Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological process...Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological processes,including vascular smooth muscle relaxation,myocardial cell function regulation,neuron growth,and synaptic plasticity,et al.In recent years,the role of PKG in diseases has gradually attracted attention,and the abnormalities in its signaling pathway are closely related to the occurrence and development of cardiovascular and neurological diseases.Although PKG has been widely studied,its complex functions in different physiological systems and potential innovative applications still need to be further explored.This article reviews the purification techniques for PKG,discusses the advantages and disadvantages of different extraction methods,summarizes the structure and activation mechanism of each domain of PKG,and analyzes the physiological functions of PKG in organisms,especially the well-established roles in the cardiovascular system,nervous system,and endocrine system.The emerging therapeutic applications of PKG are also reviewed.In addition,the challenges of this field are proposed at the end.展开更多
Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM...Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].展开更多
GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动...GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。展开更多
Gastrointestinal stromal tumours(GISTs)are tumours that originate from mesenchymal tissue,are predominantly located in the stomach,and typically do not metastasize to the lymph nodes.Surgical intervention remains the ...Gastrointestinal stromal tumours(GISTs)are tumours that originate from mesenchymal tissue,are predominantly located in the stomach,and typically do not metastasize to the lymph nodes.Surgical intervention remains the primary treatment modality for GISTs.Historically,open surgery was the predominant approach;however,advancements in medical technology have led to laparoscopic surgery becoming the standard practice.Compared with traditional open surgical techniques,laparoscopic surgery is less invasive and facilitates more rapid postoperative recovery.Given that GISTs can arise at any location within the gas-trointestinal tract,the specific surgical methods employed vary according to both the tumour's anatomical site and its growth characteristics.The aim of this review is to examine laparoscopic surgical strategies for managing GISTs across different regions of the gastrointestinal tract by synthesizing recent research trends and relevant evidence-based medical literature.展开更多
The advancement of 6G wireless communication technology has facilitated the integration of Vehicular Ad-hoc Networks(VANETs).However,the messages transmitted over the public channel in the open and dynamic VANETs are ...The advancement of 6G wireless communication technology has facilitated the integration of Vehicular Ad-hoc Networks(VANETs).However,the messages transmitted over the public channel in the open and dynamic VANETs are vulnerable to malicious attacks.Although numerous researchers have proposed authentication schemes to enhance the security of Vehicle-to-Vehicle(V2V)communication,most existing methodologies face two significant challenges:(1)the majority of the schemes are not lightweight enough to support realtime message interaction among vehicles;(2)the sensitive information like identity and position is at risk of being compromised.To tackle these issues,we propose a lightweight dual authentication protocol for V2V communication based on Physical Unclonable Function(PUF).The proposed scheme accomplishes dual authentication between vehicles by the combination of Zero-Knowledge Proof(ZKP)and MASK function.The security analysis proves that our scheme provides both anonymous authentication and information unlinkability.Additionally,the performance analysis demonstrates that the computation overhead of our scheme is approximately reduced 23.4% compared to the state-of-the-art schemes.The practical simulation conducted in a 6G network environment demonstrates the feasibility of 6G-based VANETs and their potential for future advancements.展开更多
In this paper,the class of starlike functions of complex order γ(γ∈ℂ−{0})is extended from the case on unit disk U=(z∈C:|z|<1)to the case on the unit ball B in a complex Banach space or the unit polydisk U^(n) i...In this paper,the class of starlike functions of complex order γ(γ∈ℂ−{0})is extended from the case on unit disk U=(z∈C:|z|<1)to the case on the unit ball B in a complex Banach space or the unit polydisk U^(n) in C^(n).Let g be a convex function in U. We mainly establish the sharp bounds of all terms of homogeneous polynomial expansions for a subclass of g-parametric starlike mappings of complex order γ on B (resp.U^(n))when the mappings f are k-fold symmetric, k ∈ N. Our results partly solve the Bieberbach conjecture in several complex variables and generalize some prior works.展开更多
In this paper,the dust particle surface potential for argon-helium plasma is evaluated analytically and numerically in the context of negatively charged dust particles by employing a power-law(r,q)-distribution functi...In this paper,the dust particle surface potential for argon-helium plasma is evaluated analytically and numerically in the context of negatively charged dust particles by employing a power-law(r,q)-distribution function.Recent studies have reported the argon-helium plasma and conducted a brief theoretical and experimental survey.To deepen our understanding further,this study aims to analyze the argon-helium plasma comprehensively using the same pattern but with the(r,q)-distribution function.For this purpose,the current balance equations are derived for electron,helium and argon ions,when these charge species attain the quasineutrality condition.We numerically examined the currents of plasma species for a broad range of effective distribution function parameters r and q.It is revealed that the surface potential of dust particles is significantly affected by the parameters r and q,helium ion-to-electron temperature ratio,argon ion-to-electron temperature ratio,and helium ion to argon ion number density ratio.By incorporating the multi-ion(argon-helium)species,the significance of low-temperature nonMaxwellian dusty(complex)plasma is briefly examined.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22374033,22174031,22407037)the Natural Science Foundation of Heilongjiang Province(No.ZD2022B001).
文摘Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological processes,including vascular smooth muscle relaxation,myocardial cell function regulation,neuron growth,and synaptic plasticity,et al.In recent years,the role of PKG in diseases has gradually attracted attention,and the abnormalities in its signaling pathway are closely related to the occurrence and development of cardiovascular and neurological diseases.Although PKG has been widely studied,its complex functions in different physiological systems and potential innovative applications still need to be further explored.This article reviews the purification techniques for PKG,discusses the advantages and disadvantages of different extraction methods,summarizes the structure and activation mechanism of each domain of PKG,and analyzes the physiological functions of PKG in organisms,especially the well-established roles in the cardiovascular system,nervous system,and endocrine system.The emerging therapeutic applications of PKG are also reviewed.In addition,the challenges of this field are proposed at the end.
基金supported by the Office of Naval Research Grant(N00014-22-1-2184)。
文摘Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].
文摘GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。
基金Supported by Quanzhou Science and Technology Plan Projects,No.2024NY033Key Clinical Specialty Discipline Construction Program of Fujian(Fujian Health Medicine and Politics),No.[2022]884.
文摘Gastrointestinal stromal tumours(GISTs)are tumours that originate from mesenchymal tissue,are predominantly located in the stomach,and typically do not metastasize to the lymph nodes.Surgical intervention remains the primary treatment modality for GISTs.Historically,open surgery was the predominant approach;however,advancements in medical technology have led to laparoscopic surgery becoming the standard practice.Compared with traditional open surgical techniques,laparoscopic surgery is less invasive and facilitates more rapid postoperative recovery.Given that GISTs can arise at any location within the gas-trointestinal tract,the specific surgical methods employed vary according to both the tumour's anatomical site and its growth characteristics.The aim of this review is to examine laparoscopic surgical strategies for managing GISTs across different regions of the gastrointestinal tract by synthesizing recent research trends and relevant evidence-based medical literature.
文摘The advancement of 6G wireless communication technology has facilitated the integration of Vehicular Ad-hoc Networks(VANETs).However,the messages transmitted over the public channel in the open and dynamic VANETs are vulnerable to malicious attacks.Although numerous researchers have proposed authentication schemes to enhance the security of Vehicle-to-Vehicle(V2V)communication,most existing methodologies face two significant challenges:(1)the majority of the schemes are not lightweight enough to support realtime message interaction among vehicles;(2)the sensitive information like identity and position is at risk of being compromised.To tackle these issues,we propose a lightweight dual authentication protocol for V2V communication based on Physical Unclonable Function(PUF).The proposed scheme accomplishes dual authentication between vehicles by the combination of Zero-Knowledge Proof(ZKP)and MASK function.The security analysis proves that our scheme provides both anonymous authentication and information unlinkability.Additionally,the performance analysis demonstrates that the computation overhead of our scheme is approximately reduced 23.4% compared to the state-of-the-art schemes.The practical simulation conducted in a 6G network environment demonstrates the feasibility of 6G-based VANETs and their potential for future advancements.
基金supported by the National Natural Science Foundation of China(12061035)the Research Foundation of Jiangxi Science and Technology Normal University of China(2021QNBJRC003)supported by the Graduate Innovation Fund of Jiangxi Science and Technology Normal University(YC2024-X10).
文摘In this paper,the class of starlike functions of complex order γ(γ∈ℂ−{0})is extended from the case on unit disk U=(z∈C:|z|<1)to the case on the unit ball B in a complex Banach space or the unit polydisk U^(n) in C^(n).Let g be a convex function in U. We mainly establish the sharp bounds of all terms of homogeneous polynomial expansions for a subclass of g-parametric starlike mappings of complex order γ on B (resp.U^(n))when the mappings f are k-fold symmetric, k ∈ N. Our results partly solve the Bieberbach conjecture in several complex variables and generalize some prior works.
文摘In this paper,the dust particle surface potential for argon-helium plasma is evaluated analytically and numerically in the context of negatively charged dust particles by employing a power-law(r,q)-distribution function.Recent studies have reported the argon-helium plasma and conducted a brief theoretical and experimental survey.To deepen our understanding further,this study aims to analyze the argon-helium plasma comprehensively using the same pattern but with the(r,q)-distribution function.For this purpose,the current balance equations are derived for electron,helium and argon ions,when these charge species attain the quasineutrality condition.We numerically examined the currents of plasma species for a broad range of effective distribution function parameters r and q.It is revealed that the surface potential of dust particles is significantly affected by the parameters r and q,helium ion-to-electron temperature ratio,argon ion-to-electron temperature ratio,and helium ion to argon ion number density ratio.By incorporating the multi-ion(argon-helium)species,the significance of low-temperature nonMaxwellian dusty(complex)plasma is briefly examined.
