Gastric cancer is the fourth commonest cancer and the second leading cause of cancer-related death worldwide[1].Its incidence ranks no.2 and its mortality rate ranks no.3 among all malignant tumors in China according ...Gastric cancer is the fourth commonest cancer and the second leading cause of cancer-related death worldwide[1].Its incidence ranks no.2 and its mortality rate ranks no.3 among all malignant tumors in China according to the latest cancer disease spectrum[2].The gastric cancer prognosis is very poor with 5-year survivals below 24%[3].Early gastric cancer can be cured with surgery;advanced gastric cancer often needs multidisciplinary combined therapy.Gastric cancer seems insensitive to current chemotherapy agents,which may be closely related to stomach cancer stem cells[4].Early gastric cancer refers to the in situ gastric cancer which locates only in stomach mucous membraneand does not infiltrate into thin submucosa.In China,early gastric cancer diagnosis rate is less than 20%,while the diagnosis rate of early gastric cancer in Japan and South Korea has reached 30%-50%[5,6].It is definite to classify H.pylori as the class I carcinogen by the World Health Organization.Approximately 75%of the global gastric cancer are attributable to H.pylori-induced inflammation and injury[7].To date,the precise mechanism of H.pylori-associated gastric carcinogenesis has not been well clarified.To develop prewarning and early theranostic system of gastric cancer can save a lot of patients with gastric cancer and can also reduce the cost of treatment and even cure or significantly prolong the lifespan of patients.展开更多
文摘Gastric cancer is the fourth commonest cancer and the second leading cause of cancer-related death worldwide[1].Its incidence ranks no.2 and its mortality rate ranks no.3 among all malignant tumors in China according to the latest cancer disease spectrum[2].The gastric cancer prognosis is very poor with 5-year survivals below 24%[3].Early gastric cancer can be cured with surgery;advanced gastric cancer often needs multidisciplinary combined therapy.Gastric cancer seems insensitive to current chemotherapy agents,which may be closely related to stomach cancer stem cells[4].Early gastric cancer refers to the in situ gastric cancer which locates only in stomach mucous membraneand does not infiltrate into thin submucosa.In China,early gastric cancer diagnosis rate is less than 20%,while the diagnosis rate of early gastric cancer in Japan and South Korea has reached 30%-50%[5,6].It is definite to classify H.pylori as the class I carcinogen by the World Health Organization.Approximately 75%of the global gastric cancer are attributable to H.pylori-induced inflammation and injury[7].To date,the precise mechanism of H.pylori-associated gastric carcinogenesis has not been well clarified.To develop prewarning and early theranostic system of gastric cancer can save a lot of patients with gastric cancer and can also reduce the cost of treatment and even cure or significantly prolong the lifespan of patients.
