Genome-scale studies focusing on molecular profiling of cancers across tissue types have revealed a plethora of aberrations across the genomic,transcriptomic,and epigenomic scales.The significant molecular heterogenei...Genome-scale studies focusing on molecular profiling of cancers across tissue types have revealed a plethora of aberrations across the genomic,transcriptomic,and epigenomic scales.The significant molecular heterogeneity across individual tumors even within the same tissue context complicates decoding the key etiologic mechanisms of this disease.Furthermore,it is increasingly likely that biologic mechanisms underlying the pathobiology of cancer involve multiple molecular entities interacting across functional scales.This has motivated the development of computational approaches that integrate molecular measurements with prior biological knowledge in increasingly intricate ways to enable the discovery of driver genomic aberrations across cancers.Here,we review diverse methodological approaches that have powered significant advances in our understanding of the genomic underpinnings of cancer at the cohort and at the individual tumor scales.We outline the key advances and challenges in the computational discovery of cancer mechanisms while motivating the development of systems biology approaches to comprehensively decode the biologic drivers of this complex disease.展开更多
It is necessary that the laser inertial system is used to further improve the fire accuracy and quick reaction capability in the ballistic missile strapdown inertial navigation system. According to the guidance contro...It is necessary that the laser inertial system is used to further improve the fire accuracy and quick reaction capability in the ballistic missile strapdown inertial navigation system. According to the guidance controlling method and the output and error model of ballistic missile laser SIMU, the mathematical model of error propagation mechanism is set up and any transfer environmental function of error coefficient that affects the fire accuracy is deduced. Also, the missile longitudinal/lateral impact point is calculated using MATLAB. These establish the technical foundation for further researching the dispersion characteristics of impact point and reducing the laser guidance error.展开更多
The nitrate ester substitution derivatives of prismane were studied at the B3LYP/6-311G＊＊ level. The sublimation enthalpies and heats of formation in gas phase and solid state were calculated. The detonation perform...The nitrate ester substitution derivatives of prismane were studied at the B3LYP/6-311G＊＊ level. The sublimation enthalpies and heats of formation in gas phase and solid state were calculated. The detonation performances were also predicted by using the famous Kamlet-Jacbos equation. Our calculated results show that introducing nitrate ester group into prismane is helpful to enhance its detonation properties. Stabilities were evaluated through the bond dissociation energies, bond order, characteristic heights（H50） and band gap calculations. The trigger bonds in the pyrolysis process of prismane derivatives were confirmed as O–ON2 bond. The BDEs of all compounds were large, so these prismane derivatives have excellent stability consistent with the results of H50 and band gap.展开更多
The myostatin(MSTN)gene,also known as growth and differentiation factor 8(GDF8),plays a critical role in regulating muscle mass in animals by negatively controlling the number and size of skeletal myocytes.MSTN mutati...The myostatin(MSTN)gene,also known as growth and differentiation factor 8(GDF8),plays a critical role in regulating muscle mass in animals by negatively controlling the number and size of skeletal myocytes.MSTN mutations have been demonstrated to cause the double-muscling(DBM)phenomenon in various species,including cattle,sheep,mice,pigs,dogs,rabbits,and even humans.1 In this study,we explored the evolutionary characteristics,biochemical structure and function impacts of the sheep MSTN gene(oMSTN)using phylogenetic analysis,mutation effect evaluation,residue conservation studies,structural modeling,and protein–protein docking.展开更多
基金supported by PHS awards:T32 CA094186 to S.K.,K25 DK115904 to V.V.,P30 CA043703 to V.V.,and P20 CA233216 to V.V.
文摘Genome-scale studies focusing on molecular profiling of cancers across tissue types have revealed a plethora of aberrations across the genomic,transcriptomic,and epigenomic scales.The significant molecular heterogeneity across individual tumors even within the same tissue context complicates decoding the key etiologic mechanisms of this disease.Furthermore,it is increasingly likely that biologic mechanisms underlying the pathobiology of cancer involve multiple molecular entities interacting across functional scales.This has motivated the development of computational approaches that integrate molecular measurements with prior biological knowledge in increasingly intricate ways to enable the discovery of driver genomic aberrations across cancers.Here,we review diverse methodological approaches that have powered significant advances in our understanding of the genomic underpinnings of cancer at the cohort and at the individual tumor scales.We outline the key advances and challenges in the computational discovery of cancer mechanisms while motivating the development of systems biology approaches to comprehensively decode the biologic drivers of this complex disease.
文摘It is necessary that the laser inertial system is used to further improve the fire accuracy and quick reaction capability in the ballistic missile strapdown inertial navigation system. According to the guidance controlling method and the output and error model of ballistic missile laser SIMU, the mathematical model of error propagation mechanism is set up and any transfer environmental function of error coefficient that affects the fire accuracy is deduced. Also, the missile longitudinal/lateral impact point is calculated using MATLAB. These establish the technical foundation for further researching the dispersion characteristics of impact point and reducing the laser guidance error.
基金supported by the Natural Science Foundation of Guizhou Province(QKJ[2014]2140 and QJTD[2012]052)
文摘The nitrate ester substitution derivatives of prismane were studied at the B3LYP/6-311G＊＊ level. The sublimation enthalpies and heats of formation in gas phase and solid state were calculated. The detonation performances were also predicted by using the famous Kamlet-Jacbos equation. Our calculated results show that introducing nitrate ester group into prismane is helpful to enhance its detonation properties. Stabilities were evaluated through the bond dissociation energies, bond order, characteristic heights（H50） and band gap calculations. The trigger bonds in the pyrolysis process of prismane derivatives were confirmed as O–ON2 bond. The BDEs of all compounds were large, so these prismane derivatives have excellent stability consistent with the results of H50 and band gap.
文摘The myostatin(MSTN)gene,also known as growth and differentiation factor 8(GDF8),plays a critical role in regulating muscle mass in animals by negatively controlling the number and size of skeletal myocytes.MSTN mutations have been demonstrated to cause the double-muscling(DBM)phenomenon in various species,including cattle,sheep,mice,pigs,dogs,rabbits,and even humans.1 In this study,we explored the evolutionary characteristics,biochemical structure and function impacts of the sheep MSTN gene(oMSTN)using phylogenetic analysis,mutation effect evaluation,residue conservation studies,structural modeling,and protein–protein docking.
