The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the centra...The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the central nervous system and peripheral immune system,though the mechanisms are unclear.Here,we found that gamma-type immunoglobulin,a product originating from peripheral blood B cells,localized in the brain parenchyma of multiple mouse models with amyloid pathology,and was enriched on microglia but not on other brain cell types.Further experiments showed that gamma-type immunoglobulin bound to microglial cell membranes and led to diverse transcriptomic changes,including upregulation of pathways related to phagocytosis and immunity.Functional assays demonstrated that gamma-type immunoglobulin enhanced microglial phagocytic capacity for amyloid-beta fibrils via its Fc fragment,but not Fab fragment,fragment.Our data indicate that microglia,when exposed to gamma-type immunoglobulin,exhibit an enhanced capacity for clearing amyloid-beta fibrils,potentially via the gamma-type immunoglobulin Fc fragment signaling pathway.This suggests that parenchymal gamma-type immunoglobulin should be further investigated to determine whether it may play a beneficial role against Alzheimer’s disease by enhancing microglial function.展开更多
The non-elementary integrals involving elementary exponential, hyperbolic and trigonometric functions, <img src="Edit_699140d3-f569-463e-b835-7ccdab822717.png" width="290" height="22" ...The non-elementary integrals involving elementary exponential, hyperbolic and trigonometric functions, <img src="Edit_699140d3-f569-463e-b835-7ccdab822717.png" width="290" height="22" alt="" /><img src="Edit_bdd10470-9b63-4b2d-9cec-636969547ca5.png" width="90" height="22" alt="" /><span style="white-space:normal;">and <img src="Edit_e9cd6876-e2b8-45cf-ba17-391f054679b4.png" width="90" height="21" alt="" /></span>where <span style="white-space:nowrap;"><em>α</em>,<span style="white-space:nowrap;"><em>η</em></span><em></em></span> and <span style="white-space:nowrap;"><em>β</em></span> are real or complex constants are evaluated in terms of the confluent hypergeometric function <sub>1</sub><em>F</em><sub>1</sub> and the hypergeometric function <sub>1</sub><em>F</em><sub>2</sub>. The hyperbolic and Euler identities are used to derive some identities involving exponential, hyperbolic, trigonometric functions and the hypergeometric functions <sub style="white-space:normal;">1</sub><em style="white-space:normal;">F</em><sub style="white-space:normal;">1</sub> and <sub style="white-space:normal;">1</sub><em style="white-space:normal;">F</em><sub style="white-space:normal;">2</sub>. Having evaluated, these non-elementary integrals, some new probability measures generalizing the gamma-type and Gaussian distributions are also obtained. The obtained generalized probability distributions may, for example, allow to perform better statistical tests than those already known (e.g. chi-square (<span style="white-space:nowrap;"><em>x</em><sup>2</sup></span>) statistical tests and other statistical tests constructed based on the central limit theorem (CLT)), while avoiding the use of computational approximations (or methods) which are in general expensive and associated with numerical errors.展开更多
目的探讨血清γ-谷氨酰基转移酶(GGT)、丙氨酸氨基转移酶(ALT)对2型糖尿病早期诊断的临床应用价值。方法采用Roche Modu lar全自动生化分析仪及配套试剂检测200例2型糖尿病患者(男、女各100例)及200名正常对照者的血清葡萄糖(G lu)、GGT...目的探讨血清γ-谷氨酰基转移酶(GGT)、丙氨酸氨基转移酶(ALT)对2型糖尿病早期诊断的临床应用价值。方法采用Roche Modu lar全自动生化分析仪及配套试剂检测200例2型糖尿病患者(男、女各100例)及200名正常对照者的血清葡萄糖(G lu)、GGT和ALT水平,并进行统计分析。结果 2型糖尿病患者男性及女性的G lu、GGT水平与对照组比较,差异均有统计学意义(P<0.05),而ALT则无差异;男性和女性2型糖尿病患者中GGT浓度超出参考区间的百分率分别是13%和16%,明显高于对照组。结论 GGT对于2型糖尿病的早期诊断有一定意义。展开更多
基金supported by the National Natural Science Foundation of China,Nos.82171082(to ZX),32000727(to TZ),32370731(to YZ)Guangdong Basic and Applied Basic Research Foundation,No.2024A151501069(to ZX)+1 种基金Shenzhen Science and Technology Program,Nos.JCYJ20210324101603009(to ZX),GJHZ20220913142807015(to TZ),JCYJ20220531100204010(to TZ),JCYJ20230807091308018(to YZ)Shenzhen Medical Research Funds,No.A2303068(to TZ).
文摘The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the central nervous system and peripheral immune system,though the mechanisms are unclear.Here,we found that gamma-type immunoglobulin,a product originating from peripheral blood B cells,localized in the brain parenchyma of multiple mouse models with amyloid pathology,and was enriched on microglia but not on other brain cell types.Further experiments showed that gamma-type immunoglobulin bound to microglial cell membranes and led to diverse transcriptomic changes,including upregulation of pathways related to phagocytosis and immunity.Functional assays demonstrated that gamma-type immunoglobulin enhanced microglial phagocytic capacity for amyloid-beta fibrils via its Fc fragment,but not Fab fragment,fragment.Our data indicate that microglia,when exposed to gamma-type immunoglobulin,exhibit an enhanced capacity for clearing amyloid-beta fibrils,potentially via the gamma-type immunoglobulin Fc fragment signaling pathway.This suggests that parenchymal gamma-type immunoglobulin should be further investigated to determine whether it may play a beneficial role against Alzheimer’s disease by enhancing microglial function.
文摘The non-elementary integrals involving elementary exponential, hyperbolic and trigonometric functions, <img src="Edit_699140d3-f569-463e-b835-7ccdab822717.png" width="290" height="22" alt="" /><img src="Edit_bdd10470-9b63-4b2d-9cec-636969547ca5.png" width="90" height="22" alt="" /><span style="white-space:normal;">and <img src="Edit_e9cd6876-e2b8-45cf-ba17-391f054679b4.png" width="90" height="21" alt="" /></span>where <span style="white-space:nowrap;"><em>α</em>,<span style="white-space:nowrap;"><em>η</em></span><em></em></span> and <span style="white-space:nowrap;"><em>β</em></span> are real or complex constants are evaluated in terms of the confluent hypergeometric function <sub>1</sub><em>F</em><sub>1</sub> and the hypergeometric function <sub>1</sub><em>F</em><sub>2</sub>. The hyperbolic and Euler identities are used to derive some identities involving exponential, hyperbolic, trigonometric functions and the hypergeometric functions <sub style="white-space:normal;">1</sub><em style="white-space:normal;">F</em><sub style="white-space:normal;">1</sub> and <sub style="white-space:normal;">1</sub><em style="white-space:normal;">F</em><sub style="white-space:normal;">2</sub>. Having evaluated, these non-elementary integrals, some new probability measures generalizing the gamma-type and Gaussian distributions are also obtained. The obtained generalized probability distributions may, for example, allow to perform better statistical tests than those already known (e.g. chi-square (<span style="white-space:nowrap;"><em>x</em><sup>2</sup></span>) statistical tests and other statistical tests constructed based on the central limit theorem (CLT)), while avoiding the use of computational approximations (or methods) which are in general expensive and associated with numerical errors.
