Erectile dysfunction(ED)is prevalent among men,but its relationship with dietary habits is uncertain.The aim of our study was to assess whether dietary patterns enhance erectile function by reviewing the literature pu...Erectile dysfunction(ED)is prevalent among men,but its relationship with dietary habits is uncertain.The aim of our study was to assess whether dietary patterns enhance erectile function by reviewing the literature published before August 1,2022,via PubMed,Web of Science,and EMBASE databases.The data compiled included author details;publication dates,countries,treatments,patient numbers,ages,follow-ups,and clinical trial outcomes,such as ED cases,odds ratios(ORs),confidence intervals(CIs),and International Index of Erectile Function-5(IIEF-5)scores with means and standard deviations.An analysis of 14 studies with 27389 participants revealed that plant-based diets(OR=0.71,95%CI:0.66-0.75;P<0.00001),low-fat diets(OR=0.27,95%CI:0.13-0.53;P=0.0002),and alternative diets such as intermittent fasting and organic diets(OR=0.54,95%CI:0.36-0.80;P=0.002)significantly reduced ED risk.High-protein low-fat diets(hazard ratio[HR]=1.38,95%CI:1.12-1.64;P<0.00001)and high-carb low-fat diets(HR=0.79,95%CI:0.55-1.04;P<0.00001)improved IIEF-5 scores.Combined diet and exercise interventions decreased the likelihood of ED(OR=0.49,95%CI:0.28-0.85;P=0.01)and increased the IIEF-5 score(OR=3.40,95%CI:1.69-5.11;P<0.0001).Diets abundant in fruits and vegetables(OR=0.97,95%CI:0.96-0.98;P<0.00001)and nuts(OR=0.54,95%CI:0.37-0.80;P=0.002)were also correlated with lower ED risk.Our meta-analysis underscores a strong dietary-ED association,suggesting that low-fat/Mediterranean diets rich in produce and nuts could benefit ED management.展开更多
Currently,single atom(SA),quantum dots(QDs)and heterogeneous interfaces have been extensively em-ployed for the design of nov-el catalysts for overall water splitting.However,there are still few literatures about the ...Currently,single atom(SA),quantum dots(QDs)and heterogeneous interfaces have been extensively em-ployed for the design of nov-el catalysts for overall water splitting.However,there are still few literatures about the hydrogen(HER)and oxygen(OER)evolution perfor-mances for three different morphologies of the same metal loaded on MXenes substrates.Herein,the HER and OER per-formances of Mo_(2)CO_(2)modified by transition metals(TM,TM=Fe,Co,and Ni)with differ-ent SA loading(STM/Mo_(2)CO_(2)),QDs(QTM/Mo_(2)CO_(2))and heterogeneous interface(ITM/Mo_(2)CO_(2)),and TM loading and N3(TMN_(3)/Mo_(2)CO_(2))or N4 doping co-modification(TMN4/Mo_(2)CO_(2))are investigated by density functional theory(DFT)calculations.The re-sults show that the HER and OER performances of STM/Mo_(2)CO_(2)are better than those of ITM/Mo_(2)CO_(2)and QTM/Mo_(2)CO_(2).Especially,SNi/Mo_(2)CO_(2)exhibits the best HER and OER properties among the studied structures,with the correspondingΔGH*andηOER of−0.04 eV and 0.53 V,respectively.It is noteworthy that theΔGH*absolute value,ηOER,work function(Φ)and TM valence charges are significantly correlated,whereΔGH*absolute value,ηOER,andΦall present an increase trend following the order of STM/Mo_(2)CO_(2),ITM/Mo_(2)CO_(2),and QTM/Mo_(2)CO_(2),whereas TM valence charges exhibit a decrease trend with the above order.Furthermore,integral crystal orbital Hamilton population(ICOHP)results indicate that the more negative the ICOHP,the stronger bonding strength between TM and H atoms,and the better the corresponding HER performance in STM/Mo_(2)CO_(2).Campared with SNi/Mo_(2)CO_(2),Ni loading and N3 doping co-modification Mo_(2)CO_(2)(NiN_(3)/Mo_(2)CO_(2))shows better HER(ΔGH*=−0.01 eV)and OER catalytic activities(ηOER=0.36 V).Molecular dynamics simula-tions results indicate that most of the modified systems are stable at reaction temperature.In summary,NiN_(3)/Mo_(2)CO_(2)can be used as an efficient electrocatalyst for overall water splitting.展开更多
The premature ejaculation diagnostic tool （PEDT） is a brief diagnostic measure to assess premature ejaculation （PE）. However, there is insufficient evidence regarding its validity in the new evidence-based-defined...The premature ejaculation diagnostic tool （PEDT） is a brief diagnostic measure to assess premature ejaculation （PE）. However, there is insufficient evidence regarding its validity in the new evidence-based-defined PE. This study was performed to evaluate the validity of PEDT and its association with IIEF-15 in different types of evidence-based-defined PE. From June 2015 to January 2016, a total of 260 men complaining of PE and defined as lifelong PE （LPE）/acquired PE （APE） according to the evidence-based definition from Andrology Clinic of the First Affiliated Hospital of Anhui Medical University, along with 104 male healthy controls without PE from a medical examination center, were enrolled in this study. All individuals completed questionnaires including demographics, medical and sexual history, as well as PEDT and IIEF-15. After statistical analysis, it was found that men with PE reported higher PEDT scores （14.28 ± 3.05） and lower IIEF-15 （41.26 ± 8.20） than men without PE （PEDT： 5.32 ± 3.42, IIEF-15：52.66 ± 6.86, P 〈 0.001 for both）. It was suggested that a score of 〉9 indicated PE in both LPE and APE by sensitivity and specificity analyses （sensitivity： 0.875, 0.913; specificity： 0.865, 0.865, respectively）. In addition, IIEF-15 were higher in men with LPE （42.64 ± 8.11） than APE （39.43 ± 7.84, P 〈 0.001）. After adjusting for age, IIEF-15 was negatively related to PEDT in men with LPE （adjust r = -0.225, P 〈 0.001） and APE （adjust r = -0.378, P 〈 0.001）. In this study, we concluded that PEDT was valid in the diagnosis of evidenced-based-defined PE. Furthermore, IIEF-15 was negatively related to PEDT in men with different types of PE.展开更多
Objective:Cryptorchidism affects up to 6% of full-term male infants, and orchidopexy has been shown to reduce impaired spermatogenesis and malignant risks significantly. However, the relationship between orchidopexy a...Objective:Cryptorchidism affects up to 6% of full-term male infants, and orchidopexy has been shown to reduce impaired spermatogenesis and malignant risks significantly. However, the relationship between orchidopexy and sexual function has not been investigated. Therefore, this study aimed to evaluate sexual function outcomes in adult patients who underwent orchidopexy for unilateral undescended testis in childhood.Methods:Totally, 58 adult patients who underwent unilateral orchidopexy in childhood were enrolled in the study. Erectile dysfunction (ED) was assessed by the International Index of Erectile Function (IIEF)-15 questionnaire. All participants underwent serum (testosterone and follicular stimulating hormone levels) measurement and semen analysis. Paternity rates were evaluated to assess the patient's fertility. Additionally, anxiety, depression, and stress were measured by the self-rating anxiety scale, self-rating depression scale, and visual analogue scale, respectively.Results:There was no statistically significant difference between IIEF-15 scores (intercourse satisfaction, orgasmic function, sexual desire, or overall satisfaction) comparing the cryptorchidism group with the control group;however, the ED was significantly higher in the cryptorchidism patients (p=0.000). At the median follow-up of 16.3 years, 15.5% of our patients complained of moderate to severe ED. Most patients were satisfied with their overall relationship and only 34.5% were not satisfied. Anxiety, depression, and stress were more prevalent in cryptorchidism than in healthy men (anxiety: 72.4% vs. 20.7%;depression: 19.0% vs. 5.2%;stress: 60.3% vs. 10.3%;p<0.05). Additionally, ED was negatively associated with anxiety, depression, and stress symptoms (r=−0.518, p=0.000;r=−0.448, p=0.000;r=−0.591, p=0.000, respectively). Moreover, ED had a significant correlation with advancing age, psychological factors (anxiety, depression, and stress), infertility, and low levels of testosterone (p<0.05).Conclusion:Low testosterone, infertility, and psychological burden (anxiety, depression, and stress) are used as factors for predicting ED outcomes after orchidopexy for undescended testis to guide physicians to evaluate the efficacy of testosterone replacement and psychological support in their management.展开更多
A multi-group epidemic model with a variables separated incidence rate and delays is analyzed. For strongly and non-strongly connected networks, the basic reproductive number Ro is calculated, respectively. By applyin...A multi-group epidemic model with a variables separated incidence rate and delays is analyzed. For strongly and non-strongly connected networks, the basic reproductive number Ro is calculated, respectively. By applying the Lyapunov functionals and the LaSalle invariance principle, we prove the global asymptotic stability of infection-free equilibrium P0 when Ro 〈 1 and the endemic equilibrium P＊ when Ro 〉 1.展开更多
Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effect...Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effects of acupuncture on brain function in a pathological context. Sixteen patients with ischemic stroke were randomly assigned to true point group （true acupuncture at right Waiguan （SJ5）） and sham point group （sham acupuncture）. Results of functional magnetic resonance imaging revealed activation in right parietal lobe （Brodmann areas 7 and 19）, the right temporal lobe （Brodmann area 39）, the right limbic lobe （Brodmann area 23） and bilateral oc-cipital lobes （Brodmann area 18）. Furthermore, inhibition of bilateral frontal lobes （Brodmann area 4, 6, and 45）, right parietal lobe （Brodmann areas 1 and 5） and left temporal lobe （Brodmann area 21 ） were observed in the true point group. Activation in the precuneus of right parietal lobe （Brodmann area 7） and inhibition of the left superior frontal gyrus （Brodmann area 10） was observed in the sham group. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann area 5 on the healthy side. Results indicated that the altered specificity of sensation-associated cortex （Brodmann area 5） is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients.展开更多
AIM: To investigate the prevalence of erectile dysfunction(ED) and its association with depression in patients with chronic viral hepatitis.METHODS: This single center cross-sectional study was conducted from August 2...AIM: To investigate the prevalence of erectile dysfunction(ED) and its association with depression in patients with chronic viral hepatitis.METHODS: This single center cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis in our liver clinic between 18 and 80 years of age were considered eligible for this study. The exclusion criteria included well-established causes of ED, such as diabetes, hypertension, hyperlipidemia, alcohol abuse, liver cirrhosis, ischemic heart disease, renal disease, neurologic disease, and malignancy. We also excluded the patients who had incompletely answered the questionnaires. ED was assessed using the validated Korean version of the International Index of Erectile Function(IIEF-5) scale. The Korean version of the self-administered Beck Depression Inventory(BDI) scale was used to assess depression in the patients. Demographic and medical data were obtained from the patients' medical records. Current or past history of psychiatric diagnosis and drug history including the use of an antiviral agent and an antidepressant were also recorded. RESULTS: A total of 727 patients met the initial eligibility criteria. Six hundred seventeen patients were excluded because their medical records contained one or more of the previously determined exclusion criteria. The remaining 110 patients were assessed based on the BDI and IIEF-5 questionnaires. Based on the IIEF-5 scale, the prevalence of ED among patients with chronic viral hepatitis was 40%. Compared with the non-ED group, patients in the ED group were older. The proportion of patients in the ED group who had a job or who were na?ve peg-interferon users was lower than that in patients in the non-ED group. Patients with ED had significantly lower scores on the IIEF-5 scale than patients without ED(11.75 ± 4.88 vs 21.33 ± 1.86, P = 0.000). Patients with ED rated significantly higher scores on the BDI scale compared with patients without ED(12.59 ± 7.08 vs 5.30 ± 4.00, P = 0.000). Also, the IIEF-5 scores were negatively correlated with age, employment, and BDI scores. In the multiple logistic regression analysis, age and depression were independently associated with erectile dysfunction(P =0.019 and 0.000,respectively).CONCLUSION:Patients with chronic viral hepatitis have a high prevalence of ED.Age and depression are independent factors for ED in male patients with chronic viral hepatitis.展开更多
Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with obesity.In this study,we aimed to determine the prevalence of ED and evaluate the associated...Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with obesity.In this study,we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BMI]≥30 kg m−2)men from primary care.Erectile function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging Males'Symptoms[AMS scale]),and body composition analysis(Tanita MC-180MA)were determined.Total testosterone was determined using high-performance liquid chromatography–mass spectrometry.Multivariate logistic regression analysis was used to study the factors associated with ED.ED prevalence was 42.1%.Subjects with ED presented higher BMI,waist circumference,number of components of the metabolic syndrome,AMS score,insulin resistance,and a more unfavorable body composition than those without ED.Multivariate logistic regression analysis showed that a pathological AMS score(odds ratio[OR]:4.238,P<0.001),degree of obesity(BMI≥40 kg m−2,OR:2.602,P=0.005,compared with BMI 30–34.9 kg m−2),high-density lipoprotein(HDL)-cholesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were factors independently associated with ED.In conclusion,we demonstrate that,in a primary care-based cohort of nondiabetic young obese men,ED affected>40%of subjects.A pathological AMS score,the degree of obesity,and age were positively associated with ED,while elevated HDL-cholesterol levels were inversely associated with the odds of presenting ED.Further prospective studies are needed to evaluate the long-term consequences of ED in this population.展开更多
A quasi-three dimensional model is proposed for the vibration analysis of functionally graded(FG)micro-beams with general boundary conditions based on the modified strain gradient theory.To consider the effects of tra...A quasi-three dimensional model is proposed for the vibration analysis of functionally graded(FG)micro-beams with general boundary conditions based on the modified strain gradient theory.To consider the effects of transverse shear and nor-mal deformations,a general displacement field is achieved by relaxing the assumption of the constant transverse displacement through the thickness.The conventional beam theories including the classical beam theory,the first-order beam theory,and the higher-order beam theory are regarded as the special cases of this model.The material proper-ties changing gradually along the thickness direction are calculated by the Mori-Tanaka scheme.The energy-based formulation is derived by a variational method integrated with the penalty function method,where the Chebyshev orthogonal polynomials are used as the basis function of the displacement variables.The formulation is validated by some comparative examples,and then the parametric studies are conducted to investigate the effects of transverse shear and normal deformations on vibration behaviors.展开更多
Noninvasive low-intensity extracorporeal shockwave treatment(Li-ESWT)has been widely used to treat erection disorders.There is no clear information regarding either the selection of patients for the treatment or the t...Noninvasive low-intensity extracorporeal shockwave treatment(Li-ESWT)has been widely used to treat erection disorders.There is no clear information regarding either the selection of patients for the treatment or the treatment protocol.In this study,we aimed to investigate the efficacy of extracorporeal shockwave therapy in diabetic patients with severe erectile dysfunction(International Index of Erectile Function-5[IIEF-5]scores of 5 to 7).Sixty-three diabetes mellitus patients with erectile dysfunction having IIEF-5 scores of 5 to 7 and not showing a recovery of potency despite phosphodiesterase type 5 inhibitor therapy for the past 6 months were included in the study.The patients were evaluated based on their IIEF-5 scores and Erection Hardness Scale scores.The IIEF-5 score(mean±standard deviation[s.d.])increased from 5.29±1.67 to 5.56±1.85,with a difference of 0.27±0.18(P>0.05).The Erection Hardness Scale scores(mean±s.d.),on the other hand,increased from 1.46±0.50 to 1.48±0.50,with a difference of 0.02±0(P>0.05).In conclusion,the response to phosphodiesterase type 5 inhibitors did not change after extracorporeal shockwave treatment in diabetes mellitus patients with severe erectile dysfunction(IIEF-5 scores of 5 to 7).展开更多
Prostate cancer(PCa)accounted for over 300000 deaths world-wide in 2018.Most of the PCa deaths occurred due to the aggressive castration-resistant PCa(CRPC).Since the androgen receptor(AR)and its ligands contribute to...Prostate cancer(PCa)accounted for over 300000 deaths world-wide in 2018.Most of the PCa deaths occurred due to the aggressive castration-resistant PCa(CRPC).Since the androgen receptor(AR)and its ligands contribute to the continued growth of androgendependent PCa(ADPCa)and CRPC,AR has become a well-characterized and pivotal therapeutic-target.Although AR signaling was identified as therapeutic-target in PCa over five-decades ago,there remains several practical issues such as lack of antagonist-bound AR crystal structure,stabilization of the AR in the presence of agonists due to N-terminus and C-terminus interaction,unfavorable large-molecule accommodation of the ligand-binding domain(LBD),and generation of AR splice variants that lack the LBD that impede the discovery of highly potent fail-safe drugs.This review summarizes the AR-signaling pathway targeted therapeutics currently used in PCa and the approaches that could be used in future ARtargeted drug development of potent next-generation molecules.The review also outlines the discovery of molecules that bind to domains other than the LBD and those that inhibit both the full length and splice variant of ARs.展开更多
Quantum measurement problem has existed many years and inspired a large of literature in both physics and philosophy,but there is still no conclusion and consensus on it.We show it can be subsumed into the quantum the...Quantum measurement problem has existed many years and inspired a large of literature in both physics and philosophy,but there is still no conclusion and consensus on it.We show it can be subsumed into the quantum theory if we extend the Feynman path integral by considering the relativistic effect of Feynman paths.According to this extended theory,we deduce not only the Klein-Gordon equation,but also the wave-function-collapse equation.It is shown that the stochastic and instantaneous collapse of the quantum measurement is due to the "potential noise" of the apparatus or environment and "inner correlation" of wave function respectively.Therefore,the definite-status of the macroscopic matter is due to itself and this does not disobey the quantum mechanics.This work will give a new recognition for the measurement problem.展开更多
We study the inner structure of a neutron star from a theoretical point of view and the outcome results are compared with observed data. We propose a stiff equation of state relating pressure with matter density. From...We study the inner structure of a neutron star from a theoretical point of view and the outcome results are compared with observed data. We propose a stiff equation of state relating pressure with matter density. From our study we calculate mass（M）,compactness（u） and surface redshift（Zs） for two binary millisecond pulsars,namely PSR J1614–2230 and PSR J1903＋327,and four X-ray binaries,namely Cen X-3,SMC X-1,Vela X-1 and Her X-1,and compare them with recent observational data.Finally,we examine the stability for such a type of theoretical structure.展开更多
基金supported by the grant from National Natural Science Foundation of China(grant No.81602236).
文摘Erectile dysfunction(ED)is prevalent among men,but its relationship with dietary habits is uncertain.The aim of our study was to assess whether dietary patterns enhance erectile function by reviewing the literature published before August 1,2022,via PubMed,Web of Science,and EMBASE databases.The data compiled included author details;publication dates,countries,treatments,patient numbers,ages,follow-ups,and clinical trial outcomes,such as ED cases,odds ratios(ORs),confidence intervals(CIs),and International Index of Erectile Function-5(IIEF-5)scores with means and standard deviations.An analysis of 14 studies with 27389 participants revealed that plant-based diets(OR=0.71,95%CI:0.66-0.75;P<0.00001),low-fat diets(OR=0.27,95%CI:0.13-0.53;P=0.0002),and alternative diets such as intermittent fasting and organic diets(OR=0.54,95%CI:0.36-0.80;P=0.002)significantly reduced ED risk.High-protein low-fat diets(hazard ratio[HR]=1.38,95%CI:1.12-1.64;P<0.00001)and high-carb low-fat diets(HR=0.79,95%CI:0.55-1.04;P<0.00001)improved IIEF-5 scores.Combined diet and exercise interventions decreased the likelihood of ED(OR=0.49,95%CI:0.28-0.85;P=0.01)and increased the IIEF-5 score(OR=3.40,95%CI:1.69-5.11;P<0.0001).Diets abundant in fruits and vegetables(OR=0.97,95%CI:0.96-0.98;P<0.00001)and nuts(OR=0.54,95%CI:0.37-0.80;P=0.002)were also correlated with lower ED risk.Our meta-analysis underscores a strong dietary-ED association,suggesting that low-fat/Mediterranean diets rich in produce and nuts could benefit ED management.
基金financially supported by the National Natural Science Foundation of China(No.51971002)National Natural Science Foundation of Anhui,China(No.2108085QE188)Natural Science Foundation of Anhui Provincial Education Department(No.KJ2021A0361)。
文摘Currently,single atom(SA),quantum dots(QDs)and heterogeneous interfaces have been extensively em-ployed for the design of nov-el catalysts for overall water splitting.However,there are still few literatures about the hydrogen(HER)and oxygen(OER)evolution perfor-mances for three different morphologies of the same metal loaded on MXenes substrates.Herein,the HER and OER per-formances of Mo_(2)CO_(2)modified by transition metals(TM,TM=Fe,Co,and Ni)with differ-ent SA loading(STM/Mo_(2)CO_(2)),QDs(QTM/Mo_(2)CO_(2))and heterogeneous interface(ITM/Mo_(2)CO_(2)),and TM loading and N3(TMN_(3)/Mo_(2)CO_(2))or N4 doping co-modification(TMN4/Mo_(2)CO_(2))are investigated by density functional theory(DFT)calculations.The re-sults show that the HER and OER performances of STM/Mo_(2)CO_(2)are better than those of ITM/Mo_(2)CO_(2)and QTM/Mo_(2)CO_(2).Especially,SNi/Mo_(2)CO_(2)exhibits the best HER and OER properties among the studied structures,with the correspondingΔGH*andηOER of−0.04 eV and 0.53 V,respectively.It is noteworthy that theΔGH*absolute value,ηOER,work function(Φ)and TM valence charges are significantly correlated,whereΔGH*absolute value,ηOER,andΦall present an increase trend following the order of STM/Mo_(2)CO_(2),ITM/Mo_(2)CO_(2),and QTM/Mo_(2)CO_(2),whereas TM valence charges exhibit a decrease trend with the above order.Furthermore,integral crystal orbital Hamilton population(ICOHP)results indicate that the more negative the ICOHP,the stronger bonding strength between TM and H atoms,and the better the corresponding HER performance in STM/Mo_(2)CO_(2).Campared with SNi/Mo_(2)CO_(2),Ni loading and N3 doping co-modification Mo_(2)CO_(2)(NiN_(3)/Mo_(2)CO_(2))shows better HER(ΔGH*=−0.01 eV)and OER catalytic activities(ηOER=0.36 V).Molecular dynamics simula-tions results indicate that most of the modified systems are stable at reaction temperature.In summary,NiN_(3)/Mo_(2)CO_(2)can be used as an efficient electrocatalyst for overall water splitting.
文摘The premature ejaculation diagnostic tool （PEDT） is a brief diagnostic measure to assess premature ejaculation （PE）. However, there is insufficient evidence regarding its validity in the new evidence-based-defined PE. This study was performed to evaluate the validity of PEDT and its association with IIEF-15 in different types of evidence-based-defined PE. From June 2015 to January 2016, a total of 260 men complaining of PE and defined as lifelong PE （LPE）/acquired PE （APE） according to the evidence-based definition from Andrology Clinic of the First Affiliated Hospital of Anhui Medical University, along with 104 male healthy controls without PE from a medical examination center, were enrolled in this study. All individuals completed questionnaires including demographics, medical and sexual history, as well as PEDT and IIEF-15. After statistical analysis, it was found that men with PE reported higher PEDT scores （14.28 ± 3.05） and lower IIEF-15 （41.26 ± 8.20） than men without PE （PEDT： 5.32 ± 3.42, IIEF-15：52.66 ± 6.86, P 〈 0.001 for both）. It was suggested that a score of 〉9 indicated PE in both LPE and APE by sensitivity and specificity analyses （sensitivity： 0.875, 0.913; specificity： 0.865, 0.865, respectively）. In addition, IIEF-15 were higher in men with LPE （42.64 ± 8.11） than APE （39.43 ± 7.84, P 〈 0.001）. After adjusting for age, IIEF-15 was negatively related to PEDT in men with LPE （adjust r = -0.225, P 〈 0.001） and APE （adjust r = -0.378, P 〈 0.001）. In this study, we concluded that PEDT was valid in the diagnosis of evidenced-based-defined PE. Furthermore, IIEF-15 was negatively related to PEDT in men with different types of PE.
文摘Objective:Cryptorchidism affects up to 6% of full-term male infants, and orchidopexy has been shown to reduce impaired spermatogenesis and malignant risks significantly. However, the relationship between orchidopexy and sexual function has not been investigated. Therefore, this study aimed to evaluate sexual function outcomes in adult patients who underwent orchidopexy for unilateral undescended testis in childhood.Methods:Totally, 58 adult patients who underwent unilateral orchidopexy in childhood were enrolled in the study. Erectile dysfunction (ED) was assessed by the International Index of Erectile Function (IIEF)-15 questionnaire. All participants underwent serum (testosterone and follicular stimulating hormone levels) measurement and semen analysis. Paternity rates were evaluated to assess the patient's fertility. Additionally, anxiety, depression, and stress were measured by the self-rating anxiety scale, self-rating depression scale, and visual analogue scale, respectively.Results:There was no statistically significant difference between IIEF-15 scores (intercourse satisfaction, orgasmic function, sexual desire, or overall satisfaction) comparing the cryptorchidism group with the control group;however, the ED was significantly higher in the cryptorchidism patients (p=0.000). At the median follow-up of 16.3 years, 15.5% of our patients complained of moderate to severe ED. Most patients were satisfied with their overall relationship and only 34.5% were not satisfied. Anxiety, depression, and stress were more prevalent in cryptorchidism than in healthy men (anxiety: 72.4% vs. 20.7%;depression: 19.0% vs. 5.2%;stress: 60.3% vs. 10.3%;p<0.05). Additionally, ED was negatively associated with anxiety, depression, and stress symptoms (r=−0.518, p=0.000;r=−0.448, p=0.000;r=−0.591, p=0.000, respectively). Moreover, ED had a significant correlation with advancing age, psychological factors (anxiety, depression, and stress), infertility, and low levels of testosterone (p<0.05).Conclusion:Low testosterone, infertility, and psychological burden (anxiety, depression, and stress) are used as factors for predicting ED outcomes after orchidopexy for undescended testis to guide physicians to evaluate the efficacy of testosterone replacement and psychological support in their management.
基金Supported by Weihai Science and Technology Development Plan Project(Grant No.2013DXGJ06)the Natural Science Foundation of Shandong Province(Grant No.ZR2015AM018)
文摘A multi-group epidemic model with a variables separated incidence rate and delays is analyzed. For strongly and non-strongly connected networks, the basic reproductive number Ro is calculated, respectively. By applying the Lyapunov functionals and the LaSalle invariance principle, we prove the global asymptotic stability of infection-free equilibrium P0 when Ro 〈 1 and the endemic equilibrium P＊ when Ro 〉 1.
基金the State Plan for Development of Basic Research in Key Areas(973 Program)in China,No.2006CB504505,2012CB518504the Key Subject Construction Project of"211 Engineering"III Stage of Guangdong Province in Chinathe Guangdong Provincial"College Students’Innovative Experiment Plan"Project in China,No.1212112038
文摘Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effects of acupuncture on brain function in a pathological context. Sixteen patients with ischemic stroke were randomly assigned to true point group （true acupuncture at right Waiguan （SJ5）） and sham point group （sham acupuncture）. Results of functional magnetic resonance imaging revealed activation in right parietal lobe （Brodmann areas 7 and 19）, the right temporal lobe （Brodmann area 39）, the right limbic lobe （Brodmann area 23） and bilateral oc-cipital lobes （Brodmann area 18）. Furthermore, inhibition of bilateral frontal lobes （Brodmann area 4, 6, and 45）, right parietal lobe （Brodmann areas 1 and 5） and left temporal lobe （Brodmann area 21 ） were observed in the true point group. Activation in the precuneus of right parietal lobe （Brodmann area 7） and inhibition of the left superior frontal gyrus （Brodmann area 10） was observed in the sham group. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann area 5 on the healthy side. Results indicated that the altered specificity of sensation-associated cortex （Brodmann area 5） is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients.
文摘AIM: To investigate the prevalence of erectile dysfunction(ED) and its association with depression in patients with chronic viral hepatitis.METHODS: This single center cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis in our liver clinic between 18 and 80 years of age were considered eligible for this study. The exclusion criteria included well-established causes of ED, such as diabetes, hypertension, hyperlipidemia, alcohol abuse, liver cirrhosis, ischemic heart disease, renal disease, neurologic disease, and malignancy. We also excluded the patients who had incompletely answered the questionnaires. ED was assessed using the validated Korean version of the International Index of Erectile Function(IIEF-5) scale. The Korean version of the self-administered Beck Depression Inventory(BDI) scale was used to assess depression in the patients. Demographic and medical data were obtained from the patients' medical records. Current or past history of psychiatric diagnosis and drug history including the use of an antiviral agent and an antidepressant were also recorded. RESULTS: A total of 727 patients met the initial eligibility criteria. Six hundred seventeen patients were excluded because their medical records contained one or more of the previously determined exclusion criteria. The remaining 110 patients were assessed based on the BDI and IIEF-5 questionnaires. Based on the IIEF-5 scale, the prevalence of ED among patients with chronic viral hepatitis was 40%. Compared with the non-ED group, patients in the ED group were older. The proportion of patients in the ED group who had a job or who were na?ve peg-interferon users was lower than that in patients in the non-ED group. Patients with ED had significantly lower scores on the IIEF-5 scale than patients without ED(11.75 ± 4.88 vs 21.33 ± 1.86, P = 0.000). Patients with ED rated significantly higher scores on the BDI scale compared with patients without ED(12.59 ± 7.08 vs 5.30 ± 4.00, P = 0.000). Also, the IIEF-5 scores were negatively correlated with age, employment, and BDI scores. In the multiple logistic regression analysis, age and depression were independently associated with erectile dysfunction(P =0.019 and 0.000,respectively).CONCLUSION:Patients with chronic viral hepatitis have a high prevalence of ED.Age and depression are independent factors for ED in male patients with chronic viral hepatitis.
基金The authors wish to thank all the study participants for their collaboration.The research group belongs to the“Centros de Investigacion en Red”(CIBERobn,of the“Instituto de Salud Carlos III).MMV was supported by a“Rio Hortega”grant from“Instituto de Salud Carlos III,”Madrid,Spain(CM18/00120)JCFG was supported by a research contract from Servicio Andaluz de Salud(SAS,B-0003-2017)+2 种基金FCD and LGS were supported by Nicolas Monardes(C-0032-2016,C-0028-2018)from Consejeria de Salud,cofunded by the Fondo Europeo de Desarrollo Regional-FEDER,Madrid,SpainDCC by FPU(FPU13/04211)from Ministerio de Educacion,Cultura y DeporteThis work was supported in part by a grant from Servicio Andaluz de Salud(PI-0173-2013).
文摘Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with obesity.In this study,we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BMI]≥30 kg m−2)men from primary care.Erectile function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging Males'Symptoms[AMS scale]),and body composition analysis(Tanita MC-180MA)were determined.Total testosterone was determined using high-performance liquid chromatography–mass spectrometry.Multivariate logistic regression analysis was used to study the factors associated with ED.ED prevalence was 42.1%.Subjects with ED presented higher BMI,waist circumference,number of components of the metabolic syndrome,AMS score,insulin resistance,and a more unfavorable body composition than those without ED.Multivariate logistic regression analysis showed that a pathological AMS score(odds ratio[OR]:4.238,P<0.001),degree of obesity(BMI≥40 kg m−2,OR:2.602,P=0.005,compared with BMI 30–34.9 kg m−2),high-density lipoprotein(HDL)-cholesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were factors independently associated with ED.In conclusion,we demonstrate that,in a primary care-based cohort of nondiabetic young obese men,ED affected>40%of subjects.A pathological AMS score,the degree of obesity,and age were positively associated with ED,while elevated HDL-cholesterol levels were inversely associated with the odds of presenting ED.Further prospective studies are needed to evaluate the long-term consequences of ED in this population.
基金Project supported by the National Natural Science Foundation of China(Nos.51805250 and 11602145)the Natural Science Foundation of Jiangsu Province of China(No.BK20180429)+1 种基金the China Postdoctoral Science Foundation(No.2019M660114)the Jiangsu Planned Projects for Postdoctoral Research Funds of China(No.2019K054)。
文摘A quasi-three dimensional model is proposed for the vibration analysis of functionally graded(FG)micro-beams with general boundary conditions based on the modified strain gradient theory.To consider the effects of transverse shear and nor-mal deformations,a general displacement field is achieved by relaxing the assumption of the constant transverse displacement through the thickness.The conventional beam theories including the classical beam theory,the first-order beam theory,and the higher-order beam theory are regarded as the special cases of this model.The material proper-ties changing gradually along the thickness direction are calculated by the Mori-Tanaka scheme.The energy-based formulation is derived by a variational method integrated with the penalty function method,where the Chebyshev orthogonal polynomials are used as the basis function of the displacement variables.The formulation is validated by some comparative examples,and then the parametric studies are conducted to investigate the effects of transverse shear and normal deformations on vibration behaviors.
文摘Noninvasive low-intensity extracorporeal shockwave treatment(Li-ESWT)has been widely used to treat erection disorders.There is no clear information regarding either the selection of patients for the treatment or the treatment protocol.In this study,we aimed to investigate the efficacy of extracorporeal shockwave therapy in diabetic patients with severe erectile dysfunction(International Index of Erectile Function-5[IIEF-5]scores of 5 to 7).Sixty-three diabetes mellitus patients with erectile dysfunction having IIEF-5 scores of 5 to 7 and not showing a recovery of potency despite phosphodiesterase type 5 inhibitor therapy for the past 6 months were included in the study.The patients were evaluated based on their IIEF-5 scores and Erection Hardness Scale scores.The IIEF-5 score(mean±standard deviation[s.d.])increased from 5.29±1.67 to 5.56±1.85,with a difference of 0.27±0.18(P>0.05).The Erection Hardness Scale scores(mean±s.d.),on the other hand,increased from 1.46±0.50 to 1.48±0.50,with a difference of 0.02±0(P>0.05).In conclusion,the response to phosphodiesterase type 5 inhibitors did not change after extracorporeal shockwave treatment in diabetes mellitus patients with severe erectile dysfunction(IIEF-5 scores of 5 to 7).
基金supported by a grant from National Cancer Institute(NCI)1R01CA229164-01A1.
文摘Prostate cancer(PCa)accounted for over 300000 deaths world-wide in 2018.Most of the PCa deaths occurred due to the aggressive castration-resistant PCa(CRPC).Since the androgen receptor(AR)and its ligands contribute to the continued growth of androgendependent PCa(ADPCa)and CRPC,AR has become a well-characterized and pivotal therapeutic-target.Although AR signaling was identified as therapeutic-target in PCa over five-decades ago,there remains several practical issues such as lack of antagonist-bound AR crystal structure,stabilization of the AR in the presence of agonists due to N-terminus and C-terminus interaction,unfavorable large-molecule accommodation of the ligand-binding domain(LBD),and generation of AR splice variants that lack the LBD that impede the discovery of highly potent fail-safe drugs.This review summarizes the AR-signaling pathway targeted therapeutics currently used in PCa and the approaches that could be used in future ARtargeted drug development of potent next-generation molecules.The review also outlines the discovery of molecules that bind to domains other than the LBD and those that inhibit both the full length and splice variant of ARs.
基金Supported by the National Basic Research Program of China (973 Program) under Grant No. G2009CB929300the National Natural Science Foundation of China under Grant Nos. 10905016,10874013,60776061 and 60821061
文摘Quantum measurement problem has existed many years and inspired a large of literature in both physics and philosophy,but there is still no conclusion and consensus on it.We show it can be subsumed into the quantum theory if we extend the Feynman path integral by considering the relativistic effect of Feynman paths.According to this extended theory,we deduce not only the Klein-Gordon equation,but also the wave-function-collapse equation.It is shown that the stochastic and instantaneous collapse of the quantum measurement is due to the "potential noise" of the apparatus or environment and "inner correlation" of wave function respectively.Therefore,the definite-status of the macroscopic matter is due to itself and this does not disobey the quantum mechanics.This work will give a new recognition for the measurement problem.
基金support from IUCAA,in Pune,IndiaMSc,in Chennai,India for providing research facilities under the Visiting Associateship Programme
文摘We study the inner structure of a neutron star from a theoretical point of view and the outcome results are compared with observed data. We propose a stiff equation of state relating pressure with matter density. From our study we calculate mass（M）,compactness（u） and surface redshift（Zs） for two binary millisecond pulsars,namely PSR J1614–2230 and PSR J1903＋327,and four X-ray binaries,namely Cen X-3,SMC X-1,Vela X-1 and Her X-1,and compare them with recent observational data.Finally,we examine the stability for such a type of theoretical structure.
