Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological process...Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological processes,including vascular smooth muscle relaxation,myocardial cell function regulation,neuron growth,and synaptic plasticity,et al.In recent years,the role of PKG in diseases has gradually attracted attention,and the abnormalities in its signaling pathway are closely related to the occurrence and development of cardiovascular and neurological diseases.Although PKG has been widely studied,its complex functions in different physiological systems and potential innovative applications still need to be further explored.This article reviews the purification techniques for PKG,discusses the advantages and disadvantages of different extraction methods,summarizes the structure and activation mechanism of each domain of PKG,and analyzes the physiological functions of PKG in organisms,especially the well-established roles in the cardiovascular system,nervous system,and endocrine system.The emerging therapeutic applications of PKG are also reviewed.In addition,the challenges of this field are proposed at the end.展开更多
Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly...Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly measured masses for 296 nuclides from 40 references published between 2021 and 2024,subsequent to the release of the latest atomic mass evalu-ation.These data were used to benchmark the performance of several relativistic and nonrelativistic density functionals,including PC-PK1,TMA,SLy4,SV-min,UNEDF1,and the recently proposed PC-L3R.The results for PC-PK1 and PC-L3R were obtained using the state-of-the-art deformed relativistic Hartree-Bogoliubov theory in continuum(DRHBc),whereas the others were adopted from the existing literature.It was found that the DRHBc calculations with PC-PK1 and PC-L3R achieved an accuracy better than 1.5 MeV,outperforming the other functionals,which all exhibited root-mean-square devia-tions exceeding 2 MeV.The odd-even effects and isospin dependence in these theoretical descriptions were examined.The PC-PK1 and PC-L3R descriptions were qualitatively similar,exhibiting robust isospin dependence along the isotopic chains.Finally,a quantitative comparison between the PC-PK1 and PC-L3R results is presented,with the largest discrepancies analyzed in terms of the potential energy curves from the constrained DRHBc calculations.展开更多
Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM...Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].展开更多
GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动...GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。展开更多
AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric ...AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric emptying was assessed with solid radiopaque markers in 54 FD patients, and the patients were divided into two groups according to the results, one with delayed gastric emptying and the other with normal gastric emptying. Seventeen healthy volunteers acted as normal controls. Fasting and postprandial plasma levels and gastroduodenal mucosal levels of gastrointestinal hormones gastrin, somatostatin (SS) and neurotensin (NT)were measured by radioimmunoassay in all the subjects.G cells (gastrin-producing cells) and D cells (SS-producing cells) in gastric antral mucosa were immunostained with rabbit anti-gastrin polyclonal antibody and rabbit anti-SS polyclonal antibody, respectively, and analyzed quantitatively by computerized image analysis.RESULTS: The postprandial plasma gastrin levels, the fasting and postprandial plasma levels and the gastric and duodenal mucosal levels of NT were significantly higher in the FD patients with delayed gastric emptying than in those with normal gastric emptying and normal controls. The number and gray value of G and D cells and the G cell/D cell number ratio did not differ significantly between normal controls and the FD patients with or without delayed gastric emptying.CONCLUSION: Our findings suggest that the abnormalities of gastrin and NT may play a role in the pathophysiology of gastric dysmotility in FD patients, and the abnormality of postprandial plasma gastrin levels in FD patients with delayed gastric emptying is not related to the changes both in the number and gray value of G cells and in the G cell/D cell number ratio in gastric antral mucosa.展开更多
Non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau...Non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau damping of electron plasma （Langmuir） waves and ion-acoustic waves in a hot, isotropic, unmagnetized plasma is studied with the generalized （r, q） distribution function. The results show that for the Langmuir oscillations Landau damping becomes severe as the spectral index r or q reduces. However, for the ion-acoustic waves Landau damping is more sensitive to the ion temperature than the spectral indices.展开更多
Equilibrium structures and infrared spectra of four typical molecular models of coal have been studied by density functional calculations. Combining theoretical calculations on the coal models with experimental FT-IR ...Equilibrium structures and infrared spectra of four typical molecular models of coal have been studied by density functional calculations. Combining theoretical calculations on the coal models with experimental FT-IR spectra of selected low rank perhydrous coals, a plausible molecular representation for this kind of coals was proposed, and its predicted IR spectra reasonably match the experimental observation. Calculations indicate that the cleavage of the C-C bridge bond for the coal structures considered here occurs at about 540 ℃ and the C-O ether bridge bond may break under temperature ranging from 500 to 600 ℃for the aryl-CH2-O-CH2-aryl ether bond or from 200 to 300 ℃ for the aryl-CH2-O-aryl ether bond, showing remarkable effect of the local structural environment. The coal model containing the carboxyl group may release CO2 at about 300 ℃ through the decarboxylation with a barrier of 69 kcal/mol.展开更多
Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,...Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,there exists performance trade-offbetween communication and sensing,in that they have competitions on the physical resources.Different resource allocation schemes will result in different sensing and communication performance,thus influencing the system’s overall performance.Therefore,how to model the system’s overall performance,and how to optimize it are key issues for ISAC.Relying on the large-scale deployment of the networks,cooperative ISAC has the advantages of wider coverage,more robust performance and good compatibility of multiple monostatic and multistatic sensing,compared to the non-cooperative ISAC.How to capture the performance gain of cooperation is a key issue for cooperative ISAC.To address the aforementioned vital problems,in this paper,we analyze the sensing accuracy gain,propose a unified ISAC performance evaluation framework and design several optimization methods in cooperative ISAC systems.The cooperative sensing accuracy gain is theoretically analyzed via Cramér Rao lower bound.The unified ISAC performance evaluation model is established by converting the communication mutual information to the effective minimum mean squared error.To optimize the unified ISAC performance,we design the optimization algorithms considering three factors:base stations’working modes,power allocation schemes and waveform design.Through simulations,we show the performance gain of the cooperative ISAC system and the effectiveness of the proposed optimization methods.展开更多
This paper is aimed at detecting the neutron spectrum of^(241)Am–Be, a widely used neutron source, with the SP9 ~3He proportional counter, which is a multi-sphere spectrometer system of eight thermal neutron detector...This paper is aimed at detecting the neutron spectrum of^(241)Am–Be, a widely used neutron source, with the SP9 ~3He proportional counter, which is a multi-sphere spectrometer system of eight thermal neutron detectors embedded in eight polyethylene(PE) spheres of varying diameters. The transport processes of a neutron in the multi-sphere spectrometer are simulated using the Geant4 code. Two sets of response functions of the PE spheres are obtained for calculating the^(241)Am–Be neutron spectrum.Response Function 1 utilizes the thermal neutron scattering model G4 Neutron HPThermal Scattering for neutron energies of ≤4 eV, and Response Function 2 has no thermal treatment. Neutron spectra of an^(241)Am–Be neutron source are measured and compared to those calculated by using the response functions. The results show that response function with thermal treatment is more accurate and closer to the real spectrum.展开更多
The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This fu...The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This function satisfies the homogeneous boundary condition of the problem.The mode shape differential equation of the free vibration problem of clamped thin plates is reduced to Fredholm integral equation of the second kind by Green formula.Irregularity of the kernel of integral equation is overcome by choosing a suitable form of the normalized boundary equation.Two examples demonstrate the validity of the present method.Comparison with both the series solution and ANSYS finite-element solution shows fine agreement.The present method is a novel and effective mathematical one.展开更多
Structural and electronic properties of bimetallic clusters AlnCom with n=1～7 and m=1～2 have been investigated using the B3LYP-DFT method.Structural optimization and frequency analysis were performed at the CEP-121G...Structural and electronic properties of bimetallic clusters AlnCom with n=1～7 and m=1～2 have been investigated using the B3LYP-DFT method.Structural optimization and frequency analysis were performed at the CEP-121G level.The charge-induced structural changes in these anions were discussed.In addition,the corresponding total energies,binding energies,adiabatic electron affinities and vertical electron affinity were also presented and discussed.Our predicted vertical ionization potentials are in reasonable agreement with the experimental ionization potentials.Among different AlnCom and AlnCom-anions （n=1～7,m=1～2）,Al4Co,Al6Co,Al4Co-,Al6Co-and Al4Co2-are predicted to be species with high stabilities.展开更多
Abstract Olfactory dysfunction has been reported in Parkinson＇s disease （PD） patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed g...Abstract Olfactory dysfunction has been reported in Parkinson＇s disease （PD） patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed genotyping for the LRRK2 G2385R variant in PD patients recruited from the Movement Disorder ClttliC of Xualwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort. The ＂five-odor olfactory detection array＂, an olfactory threshold test, was used to assess olfactory function. One hundred and eighty-six participants were enrolled, comprising 43 PD patients without （iPD） and 25 with （LRRK2-PD） the LRRK2 G2385R variant, and 118 healthy controls. Our results showed that the threshold of olfactory identification was significantly worse in PD patients than in controls, but not significantly different between the iPD and LRRK2-PD groups. These findings suggested that although olfactory function in LRRK2-PD patients is impaired, it is similar to that in iPD patients.展开更多
We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,inc...We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including microglia.To examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 months.We conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain tissue.We confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-βdeposition.The expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed group.Subsequently,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated group.Both radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by PLX3397.These results showed that radiofrequency electromagnetic fields ameliorated amyloid-βpathology and cognitive impairment by suppressing amyloid-βdeposition-induced microgliosis and their key regulator,CSF1R.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22374033,22174031,22407037)the Natural Science Foundation of Heilongjiang Province(No.ZD2022B001).
文摘Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological processes,including vascular smooth muscle relaxation,myocardial cell function regulation,neuron growth,and synaptic plasticity,et al.In recent years,the role of PKG in diseases has gradually attracted attention,and the abnormalities in its signaling pathway are closely related to the occurrence and development of cardiovascular and neurological diseases.Although PKG has been widely studied,its complex functions in different physiological systems and potential innovative applications still need to be further explored.This article reviews the purification techniques for PKG,discusses the advantages and disadvantages of different extraction methods,summarizes the structure and activation mechanism of each domain of PKG,and analyzes the physiological functions of PKG in organisms,especially the well-established roles in the cardiovascular system,nervous system,and endocrine system.The emerging therapeutic applications of PKG are also reviewed.In addition,the challenges of this field are proposed at the end.
基金supported by the National Natural Science Foundation of China(Nos.12265012 and 12305125)Guizhou Provincial Science and Technology Projects(No.ZK[2022]203)+2 种基金PhD fund of Guizhou Minzu University(No.GZMUZK[2024]QD76)the National Key Laboratory of Neutron Science and Technology(No.NST202401016)the Sichuan Science and Technology Program(No.2024NSFSC1356).
文摘Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly measured masses for 296 nuclides from 40 references published between 2021 and 2024,subsequent to the release of the latest atomic mass evalu-ation.These data were used to benchmark the performance of several relativistic and nonrelativistic density functionals,including PC-PK1,TMA,SLy4,SV-min,UNEDF1,and the recently proposed PC-L3R.The results for PC-PK1 and PC-L3R were obtained using the state-of-the-art deformed relativistic Hartree-Bogoliubov theory in continuum(DRHBc),whereas the others were adopted from the existing literature.It was found that the DRHBc calculations with PC-PK1 and PC-L3R achieved an accuracy better than 1.5 MeV,outperforming the other functionals,which all exhibited root-mean-square devia-tions exceeding 2 MeV.The odd-even effects and isospin dependence in these theoretical descriptions were examined.The PC-PK1 and PC-L3R descriptions were qualitatively similar,exhibiting robust isospin dependence along the isotopic chains.Finally,a quantitative comparison between the PC-PK1 and PC-L3R results is presented,with the largest discrepancies analyzed in terms of the potential energy curves from the constrained DRHBc calculations.
基金supported by the Office of Naval Research Grant(N00014-22-1-2184)。
文摘Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].
文摘GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。
文摘AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric emptying was assessed with solid radiopaque markers in 54 FD patients, and the patients were divided into two groups according to the results, one with delayed gastric emptying and the other with normal gastric emptying. Seventeen healthy volunteers acted as normal controls. Fasting and postprandial plasma levels and gastroduodenal mucosal levels of gastrointestinal hormones gastrin, somatostatin (SS) and neurotensin (NT)were measured by radioimmunoassay in all the subjects.G cells (gastrin-producing cells) and D cells (SS-producing cells) in gastric antral mucosa were immunostained with rabbit anti-gastrin polyclonal antibody and rabbit anti-SS polyclonal antibody, respectively, and analyzed quantitatively by computerized image analysis.RESULTS: The postprandial plasma gastrin levels, the fasting and postprandial plasma levels and the gastric and duodenal mucosal levels of NT were significantly higher in the FD patients with delayed gastric emptying than in those with normal gastric emptying and normal controls. The number and gray value of G and D cells and the G cell/D cell number ratio did not differ significantly between normal controls and the FD patients with or without delayed gastric emptying.CONCLUSION: Our findings suggest that the abnormalities of gastrin and NT may play a role in the pathophysiology of gastric dysmotility in FD patients, and the abnormality of postprandial plasma gastrin levels in FD patients with delayed gastric emptying is not related to the changes both in the number and gray value of G cells and in the G cell/D cell number ratio in gastric antral mucosa.
基金The project supported by National Natural Science Foundation of China under Grant No. 40390150 and the International Collaboration Research Team Program of the Chinese Academy of Sciences
文摘Non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau damping of electron plasma （Langmuir） waves and ion-acoustic waves in a hot, isotropic, unmagnetized plasma is studied with the generalized （r, q） distribution function. The results show that for the Langmuir oscillations Landau damping becomes severe as the spectral index r or q reduces. However, for the ion-acoustic waves Landau damping is more sensitive to the ion temperature than the spectral indices.
基金supported by the Ministry of Science and Technology (2012CB214900 and 2011CB808504)the National Science Foundation of China (21133007)
文摘Equilibrium structures and infrared spectra of four typical molecular models of coal have been studied by density functional calculations. Combining theoretical calculations on the coal models with experimental FT-IR spectra of selected low rank perhydrous coals, a plausible molecular representation for this kind of coals was proposed, and its predicted IR spectra reasonably match the experimental observation. Calculations indicate that the cleavage of the C-C bridge bond for the coal structures considered here occurs at about 540 ℃ and the C-O ether bridge bond may break under temperature ranging from 500 to 600 ℃for the aryl-CH2-O-CH2-aryl ether bond or from 200 to 300 ℃ for the aryl-CH2-O-aryl ether bond, showing remarkable effect of the local structural environment. The coal model containing the carboxyl group may release CO2 at about 300 ℃ through the decarboxylation with a barrier of 69 kcal/mol.
文摘Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,there exists performance trade-offbetween communication and sensing,in that they have competitions on the physical resources.Different resource allocation schemes will result in different sensing and communication performance,thus influencing the system’s overall performance.Therefore,how to model the system’s overall performance,and how to optimize it are key issues for ISAC.Relying on the large-scale deployment of the networks,cooperative ISAC has the advantages of wider coverage,more robust performance and good compatibility of multiple monostatic and multistatic sensing,compared to the non-cooperative ISAC.How to capture the performance gain of cooperation is a key issue for cooperative ISAC.To address the aforementioned vital problems,in this paper,we analyze the sensing accuracy gain,propose a unified ISAC performance evaluation framework and design several optimization methods in cooperative ISAC systems.The cooperative sensing accuracy gain is theoretically analyzed via Cramér Rao lower bound.The unified ISAC performance evaluation model is established by converting the communication mutual information to the effective minimum mean squared error.To optimize the unified ISAC performance,we design the optimization algorithms considering three factors:base stations’working modes,power allocation schemes and waveform design.Through simulations,we show the performance gain of the cooperative ISAC system and the effectiveness of the proposed optimization methods.
基金supported by ITER Plan National Major Project(No.2008GB109000)the Introduces Talents Scientific Research Project of Guizhou University(2014,No.32)
文摘This paper is aimed at detecting the neutron spectrum of^(241)Am–Be, a widely used neutron source, with the SP9 ~3He proportional counter, which is a multi-sphere spectrometer system of eight thermal neutron detectors embedded in eight polyethylene(PE) spheres of varying diameters. The transport processes of a neutron in the multi-sphere spectrometer are simulated using the Geant4 code. Two sets of response functions of the PE spheres are obtained for calculating the^(241)Am–Be neutron spectrum.Response Function 1 utilizes the thermal neutron scattering model G4 Neutron HPThermal Scattering for neutron energies of ≤4 eV, and Response Function 2 has no thermal treatment. Neutron spectra of an^(241)Am–Be neutron source are measured and compared to those calculated by using the response functions. The results show that response function with thermal treatment is more accurate and closer to the real spectrum.
文摘The Green quasifunction method is employed to solve the free vibration problem of clamped thin plates.A Green quasifunction is established by using the fundamental solution and boundary equation of the problem.This function satisfies the homogeneous boundary condition of the problem.The mode shape differential equation of the free vibration problem of clamped thin plates is reduced to Fredholm integral equation of the second kind by Green formula.Irregularity of the kernel of integral equation is overcome by choosing a suitable form of the normalized boundary equation.Two examples demonstrate the validity of the present method.Comparison with both the series solution and ANSYS finite-element solution shows fine agreement.The present method is a novel and effective mathematical one.
基金supported by the National Natural Science Foundation of China (20603021)Youth Foundation of Shanxi Province (2007021009)
文摘Structural and electronic properties of bimetallic clusters AlnCom with n=1～7 and m=1～2 have been investigated using the B3LYP-DFT method.Structural optimization and frequency analysis were performed at the CEP-121G level.The charge-induced structural changes in these anions were discussed.In addition,the corresponding total energies,binding energies,adiabatic electron affinities and vertical electron affinity were also presented and discussed.Our predicted vertical ionization potentials are in reasonable agreement with the experimental ionization potentials.Among different AlnCom and AlnCom-anions （n=1～7,m=1～2）,Al4Co,Al6Co,Al4Co-,Al6Co-and Al4Co2-are predicted to be species with high stabilities.
基金supported by grants from the Scientific Project of Ministry of Science and Technology of China (2012AA02A514)the National Basic Research Development Program of China(2011CB504101)the Beijing High Standard Health Human Resource Cultural Program in Health System,China (2009elel2)
文摘Abstract Olfactory dysfunction has been reported in Parkinson＇s disease （PD） patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed genotyping for the LRRK2 G2385R variant in PD patients recruited from the Movement Disorder ClttliC of Xualwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort. The ＂five-odor olfactory detection array＂, an olfactory threshold test, was used to assess olfactory function. One hundred and eighty-six participants were enrolled, comprising 43 PD patients without （iPD） and 25 with （LRRK2-PD） the LRRK2 G2385R variant, and 118 healthy controls. Our results showed that the threshold of olfactory identification was significantly worse in PD patients than in controls, but not significantly different between the iPD and LRRK2-PD groups. These findings suggested that although olfactory function in LRRK2-PD patients is impaired, it is similar to that in iPD patients.
基金Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by Korea government(MSIT),Nos.2017-0-00961 and 2019-0-00102(to HDC)。
文摘We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5xFAD mice with severe late-stage Alzheimer’s disease reduced both amyloid-βdeposition and glial activation,including microglia.To examine whether this therapeutic effect is due to the regulation of activated microglia,we analyzed mic roglial gene expression profiles and the existence of microglia in the brain in this study.5xFAD mice at the age of 1.5 months were assigned to sham-and radiofrequency electromagnetic fields-exposed groups and then animals were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours/day and 5 days/week for 6 months.We conducted behavioral tests including the object recognition and Y-maze tests and molecular and histopathological analysis of amyloid precursor protein/a myloid-beta metabolism in brain tissue.We confirmed that radiofrequency electromagnetic field exposure for 6 months ameliorated cognitive impairment and amyloid-βdeposition.The expression levels of Iba1(pan-microglial marker)and colony-stimulating factor 1 receptor(CSF1R;regulates microglial prolife ration)in the hippocampus in 5xFAD mice treated with radiofrequency electromagnetic fields were significantly reduced compared with those of the sham-exposed group.Subsequently,we analyzed the expression levels of genes related to mic rogliosis and microglial function in the radiofrequency electromagnetic fields-exposed group compared to those of a CSF1R inhibitor(PLX3397)-treated group.Both radiofrequency electromagnetic fields and PLX3397 suppressed the levels of genes related to microgliosis(Csf1r,CD68,and Ccl6)and pro-inflammatory cytokine interleukin-1β.N otably,the expression levels of genes related to mic roglial function,including Trem2,Fcgr1α,Ctss,and Spi1,were decreased after long-term radiofrequency electromagnetic field exposure,which was also observed in response to microglial suppression by PLX3397.These results showed that radiofrequency electromagnetic fields ameliorated amyloid-βpathology and cognitive impairment by suppressing amyloid-βdeposition-induced microgliosis and their key regulator,CSF1R.
