Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how...Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.展开更多
近日,《临床心身疾病杂志》主编、河南省生物精神病学重点实验室吕路线教授团队在国际知名期刊《Translational Psychiatry》上发表题为《Prediction of Antipsychotic Drug Efficacy for Schizophrenia Treatment Based on Neural Feat...近日,《临床心身疾病杂志》主编、河南省生物精神病学重点实验室吕路线教授团队在国际知名期刊《Translational Psychiatry》上发表题为《Prediction of Antipsychotic Drug Efficacy for Schizophrenia Treatment Based on Neural Features of the Resting-State Functional Connectome》的研究论文。展开更多
The structural and functional connectomes interact and depend on each other to jointly maintain the functioning of the brain and further support cognitive processing.Elucidating the complex interplay between the struc...The structural and functional connectomes interact and depend on each other to jointly maintain the functioning of the brain and further support cognitive processing.Elucidating the complex interplay between the structural connectome(SC)and functional connectome(FC)is one of the central challenges in network neuroscience.While previous studies have consistently reported SC-FC coupling or SC constraints on FC[1],[2],[3],they typically analyzed these networks in isolation.展开更多
Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions.Different brain connection abnormalities were found to be corr...Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions.Different brain connection abnormalities were found to be correlated with various clinical manifestations,but whether a common deficit in functional connectivity(FC)in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains elusive.Objective To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations.Methods A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors.A principal component analysis was performed on the clinical ratings of symptom and cognition.Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients.Results Using the principal component analysis,the first principal component(PC1)explained 37%of the total variance of seven clinical features.The ratings of GAF and BACS contributed negatively to PC1,while those of PANSS,HAMD,and HAMA contributed positively.The FCs positively correlated with PC1 mainly included connections related to the insula,precuneus gyrus,and some frontal brain regions.FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions.Conclusion In conclusion,we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-na¨ıve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex,which may represent a core deficit of brain FC in patients with schizophrenia.展开更多
基金supported by the National Natural Science Foundation of China(31830034,82021004,81620108016,31221003,31521063,81671767,82071998,81971690,32130045,and 61761166004)Changjiang Scholar Professorship Award(T2015027)+3 种基金the National Key Research and Development Project of China(2018YFA0701402)Beijing Nova Program(Z191100001119023)the Beijing Brain Initiative of Beijing Municipal Science&Technology Commission(Z181100001518003)the Fundamental Research Funds for the Central Universities(2020NTST29)。
文摘Connectome mapping studies have documented a principal primary-to-transmodal gradient in the adult brain network,capturing a functional spectrum that ranges from perception and action to abstract cognition.However,how this gradient pattern develops and whether its development is linked to cognitive growth,topological reorganization,and gene expression profiles remain largely unknown.Using longitudinal resting-state functional magnetic resonance imaging data from 305 children(aged 6-14 years),we describe substantial changes in the primary-to-transmodal gradient between childhood and adolescence,including emergence as the principal gradient,expansion of global topography,and focal tuning in primary and default-mode regions.These gradient changes are mediated by developmental changes in network integration and segregation,and are associated with abstract processing functions such as working memory and expression levels of calcium ion regulated exocytosis and synaptic transmission-related genes.Our findings have implications for understanding connectome maturation principles in normal development and developmental disorders.
文摘近日,《临床心身疾病杂志》主编、河南省生物精神病学重点实验室吕路线教授团队在国际知名期刊《Translational Psychiatry》上发表题为《Prediction of Antipsychotic Drug Efficacy for Schizophrenia Treatment Based on Neural Features of the Resting-State Functional Connectome》的研究论文。
基金supported by the National Natural Science Foundation of China(82021004,82327807,and T24B2012)the Beijing Natural Science Foundation(JQ23033)the Fundamental Research Funds for the Central Universities(2233100018 and 2233300002).
文摘The structural and functional connectomes interact and depend on each other to jointly maintain the functioning of the brain and further support cognitive processing.Elucidating the complex interplay between the structural connectome(SC)and functional connectome(FC)is one of the central challenges in network neuroscience.While previous studies have consistently reported SC-FC coupling or SC constraints on FC[1],[2],[3],they typically analyzed these networks in isolation.
基金This study was supported by the National Natural Science Foundation of China(Grant Nos.8212018014,82071908,81761128023,and 82101998)Sichuan Science and Technology Program(Grant Nos.2021JDTD0002 and 2020YJ0018)+4 种基金Post-Doctor Research Project,West China Hospital,Sichuan University(Grant No.2020HXBH005)the Fundamental Research Funds for the Central Universities(Grant No.2020SCU12053)Miaozi Project in Science and Technology Innovation Program of Sichuan Province(Grant No.2021028)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Project Nos.ZYYC08001 and ZYJC18020)Dr Lui acknowledges the support from Humboldt Foundation Friedrich Wilhelm Bessel Research Award and Chang Jiang Scholars(Program No.T2019069).
文摘Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain regions.Different brain connection abnormalities were found to be correlated with various clinical manifestations,but whether a common deficit in functional connectivity(FC)in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains elusive.Objective To find a core deficit in the brain connectome that is related to both psychopathological and cognitive manifestations.Methods A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors.A principal component analysis was performed on the clinical ratings of symptom and cognition.Partial correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia patients.Results Using the principal component analysis,the first principal component(PC1)explained 37%of the total variance of seven clinical features.The ratings of GAF and BACS contributed negatively to PC1,while those of PANSS,HAMD,and HAMA contributed positively.The FCs positively correlated with PC1 mainly included connections related to the insula,precuneus gyrus,and some frontal brain regions.FCs negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital regions.Conclusion In conclusion,we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-na¨ıve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex,which may represent a core deficit of brain FC in patients with schizophrenia.
