over Africa:Progress,Challenges,and Prospects
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作者 A.A.AKINSANOLA C.N.WENHAJI +21 位作者 R.BARIMALALA P.-A.MONERIE R.D.DIXON A.T.TAMOFFO M.O.ADENIYI V.ONGOMA I.DIALLO M.GUDOSHAVA C.M.WAINWRIGHT R.JAMES K.C.SILVERIO A.FAYE S.S.NANGOMBE M.W.POKAM D.A.VONDOU N.C.G.HART I.PINTO M.KILAVI S.HAGOS E.N.RAJAGOPAL R.K.KOLLI S.JOSEPH 《Advances in Atmospheric Sciences》 2026年第1期59-86,共28页
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha... In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain. 展开更多
关键词 RAINFALL MONSOON climate modeling CORDEX CMIP6 convection-permitting models
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Modeling reaction between high-Al steel and slag with consideration of MgO-refractory dissolution into slag
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作者 Rong-Zhen Mo Chi-Hao Zhang +1 位作者 Ying Ren Li-Feng Zhang 《Journal of Iron and Steel Research International》 2026年第3期106-115,共10页
The dissolution of MgO-refractory into the slag had an obvious influence on the steel-slag reaction and the slag property,especially for high-aluminum steels.The dissolution behavior of MgO-refractory was investigated... The dissolution of MgO-refractory into the slag had an obvious influence on the steel-slag reaction and the slag property,especially for high-aluminum steels.The dissolution behavior of MgO-refractory was investigated under various conditions,including the temperature,the initial steel composition,and the initial slag composition.A steel-slag-refractory kinetic model for high-aluminum steel was developed,which incorporated the process of MgO-refractory dissolution.The dependence of the MgO mass transfer coefficient k_(MgO)^(r)on temperature T during MgO-refractory dissolution process was established,as described by ln k_(MgO)^(r)=63,754/T+24.38524.It was indicated that the MgO dissolution rate was significantly influenced by the temperature.A higher temperature increased the dissolution rate of MgO.The initial steel composition had a slight impact on the MgO dissolution rate.Additionally,the initial slag composition strongly impacted the MgO saturation concentration and the dissolution rate.A lower initial Al_(2)O_(3)/SiO_(2)ratio increased the MgO dissolution rate.The steel-slag-refractory kinetic model accurately predicted the dissolution of MgO-refractory and the influence of dissolved MgO on the viscosity and composition change during steel-slag-refractory reactions.It was suggested that a higher temperature can hardly reduce the viscosity due to the dissolution of the MgO-refractory. 展开更多
关键词 MgO-refractory Steel-slag-refractory model Kinetic model High-aluminum steel Mold flux
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Preferences of Chinese Dermatologists for Large Language Model Responses in Clinical Psoriasis Scenarios:A Nationwide Cross-Sectional Survey in China
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作者 Jungang Yang Jingkai Xu +6 位作者 Xuejiao Song Chengxu Li Lili Chen Lingbo Bi Tingting Jiang Xianbo Zuo Yong Cui 《Health Care Science》 2026年第1期40-48,共9页
Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the prefere... Background:Large language models(LLMs)have shown considerable promise in supporting clinical decision-making.However,their adoption and evaluation in dermatology remains limited.This study aimed to explore the preferences of Chinese dermatologists regarding LLM-generated responses in clinical psoriasis scenarios and to assess how they prioritize key quality dimensions,including accuracy,traceability,and logicality.Methods:A cross-sectional,web-based survey was conducted between December 25,2024,and January 22,2025,following the Checklist for Reporting Results of Internet E-Surveys guidelines.A total of 1247 valid responses were collected from practicing dermatologists across 33 of China's provincial-level administrative divisions.Participants evaluated responses to five categories of clinical questions(etiology,clinical presentation,differential diagnosis,treatment,and case study)generated by five LLMs:ChatGPT-4o,Kimi.ai,Doubao,ZuoYiGPT,and Lingyi-agent.Statistical associations between participant characteristics and model preferences were examined using chi-square tests.Results:ChatGPT-4o(Model 1)emerged as the most preferred model across all clinical tasks,consistently receiving the highest number of votes in case study(n=740),clinical presentation(n=666),differential diagnosis(n=707),etiology(n=602),and treatment(n=656).Significant variation in model preference by professional title was observed only for the differential diagnosis task(χ^(2)=21.13,df=12,p=0.0485),while no significant differences were found across hospital tiers(p>0.05).In terms of evaluation dimensions,accuracy was most frequently rated as“very important”(n=635).A significant association existed between hospital tier and the most valued dimension(χ^(2)=27.667,df=9,p=0.0011),with dermatologists in primary hospitals prioritizing traceability more than their peers in higher-tier hospitals.No significant associations were found across professional titles(p=0.127).Conclusions:Chinese dermatologists suggest a strong preference for ChatGPT-4o over domestic LLMs in psoriasis-related clinical tasks.While accuracy remains the primary criterion,traceability and logicality are also critical,particularly for clinicians in lower-tier hospitals.These findings suggest that future clinical LLMs should prioritize not only content accuracy but also source transparency and structural clarity to meet the diverse needs of different clinical settings. 展开更多
关键词 DERMATOLOGY large language model model evaluation
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Stability of k-ε model in Kolmogorov flow
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作者 Jiashuo GUO Le FANG 《Applied Mathematics and Mechanics(English Edition)》 2026年第1期165-184,共20页
The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpec... The Reynolds-averaged Navier-Stokes(RANS)technique enables critical engineering predictions and is widely adopted.However,since this iterative computation relies on the fixed-point iteration,it may converge to unexpected non-physical phase points in practice.We conduct an analysis on the phase-space characteristics and the fixed-point theory underlying the k-ε turbulence model,and employ the classical Kolmogorov flow as a framework,leveraging its direct numerical simulation(DNS)data to construct a one-dimensional(1D)system under periodic/fixed boundary conditions.The RANS results demonstrate that under periodic boundary conditions,the k-ε model exhibits only a unique trivial fixed point,with asymptotes capturing the phase portraits.The stability of this trivial fixed point is determined by a mathematically derived stability phase diagram,indicating the fact that the k-ε model will never converge to correct values under periodic conditions.In contrast,under fixed boundary conditions,the model can yield a stable non-trivial fixed point.The evolutionary mechanisms and their relationship with boundary condition settings systematically explain the inherent limitations of the k-ε model,i.e.,its deficiency in computing the flow field under periodic boundary conditions and sensitivity to boundary-value specifications under fixed boundary conditions.These conclusions are finally validated with the open-source code OpenFOAM. 展开更多
关键词 k-εmodel Kolmogorov flow INSTABILITY turbulence model
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Design optimization and FEA of B-6 and B-7 levels ballistics armor:A modelling approach
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作者 Muhammad Naveed CHU Jinkui +1 位作者 Atif Ur Rehman Arsalan Hyder 《大连理工大学学报》 北大核心 2026年第1期66-77,共12页
Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is empl... Utilizing finite element analysis,the ballistic protection provided by a combination of perforated D-shaped and base armor plates,collectively referred to as radiator armor,is evaluated.ANSYS Explicit Dynamics is employed to simulate the ballistic impact of 7.62 mm armor-piercing projectiles on Aluminum AA5083-H116 and Steel Secure 500 armors,focusing on the evaluation of material deformation and penetration resistance at varying impact points.While the D-shaped armor plate is penetrated by the armor-piercing projectiles,the combination of the perforated D-shaped and base armor plates successfully halts penetration.A numerical model based on the finite element method is developed using software such as SolidWorks and ANSYS to analyze the interaction between radiator armor and bullet.The perforated design of radiator armor is to maintain airflow for radiator function,with hole sizes smaller than the bullet core diameter to protect radiator assemblies.Predictions are made regarding the brittle fracture resulting from the projectile core′s bending due to asymmetric impact,and the resulting fragments failed to penetrate the perforated base armor plate.Craters are formed on the surface of the perforated D-shaped armor plate due to the impact of projectile fragments.The numerical model accurately predicts hole growth and projectile penetration upon impact with the armor,demonstrating effective protection of the radiator assemblies by the radiator armor. 展开更多
关键词 radiator armor ballistics simulation Johnson-Cook model armor-piercing projectile perforated D-shaped armor plate
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Large Language Model-Enabled Constitutive Modeling for Rate-Dependent Plasticity and Automatic UMAT Subroutine Generation
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作者 Yuchuan Gu Lusheng Wang +3 位作者 Jun Ding Yanhong Peng Changgeng Li Shaojie Gu 《Computers, Materials & Continua》 2026年第5期315-329,共15页
In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the deve... In materials science and engineering design,high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation.To address longstanding bottlenecks in the development of conventional material constitutive models—such as lengthy modeling cycles and difficulties in numerical implementation—this study proposes an intelligent modeling and code generation approach powered by large languagemodels.A structured knowledge base integrating constitutive theory,numerical algorithms,and UMAT(User Material)interface specifications is constructed,and a retrieval-augmented generation strategy is employed to establish an end-to-end workflow spanning experimental data parsing,constitutive model formulation,and automatic UMAT subroutine generation.Experimental results show that the method achieves high accuracy for both a classical Johnson–Cookmodel and a physics-informed neural network(PINN)model,with key parameter identification errors below 5%.Moreover,the automatically generated UMAT subroutines yield finite element simulation results in Abaqus that are highly consistent with theoretical predictions(coefficient of determination R2>0.98)while maintaining good numerical stability.This framework is currently focused on the automatic construction of rate-dependent elastoplastic material models,and its core method also provides a clear path for extending to other constitutive categories such as hyperelasticity and viscoelasticity.This work provides an effective technical route for the rapid development and reliable numerical implementation of material constitutive models,significantly advancing the intelligence level of computational mechanics research and improving engineering application efficiency. 展开更多
关键词 Large language model constitutive model UMAT subroutine
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