Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, ther...Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, there exist two types of hazards models： the multiplicative hazards model and the additive hazards model. In the paper, we propose a more flexible additive-multiplicative hazards model for multiple type of recurrent gap times data, wherein some covariates are assumed to be additive while others are multiplicative. An estimating equation approach is presented to estimate the regression parameters. We establish asymptotic properties of the proposed estimators.展开更多
In this article, clustered recurrent gap time is investigated. A marginal additive haz- ards model is proposed without specifying the association of the individuals within the same cluster. The relationship among the ...In this article, clustered recurrent gap time is investigated. A marginal additive haz- ards model is proposed without specifying the association of the individuals within the same cluster. The relationship among the gap times for the same individual is also left unspecified. An estimating equation-based inference procedure is developed for the model parameters, and the asymptotic proper- ties of the resulting estimators are established. In addition, a lack-of-fit test is presented to assess the adequacy of the model. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a clinic study on chronic granulomatous disease （CGD） is illustrated.展开更多
Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of interest.In this paper,we consi...Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of interest.In this paper,we consider a proportional hazards model for multiple type recurrent gap times data to assess the effect of covaxiates on the censored event processes of interest.An estimating equation approach is used to obtain the estimators of regression coefficients and baseline cumulative hazard functions.We examine asymptotic properties of the proposed estimators.Finite sample properties of these estimators are demonstrated by simulations.展开更多
In the article,we investigate a general class of semiparametric hazards regression models for recurrent gap times.The general class includes the proportional hazards model,the accelerated failure time model and the ac...In the article,we investigate a general class of semiparametric hazards regression models for recurrent gap times.The general class includes the proportional hazards model,the accelerated failure time model and the accelerated hazards models as special cases.The model is flexible in modelling recurrent gap times since a covariate effect is identified as having two separate components,namely a time-scale change on hazard progression and a relative hazards ratio.In order to infer the model parameters,the procedure is proposed based on estimating equations.The asymptotic properties of the proposed estimators are established and the finite sample properties are investigated via simulation studies.In addition,a lack of fit test is presented to assess the adequacy of the model and an application of data from a bladder cancer study is reported for illustration.展开更多
The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the ...The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the help of preciously published isotopic ages of some typical gold deposits and their related rocks in China,the authors have discussed and quantified the distribution characteristics and scope of the TGDM. Statistical analyses and Kolmogorov tests showed that mineralizing events are either contemporaneous with or slightly postdate their cognate magma. The TGDM conforms with normal distributions at a 0.05 confidence level and clusters between 0 and 16.0 Ma with a mean of 7.0 Ma. Thus,if the TGDM of CGD is less than 16.0 Ma,it is reasonable to consider,with the aid of other evidence,the possibility of its comagmatic genetic affiliation. The authors also emphasized that to get a precise time gap it is necessary to strengthen the diagenesis-mineralization geological background of the deposits studied,and to pay attention to the study of time gap in combination with trace elements and isotope tracing.展开更多
We numerically solve the time-dependent Ginzburg–Landau equations for two-gap superconductors using the finite-element technique. The real-time simulation shows that at low magnetic field, the vortices in small-size ...We numerically solve the time-dependent Ginzburg–Landau equations for two-gap superconductors using the finite-element technique. The real-time simulation shows that at low magnetic field, the vortices in small-size samples tend to form clusters or other disorder structures. When the sample size is large, stripes appear in the pattern. These results are in good agreement with the previous experimental observations of the intriguing anomalous vortex pattern, providing a reliable theoretical basis for the future applications of multi-gap superconductors.展开更多
A theory is presented to investigate the existence and propagation stability of gap solitons in a parity-time （PT） com- plex superlattice with dual periods. In this superlattice, the real and imaginary parts are bot...A theory is presented to investigate the existence and propagation stability of gap solitons in a parity-time （PT） com- plex superlattice with dual periods. In this superlattice, the real and imaginary parts are both in the form of superlattices with dual periods. In the self-focusing nonlinearity, PT solitons can exist in the semi-infinite gap. However, only those gap solitons with low powers can propagate stably, whereas the high-power solitons present periodic oscillation and simultane- ously suffer energy decay. In the self-defocusing nonlinearity, PT solitons only exist in the first gap and all these solitons are stable.展开更多
Computations for air gap response of a semisubmersible platform based on a 3D numerical wave tank approach are presented.The developed method is in time domain and can consider nonlinearities associated with incident ...Computations for air gap response of a semisubmersible platform based on a 3D numerical wave tank approach are presented.The developed method is in time domain and can consider nonlinearities associated with incident wave and hydrostatic forces exactly in determining the body response, but the interaction hydrodynamics of radiation and diffraction are based on simplified linearization assumptions. The incident wave can be defined by any suitable wave theory and here defined by a fully nonlinear numerical wave model. After verifying the present computations results in its degenerated linearized version against the usual linear 3D Green function–based frequency-domain results for air gap predictions, systematic comparative studies are undertaken between linear and the approximate nonlinear solutions. It is found that nonlinear computations can yield considerably conservative predictions as compared to fully linear calculations, amounting to a difference of up to 30%–40% in the minimum air gap in steep ambient incident waves at high and moderate frequencies.展开更多
A three-dimensional time-domain potential flow model is developed and applied to simulate the wave resonance in a gap between two side-by-side rectangular barges. A fourth-order predict-correct method is implemented t...A three-dimensional time-domain potential flow model is developed and applied to simulate the wave resonance in a gap between two side-by-side rectangular barges. A fourth-order predict-correct method is implemented to update free surface boundary conditions. The response of an up-wave barge is predicted by solving the motion equation with the Newmark-β method. Following the validation of the developed numerical model for wave radiation and diffraction around two side-by-side barges, the influence of up-wave barge motion on the gap surfaceresonance is investigated in two different locations of the up-wave barge relative to the back-wave barge at various frequencies. The results reveal that the freely floating up-wave barge significantly influences the resonance frequency and the resonance wave amplitude. Simultaneously, the up-wave barge located in the middle of the back-wave barge leads to a reduction in the resonance wave amplitude and motion response when compared with other configurations.展开更多
This paper presents the simulation results of DC,small-signal and noise properties of GaP based Double Drift Region( DDR) Impact Avalanche Transit Time( IMPATT) diodes. In simulation study we have considered the flat ...This paper presents the simulation results of DC,small-signal and noise properties of GaP based Double Drift Region( DDR) Impact Avalanche Transit Time( IMPATT) diodes. In simulation study we have considered the flat DDR structures of IMPATT diode based on GaP,GaAs,Si and GaN( wurtzite,wz) material. The diodes are designed to operate at the millimeter window frequencies of 94 GHz and 220 GHz. The simulation results of these diodes reveal GaP is a promising material for IMPATT applications based on DDR structure with high break down voltage( V_B) as compared to Si and GaAs IMPATTs. It is also encouraging to worth note GaP base IMPATT diode shows a better output power density of 4. 9 × 10~9 W/m^2 as compared to Si and GaAs based IMPATT diode. But IMPATT diode based on GaN( wz) displays large values of break down voltage,efficiency and power density as compared to Si,GaAs and GaP IMPATTs.展开更多
The factors affecting one dimensional （1D） and two dimensional （2D） photonic crystals （PhCs） are systemically analyzed in this paper by numerical simulation. Transfer matrix method （TMM） is employed for 1D PCs...The factors affecting one dimensional （1D） and two dimensional （2D） photonic crystals （PhCs） are systemically analyzed in this paper by numerical simulation. Transfer matrix method （TMM） is employed for 1D PCs, both finite difference time domain method （FDTD） and plane wave expansion method （PWE） are employed for 2D PCs. The result shows that the photonic bandgaps （PBG） are directly affected by crystal type, crystal lattice constant, modulation of refractive index and periodicity, and it is should be useful for design of different type photonic crystals with the required PBG and functional devices. Finally, as an example, a near-IR 1D PCs narrow filter was designed.展开更多
It has been proved recently that the spike timing can play an important role in information transmission, so in this paper we develop a network with N-unlt FitzHugh-Nagumo neurons coupled by gap junctions and discuss ...It has been proved recently that the spike timing can play an important role in information transmission, so in this paper we develop a network with N-unlt FitzHugh-Nagumo neurons coupled by gap junctions and discuss the dependence of the spike timing precision on synaptic coupling strength, the noise intensity and the size of the neuron ensemble. The calculated results show that the spike timing precision decreases as the noise intensity increases; and the ensemble spike timing precision increases with coupling strength increasing. The electric synapse coupling has a more important effect on the spike timing precision than the chemical synapse coupling.展开更多
基金The Science Foundation(JA12301)of Fujian Educational Committeethe Teaching Quality Project(ZL0902/TZ(SJ))of Higher Education in Fujian Provincial Education Department
文摘Recurrent event gap times data frequently arise in biomedical studies and often more than one type of event is of interest. To evaluate the effects of covariates on the marginal recurrent event hazards functions, there exist two types of hazards models： the multiplicative hazards model and the additive hazards model. In the paper, we propose a more flexible additive-multiplicative hazards model for multiple type of recurrent gap times data, wherein some covariates are assumed to be additive while others are multiplicative. An estimating equation approach is presented to estimate the regression parameters. We establish asymptotic properties of the proposed estimators.
基金supported by the National Natural Science Foundation of China under Grant Nos.11501037,11771431,and 11690015
文摘In this article, clustered recurrent gap time is investigated. A marginal additive haz- ards model is proposed without specifying the association of the individuals within the same cluster. The relationship among the gap times for the same individual is also left unspecified. An estimating equation-based inference procedure is developed for the model parameters, and the asymptotic proper- ties of the resulting estimators are established. In addition, a lack-of-fit test is presented to assess the adequacy of the model. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a clinic study on chronic granulomatous disease （CGD） is illustrated.
基金supported in part by Natural Science Foundation of Hubei(08BA164)Major Research Program of Hubei Provincial Department of Education(09B2001)+2 种基金supported in part by National Natural Science Foundation of China(1117112)Doctoral Fund of Ministry of Education of China(20090076110001)National Statistical Science Research Major Program of China(2011LZ051)
文摘Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of interest.In this paper,we consider a proportional hazards model for multiple type recurrent gap times data to assess the effect of covaxiates on the censored event processes of interest.An estimating equation approach is used to obtain the estimators of regression coefficients and baseline cumulative hazard functions.We examine asymptotic properties of the proposed estimators.Finite sample properties of these estimators are demonstrated by simulations.
基金supported by the National Natural Science Foundation of China(No.11471135,11861030)by the Natural Science Foundation of Hubei Province(No.2018CFC825)by National Statistical Scientific Research Project(No.2018LY17)
文摘In the article,we investigate a general class of semiparametric hazards regression models for recurrent gap times.The general class includes the proportional hazards model,the accelerated failure time model and the accelerated hazards models as special cases.The model is flexible in modelling recurrent gap times since a covariate effect is identified as having two separate components,namely a time-scale change on hazard progression and a relative hazards ratio.In order to infer the model parameters,the procedure is proposed based on estimating equations.The asymptotic properties of the proposed estimators are established and the finite sample properties are investigated via simulation studies.In addition,a lack of fit test is presented to assess the adequacy of the model and an application of data from a bladder cancer study is reported for illustration.
基金supported by the Doctoral Education Program Fund of the Ministry of Education,Peoples Republic of China (No. 20040491502)
文摘The time gap between diagenesis and mineralization (TGDM) for comagmatic gold deposits (CGD) plays an important role in confirming the genetic relationship between gold deposits and their related intrusions. With the help of preciously published isotopic ages of some typical gold deposits and their related rocks in China,the authors have discussed and quantified the distribution characteristics and scope of the TGDM. Statistical analyses and Kolmogorov tests showed that mineralizing events are either contemporaneous with or slightly postdate their cognate magma. The TGDM conforms with normal distributions at a 0.05 confidence level and clusters between 0 and 16.0 Ma with a mean of 7.0 Ma. Thus,if the TGDM of CGD is less than 16.0 Ma,it is reasonable to consider,with the aid of other evidence,the possibility of its comagmatic genetic affiliation. The authors also emphasized that to get a precise time gap it is necessary to strengthen the diagenesis-mineralization geological background of the deposits studied,and to pay attention to the study of time gap in combination with trace elements and isotope tracing.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11564003 and 11865005)the Natural Science Foundation of Guangxi Province of China(Grant No.2018GXNSFAA281024)。
文摘We numerically solve the time-dependent Ginzburg–Landau equations for two-gap superconductors using the finite-element technique. The real-time simulation shows that at low magnetic field, the vortices in small-size samples tend to form clusters or other disorder structures. When the sample size is large, stripes appear in the pattern. These results are in good agreement with the previous experimental observations of the intriguing anomalous vortex pattern, providing a reliable theoretical basis for the future applications of multi-gap superconductors.
基金supported by the National Natural Science Foundation of China(Grant No.61308019)the Foundation for Distinguished Young Talents in Higher Education of Guangdong Province,China(Grant No.Yq2013157)
文摘A theory is presented to investigate the existence and propagation stability of gap solitons in a parity-time （PT） com- plex superlattice with dual periods. In this superlattice, the real and imaginary parts are both in the form of superlattices with dual periods. In the self-focusing nonlinearity, PT solitons can exist in the semi-infinite gap. However, only those gap solitons with low powers can propagate stably, whereas the high-power solitons present periodic oscillation and simultane- ously suffer energy decay. In the self-defocusing nonlinearity, PT solitons only exist in the first gap and all these solitons are stable.
文摘Computations for air gap response of a semisubmersible platform based on a 3D numerical wave tank approach are presented.The developed method is in time domain and can consider nonlinearities associated with incident wave and hydrostatic forces exactly in determining the body response, but the interaction hydrodynamics of radiation and diffraction are based on simplified linearization assumptions. The incident wave can be defined by any suitable wave theory and here defined by a fully nonlinear numerical wave model. After verifying the present computations results in its degenerated linearized version against the usual linear 3D Green function–based frequency-domain results for air gap predictions, systematic comparative studies are undertaken between linear and the approximate nonlinear solutions. It is found that nonlinear computations can yield considerably conservative predictions as compared to fully linear calculations, amounting to a difference of up to 30%–40% in the minimum air gap in steep ambient incident waves at high and moderate frequencies.
基金The Research Innovation Foundation of Tianjin Research Institute for Water Transportation Engineering of China under contract No.TKS 170215the Research Foundation of State Key Laboratory of Coastal and Offshore Engineering of Dalian University of Technology of China under contract No.TKS 170215
文摘A three-dimensional time-domain potential flow model is developed and applied to simulate the wave resonance in a gap between two side-by-side rectangular barges. A fourth-order predict-correct method is implemented to update free surface boundary conditions. The response of an up-wave barge is predicted by solving the motion equation with the Newmark-β method. Following the validation of the developed numerical model for wave radiation and diffraction around two side-by-side barges, the influence of up-wave barge motion on the gap surfaceresonance is investigated in two different locations of the up-wave barge relative to the back-wave barge at various frequencies. The results reveal that the freely floating up-wave barge significantly influences the resonance frequency and the resonance wave amplitude. Simultaneously, the up-wave barge located in the middle of the back-wave barge leads to a reduction in the resonance wave amplitude and motion response when compared with other configurations.
文摘This paper presents the simulation results of DC,small-signal and noise properties of GaP based Double Drift Region( DDR) Impact Avalanche Transit Time( IMPATT) diodes. In simulation study we have considered the flat DDR structures of IMPATT diode based on GaP,GaAs,Si and GaN( wurtzite,wz) material. The diodes are designed to operate at the millimeter window frequencies of 94 GHz and 220 GHz. The simulation results of these diodes reveal GaP is a promising material for IMPATT applications based on DDR structure with high break down voltage( V_B) as compared to Si and GaAs IMPATTs. It is also encouraging to worth note GaP base IMPATT diode shows a better output power density of 4. 9 × 10~9 W/m^2 as compared to Si and GaAs based IMPATT diode. But IMPATT diode based on GaN( wz) displays large values of break down voltage,efficiency and power density as compared to Si,GaAs and GaP IMPATTs.
基金Sponsored by the Ministerial Level Advanced Research Foundation (1006513002060)
文摘The factors affecting one dimensional （1D） and two dimensional （2D） photonic crystals （PhCs） are systemically analyzed in this paper by numerical simulation. Transfer matrix method （TMM） is employed for 1D PCs, both finite difference time domain method （FDTD） and plane wave expansion method （PWE） are employed for 2D PCs. The result shows that the photonic bandgaps （PBG） are directly affected by crystal type, crystal lattice constant, modulation of refractive index and periodicity, and it is should be useful for design of different type photonic crystals with the required PBG and functional devices. Finally, as an example, a near-IR 1D PCs narrow filter was designed.
基金Project supported by the National Natural Science Foundation of China （Grant Nos 10375016 and 10474018） and the Natural Science Foundation of Hebei Province （Grant Nos C2005000011and A2004000005） and the Key Subject Construction Project of Hebei Provincial University.
文摘It has been proved recently that the spike timing can play an important role in information transmission, so in this paper we develop a network with N-unlt FitzHugh-Nagumo neurons coupled by gap junctions and discuss the dependence of the spike timing precision on synaptic coupling strength, the noise intensity and the size of the neuron ensemble. The calculated results show that the spike timing precision decreases as the noise intensity increases; and the ensemble spike timing precision increases with coupling strength increasing. The electric synapse coupling has a more important effect on the spike timing precision than the chemical synapse coupling.
