In this paper we introduce the notions of mean dimension and metric mean dimension for non-autonomous iterated function systems(NAIFSs for short)on countably infinite alphabets which can be regarded as generalizations...In this paper we introduce the notions of mean dimension and metric mean dimension for non-autonomous iterated function systems(NAIFSs for short)on countably infinite alphabets which can be regarded as generalizations of the mean dimension and the Lindenstrauss metric mean dimension for non-autonomous iterated function systems.We also show the relationship between the mean topological dimension and the metric mean dimension.展开更多
We propose a new approach to the investigation of deterministic self-similar networks by using contractive iterated multifunction systems (briefly IMSs). Our paper focuses on the generalized version of two graph model...We propose a new approach to the investigation of deterministic self-similar networks by using contractive iterated multifunction systems (briefly IMSs). Our paper focuses on the generalized version of two graph models introduced by Barabási, Ravasz and Vicsek ([1] [2]). We generalize the graph models using stars and cliques: both algorithm construct graph sequences such that the next iteration is always based on n replicas of the current iteration, where n is the size of the initial graph structure, being a star or a clique. We analyze these self-similar graph sequences using IMSs in function of the size of the initial star and clique, respectively. Our research uses the Cantor set for the description of the fixed set of these IMSs, which we interpret as the limit object of the analyzed self-similar networks.展开更多
In this paper, a robust digital watermarking method against shearing based on Haar orthogonal function system was introduced. The proposed method adopted the complete generalized orthogonal properties of Haar ortbogon...In this paper, a robust digital watermarking method against shearing based on Haar orthogonal function system was introduced. The proposed method adopted the complete generalized orthogonal properties of Haar ortbogonal function system to achieve the piece-based orthogonal transform on the image. The significant middle frequency coefficients in the transformation matrix are picked up, based on characteristics of the image visual system and the Haar orthogonal transform. The watermark is adoptively weighed to the middle frequency matrix. The method improves the validity of watermarking and shows excellent advantage against shearing attack. Experimental results show that the Haar orthogonal function system based watermark approach can provide an excellent protection under geometric attacks.展开更多
A set of contraction maps of a metric space is called an iterated function systems. Iterated function systems with condensation, can be considered infinite iterated function systems. Infinite iterated function systems...A set of contraction maps of a metric space is called an iterated function systems. Iterated function systems with condensation, can be considered infinite iterated function systems. Infinite iterated function systems on compact metric spaces were studied. Using the properties of Banach limit and uniform contractiveness, it was proved that the random iterating algorithms for infinite iterated function systems on compact metric spaces-satisfy ergodicity. So the random iterating algorithms for iterated function systems with condensation satisfy ergodicity, too.展开更多
Random iterated function systems (IFSs) is discussed, which is one of the methods for fractal drawing. A certain figure can be reconstructed by a random IFS. One approach is presented to determine a new random IFS, th...Random iterated function systems (IFSs) is discussed, which is one of the methods for fractal drawing. A certain figure can be reconstructed by a random IFS. One approach is presented to determine a new random IFS, that the figure reconstructed by the new random IFS is the image of the origin figure reconstructed by old IFS under a given affine transformation. Two particular examples are used to show this approach.展开更多
Iterated function systems （IFS） were introduced by Hutchinson in 1981 as a natural generalization of the well-known Banach contraction principle. In 2010, D. R. Sahu and A. Chakraborty introduced K-Iterated Function...Iterated function systems （IFS） were introduced by Hutchinson in 1981 as a natural generalization of the well-known Banach contraction principle. In 2010, D. R. Sahu and A. Chakraborty introduced K-Iterated Function System using Kannan mapping which would cover a larger range of mappings. In this paper, following Hutchinson, D. R. Sahu and A. Chakraborty, we present some new iterated function systems by using the so-called generalized contractive mappings, which will also cover a large range of mappings. Our purpose is to prove the existence and uniqueness of attractors for such class of iterated function systems by virtue of a Banach-like fixed point theorem concerning generalized contractive mappings.展开更多
In this paper, we present some fixed point theorems of iterated function systems consisting of α-ψ-contractive type mappings in Fractal space constituted by the compact subset of metric space and iterated function s...In this paper, we present some fixed point theorems of iterated function systems consisting of α-ψ-contractive type mappings in Fractal space constituted by the compact subset of metric space and iterated function systems consisting of Banach contractive mappings in Fractal space constituted by the compact subset of generalized metric space, which is Mso extensively applied in topological dynamic system.展开更多
The definition of generalized product of fractal is first put forward for the research on the relations between original fractal and its product of fractal when the transformations of iteration function system （IFS）...The definition of generalized product of fractal is first put forward for the research on the relations between original fractal and its product of fractal when the transformations of iteration function system （IFS） are incomplete. Then the representations of generalized product of IFS are discussed based on the theory of the product of fractal. Furthermore, the dimensional relations between the product of fractal and its semi-product are obtained. The dimensional relations of self-similar set are discussed. Finally, the examples for rendering fractal graphs are given. These results posses potentials in image compression and pattern recognition.展开更多
Chaos game representation (CGR) of DNA sequences and linked protein sequences from genomes was proposed by Jeffrey (1990) and Yu et al. (2004), respectively. In this paper, we consider the CGR of three kinds of sequen...Chaos game representation (CGR) of DNA sequences and linked protein sequences from genomes was proposed by Jeffrey (1990) and Yu et al. (2004), respectively. In this paper, we consider the CGR of three kinds of sequences from complete genomes: whole genome DNA sequences, linked coding DNA sequences and linked protein sequences. Some fractal patterns are found in these CGRs. A recurrent iterated function systems (RIFS) model is proposed to simulate the CGRs of these sequences from genomes and their induced measures. Numerical results on 50 genomes show that the RIFS model can simulate very well the CGRs and their induced measures. The parameters estimated in the RIFS model reflect information on species classification.展开更多
Given a system {S1,…, SN} of N contractive similarities satisfying some strong separation condition, it has an invariant Set K for the system. In this article, the authors construct some random measure μω supported...Given a system {S1,…, SN} of N contractive similarities satisfying some strong separation condition, it has an invariant Set K for the system. In this article, the authors construct some random measure μω supported on random subset Kω of K, μω having some ＂non-standard＂ multifractal structure, which contrasts the well-knoWn multifractal formalism for the invariant measure of system {S1,.., SN} may possess. The main tool is the multifractal structures of a Galton-Watson tree, which are obtained by Liu [9], Shieh-Taylor [14], and MSrters-Shieh [12].展开更多
An iterated function system crossover (IFSX) operation for real-coded genetic algorithms (RCGAs) is presented in this paper. Iterated?function system (IFS) is one type of fractals that maintains a similarity character...An iterated function system crossover (IFSX) operation for real-coded genetic algorithms (RCGAs) is presented in this paper. Iterated?function system (IFS) is one type of fractals that maintains a similarity characteristic. By introducing the IFS into the crossover operation, the RCGA performs better searching solution with a faster convergence in a set of benchmark test functions.展开更多
Mutations in the protocadherin-19(PCDH19)gene(Xq22.1)cause the X-linked syndrome known as developmental and epileptic encephalopathy 9(DEE9,OMIM#300088)(Dibbens et al.,2008).DEE9 is characterized by early-onset cluste...Mutations in the protocadherin-19(PCDH19)gene(Xq22.1)cause the X-linked syndrome known as developmental and epileptic encephalopathy 9(DEE9,OMIM#300088)(Dibbens et al.,2008).DEE9 is characterized by early-onset clustering epilepsy associated with intellectual disability ranging from mild to profound,autism spectrum disorder,and other neuropsychiatric features including schizophrenia,anxiety,attentiondeficit/hyperactivity,and obsessive or aggressive behaviors.While seizures may become less frequent in adolescence,psychiatric comorbidities persist and often worsen with age(Dibbens et al.,2008;Kolc et al.,2020).展开更多
This paper presents a predefined-time controller for Multiple Space transportation Robots System (MSRS), which can be applied in on-orbit assembly tasks to transport modules to pre-assembly configuration quickly. Firs...This paper presents a predefined-time controller for Multiple Space transportation Robots System (MSRS), which can be applied in on-orbit assembly tasks to transport modules to pre-assembly configuration quickly. Firstly, to simplify the analysis and design of predefined-time controller, a Predefined-time Stability Criterion is proposed in the form of Composite Lyapunov Function (CLF-PSC). Besides simplicity, the CLF-PSC also has the advantage of less conservativeness due to utilization of initial state information. Secondly, a concept of Lp-Norm-Normalized Sign Function (LPNNSF) is proposed based on the CLF-PSC. Different from traditional norm-normalized sign function, the Lp-norm of LPNNSF can be selected arbitrarily according to practical control task requirements, which means that the proposed LPNNSF is more generalized and more convenient for calculation. Thirdly, a predefined-time disturbance observer and predefined-time controller are designed based on the LPNNSF. The observer has the property of predefined-time convergence to achieve quicker and more accurate estimation of the lumped disturbance. The controller has less control input and chattering phenomenon than traditional predefined-time controller. In addition, by introducing the observer into the controller, the closed-loop system enjoys high precision and strong robustness. Finally, the effectiveness of the proposed controller is verified by numerical simulations. By employing the controller, the MSRS can carry assembly modules to the desired pre-assembly configuration accurately within predefined time.展开更多
Objective:To systematically evaluate the impact of phase I cardiac rehabilitation exercise prescriptions on cardiac function levels in patients after coronary intervention.Methods:Seven Chinese and English databases,i...Objective:To systematically evaluate the impact of phase I cardiac rehabilitation exercise prescriptions on cardiac function levels in patients after coronary intervention.Methods:Seven Chinese and English databases,including Cochrane Library,PubMed,Web of Science,ESC(European Society of Cardiology),and CNKI,as well as professional association websites,were searched using computers,with manual searching as a complement.Relevant literature published from the establishment of the database to February 2025 was retrieved.Two researchers independently screened the literature,extracted data,and evaluated the quality of the literature.Meta-analysis was performed using RevMan 5.3 software.Results:A total of 8 articles were included,involving 843 patients.Meta-analysis results showed that compared with routine nursing,phase I cardiac rehabilitation exercise prescriptions helped increase the 6-minute walking distance in patients after coronary intervention[MD=0.84,95%CI(0.57,1.10),P<0.001],increase the level of left ventricular ejection fraction in patients after coronary intervention[MD=0.67,95%CI(0.33,1.00),P<0.001],and cardiac rehabilitation combined with respiratory rehabilitation exercise could improve the level of left ventricular ejection fraction in patients after coronary intervention[MD=0.58,95%CI(0.40,0.76),P<0.001].Conclusion:The implementation of phase I cardiac rehabilitation exercise prescriptions can help improve cardiac function levels in patients after coronary intervention.However,the standardization of outcome evaluation indicators needs to be improved,and the long-term effects of rehabilitation still require verification through a large number of high-quality studies.展开更多
BACKGROUND Functional gastrointestinal disorders(FGIDs),defined as‘Disorders of Gut-Brain Interaction’,are now considered a global health problem.There is a dearth of concepts and scales to assess the severity of th...BACKGROUND Functional gastrointestinal disorders(FGIDs),defined as‘Disorders of Gut-Brain Interaction’,are now considered a global health problem.There is a dearth of concepts and scales to assess the severity of the different symptoms encountered while dealing with the variety of FGIDs as described in the ROME IV classi-fication.We introduced a novel scoring system with the incorporation of 16 different symptoms called Bacharyya’s Questionnaire Scale and started using it while dealing with children suffering from FGIDs.AIM To verify the usefulness and applicability of this recently developed scale,this study was undertaken with the objectives to establish the validity of this scoring system in assessing the severity of symptoms associated with a specific FGID in children and to determine the scoring system's applicability in assessing the treatment response.METHODS The study included children aged 5 to 18 years diagnosed with any FGID based on ROME IV criteria.They completed the newly developed scale and a Visual Analog Scale at initial diagnosis and after a 2-month treatment period.A control group without FGID participated for comparative baseline purposes.Treatment response was defined as a less than or equal to 50%reduction in the total score,which is statistically significant.RESULTS Results from a comprehensive cohort of 190 cases and 90 controls indicated a female preponderance(57.9%)and prevalent disorders such as functional constipation(28%)and functional abdominal pain,not otherwise specified(21%).The grade of FGID(mild,moderate,severe)experienced by the patients was also derived.Post-treatment,96 children demonstrated symptom improvement.The Spearman rank correlation coefficient for pre(r=0.72,95%CI:0.65-0.77,P value<0.0001)and post(r=0.49,95%CI:0.3-0.64,P value<0.0001)treatment data showed positive results with significant P values.CONCLUSION The novel scoring system shows high comprehensibility and gives an objective view of the symptomatology of FGIDs.The use of this novel score in clinical settings will be helpful to typify the FGIDs and may significantly improve decision-making processes to initiate appropriate treatment.展开更多
The cochlea is one of the most complex organs in the human body,exhibiting a complex interplay of characteristics in acoustic,mechanical,electrical,and biological functions.Functional cochlea models are an essential p...The cochlea is one of the most complex organs in the human body,exhibiting a complex interplay of characteristics in acoustic,mechanical,electrical,and biological functions.Functional cochlea models are an essential platform for studying hearing mechanics and are crucial for developing next-generation auditory prostheses and artificial hearing systems for sensorineural hearing restoration.Recent advances in additive manufacturing,organ-on-a-chip models,drug delivery platforms,and artificial intelligence have provided valuable insights into how to manufacture artificial cochlea models that more accurately replicate the complex anatomy and physiology of the inner ear.This paper reviews recent advancements in the applications of advanced manufacturing techniques in reproducing the physical,biological,and intelligent functions of the cochlea.It also outlines the current challenges to developing mechanically,electrically,and anatomically accurate functional models of the inner ear.Finally,this review identifies the major requirements and outlook for impactful research in this field going forward.Through interdisciplinary collaboration and innovation,these functional cochlea models are poised to drive significant advancements in hearing treatments,and ultimately enhance the quality of life for individuals with hearing loss.展开更多
BACKGROUND Studies have shown that locomotive syndrome(LS)is significantly correlated with adverse outcomes,such as decreased self-care abilities,fractures,and increased mortality.Subthreshold depression(StD)is consid...BACKGROUND Studies have shown that locomotive syndrome(LS)is significantly correlated with adverse outcomes,such as decreased self-care abilities,fractures,and increased mortality.Subthreshold depression(StD)is considered an independent predictor of clinical depression,regarded as its prodromal stage,and even linked to increased mortality risk.Limited research has addressed the prevalence and relationship between LS and StD in elderly cancer patients.Understanding the prevalence of LS and StD among elderly cancer patients and elucidating their relationship will provide evidence to support the development of targeted interventions,thereby improving health outcomes in this population.AIM To investigate the relationship between musculoskeletal system function and predepressive states in elderly cancer patients.METHODS A convenience sampling method was employed to recruit 500 elderly cancer patients undergoing follow-up visits at the Department of Oncology,Affiliated Hospital of Jiangnan University,from April 2024 to December 2024.Participants completed the general information questionnaire, the 25-question Geriatric Locomotive Function Scale, and theGeriatric Depression Scale-Short Form-15. Influencing factors were analyzed, and correlation analyses wereperformed.RESULTSA total of 483 elderly cancer patients successfully completed the study. The prevalence of LS and StD amongparticipants was 56.5% and 38.7%, respectively. Logistic regression analysis identified age, tumor metastasis,exercise habits, and the presence of StD as significant risk factors for LS in elderly cancer patients. Additionally,having three or more chronic diseases and LS were significant predictors for developing StD. Spearman’s correlationanalysis revealed a significant positive correlation between LS and StD (r = 0.424, P < 0.001).CONCLUSIONElderly cancer patients exhibit a high prevalence of LS and StD, conditions which are positively correlated andmutually influential. Thus, it is critical to monitor and address pre-depressive states while evaluating and managingmotor function in this population.展开更多
High entropy materials(HEMs)are the promising electrocatalysts for anion exchange membrane electrolyser(AEMs)and proton exchange membrane fuel cells(PEMFCs)due to the intriguing cocktail effect,wide design space,tailo...High entropy materials(HEMs)are the promising electrocatalysts for anion exchange membrane electrolyser(AEMs)and proton exchange membrane fuel cells(PEMFCs)due to the intriguing cocktail effect,wide design space,tailorable electronic structure,and entropy stabilization effect.The precise fabrication of HEMs with functional nanostructures provides a crucial avenue to optimize the adsorption strength and catalytic activity for electrocatalysis.This review comprehensively summarizes the development of HEMs,focusing on the principles and strategies of structural design,and the catalytic mechanism towards hydrogen evolution reaction,oxygen evolution reaction and oxygen reduction reaction for the development of high-performance electrocatalysts.The complexity inherent in the interactions between different elements,the changes in the d-band center and the Gibbs free energies during the catalytic progress,as well as the coordination environment of the active sites associated with the unique crystal structure to improve the catalytic performance are discussed.We also provide a perspective on the challenges and future development direction of HEMs in electrocatalysis.This review will contribute to the design and development of HEMs-based catalysts for the next generation of electrochemical applications.展开更多
This paper proposed a new systematic approach-functional evidential reasoning model(FERM) for exploring hazardous chemical operational accidents under uncertainty. First, FERM was introduced to identify various causal...This paper proposed a new systematic approach-functional evidential reasoning model(FERM) for exploring hazardous chemical operational accidents under uncertainty. First, FERM was introduced to identify various causal factors and their performance changes in hazardous chemical operational accidents, along with determining the functional failure link relationships. Subsequently, FERM was employed to elucidate both qualitative and quantitative operational accident information within a unified framework, which could be regarded as the input of information fusion to obtain the fuzzy belief distribution of each cause factor. Finally, the derived risk values of the causal factors were ranked while constructing multi-level accident causation chains to unveil the weak links in system functionality and the primary roots of operational accidents. Using the specific case of the “1·15” major explosion and fire accident at Liaoning Panjin Haoye Chemical Co., Ltd., seven causal factors and their corresponding performance changes were identified. Additionally, five accident causation chains were uncovered based on the fuzzy joint distribution of the functional assessment level(FAL) and reliability distribution(RD),revealing an overall increase in risk along the accident evolution path. The research findings demonstrated that FERM enabled the effective characterization, rational quantification and accurate analysis of the inherent uncertainties in hazardous chemical operational accident risks from a systemic perspective.展开更多
This article takes the current autonomous driving technology as the research background and studies the collaborative protection mechanism between its system-on-chip(SoC)functional safety and information security.It i...This article takes the current autonomous driving technology as the research background and studies the collaborative protection mechanism between its system-on-chip(SoC)functional safety and information security.It includes an introduction to the functions and information security of autonomous driving SoCs,as well as the main design strategies for the collaborative prevention and control mechanism of SoC functional safety and information security in autonomous driving.The research shows that in the field of autonomous driving,there is a close connection between the functional safety of SoCs and their information security.In the design of the safety collaborative protection mechanism,the overall collaborative protection architecture,SoC functional safety protection mechanism,information security protection mechanism,the workflow of the collaborative protection mechanism,and its strategies are all key design elements.It is hoped that this analysis can provide some references for the collaborative protection of SoC functional safety and information security in the field of autonomous driving,so as to improve the safety of autonomous driving technology and meet its practical application requirements.展开更多
文摘In this paper we introduce the notions of mean dimension and metric mean dimension for non-autonomous iterated function systems(NAIFSs for short)on countably infinite alphabets which can be regarded as generalizations of the mean dimension and the Lindenstrauss metric mean dimension for non-autonomous iterated function systems.We also show the relationship between the mean topological dimension and the metric mean dimension.
文摘We propose a new approach to the investigation of deterministic self-similar networks by using contractive iterated multifunction systems (briefly IMSs). Our paper focuses on the generalized version of two graph models introduced by Barabási, Ravasz and Vicsek ([1] [2]). We generalize the graph models using stars and cliques: both algorithm construct graph sequences such that the next iteration is always based on n replicas of the current iteration, where n is the size of the initial graph structure, being a star or a clique. We analyze these self-similar graph sequences using IMSs in function of the size of the initial star and clique, respectively. Our research uses the Cantor set for the description of the fixed set of these IMSs, which we interpret as the limit object of the analyzed self-similar networks.
文摘In this paper, a robust digital watermarking method against shearing based on Haar orthogonal function system was introduced. The proposed method adopted the complete generalized orthogonal properties of Haar ortbogonal function system to achieve the piece-based orthogonal transform on the image. The significant middle frequency coefficients in the transformation matrix are picked up, based on characteristics of the image visual system and the Haar orthogonal transform. The watermark is adoptively weighed to the middle frequency matrix. The method improves the validity of watermarking and shows excellent advantage against shearing attack. Experimental results show that the Haar orthogonal function system based watermark approach can provide an excellent protection under geometric attacks.
文摘A set of contraction maps of a metric space is called an iterated function systems. Iterated function systems with condensation, can be considered infinite iterated function systems. Infinite iterated function systems on compact metric spaces were studied. Using the properties of Banach limit and uniform contractiveness, it was proved that the random iterating algorithms for infinite iterated function systems on compact metric spaces-satisfy ergodicity. So the random iterating algorithms for iterated function systems with condensation satisfy ergodicity, too.
文摘Random iterated function systems (IFSs) is discussed, which is one of the methods for fractal drawing. A certain figure can be reconstructed by a random IFS. One approach is presented to determine a new random IFS, that the figure reconstructed by the new random IFS is the image of the origin figure reconstructed by old IFS under a given affine transformation. Two particular examples are used to show this approach.
基金Partially supported by National Natural Science Foundation of China (No. 10961003)
文摘Iterated function systems （IFS） were introduced by Hutchinson in 1981 as a natural generalization of the well-known Banach contraction principle. In 2010, D. R. Sahu and A. Chakraborty introduced K-Iterated Function System using Kannan mapping which would cover a larger range of mappings. In this paper, following Hutchinson, D. R. Sahu and A. Chakraborty, we present some new iterated function systems by using the so-called generalized contractive mappings, which will also cover a large range of mappings. Our purpose is to prove the existence and uniqueness of attractors for such class of iterated function systems by virtue of a Banach-like fixed point theorem concerning generalized contractive mappings.
基金The NSF(11271150)of ChinaChina Government Scholarship
文摘In this paper, we present some fixed point theorems of iterated function systems consisting of α-ψ-contractive type mappings in Fractal space constituted by the compact subset of metric space and iterated function systems consisting of Banach contractive mappings in Fractal space constituted by the compact subset of generalized metric space, which is Mso extensively applied in topological dynamic system.
基金supported by National Natural Science Foundation of China (50575026, 50275013), National High-Tech. R&D Program for CIMS (2001AA412011).
文摘The definition of generalized product of fractal is first put forward for the research on the relations between original fractal and its product of fractal when the transformations of iteration function system （IFS） are incomplete. Then the representations of generalized product of IFS are discussed based on the theory of the product of fractal. Furthermore, the dimensional relations between the product of fractal and its semi-product are obtained. The dimensional relations of self-similar set are discussed. Finally, the examples for rendering fractal graphs are given. These results posses potentials in image compression and pattern recognition.
文摘Chaos game representation (CGR) of DNA sequences and linked protein sequences from genomes was proposed by Jeffrey (1990) and Yu et al. (2004), respectively. In this paper, we consider the CGR of three kinds of sequences from complete genomes: whole genome DNA sequences, linked coding DNA sequences and linked protein sequences. Some fractal patterns are found in these CGRs. A recurrent iterated function systems (RIFS) model is proposed to simulate the CGRs of these sequences from genomes and their induced measures. Numerical results on 50 genomes show that the RIFS model can simulate very well the CGRs and their induced measures. The parameters estimated in the RIFS model reflect information on species classification.
基金Both authors are supported by a grant NSC 2002/3-2115-M-002-017.
文摘Given a system {S1,…, SN} of N contractive similarities satisfying some strong separation condition, it has an invariant Set K for the system. In this article, the authors construct some random measure μω supported on random subset Kω of K, μω having some ＂non-standard＂ multifractal structure, which contrasts the well-knoWn multifractal formalism for the invariant measure of system {S1,.., SN} may possess. The main tool is the multifractal structures of a Galton-Watson tree, which are obtained by Liu [9], Shieh-Taylor [14], and MSrters-Shieh [12].
文摘An iterated function system crossover (IFSX) operation for real-coded genetic algorithms (RCGAs) is presented in this paper. Iterated?function system (IFS) is one type of fractals that maintains a similarity characteristic. By introducing the IFS into the crossover operation, the RCGA performs better searching solution with a faster convergence in a set of benchmark test functions.
基金supported by a grant from Telethon Foundation(grant No.GGP20056 to SB)The generation of Pcdh19 floxed mouse model was funded by Cariplo Foundation(grant No.2014-0972 to SB)。
文摘Mutations in the protocadherin-19(PCDH19)gene(Xq22.1)cause the X-linked syndrome known as developmental and epileptic encephalopathy 9(DEE9,OMIM#300088)(Dibbens et al.,2008).DEE9 is characterized by early-onset clustering epilepsy associated with intellectual disability ranging from mild to profound,autism spectrum disorder,and other neuropsychiatric features including schizophrenia,anxiety,attentiondeficit/hyperactivity,and obsessive or aggressive behaviors.While seizures may become less frequent in adolescence,psychiatric comorbidities persist and often worsen with age(Dibbens et al.,2008;Kolc et al.,2020).
基金co-supported by the National Natural Science Foundation of China(Nos.12372048,12102343)the Key Program of the National Natural Science Foundation of China(No.U2013206)+1 种基金the China Postdoctoral Science Foundation(No.2023M742835)the Guangdong Basic and Applied Basic Research Foundation,China(No.2023A1515011421).
文摘This paper presents a predefined-time controller for Multiple Space transportation Robots System (MSRS), which can be applied in on-orbit assembly tasks to transport modules to pre-assembly configuration quickly. Firstly, to simplify the analysis and design of predefined-time controller, a Predefined-time Stability Criterion is proposed in the form of Composite Lyapunov Function (CLF-PSC). Besides simplicity, the CLF-PSC also has the advantage of less conservativeness due to utilization of initial state information. Secondly, a concept of Lp-Norm-Normalized Sign Function (LPNNSF) is proposed based on the CLF-PSC. Different from traditional norm-normalized sign function, the Lp-norm of LPNNSF can be selected arbitrarily according to practical control task requirements, which means that the proposed LPNNSF is more generalized and more convenient for calculation. Thirdly, a predefined-time disturbance observer and predefined-time controller are designed based on the LPNNSF. The observer has the property of predefined-time convergence to achieve quicker and more accurate estimation of the lumped disturbance. The controller has less control input and chattering phenomenon than traditional predefined-time controller. In addition, by introducing the observer into the controller, the closed-loop system enjoys high precision and strong robustness. Finally, the effectiveness of the proposed controller is verified by numerical simulations. By employing the controller, the MSRS can carry assembly modules to the desired pre-assembly configuration accurately within predefined time.
基金Science Research Fund Project of Yunnan Provincial Department of Education(Project No.:2024J0832)Science Research Fund Project of Yunnan Provincial Department of Education(Project No.:2025Y1186)。
文摘Objective:To systematically evaluate the impact of phase I cardiac rehabilitation exercise prescriptions on cardiac function levels in patients after coronary intervention.Methods:Seven Chinese and English databases,including Cochrane Library,PubMed,Web of Science,ESC(European Society of Cardiology),and CNKI,as well as professional association websites,were searched using computers,with manual searching as a complement.Relevant literature published from the establishment of the database to February 2025 was retrieved.Two researchers independently screened the literature,extracted data,and evaluated the quality of the literature.Meta-analysis was performed using RevMan 5.3 software.Results:A total of 8 articles were included,involving 843 patients.Meta-analysis results showed that compared with routine nursing,phase I cardiac rehabilitation exercise prescriptions helped increase the 6-minute walking distance in patients after coronary intervention[MD=0.84,95%CI(0.57,1.10),P<0.001],increase the level of left ventricular ejection fraction in patients after coronary intervention[MD=0.67,95%CI(0.33,1.00),P<0.001],and cardiac rehabilitation combined with respiratory rehabilitation exercise could improve the level of left ventricular ejection fraction in patients after coronary intervention[MD=0.58,95%CI(0.40,0.76),P<0.001].Conclusion:The implementation of phase I cardiac rehabilitation exercise prescriptions can help improve cardiac function levels in patients after coronary intervention.However,the standardization of outcome evaluation indicators needs to be improved,and the long-term effects of rehabilitation still require verification through a large number of high-quality studies.
文摘BACKGROUND Functional gastrointestinal disorders(FGIDs),defined as‘Disorders of Gut-Brain Interaction’,are now considered a global health problem.There is a dearth of concepts and scales to assess the severity of the different symptoms encountered while dealing with the variety of FGIDs as described in the ROME IV classi-fication.We introduced a novel scoring system with the incorporation of 16 different symptoms called Bacharyya’s Questionnaire Scale and started using it while dealing with children suffering from FGIDs.AIM To verify the usefulness and applicability of this recently developed scale,this study was undertaken with the objectives to establish the validity of this scoring system in assessing the severity of symptoms associated with a specific FGID in children and to determine the scoring system's applicability in assessing the treatment response.METHODS The study included children aged 5 to 18 years diagnosed with any FGID based on ROME IV criteria.They completed the newly developed scale and a Visual Analog Scale at initial diagnosis and after a 2-month treatment period.A control group without FGID participated for comparative baseline purposes.Treatment response was defined as a less than or equal to 50%reduction in the total score,which is statistically significant.RESULTS Results from a comprehensive cohort of 190 cases and 90 controls indicated a female preponderance(57.9%)and prevalent disorders such as functional constipation(28%)and functional abdominal pain,not otherwise specified(21%).The grade of FGID(mild,moderate,severe)experienced by the patients was also derived.Post-treatment,96 children demonstrated symptom improvement.The Spearman rank correlation coefficient for pre(r=0.72,95%CI:0.65-0.77,P value<0.0001)and post(r=0.49,95%CI:0.3-0.64,P value<0.0001)treatment data showed positive results with significant P values.CONCLUSION The novel scoring system shows high comprehensibility and gives an objective view of the symptomatology of FGIDs.The use of this novel score in clinical settings will be helpful to typify the FGIDs and may significantly improve decision-making processes to initiate appropriate treatment.
基金support from the UCL GRS/ORS scholarshipUCL Fellowship Incubator Award+9 种基金supported by the NIHR Cambridge Biomedical Research Centre(NIHR203312)funded by the Royal National Institute for Deaf People(RNID,G100138)funded by the Rosetrees Trust Enterprise Fellowship(EF2020100099)RNID Flexigrant(F112)Wellcome Trust Developing Concept Fund(RG93172/BANCE/40181)by the Evelyn Trustfunded by the Woolf Fisher Trust,New Zealandthe Cambridge Commonwealth,European,&International Trustby Trinity CollegeUniversity of Cambridge。
文摘The cochlea is one of the most complex organs in the human body,exhibiting a complex interplay of characteristics in acoustic,mechanical,electrical,and biological functions.Functional cochlea models are an essential platform for studying hearing mechanics and are crucial for developing next-generation auditory prostheses and artificial hearing systems for sensorineural hearing restoration.Recent advances in additive manufacturing,organ-on-a-chip models,drug delivery platforms,and artificial intelligence have provided valuable insights into how to manufacture artificial cochlea models that more accurately replicate the complex anatomy and physiology of the inner ear.This paper reviews recent advancements in the applications of advanced manufacturing techniques in reproducing the physical,biological,and intelligent functions of the cochlea.It also outlines the current challenges to developing mechanically,electrically,and anatomically accurate functional models of the inner ear.Finally,this review identifies the major requirements and outlook for impactful research in this field going forward.Through interdisciplinary collaboration and innovation,these functional cochlea models are poised to drive significant advancements in hearing treatments,and ultimately enhance the quality of life for individuals with hearing loss.
基金Supported by Wuxi Institute of Translational Medicine Project Program,No.LCYJ202336the Scientific and Technological Achievements Promotion Project of Wuxi Municipal Health Commission Project Program,No.T202336+1 种基金the Hospital Management Innovation Research Project of Jiangsu Hospital Association,No.JSYGY-3-2024-601Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Plan Project,No.MS2024063.
文摘BACKGROUND Studies have shown that locomotive syndrome(LS)is significantly correlated with adverse outcomes,such as decreased self-care abilities,fractures,and increased mortality.Subthreshold depression(StD)is considered an independent predictor of clinical depression,regarded as its prodromal stage,and even linked to increased mortality risk.Limited research has addressed the prevalence and relationship between LS and StD in elderly cancer patients.Understanding the prevalence of LS and StD among elderly cancer patients and elucidating their relationship will provide evidence to support the development of targeted interventions,thereby improving health outcomes in this population.AIM To investigate the relationship between musculoskeletal system function and predepressive states in elderly cancer patients.METHODS A convenience sampling method was employed to recruit 500 elderly cancer patients undergoing follow-up visits at the Department of Oncology,Affiliated Hospital of Jiangnan University,from April 2024 to December 2024.Participants completed the general information questionnaire, the 25-question Geriatric Locomotive Function Scale, and theGeriatric Depression Scale-Short Form-15. Influencing factors were analyzed, and correlation analyses wereperformed.RESULTSA total of 483 elderly cancer patients successfully completed the study. The prevalence of LS and StD amongparticipants was 56.5% and 38.7%, respectively. Logistic regression analysis identified age, tumor metastasis,exercise habits, and the presence of StD as significant risk factors for LS in elderly cancer patients. Additionally,having three or more chronic diseases and LS were significant predictors for developing StD. Spearman’s correlationanalysis revealed a significant positive correlation between LS and StD (r = 0.424, P < 0.001).CONCLUSIONElderly cancer patients exhibit a high prevalence of LS and StD, conditions which are positively correlated andmutually influential. Thus, it is critical to monitor and address pre-depressive states while evaluating and managingmotor function in this population.
基金supported by the Guangdong Basic and Applied Basic Research Fund Project(2022A1515140061,No.11000-2344014)Startup Foundation for Postdoctor by Dongguan University of Technology(No.11000-221110149)the High-level Talents Program(contract number 2023JC10L014)of the Department of Science and Technology of Guangdong Province。
文摘High entropy materials(HEMs)are the promising electrocatalysts for anion exchange membrane electrolyser(AEMs)and proton exchange membrane fuel cells(PEMFCs)due to the intriguing cocktail effect,wide design space,tailorable electronic structure,and entropy stabilization effect.The precise fabrication of HEMs with functional nanostructures provides a crucial avenue to optimize the adsorption strength and catalytic activity for electrocatalysis.This review comprehensively summarizes the development of HEMs,focusing on the principles and strategies of structural design,and the catalytic mechanism towards hydrogen evolution reaction,oxygen evolution reaction and oxygen reduction reaction for the development of high-performance electrocatalysts.The complexity inherent in the interactions between different elements,the changes in the d-band center and the Gibbs free energies during the catalytic progress,as well as the coordination environment of the active sites associated with the unique crystal structure to improve the catalytic performance are discussed.We also provide a perspective on the challenges and future development direction of HEMs in electrocatalysis.This review will contribute to the design and development of HEMs-based catalysts for the next generation of electrochemical applications.
基金supported by the National Key Research&Development Program of China(2021YFB3301100)the National Natural Science Foundation of China(52004014)the Fundamental Research Funds for the Central Universities(ZY2406).
文摘This paper proposed a new systematic approach-functional evidential reasoning model(FERM) for exploring hazardous chemical operational accidents under uncertainty. First, FERM was introduced to identify various causal factors and their performance changes in hazardous chemical operational accidents, along with determining the functional failure link relationships. Subsequently, FERM was employed to elucidate both qualitative and quantitative operational accident information within a unified framework, which could be regarded as the input of information fusion to obtain the fuzzy belief distribution of each cause factor. Finally, the derived risk values of the causal factors were ranked while constructing multi-level accident causation chains to unveil the weak links in system functionality and the primary roots of operational accidents. Using the specific case of the “1·15” major explosion and fire accident at Liaoning Panjin Haoye Chemical Co., Ltd., seven causal factors and their corresponding performance changes were identified. Additionally, five accident causation chains were uncovered based on the fuzzy joint distribution of the functional assessment level(FAL) and reliability distribution(RD),revealing an overall increase in risk along the accident evolution path. The research findings demonstrated that FERM enabled the effective characterization, rational quantification and accurate analysis of the inherent uncertainties in hazardous chemical operational accident risks from a systemic perspective.
文摘This article takes the current autonomous driving technology as the research background and studies the collaborative protection mechanism between its system-on-chip(SoC)functional safety and information security.It includes an introduction to the functions and information security of autonomous driving SoCs,as well as the main design strategies for the collaborative prevention and control mechanism of SoC functional safety and information security in autonomous driving.The research shows that in the field of autonomous driving,there is a close connection between the functional safety of SoCs and their information security.In the design of the safety collaborative protection mechanism,the overall collaborative protection architecture,SoC functional safety protection mechanism,information security protection mechanism,the workflow of the collaborative protection mechanism,and its strategies are all key design elements.It is hoped that this analysis can provide some references for the collaborative protection of SoC functional safety and information security in the field of autonomous driving,so as to improve the safety of autonomous driving technology and meet its practical application requirements.
