From the process of sedimentation the mathematical relationships among deposition Volume and powder properties as well as sedimentation parameters were deduced. Based on the formula a mathematical model was set up and...From the process of sedimentation the mathematical relationships among deposition Volume and powder properties as well as sedimentation parameters were deduced. Based on the formula a mathematical model was set up and simulated through the computer. At last the validity of mathematical model was supported by the representative experiment on Ti-Mo system FGM prepared by co-sedimentation.展开更多
In this paper, the roles of low velocity and high conductivity body inside the crust in the process of strong earth quake preparation are approached by using theoretical analysis method based on the comprehensive rese...In this paper, the roles of low velocity and high conductivity body inside the crust in the process of strong earth quake preparation are approached by using theoretical analysis method based on the comprehensive researches on the fine structure of strong seismic source in the North China. The following results are obtained. The low-velocity and high-conductivity body plays the promoting role for the action of deep-seated structure in the medium stage of earthquake preparation, except that its existence is advantageous to the stress concentrating in the overlying brittle layer during the process of earthquake preparation. And it plays the triggering role for the occurrence of strong earthquake in the later stage of earthquake preparation.展开更多
Dual-signal electrochemical sensors have inherent self-correction function to overcome disturbances of experimental and environmental factors,but suffer from electrodes'modification or functional materials'pre...Dual-signal electrochemical sensors have inherent self-correction function to overcome disturbances of experimental and environmental factors,but suffer from electrodes'modification or functional materials'preparation,resulting in cumbersome operation,weak stability and poor recognition efficiency.Herein,we propose a dual-signal electrochemical strategy for microRNA senstive detection based on target-driven T7 exonuclease(T7 Exo)-mediated signal amplification that eliminates the above-mentioned drawbacks.The recognition of methylene(MB)and ferrocene(Fc)co-tagged ssDNA(MB/Fc-ssDNA)by miRNA-155 resulted in the formation of double-stranded nucleic acids,which switched T7 Exo-assisted catalytic digestion on MB/Fc-ssDNA,achieving 1:N amplified generation of MB-mononucleotides(mNs)and Fc-mNs.Compared with MB/Fc-ssDNA,MB-mNs and Fc-mNs exhibited significantly declined electrostatic repulsion force toward working electrode,and then simultaneously generated two signals at distinct potentials,in which dual-signal analysis of miRNA-155 was achieved with limit of detection down to~fM level.This work renders a novel thinking concept to develop high-performance electrochemical sensors for early and reliable diagnosis of miRNA-related diseases,advancing the rapid development of intelligent medicines.展开更多
Ti1Al2O3 Functionally Gradient Material (FGM) was prepared by an explosive compaction/SHS process. Ten sheets of the compounding powder were laminated and pressed to get a green body of FGM. It was then compacted expl...Ti1Al2O3 Functionally Gradient Material (FGM) was prepared by an explosive compaction/SHS process. Ten sheets of the compounding powder were laminated and pressed to get a green body of FGM. It was then compacted explosively By burying the explosive compaction body into a stoichiometric Al/TiO2 mixture and igniting the combustion of the stoichiometric Al/TiO2 mixture, the SHS reaction of the explosive compaction body was initiated by the heat released from the combustion of the stoichiometric Al/TiO2 mixture. In this way, Ti/Al2O3 FGM was synthesized. The adiabatic temperatures of each gradient layer were calculated when the preheating temperatures were 298 K and 1173 K, respectively The microstructure, composition and properties of Ti/Al2O3 FGM and the reaction mechanism of each gradient layer were studied. It was found that Ti/Al2O3 FGM prepared by the explosive compaction/SHS process had a high density and a high microhardness. Its structure, composition and properties showed apparent gradient distribution. The structure of the standard stoichiometric ratio gradient layer of FGM was a network structure. Its reaction mode could be described as follows: Al powder melted first, then the molten Al penetrated into the TiO2 zone and reacted with TiO2, and big pores were left in the original positions of Al powder. The reaction of gradient layers with the addition of Al3O3 as diluents was similar to that of the standard stoichiometric ratio gradient layer, so were their structure and composition. However, the reaction of gradient layers with the addition of Ti as diluents was more complex and the composition deviated slightly from the designed one展开更多
The microstructure and the electrical, thermal, friction, and mechanical properties of Cu/Ti_2AlC fabricated by hot-pressing at 900 ℃ for 1 h were investigated in the present work. Microstructural observations have s...The microstructure and the electrical, thermal, friction, and mechanical properties of Cu/Ti_2AlC fabricated by hot-pressing at 900 ℃ for 1 h were investigated in the present work. Microstructural observations have shown that the plate-like Ti_2AlC grains distribute irregularly in the network of Cu grains, and well-structured, crack-free bonds between the layers. With the increase in the content of Ti_2AlC from layer A to layer D, the electrical resistivity increases from 1.381×10^（-7）Ω·m to 1.918 ×10^（-7）Ω·m, the hardness increases from about 980.27 MPa to about 2196.01 MPa, and the friction coefficient from above 0.20 reduces to about 0.15. Oxidation rate increases with the increases of temperature. Exfoliation was obviously observed on the surface of oxidation layer A. The surface of layer D was still intact and the spalling and other defects were not found. The mass decreases in the acid solution, and increases in the alkaline solution. The largest corrosion rate is found in 6.5% HNO_3 or 4% Na OH solution.展开更多
Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve injury.It is believed that the capability of brain plasticity is crucial for th...Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve injury.It is believed that the capability of brain plasticity is crucial for the recovery of hand function.The supplementary motor area may play a key role in brain remodeling after peripheral nerve injury.In this study,we explored the activation mode of the supplementary motor area during a motor imagery task.We investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery task.Results from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor areas.This result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain remodeling.Deactivation of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function.展开更多
文摘From the process of sedimentation the mathematical relationships among deposition Volume and powder properties as well as sedimentation parameters were deduced. Based on the formula a mathematical model was set up and simulated through the computer. At last the validity of mathematical model was supported by the representative experiment on Ti-Mo system FGM prepared by co-sedimentation.
文摘In this paper, the roles of low velocity and high conductivity body inside the crust in the process of strong earth quake preparation are approached by using theoretical analysis method based on the comprehensive researches on the fine structure of strong seismic source in the North China. The following results are obtained. The low-velocity and high-conductivity body plays the promoting role for the action of deep-seated structure in the medium stage of earthquake preparation, except that its existence is advantageous to the stress concentrating in the overlying brittle layer during the process of earthquake preparation. And it plays the triggering role for the occurrence of strong earthquake in the later stage of earthquake preparation.
基金financially supported by National Natural Science Foundation of China(82304197 and 21605093)Hebei Natural Science Foundation(B2023201013)+4 种基金Science Research Project of Hebei Education Department(QN2024135)Hebei Province Innovation Capability Enhancement Plan Project(22567620H)Interdisciplinary Research Program of Hebei University(DXK202411)Medical Science Foundation of Hebei University(2023A02)Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education(MCMDZR-2024002)。
文摘Dual-signal electrochemical sensors have inherent self-correction function to overcome disturbances of experimental and environmental factors,but suffer from electrodes'modification or functional materials'preparation,resulting in cumbersome operation,weak stability and poor recognition efficiency.Herein,we propose a dual-signal electrochemical strategy for microRNA senstive detection based on target-driven T7 exonuclease(T7 Exo)-mediated signal amplification that eliminates the above-mentioned drawbacks.The recognition of methylene(MB)and ferrocene(Fc)co-tagged ssDNA(MB/Fc-ssDNA)by miRNA-155 resulted in the formation of double-stranded nucleic acids,which switched T7 Exo-assisted catalytic digestion on MB/Fc-ssDNA,achieving 1:N amplified generation of MB-mononucleotides(mNs)and Fc-mNs.Compared with MB/Fc-ssDNA,MB-mNs and Fc-mNs exhibited significantly declined electrostatic repulsion force toward working electrode,and then simultaneously generated two signals at distinct potentials,in which dual-signal analysis of miRNA-155 was achieved with limit of detection down to~fM level.This work renders a novel thinking concept to develop high-performance electrochemical sensors for early and reliable diagnosis of miRNA-related diseases,advancing the rapid development of intelligent medicines.
文摘Ti1Al2O3 Functionally Gradient Material (FGM) was prepared by an explosive compaction/SHS process. Ten sheets of the compounding powder were laminated and pressed to get a green body of FGM. It was then compacted explosively By burying the explosive compaction body into a stoichiometric Al/TiO2 mixture and igniting the combustion of the stoichiometric Al/TiO2 mixture, the SHS reaction of the explosive compaction body was initiated by the heat released from the combustion of the stoichiometric Al/TiO2 mixture. In this way, Ti/Al2O3 FGM was synthesized. The adiabatic temperatures of each gradient layer were calculated when the preheating temperatures were 298 K and 1173 K, respectively The microstructure, composition and properties of Ti/Al2O3 FGM and the reaction mechanism of each gradient layer were studied. It was found that Ti/Al2O3 FGM prepared by the explosive compaction/SHS process had a high density and a high microhardness. Its structure, composition and properties showed apparent gradient distribution. The structure of the standard stoichiometric ratio gradient layer of FGM was a network structure. Its reaction mode could be described as follows: Al powder melted first, then the molten Al penetrated into the TiO2 zone and reacted with TiO2, and big pores were left in the original positions of Al powder. The reaction of gradient layers with the addition of Al3O3 as diluents was similar to that of the standard stoichiometric ratio gradient layer, so were their structure and composition. However, the reaction of gradient layers with the addition of Ti as diluents was more complex and the composition deviated slightly from the designed one
基金The Open Foundation of Hubei Provincial Key Laboratory of Green Material for Light Industry(No.(2013)2-general project-9)the Key Project of Education Department of Hubei(No.D20131406)the National Natural Science Foundation of China(No.51302073)
文摘The microstructure and the electrical, thermal, friction, and mechanical properties of Cu/Ti_2AlC fabricated by hot-pressing at 900 ℃ for 1 h were investigated in the present work. Microstructural observations have shown that the plate-like Ti_2AlC grains distribute irregularly in the network of Cu grains, and well-structured, crack-free bonds between the layers. With the increase in the content of Ti_2AlC from layer A to layer D, the electrical resistivity increases from 1.381×10^（-7）Ω·m to 1.918 ×10^（-7）Ω·m, the hardness increases from about 980.27 MPa to about 2196.01 MPa, and the friction coefficient from above 0.20 reduces to about 0.15. Oxidation rate increases with the increases of temperature. Exfoliation was obviously observed on the surface of oxidation layer A. The surface of layer D was still intact and the spalling and other defects were not found. The mass decreases in the acid solution, and increases in the alkaline solution. The largest corrosion rate is found in 6.5% HNO_3 or 4% Na OH solution.
基金supported by the Youth Researcher Foundation of Shanghai Health Development Planning Commission,No.20124319
文摘Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve injury.It is believed that the capability of brain plasticity is crucial for the recovery of hand function.The supplementary motor area may play a key role in brain remodeling after peripheral nerve injury.In this study,we explored the activation mode of the supplementary motor area during a motor imagery task.We investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery task.Results from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor areas.This result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain remodeling.Deactivation of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function.
