The rich club,as a community of highly interconnected nodes,serves as the topological center of the network.However,the similarities and differences in how the rich club supports functional integration and segregation...The rich club,as a community of highly interconnected nodes,serves as the topological center of the network.However,the similarities and differences in how the rich club supports functional integration and segregation in the brain across different species remain unknown.In this study,we first detected and validated the rich club in the structural networks of mouse,monkey,and human brains using neuronal tracing or diffusion magnetic resonance imaging data.Further,we assessed the role of rich clubs in functional integration,segregation,and balance using quantitative metrics.Our results indicate that the presence of a rich club facilitates whole-brain functional integration in all three species,with the functional networks of higher species exhibiting greater integration.These findings are expected to help to understand the relationship between brain structure and function from the perspective of brain evolution.展开更多
In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the max...In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the maximum distance of any pair of nodes in the support domain.The proposed method is verified and shows good performance.The results are stable and accurate with any number of nodes and an arbitrary nodal distribution.Notably,the support domain should be large enough to obtain accurate results.This method is then applied for transient analysis of curved shell structures made from functionally graded materials with complex geometries.Through several numerical examples,the accuracy of the proposed approach is demonstrated and discussed.Additionally,the influence of various factors on the dynamic behavior of the structures,including the power-law index,different materials,loading conditions,and geometrical parameters of the structures,was investigated.展开更多
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
In this paper, collective excitations in the boson-fermion model are investigated by means of functional integration method. The equations of energy gap and excitation spectrum are derived. Moreover, the Bose energy s...In this paper, collective excitations in the boson-fermion model are investigated by means of functional integration method. The equations of energy gap and excitation spectrum are derived. Moreover, the Bose energy spectrum of zero wave vector Fermi fields is also calculated.展开更多
The free energy at low temperature in 1D sine-Gordon-Thirring model with impurity coupling is studied by means of functional integrals method. For massive free sine-Gordon-Thirring model, free energy is obtained from ...The free energy at low temperature in 1D sine-Gordon-Thirring model with impurity coupling is studied by means of functional integrals method. For massive free sine-Gordon-Thirring model, free energy is obtained from perturbation expansion of functional determinant. Moreover, the free energy of massive model is calculated by use of an auxiliary Bose field method.展开更多
The generalized Thirring model with impurity coupling is defined on two-dimensional noncommutativespace-time,a modified propagator and free energy are derived by means of functional integrals method.Moreover,quantum f...The generalized Thirring model with impurity coupling is defined on two-dimensional noncommutativespace-time,a modified propagator and free energy are derived by means of functional integrals method.Moreover,quantum fluctuations and excitation energies are calculated on two-dimensional black hole and soliton background.展开更多
The normal and anomalous Green＇s functions of antiferromagnetie state in three-band Hubbard model are studied by using functional integrals and temperature Green＇s function method. The equations of energy spectrum a...The normal and anomalous Green＇s functions of antiferromagnetie state in three-band Hubbard model are studied by using functional integrals and temperature Green＇s function method. The equations of energy spectrum are derived. In addition, excitation energy of Fermi fields are calculated under long wave approximation.展开更多
The free energy in 1D sine-Gordon- Thirring model with impurity coupling is studied by means of functional integrals and variational-cumulant expansion methods. Two variational parameters are introduced to evaluate fr...The free energy in 1D sine-Gordon- Thirring model with impurity coupling is studied by means of functional integrals and variational-cumulant expansion methods. Two variational parameters are introduced to evaluate free energy and statistical averages. It is shown that the non-perturbation method of functional integrals can be applied to strongcoupling range of fcrmion systems.展开更多
A new fuzzy adaptive control method is proposed for a class of strict feedback nonlinear systems with immeasurable states and full constraints.The fuzzy logic system is used to design the approximator,which deals with...A new fuzzy adaptive control method is proposed for a class of strict feedback nonlinear systems with immeasurable states and full constraints.The fuzzy logic system is used to design the approximator,which deals with uncertain and continuous functions in the process of backstepping design.The use of an integral barrier Lyapunov function not only ensures that all states are within the bounds of the constraint,but also mixes the states and errors to directly constrain the state,reducing the conservativeness of the constraint satisfaction condition.Considering that the states in most nonlinear systems are immeasurable,a fuzzy adaptive states observer is constructed to estimate the unknown states.Combined with adaptive backstepping technique,an adaptive fuzzy output feedback control method is proposed.The proposed control method ensures that all signals in the closed-loop system are bounded,and that the tracking error converges to a bounded tight set without violating the full state constraint.The simulation results prove the effectiveness of the proposed control scheme.展开更多
The limited capability to regenerate new neurons following injuries of the central neural system（CNS）still remains a major challenge for basic and clinical neuroscience.Neural stem cells（NSCs）could nearly have the...The limited capability to regenerate new neurons following injuries of the central neural system（CNS）still remains a major challenge for basic and clinical neuroscience.Neural stem cells（NSCs）could nearly have the potential to differentiate into all kinds of neural cells in vitro.展开更多
In this paper we deal with the existence of infinitely many critical points of the even functional I(u)=integral from n=Q to (F(x,u,Du))+integral from n=(?)Q to (G(x,u)), u∈W^(1,p)(Ω),where G(x, u)=integral from n=o...In this paper we deal with the existence of infinitely many critical points of the even functional I(u)=integral from n=Q to (F(x,u,Du))+integral from n=(?)Q to (G(x,u)), u∈W^(1,p)(Ω),where G(x, u)=integral from n=o to u (g(x,t)dt), under the weak structure conditions on F(x, u, q) by the Mountain Pass Lemma.展开更多
A functional integral approach (FIA) is introduced to calculate the transition temperature of a uniform imperfect Bose gas. With this approach we find that the transition temperature is higher than that of the corresp...A functional integral approach (FIA) is introduced to calculate the transition temperature of a uniform imperfect Bose gas. With this approach we find that the transition temperature is higher than that of the corresponding ideal gas. We obtain the expression of the transition temperature shift as , where n is the density of particle number and a is the scattering length. The result has never been reported in the literature.展开更多
In this paper, we introduce the integration of algebroidal functions on Riemann surfaces for the first time. Some properties of integration are obtained. By giving the defi- nition of residues and integral function el...In this paper, we introduce the integration of algebroidal functions on Riemann surfaces for the first time. Some properties of integration are obtained. By giving the defi- nition of residues and integral function element, we obtain the condition that the integral is independent of path. At last, we prove that the integral of an irreducible algebroidal function is also an irreducible algebroidal function if all the residues at critical points are zeros.展开更多
In this article, we have two parts. In the first part, we are concerned with the locally Hlder continuity of quasi-minima of the following integral functional ∫Ωf（x, u, Du）dx, （1） where Ω is an open subset of E...In this article, we have two parts. In the first part, we are concerned with the locally Hlder continuity of quasi-minima of the following integral functional ∫Ωf（x, u, Du）dx, （1） where Ω is an open subset of Euclidean N-space （N ≥ 3）, u：Ω → R,the Carath′eodory function f satisfies the critical Sobolev exponent growth condition ｜Du｜^p＊ ｜u｜^p＊-a（x） ≤ f（x,u,Du） ≤ L（｜Du｜^p＋｜u｜^p＊ ＋ a（x））, （2） where L≥1, 1pN,p^＊ = Np/N-p , and a（x） is a nonnegative function that lies in a suitable Lp space. In the second part, we study the locally Hlder continuity of ω-minima of （1）. Our method is to compare the ω-minima of （1） with the minima of corresponding function determined by its critical Sobolev exponent growth condition. Finally, we obtain the regularity by Ekeland’s variational principal.展开更多
Area integral functions are introduced for sectorial operators on Hilbert spaces. We establish the equivalence relationship between the square and area integral functions. This immediately extends McIntosh/Yagi＇s res...Area integral functions are introduced for sectorial operators on Hilbert spaces. We establish the equivalence relationship between the square and area integral functions. This immediately extends McIntosh/Yagi＇s results on H∞ functional calculus of sectorial operators on Hilbert spaces to the case when the square functions are replaced by the area integral functions.展开更多
This work proposes a new definition of the functional Fredholm integral equation in 2D of the second kind with discontinuous kernels (FT-DFIE). Furthermore, the work is concerned to study this new equation numerically...This work proposes a new definition of the functional Fredholm integral equation in 2D of the second kind with discontinuous kernels (FT-DFIE). Furthermore, the work is concerned to study this new equation numerically. The existence of a unique solution of the equation is proved. In addition, the approximate solutions are obtained by two powerful methods Toeplitz Matrix Method (TMM) and Product Nystr?m Methods (PNM). The given numerical examples showed the efficiency and accuracy of the introduced methods.展开更多
In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of d...In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of death from coronavirus disease 2019(COVID-19).In 2024,Kavli Prize recognizes the pioneering work of integrating engineered nanocarriers with biological functions for biomedical applications.The development of nanomedicine has changed the ways we approach the fundamental understand-ing,diagnosis,treatment,and prevention of diseases.These suc-cessful cases brought great excitement to the field of nanomedicine;however,many challenges still remain.In particular,it is critical to optimize nanocarriers to improve delivery effi-ciency and selectivity as well as reduce toxic side effects.展开更多
In order to classify the minimal hepatic encephalopathy （MHE） patients from healthy controls, the independent component analysis （ICA） is used to generate the default mode network （DMN） from resting-state functi...In order to classify the minimal hepatic encephalopathy （MHE） patients from healthy controls, the independent component analysis （ICA） is used to generate the default mode network （DMN） from resting-state functional magnetic resonance imaging （fMRI）. Then a Bayesian voxel- wised method, graphical-model-based multivariate analysis （GAMMA）, is used to explore the associations between abnormal functional integration within DMN and clinical variable. Without any prior knowledge, five machine learning methods, namely, support vector machines （SVMs）, classification and regression trees （ CART ）, logistic regression, the Bayesian network, and C4.5, are applied to the classification. The functional integration patterns were alternative within DMN, which have the power to predict MHE with an accuracy of 98%. The GAMMA method generating functional integration patterns within DMN can become a simple, objective, and common imaging biomarker for detecting MIIE and can serve as a supplement to the existing diagnostic methods.展开更多
A novel spatial interpolation method based on integrated radial basis function artificial neural networks （IRBFANNs） is proposed to provide accurate and stable predictions of heavy metals concentrations in soil at u...A novel spatial interpolation method based on integrated radial basis function artificial neural networks （IRBFANNs） is proposed to provide accurate and stable predictions of heavy metals concentrations in soil at un- sampled sites in a mountain region. The IRBFANNs hybridize the advantages of the artificial neural networks and the neural networks integration approach. Three experimental projects under different sampling densities are carried out to study the performance of the proposed IRBFANNs-based interpolation method. This novel method is compared with six peer spatial interpolation methods based on the root mean square error and visual evaluation of the distribution maps of Mn elements. The experimental results show that the proposed method performs better in accuracy and stability. Moreover, the proposed method can provide more details in the spatial distribution maps than the compared interpolation methods in the cases of sparse sampling density.展开更多
基金supported by STI2030-Major Projects(2021ZD0200200)the National Natural Science Foundation of China(62327805 and 82151307)+1 种基金the Equipment Development Project of the Chinese Academy of Sciences(YJKYYQ20190040)the Science and Technology Innovation Program of Hunan Province(2024RC4028).
文摘The rich club,as a community of highly interconnected nodes,serves as the topological center of the network.However,the similarities and differences in how the rich club supports functional integration and segregation in the brain across different species remain unknown.In this study,we first detected and validated the rich club in the structural networks of mouse,monkey,and human brains using neuronal tracing or diffusion magnetic resonance imaging data.Further,we assessed the role of rich clubs in functional integration,segregation,and balance using quantitative metrics.Our results indicate that the presence of a rich club facilitates whole-brain functional integration in all three species,with the functional networks of higher species exhibiting greater integration.These findings are expected to help to understand the relationship between brain structure and function from the perspective of brain evolution.
基金Ho Chi Minh City University of Technology (HCMUT), VNU-HCM for supporting this study
文摘In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the maximum distance of any pair of nodes in the support domain.The proposed method is verified and shows good performance.The results are stable and accurate with any number of nodes and an arbitrary nodal distribution.Notably,the support domain should be large enough to obtain accurate results.This method is then applied for transient analysis of curved shell structures made from functionally graded materials with complex geometries.Through several numerical examples,the accuracy of the proposed approach is demonstrated and discussed.Additionally,the influence of various factors on the dynamic behavior of the structures,including the power-law index,different materials,loading conditions,and geometrical parameters of the structures,was investigated.
文摘Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金The project supported by the Science Foundation of Sichuan Normal University
文摘In this paper, collective excitations in the boson-fermion model are investigated by means of functional integration method. The equations of energy gap and excitation spectrum are derived. Moreover, the Bose energy spectrum of zero wave vector Fermi fields is also calculated.
基金The project supported by the Natural Science Foundation of Sichuan Normal University
文摘The free energy at low temperature in 1D sine-Gordon-Thirring model with impurity coupling is studied by means of functional integrals method. For massive free sine-Gordon-Thirring model, free energy is obtained from perturbation expansion of functional determinant. Moreover, the free energy of massive model is calculated by use of an auxiliary Bose field method.
基金Supported by the Natural Science Foundation of Sichuan Education Committee under Grant No.08ZA038
文摘The generalized Thirring model with impurity coupling is defined on two-dimensional noncommutativespace-time,a modified propagator and free energy are derived by means of functional integrals method.Moreover,quantum fluctuations and excitation energies are calculated on two-dimensional black hole and soliton background.
基金supported by the Natural Science Foundation of Sichuan Normal University
文摘The normal and anomalous Green＇s functions of antiferromagnetie state in three-band Hubbard model are studied by using functional integrals and temperature Green＇s function method. The equations of energy spectrum are derived. In addition, excitation energy of Fermi fields are calculated under long wave approximation.
基金the Natural Science Foundation of Sichuan Normal University
文摘The free energy in 1D sine-Gordon- Thirring model with impurity coupling is studied by means of functional integrals and variational-cumulant expansion methods. Two variational parameters are introduced to evaluate free energy and statistical averages. It is shown that the non-perturbation method of functional integrals can be applied to strongcoupling range of fcrmion systems.
基金supported in part by the National Natural Science Foundation of China(6202530361973147)the LiaoNing Revitalization Talents Program(XLYC1907050)。
文摘A new fuzzy adaptive control method is proposed for a class of strict feedback nonlinear systems with immeasurable states and full constraints.The fuzzy logic system is used to design the approximator,which deals with uncertain and continuous functions in the process of backstepping design.The use of an integral barrier Lyapunov function not only ensures that all states are within the bounds of the constraint,but also mixes the states and errors to directly constrain the state,reducing the conservativeness of the constraint satisfaction condition.Considering that the states in most nonlinear systems are immeasurable,a fuzzy adaptive states observer is constructed to estimate the unknown states.Combined with adaptive backstepping technique,an adaptive fuzzy output feedback control method is proposed.The proposed control method ensures that all signals in the closed-loop system are bounded,and that the tracking error converges to a bounded tight set without violating the full state constraint.The simulation results prove the effectiveness of the proposed control scheme.
基金supported by National Program on Key Basic Research Project(973 Programs 2015CB755605)National Natural Science Foundation of China(81471312)
文摘The limited capability to regenerate new neurons following injuries of the central neural system（CNS）still remains a major challenge for basic and clinical neuroscience.Neural stem cells（NSCs）could nearly have the potential to differentiate into all kinds of neural cells in vitro.
文摘In this paper we deal with the existence of infinitely many critical points of the even functional I(u)=integral from n=Q to (F(x,u,Du))+integral from n=(?)Q to (G(x,u)), u∈W^(1,p)(Ω),where G(x, u)=integral from n=o to u (g(x,t)dt), under the weak structure conditions on F(x, u, q) by the Mountain Pass Lemma.
文摘A functional integral approach (FIA) is introduced to calculate the transition temperature of a uniform imperfect Bose gas. With this approach we find that the transition temperature is higher than that of the corresponding ideal gas. We obtain the expression of the transition temperature shift as , where n is the density of particle number and a is the scattering length. The result has never been reported in the literature.
基金supported by the National Natural Science Foundation of China(11501127)Guangdong Natural Science Foundation(2015A030313628)+1 种基金the Training Plan for Outstanding Young Teachers in Higher Education of Guangdong(Yqgdufe1405)the Open Fund of the National Higher Education Quality Monitoring Data Center(Guangzhou)(G1613)
文摘In this paper, we introduce the integration of algebroidal functions on Riemann surfaces for the first time. Some properties of integration are obtained. By giving the defi- nition of residues and integral function element, we obtain the condition that the integral is independent of path. At last, we prove that the integral of an irreducible algebroidal function is also an irreducible algebroidal function if all the residues at critical points are zeros.
基金Supported by the Program of Fujian Province-HongKong
文摘In this article, we have two parts. In the first part, we are concerned with the locally Hlder continuity of quasi-minima of the following integral functional ∫Ωf（x, u, Du）dx, （1） where Ω is an open subset of Euclidean N-space （N ≥ 3）, u：Ω → R,the Carath′eodory function f satisfies the critical Sobolev exponent growth condition ｜Du｜^p＊ ｜u｜^p＊-a（x） ≤ f（x,u,Du） ≤ L（｜Du｜^p＋｜u｜^p＊ ＋ a（x））, （2） where L≥1, 1pN,p^＊ = Np/N-p , and a（x） is a nonnegative function that lies in a suitable Lp space. In the second part, we study the locally Hlder continuity of ω-minima of （1）. Our method is to compare the ω-minima of （1） with the minima of corresponding function determined by its critical Sobolev exponent growth condition. Finally, we obtain the regularity by Ekeland’s variational principal.
文摘Area integral functions are introduced for sectorial operators on Hilbert spaces. We establish the equivalence relationship between the square and area integral functions. This immediately extends McIntosh/Yagi＇s results on H∞ functional calculus of sectorial operators on Hilbert spaces to the case when the square functions are replaced by the area integral functions.
文摘This work proposes a new definition of the functional Fredholm integral equation in 2D of the second kind with discontinuous kernels (FT-DFIE). Furthermore, the work is concerned to study this new equation numerically. The existence of a unique solution of the equation is proved. In addition, the approximate solutions are obtained by two powerful methods Toeplitz Matrix Method (TMM) and Product Nystr?m Methods (PNM). The given numerical examples showed the efficiency and accuracy of the introduced methods.
文摘In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of death from coronavirus disease 2019(COVID-19).In 2024,Kavli Prize recognizes the pioneering work of integrating engineered nanocarriers with biological functions for biomedical applications.The development of nanomedicine has changed the ways we approach the fundamental understand-ing,diagnosis,treatment,and prevention of diseases.These suc-cessful cases brought great excitement to the field of nanomedicine;however,many challenges still remain.In particular,it is critical to optimize nanocarriers to improve delivery effi-ciency and selectivity as well as reduce toxic side effects.
基金The National Natural Science Foundation of China(No.8123003481271739+2 种基金81501453)the Special Program of Medical Science of Jiangsu Province(No.BL2013029)the Natural Science Foundation of Jiangsu Province(No.BK20141342)
文摘In order to classify the minimal hepatic encephalopathy （MHE） patients from healthy controls, the independent component analysis （ICA） is used to generate the default mode network （DMN） from resting-state functional magnetic resonance imaging （fMRI）. Then a Bayesian voxel- wised method, graphical-model-based multivariate analysis （GAMMA）, is used to explore the associations between abnormal functional integration within DMN and clinical variable. Without any prior knowledge, five machine learning methods, namely, support vector machines （SVMs）, classification and regression trees （ CART ）, logistic regression, the Bayesian network, and C4.5, are applied to the classification. The functional integration patterns were alternative within DMN, which have the power to predict MHE with an accuracy of 98%. The GAMMA method generating functional integration patterns within DMN can become a simple, objective, and common imaging biomarker for detecting MIIE and can serve as a supplement to the existing diagnostic methods.
基金The National Natural Science Foundation of China(No.61261007,61062005)the Key Program of Yunnan Natural Science Foundation(No.2013FA008)
文摘A novel spatial interpolation method based on integrated radial basis function artificial neural networks （IRBFANNs） is proposed to provide accurate and stable predictions of heavy metals concentrations in soil at un- sampled sites in a mountain region. The IRBFANNs hybridize the advantages of the artificial neural networks and the neural networks integration approach. Three experimental projects under different sampling densities are carried out to study the performance of the proposed IRBFANNs-based interpolation method. This novel method is compared with six peer spatial interpolation methods based on the root mean square error and visual evaluation of the distribution maps of Mn elements. The experimental results show that the proposed method performs better in accuracy and stability. Moreover, the proposed method can provide more details in the spatial distribution maps than the compared interpolation methods in the cases of sparse sampling density.
