Neuromyelitis optica spectrum disorder-related optic neuritis involves various cellular responses to inflammation and degeneration.In most patients,the primary mechanism underlying neuromyelitis optica spectrum disord...Neuromyelitis optica spectrum disorder-related optic neuritis involves various cellular responses to inflammation and degeneration.In most patients,the primary mechanism underlying neuromyelitis optica spectrum disorder-related optic neuritis is the interaction of aquaporin-4 antibodies with the aquaporin-4 protein present on astrocytes within posterior optic nerve.This binding subsequently initiates a cascade of events leading to secondary demyelination of the optic nerve,ultimately culminating in optic nerve degeneration.Earlier studies on this disorder primarily used systemic-induced animal models,which often require prior activation of a systemic immune response.This can result in primary demyelination of the optic nerve,complicating the interpretation of experimental results.Such methodologies hinder the ability to isolate immune responses triggered by specific antibodies.Additionally,the lack of a detailed profile of disease progression over time limits our capacity to identify potential intervention windows.Therefore,constructing a targeted optic neuritis animal model induced by specific antibodies and elucidate the disease progression arecrucial for exploring the mechanisms underlying neuromyelitis optica spectrum disorder-related optic neuritis.In this study,specific antibodies against aquaporin-4 were precisely injected into the retrobulbar optic nerve of mice to induce a targeted inflammatory response in the posterior optic nerve,resulting in a more representative mouse model of neuromyelitis optica spectrum disorder-related optic neuritis than current models.The progression of the disease was then dynamically observed from both histological and functional perspectives over the course of 1 month following the induction of inflammation.By the first week,astrocytes were damaged,as evidenced by the loss of aquaporin-4 and glial fibrillary acidic protein,the activation of microglia,and the upregulation of microglia-related cytokines,including tumor necrosis factor,interleukin-6,interleukin-1β,C-X-C motif ligand 10,and brain-derived neurotrophic factor.Starting from the second week,there were signs of optic nerve demyelination and significant damage to axonal fibers and retinal ganglion cell bodies.Visual-evoked potentials and dark adaptation threshold responses in electroretinogram both indicated dysfunction in the visual pathway and retina,while optical coherence tomography revealed thinning of the retinal nerve fiber layer in live mice.In summary,in this study we conducted a dynamic exploration of the occurrence and progression of neuromyelitis optica spectrum disorder-related optic neuritis triggered by specific antibodies.Our results show pathological changes at various stages and correlate histological and molecular alterations with in vivo structural and functional deterioration.The findings from this study lay an important foundation for further research on neuromyelitis optica spectrum disorder-related optic neuritis.展开更多
Securing restricted zones such as airports,research facilities,and military bases requires robust and reliable access control mechanisms to prevent unauthorized entry and safeguard critical assets.Face recognition has...Securing restricted zones such as airports,research facilities,and military bases requires robust and reliable access control mechanisms to prevent unauthorized entry and safeguard critical assets.Face recognition has emerged as a key biometric approach for this purpose;however,existing systems are often sensitive to variations in illumination,occlusion,and pose,which degrade their performance in real-world conditions.To address these challenges,this paper proposes a novel hybrid face recognition method that integrates complementary feature descriptors such as Fuzzy-Gabor 2D Fisher Linear Discriminant(FG-2DFLD),Generalized 2D Linear Discriminant Analysis(G2DLDA),andModular-Local Binary Patterns(Modular-LBP)with Dempster–Shafer(DS)evidence theory for decision fusion.The proposed framework extracts global,structural,and local texture features,models them using Gaussian distributions to estimate belief factors,and fuses these belief factors through DS theory to explicitly handle uncertainty and conflict among descriptors.Experimental validation was performed on two widely used benchmark datasets,ORL and Cropped Yale B,achieving recognition rates exceeding 98%,which outperform traditional methods as well as recent deep learning-based approaches.Furthermore,the method demonstrated strong robustness under noisy conditions,maintaining accuracies above 96%with salt-and-pepper and Gaussian noise.These results highlight the effectiveness of the proposed integration strategy in enhancing accuracy,reliability,and resilience compared to single-descriptor and conventional fusion methods.Given its high performance and efficiency,the proposed method shows strong potential for deployment in real-world restricted-zone applications such as smart parking systems,secure facility access,and other high-security domains.展开更多
目的探讨慢性阻塞性肺疾病(COPD)患者血清G蛋白偶联受体43(GPR43)、甲基转移酶3(METTL3)水平表达与肺功能和气流受限程度的相关性。方法选取2019年1月~2024年5月成都市第六人民医院收治的COPD患者150例(COPD组)和同期健康体检志愿者150...目的探讨慢性阻塞性肺疾病(COPD)患者血清G蛋白偶联受体43(GPR43)、甲基转移酶3(METTL3)水平表达与肺功能和气流受限程度的相关性。方法选取2019年1月~2024年5月成都市第六人民医院收治的COPD患者150例(COPD组)和同期健康体检志愿者150例(对照组)。根据气流受限程度将COPD患者分为轻度组(n=61)、中度组(n=46)和重度/极重度组(n=43)。检测血清GPR43、METTL3水平并测定肺功能[第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、FEV1占预计值%(%pred)]。Spearman相关性分析血清GPR43、METTL3水平与肺功能指标的相关性;通过多元有序Logistic回归分析血清GPR43、METTL3水平与COPD患者气流受限程度的关系,使用受试者工作特征(ROC)曲线分析其评估效能。结果与对照组比较,COPD组血清GPR43水平(5.32±1.07ng/ml vs 7.61±1.59ng/ml),FEV1/FVC比值[54.17(43.77,63.60)%vs 80.78(76.24,88.22)%]和FEV1%pred[72.25(44.94,84.22)%vs 93.06(89.71、95.54)%]显著降低(t/Z=-14.591,-14.247,-14.108),而METTL3水平(41.73±5.27pg/ml vs 31.85±5.03pg/ml)显著升高(t=16.614),差异具有统计学意义(均P<0.001)。重度/极重度组血清GPR43水平低于轻度、中度组(4.57±0.77ng/ml vs 5.98±1.05ng/ml、5.16±0.79 ng/ml),中度组低于轻度组(t=7.474、3.598、4.391),重度/极重度组血清METTL3水平高于轻度组、中度组(45.76±5.24pg/ml vs 38.83±4.20pg/ml、41.82±4.00pg/ml),中度组高于轻度组(t=-7.474、-4.003、-3.722),差异具有统计学意义(均P<0.001)。COPD患者FEV1/FVC比值、FEV1%pred与血清GPR43水平呈正相关(r=0.762、0.768,均P<0.001),与METTL3水平呈负相关(r=-0.758、-0.778,均P<0.001)。GPR43为COPD气流受限的独立保护因素(OR=0.689,Waldχ^(2)=14.064,P<0.05),METTL3为独立危险因素(OR=1.251,Waldχ^(2)=4.500,P<0.05)。血清GPR43与METTL3联合评估COPD重度/极重度气流受限的曲线下面积(AUC)优于GPR43和METTL3单独检测,差异具有统计学意义(Z=3.231、3.374,均P<0.05)。结论COPD患者血清GPR43水平降低、METTL3水平升高,与肺功能降低和气流受限程度加重有关,血清GPR43,METTL3水平联合评估COPD患者重度/极重度气流受限的价值较高。展开更多
Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological process...Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological processes,including vascular smooth muscle relaxation,myocardial cell function regulation,neuron growth,and synaptic plasticity,et al.In recent years,the role of PKG in diseases has gradually attracted attention,and the abnormalities in its signaling pathway are closely related to the occurrence and development of cardiovascular and neurological diseases.Although PKG has been widely studied,its complex functions in different physiological systems and potential innovative applications still need to be further explored.This article reviews the purification techniques for PKG,discusses the advantages and disadvantages of different extraction methods,summarizes the structure and activation mechanism of each domain of PKG,and analyzes the physiological functions of PKG in organisms,especially the well-established roles in the cardiovascular system,nervous system,and endocrine system.The emerging therapeutic applications of PKG are also reviewed.In addition,the challenges of this field are proposed at the end.展开更多
Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly...Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly measured masses for 296 nuclides from 40 references published between 2021 and 2024,subsequent to the release of the latest atomic mass evalu-ation.These data were used to benchmark the performance of several relativistic and nonrelativistic density functionals,including PC-PK1,TMA,SLy4,SV-min,UNEDF1,and the recently proposed PC-L3R.The results for PC-PK1 and PC-L3R were obtained using the state-of-the-art deformed relativistic Hartree-Bogoliubov theory in continuum(DRHBc),whereas the others were adopted from the existing literature.It was found that the DRHBc calculations with PC-PK1 and PC-L3R achieved an accuracy better than 1.5 MeV,outperforming the other functionals,which all exhibited root-mean-square devia-tions exceeding 2 MeV.The odd-even effects and isospin dependence in these theoretical descriptions were examined.The PC-PK1 and PC-L3R descriptions were qualitatively similar,exhibiting robust isospin dependence along the isotopic chains.Finally,a quantitative comparison between the PC-PK1 and PC-L3R results is presented,with the largest discrepancies analyzed in terms of the potential energy curves from the constrained DRHBc calculations.展开更多
Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM...Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].展开更多
GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动...GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。展开更多
AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric ...AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric emptying was assessed with solid radiopaque markers in 54 FD patients, and the patients were divided into two groups according to the results, one with delayed gastric emptying and the other with normal gastric emptying. Seventeen healthy volunteers acted as normal controls. Fasting and postprandial plasma levels and gastroduodenal mucosal levels of gastrointestinal hormones gastrin, somatostatin (SS) and neurotensin (NT)were measured by radioimmunoassay in all the subjects.G cells (gastrin-producing cells) and D cells (SS-producing cells) in gastric antral mucosa were immunostained with rabbit anti-gastrin polyclonal antibody and rabbit anti-SS polyclonal antibody, respectively, and analyzed quantitatively by computerized image analysis.RESULTS: The postprandial plasma gastrin levels, the fasting and postprandial plasma levels and the gastric and duodenal mucosal levels of NT were significantly higher in the FD patients with delayed gastric emptying than in those with normal gastric emptying and normal controls. The number and gray value of G and D cells and the G cell/D cell number ratio did not differ significantly between normal controls and the FD patients with or without delayed gastric emptying.CONCLUSION: Our findings suggest that the abnormalities of gastrin and NT may play a role in the pathophysiology of gastric dysmotility in FD patients, and the abnormality of postprandial plasma gastrin levels in FD patients with delayed gastric emptying is not related to the changes both in the number and gray value of G cells and in the G cell/D cell number ratio in gastric antral mucosa.展开更多
Non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau...Non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau damping of electron plasma （Langmuir） waves and ion-acoustic waves in a hot, isotropic, unmagnetized plasma is studied with the generalized （r, q） distribution function. The results show that for the Langmuir oscillations Landau damping becomes severe as the spectral index r or q reduces. However, for the ion-acoustic waves Landau damping is more sensitive to the ion temperature than the spectral indices.展开更多
Equilibrium structures and infrared spectra of four typical molecular models of coal have been studied by density functional calculations. Combining theoretical calculations on the coal models with experimental FT-IR ...Equilibrium structures and infrared spectra of four typical molecular models of coal have been studied by density functional calculations. Combining theoretical calculations on the coal models with experimental FT-IR spectra of selected low rank perhydrous coals, a plausible molecular representation for this kind of coals was proposed, and its predicted IR spectra reasonably match the experimental observation. Calculations indicate that the cleavage of the C-C bridge bond for the coal structures considered here occurs at about 540 ℃ and the C-O ether bridge bond may break under temperature ranging from 500 to 600 ℃for the aryl-CH2-O-CH2-aryl ether bond or from 200 to 300 ℃ for the aryl-CH2-O-aryl ether bond, showing remarkable effect of the local structural environment. The coal model containing the carboxyl group may release CO2 at about 300 ℃ through the decarboxylation with a barrier of 69 kcal/mol.展开更多
Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,...Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,there exists performance trade-offbetween communication and sensing,in that they have competitions on the physical resources.Different resource allocation schemes will result in different sensing and communication performance,thus influencing the system’s overall performance.Therefore,how to model the system’s overall performance,and how to optimize it are key issues for ISAC.Relying on the large-scale deployment of the networks,cooperative ISAC has the advantages of wider coverage,more robust performance and good compatibility of multiple monostatic and multistatic sensing,compared to the non-cooperative ISAC.How to capture the performance gain of cooperation is a key issue for cooperative ISAC.To address the aforementioned vital problems,in this paper,we analyze the sensing accuracy gain,propose a unified ISAC performance evaluation framework and design several optimization methods in cooperative ISAC systems.The cooperative sensing accuracy gain is theoretically analyzed via Cramér Rao lower bound.The unified ISAC performance evaluation model is established by converting the communication mutual information to the effective minimum mean squared error.To optimize the unified ISAC performance,we design the optimization algorithms considering three factors:base stations’working modes,power allocation schemes and waveform design.Through simulations,we show the performance gain of the cooperative ISAC system and the effectiveness of the proposed optimization methods.展开更多
基金The study was partially supported by the General Research Fund(GRF)from the Research Grants Council(RGC)of the Hong Kong Special Administrative Region,China,No.15103522(to ST)the Internal Research Grant from the Hong Kong Polytechnic University 2021-23,No.P0035512(to ST)and P0035375(to HHLC)+1 种基金the Innovation and Technology Commission of the Hong Kong Special Administrative Region(ITC InnoHK CEVR Project)The Hong Kong Polytechnics University Research Center for Sharp Vision,No.P0039595.
文摘Neuromyelitis optica spectrum disorder-related optic neuritis involves various cellular responses to inflammation and degeneration.In most patients,the primary mechanism underlying neuromyelitis optica spectrum disorder-related optic neuritis is the interaction of aquaporin-4 antibodies with the aquaporin-4 protein present on astrocytes within posterior optic nerve.This binding subsequently initiates a cascade of events leading to secondary demyelination of the optic nerve,ultimately culminating in optic nerve degeneration.Earlier studies on this disorder primarily used systemic-induced animal models,which often require prior activation of a systemic immune response.This can result in primary demyelination of the optic nerve,complicating the interpretation of experimental results.Such methodologies hinder the ability to isolate immune responses triggered by specific antibodies.Additionally,the lack of a detailed profile of disease progression over time limits our capacity to identify potential intervention windows.Therefore,constructing a targeted optic neuritis animal model induced by specific antibodies and elucidate the disease progression arecrucial for exploring the mechanisms underlying neuromyelitis optica spectrum disorder-related optic neuritis.In this study,specific antibodies against aquaporin-4 were precisely injected into the retrobulbar optic nerve of mice to induce a targeted inflammatory response in the posterior optic nerve,resulting in a more representative mouse model of neuromyelitis optica spectrum disorder-related optic neuritis than current models.The progression of the disease was then dynamically observed from both histological and functional perspectives over the course of 1 month following the induction of inflammation.By the first week,astrocytes were damaged,as evidenced by the loss of aquaporin-4 and glial fibrillary acidic protein,the activation of microglia,and the upregulation of microglia-related cytokines,including tumor necrosis factor,interleukin-6,interleukin-1β,C-X-C motif ligand 10,and brain-derived neurotrophic factor.Starting from the second week,there were signs of optic nerve demyelination and significant damage to axonal fibers and retinal ganglion cell bodies.Visual-evoked potentials and dark adaptation threshold responses in electroretinogram both indicated dysfunction in the visual pathway and retina,while optical coherence tomography revealed thinning of the retinal nerve fiber layer in live mice.In summary,in this study we conducted a dynamic exploration of the occurrence and progression of neuromyelitis optica spectrum disorder-related optic neuritis triggered by specific antibodies.Our results show pathological changes at various stages and correlate histological and molecular alterations with in vivo structural and functional deterioration.The findings from this study lay an important foundation for further research on neuromyelitis optica spectrum disorder-related optic neuritis.
文摘Securing restricted zones such as airports,research facilities,and military bases requires robust and reliable access control mechanisms to prevent unauthorized entry and safeguard critical assets.Face recognition has emerged as a key biometric approach for this purpose;however,existing systems are often sensitive to variations in illumination,occlusion,and pose,which degrade their performance in real-world conditions.To address these challenges,this paper proposes a novel hybrid face recognition method that integrates complementary feature descriptors such as Fuzzy-Gabor 2D Fisher Linear Discriminant(FG-2DFLD),Generalized 2D Linear Discriminant Analysis(G2DLDA),andModular-Local Binary Patterns(Modular-LBP)with Dempster–Shafer(DS)evidence theory for decision fusion.The proposed framework extracts global,structural,and local texture features,models them using Gaussian distributions to estimate belief factors,and fuses these belief factors through DS theory to explicitly handle uncertainty and conflict among descriptors.Experimental validation was performed on two widely used benchmark datasets,ORL and Cropped Yale B,achieving recognition rates exceeding 98%,which outperform traditional methods as well as recent deep learning-based approaches.Furthermore,the method demonstrated strong robustness under noisy conditions,maintaining accuracies above 96%with salt-and-pepper and Gaussian noise.These results highlight the effectiveness of the proposed integration strategy in enhancing accuracy,reliability,and resilience compared to single-descriptor and conventional fusion methods.Given its high performance and efficiency,the proposed method shows strong potential for deployment in real-world restricted-zone applications such as smart parking systems,secure facility access,and other high-security domains.
文摘目的探讨慢性阻塞性肺疾病(COPD)患者血清G蛋白偶联受体43(GPR43)、甲基转移酶3(METTL3)水平表达与肺功能和气流受限程度的相关性。方法选取2019年1月~2024年5月成都市第六人民医院收治的COPD患者150例(COPD组)和同期健康体检志愿者150例(对照组)。根据气流受限程度将COPD患者分为轻度组(n=61)、中度组(n=46)和重度/极重度组(n=43)。检测血清GPR43、METTL3水平并测定肺功能[第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、FEV1占预计值%(%pred)]。Spearman相关性分析血清GPR43、METTL3水平与肺功能指标的相关性;通过多元有序Logistic回归分析血清GPR43、METTL3水平与COPD患者气流受限程度的关系,使用受试者工作特征(ROC)曲线分析其评估效能。结果与对照组比较,COPD组血清GPR43水平(5.32±1.07ng/ml vs 7.61±1.59ng/ml),FEV1/FVC比值[54.17(43.77,63.60)%vs 80.78(76.24,88.22)%]和FEV1%pred[72.25(44.94,84.22)%vs 93.06(89.71、95.54)%]显著降低(t/Z=-14.591,-14.247,-14.108),而METTL3水平(41.73±5.27pg/ml vs 31.85±5.03pg/ml)显著升高(t=16.614),差异具有统计学意义(均P<0.001)。重度/极重度组血清GPR43水平低于轻度、中度组(4.57±0.77ng/ml vs 5.98±1.05ng/ml、5.16±0.79 ng/ml),中度组低于轻度组(t=7.474、3.598、4.391),重度/极重度组血清METTL3水平高于轻度组、中度组(45.76±5.24pg/ml vs 38.83±4.20pg/ml、41.82±4.00pg/ml),中度组高于轻度组(t=-7.474、-4.003、-3.722),差异具有统计学意义(均P<0.001)。COPD患者FEV1/FVC比值、FEV1%pred与血清GPR43水平呈正相关(r=0.762、0.768,均P<0.001),与METTL3水平呈负相关(r=-0.758、-0.778,均P<0.001)。GPR43为COPD气流受限的独立保护因素(OR=0.689,Waldχ^(2)=14.064,P<0.05),METTL3为独立危险因素(OR=1.251,Waldχ^(2)=4.500,P<0.05)。血清GPR43与METTL3联合评估COPD重度/极重度气流受限的曲线下面积(AUC)优于GPR43和METTL3单独检测,差异具有统计学意义(Z=3.231、3.374,均P<0.05)。结论COPD患者血清GPR43水平降低、METTL3水平升高,与肺功能降低和气流受限程度加重有关,血清GPR43,METTL3水平联合评估COPD患者重度/极重度气流受限的价值较高。
基金supported by the National Natural Science Foundation of China(Nos.22374033,22174031,22407037)the Natural Science Foundation of Heilongjiang Province(No.ZD2022B001).
文摘Protein Kinase G(PKG)is an important intracellular signal transduction enzyme,and its activity is modulated by cyclic guanosine monophosphate(cGMP).PKG plays a pivotal role in various significant physiological processes,including vascular smooth muscle relaxation,myocardial cell function regulation,neuron growth,and synaptic plasticity,et al.In recent years,the role of PKG in diseases has gradually attracted attention,and the abnormalities in its signaling pathway are closely related to the occurrence and development of cardiovascular and neurological diseases.Although PKG has been widely studied,its complex functions in different physiological systems and potential innovative applications still need to be further explored.This article reviews the purification techniques for PKG,discusses the advantages and disadvantages of different extraction methods,summarizes the structure and activation mechanism of each domain of PKG,and analyzes the physiological functions of PKG in organisms,especially the well-established roles in the cardiovascular system,nervous system,and endocrine system.The emerging therapeutic applications of PKG are also reviewed.In addition,the challenges of this field are proposed at the end.
基金supported by the National Natural Science Foundation of China(Nos.12265012 and 12305125)Guizhou Provincial Science and Technology Projects(No.ZK[2022]203)+2 种基金PhD fund of Guizhou Minzu University(No.GZMUZK[2024]QD76)the National Key Laboratory of Neutron Science and Technology(No.NST202401016)the Sichuan Science and Technology Program(No.2024NSFSC1356).
文摘Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly measured masses for 296 nuclides from 40 references published between 2021 and 2024,subsequent to the release of the latest atomic mass evalu-ation.These data were used to benchmark the performance of several relativistic and nonrelativistic density functionals,including PC-PK1,TMA,SLy4,SV-min,UNEDF1,and the recently proposed PC-L3R.The results for PC-PK1 and PC-L3R were obtained using the state-of-the-art deformed relativistic Hartree-Bogoliubov theory in continuum(DRHBc),whereas the others were adopted from the existing literature.It was found that the DRHBc calculations with PC-PK1 and PC-L3R achieved an accuracy better than 1.5 MeV,outperforming the other functionals,which all exhibited root-mean-square devia-tions exceeding 2 MeV.The odd-even effects and isospin dependence in these theoretical descriptions were examined.The PC-PK1 and PC-L3R descriptions were qualitatively similar,exhibiting robust isospin dependence along the isotopic chains.Finally,a quantitative comparison between the PC-PK1 and PC-L3R results is presented,with the largest discrepancies analyzed in terms of the potential energy curves from the constrained DRHBc calculations.
基金supported by the Office of Naval Research Grant(N00014-22-1-2184)。
文摘Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].
文摘GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。
文摘AIM: To investigate the relationship between gastric dysmotility,gastrointestinal hormone abnormalities, and neuroendocrine cells in gastrointestinal mucosa in patients with functional dyspepsia (FD).METHODS: Gastric emptying was assessed with solid radiopaque markers in 54 FD patients, and the patients were divided into two groups according to the results, one with delayed gastric emptying and the other with normal gastric emptying. Seventeen healthy volunteers acted as normal controls. Fasting and postprandial plasma levels and gastroduodenal mucosal levels of gastrointestinal hormones gastrin, somatostatin (SS) and neurotensin (NT)were measured by radioimmunoassay in all the subjects.G cells (gastrin-producing cells) and D cells (SS-producing cells) in gastric antral mucosa were immunostained with rabbit anti-gastrin polyclonal antibody and rabbit anti-SS polyclonal antibody, respectively, and analyzed quantitatively by computerized image analysis.RESULTS: The postprandial plasma gastrin levels, the fasting and postprandial plasma levels and the gastric and duodenal mucosal levels of NT were significantly higher in the FD patients with delayed gastric emptying than in those with normal gastric emptying and normal controls. The number and gray value of G and D cells and the G cell/D cell number ratio did not differ significantly between normal controls and the FD patients with or without delayed gastric emptying.CONCLUSION: Our findings suggest that the abnormalities of gastrin and NT may play a role in the pathophysiology of gastric dysmotility in FD patients, and the abnormality of postprandial plasma gastrin levels in FD patients with delayed gastric emptying is not related to the changes both in the number and gray value of G cells and in the G cell/D cell number ratio in gastric antral mucosa.
基金The project supported by National Natural Science Foundation of China under Grant No. 40390150 and the International Collaboration Research Team Program of the Chinese Academy of Sciences
文摘Non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau damping of electron plasma （Langmuir） waves and ion-acoustic waves in a hot, isotropic, unmagnetized plasma is studied with the generalized （r, q） distribution function. The results show that for the Langmuir oscillations Landau damping becomes severe as the spectral index r or q reduces. However, for the ion-acoustic waves Landau damping is more sensitive to the ion temperature than the spectral indices.
基金supported by the Ministry of Science and Technology (2012CB214900 and 2011CB808504)the National Science Foundation of China (21133007)
文摘Equilibrium structures and infrared spectra of four typical molecular models of coal have been studied by density functional calculations. Combining theoretical calculations on the coal models with experimental FT-IR spectra of selected low rank perhydrous coals, a plausible molecular representation for this kind of coals was proposed, and its predicted IR spectra reasonably match the experimental observation. Calculations indicate that the cleavage of the C-C bridge bond for the coal structures considered here occurs at about 540 ℃ and the C-O ether bridge bond may break under temperature ranging from 500 to 600 ℃for the aryl-CH2-O-CH2-aryl ether bond or from 200 to 300 ℃ for the aryl-CH2-O-aryl ether bond, showing remarkable effect of the local structural environment. The coal model containing the carboxyl group may release CO2 at about 300 ℃ through the decarboxylation with a barrier of 69 kcal/mol.
文摘Sixth Generation(6G)mobile communication networks will involve sensing as a new function,with the overwhelming trend of Integrated Sensing And Communications(ISAC).Although expanding the serving range of the networks,there exists performance trade-offbetween communication and sensing,in that they have competitions on the physical resources.Different resource allocation schemes will result in different sensing and communication performance,thus influencing the system’s overall performance.Therefore,how to model the system’s overall performance,and how to optimize it are key issues for ISAC.Relying on the large-scale deployment of the networks,cooperative ISAC has the advantages of wider coverage,more robust performance and good compatibility of multiple monostatic and multistatic sensing,compared to the non-cooperative ISAC.How to capture the performance gain of cooperation is a key issue for cooperative ISAC.To address the aforementioned vital problems,in this paper,we analyze the sensing accuracy gain,propose a unified ISAC performance evaluation framework and design several optimization methods in cooperative ISAC systems.The cooperative sensing accuracy gain is theoretically analyzed via Cramér Rao lower bound.The unified ISAC performance evaluation model is established by converting the communication mutual information to the effective minimum mean squared error.To optimize the unified ISAC performance,we design the optimization algorithms considering three factors:base stations’working modes,power allocation schemes and waveform design.Through simulations,we show the performance gain of the cooperative ISAC system and the effectiveness of the proposed optimization methods.
