目的对比分析传统支抗与微种植体支抗对口腔正畸患者正畸效果及X线头影测量指标的影响。方法选取2021年1月至2023年6月我院收治的80例口腔正畸患者作为研究对象,随机分为A组(n=40)和B组(n=40)。A组采用微种植体支抗矫治,B组采用传统支...目的对比分析传统支抗与微种植体支抗对口腔正畸患者正畸效果及X线头影测量指标的影响。方法选取2021年1月至2023年6月我院收治的80例口腔正畸患者作为研究对象,随机分为A组(n=40)和B组(n=40)。A组采用微种植体支抗矫治,B组采用传统支抗矫治。对比两组的正畸效果,矫治前及矫治18个月后的X线头影测量指标[上下齿槽座(A point-Nasion-B,ANB)角、下齿槽座(Sella-Nasion-B,SNB)角、下中切牙-下颌平面(lower incisor to mandibular plane,L1-MP)角、上下中切牙(upper incisor to lower incisor,U1-L1)角]、牙齿功能,以及并发症发生率。结果A组的磨牙移位、上中切牙凸距差、上中切牙倾斜差均较B组低,矫正时间、拔牙间隙闭合时间均较B组短(P<0.05)。矫治18个月后,A组的ANB角、SNB角、L1-MP角均较B组小,U1-L1角较B组大(P<0.05)。矫治18个月后,A组的吞咽、咀嚼、牙齿咬合、口语表达评分均较B组高(P<0.05)。A组的并发症总发生率为2.50%,较B组的20.00%低(P<0.05)。结论相较于传统支抗矫治,微种植体支抗矫治可进一步提升正畸效果,改善正畸患者的面型与牙齿功能,降低患者并发症发生风险。展开更多
BACKGROUND Spinal cord injury(SCI)often results in irreversible neurological deficits;therefore,effective treatment is urgently needed.Neural stem cells(NSCs)have excellent differentiation potential.However,the role o...BACKGROUND Spinal cord injury(SCI)often results in irreversible neurological deficits;therefore,effective treatment is urgently needed.Neural stem cells(NSCs)have excellent differentiation potential.However,the role of the long noncoding RNA X inactive-specific transcript(XIST)in NSCs and SCI remains unclear.AIM To explore the role of XIST in enhancing NSC function and its therapeutic potential in SCI.METHODS We used in vitro and in vivo models to examine the effects of XIST on NSCs.XIST was overexpressed in NSCs,and its impact on mitochondrial function,neuronal differentiation,and the insulin-like growth factor 2 mRNA binding protein 2(IGF2BP2)/carnitine palmitoyl transferase 1A(CPT1A)pathway was assessed using a series of biochemical assays,quantitative PCR,and Seahorse XF24 analysis.A mouse model of SCI was used to evaluate the therapeutic effects of XIST in vivo.RESULTS Overexpression of XIST in NSCs significantly increased mitochondrial membrane potential,ATP production,and oxygen consumption rate.XIST also promoted NSC proliferation and neuronal differentiation while inhibiting astrocytic differentiation.Mechanistically,XIST regulated CPT1A expression post-transcriptionally by interacting with IGF2BP2.In vivo XIST-treated mice exhibited improved motor scores and reduced proinflammatory cytokine expression following SCI.CONCLUSIONThese findings suggested that XIST modulated mitochondrial function and neural differentiation in NSCs throughthe IGF2BP2/CPT1A pathway. While preliminary in vivo results are encouraging, further studies are needed todetermine the long-term therapeutic relevance and underlying mechanisms of XIST in SCI recovery.展开更多
In recent years, semiconductor survey meters have been developed and are in increasing demand worldwide. This study determined if it is possible to use the X-ray system installed in each medical facility to calculate ...In recent years, semiconductor survey meters have been developed and are in increasing demand worldwide. This study determined if it is possible to use the X-ray system installed in each medical facility to calculate the time constant of a semiconductor survey meter and confirm the meter’s function. An additional filter was attached to the medical X-ray system to satisfy the standards of N-60 to N-120, more copper plates were added as needed, and the first and second half-value layers were calculated to enable comparisons of the facility’s X-ray system quality with the N-60 to N-120 quality values. Next, we used a medical X-ray system to measure the leakage dose and calculate the time constant of the survey meter. The functionality of the meter was then checked and compared with the energy characteristics of the meter. The experimental results showed that it was possible to use a medical X-ray system to reproduce the N-60 to N-120 radiation quality values and to calculate the time constant from the measured results, assuming actual leakage dosimetry for that radiation quality. We also found that the calibration factor was equivalent to that of the energy characteristics of the survey meter.展开更多
文摘目的对比分析传统支抗与微种植体支抗对口腔正畸患者正畸效果及X线头影测量指标的影响。方法选取2021年1月至2023年6月我院收治的80例口腔正畸患者作为研究对象,随机分为A组(n=40)和B组(n=40)。A组采用微种植体支抗矫治,B组采用传统支抗矫治。对比两组的正畸效果,矫治前及矫治18个月后的X线头影测量指标[上下齿槽座(A point-Nasion-B,ANB)角、下齿槽座(Sella-Nasion-B,SNB)角、下中切牙-下颌平面(lower incisor to mandibular plane,L1-MP)角、上下中切牙(upper incisor to lower incisor,U1-L1)角]、牙齿功能,以及并发症发生率。结果A组的磨牙移位、上中切牙凸距差、上中切牙倾斜差均较B组低,矫正时间、拔牙间隙闭合时间均较B组短(P<0.05)。矫治18个月后,A组的ANB角、SNB角、L1-MP角均较B组小,U1-L1角较B组大(P<0.05)。矫治18个月后,A组的吞咽、咀嚼、牙齿咬合、口语表达评分均较B组高(P<0.05)。A组的并发症总发生率为2.50%,较B组的20.00%低(P<0.05)。结论相较于传统支抗矫治,微种植体支抗矫治可进一步提升正畸效果,改善正畸患者的面型与牙齿功能,降低患者并发症发生风险。
文摘BACKGROUND Spinal cord injury(SCI)often results in irreversible neurological deficits;therefore,effective treatment is urgently needed.Neural stem cells(NSCs)have excellent differentiation potential.However,the role of the long noncoding RNA X inactive-specific transcript(XIST)in NSCs and SCI remains unclear.AIM To explore the role of XIST in enhancing NSC function and its therapeutic potential in SCI.METHODS We used in vitro and in vivo models to examine the effects of XIST on NSCs.XIST was overexpressed in NSCs,and its impact on mitochondrial function,neuronal differentiation,and the insulin-like growth factor 2 mRNA binding protein 2(IGF2BP2)/carnitine palmitoyl transferase 1A(CPT1A)pathway was assessed using a series of biochemical assays,quantitative PCR,and Seahorse XF24 analysis.A mouse model of SCI was used to evaluate the therapeutic effects of XIST in vivo.RESULTS Overexpression of XIST in NSCs significantly increased mitochondrial membrane potential,ATP production,and oxygen consumption rate.XIST also promoted NSC proliferation and neuronal differentiation while inhibiting astrocytic differentiation.Mechanistically,XIST regulated CPT1A expression post-transcriptionally by interacting with IGF2BP2.In vivo XIST-treated mice exhibited improved motor scores and reduced proinflammatory cytokine expression following SCI.CONCLUSIONThese findings suggested that XIST modulated mitochondrial function and neural differentiation in NSCs throughthe IGF2BP2/CPT1A pathway. While preliminary in vivo results are encouraging, further studies are needed todetermine the long-term therapeutic relevance and underlying mechanisms of XIST in SCI recovery.
文摘In recent years, semiconductor survey meters have been developed and are in increasing demand worldwide. This study determined if it is possible to use the X-ray system installed in each medical facility to calculate the time constant of a semiconductor survey meter and confirm the meter’s function. An additional filter was attached to the medical X-ray system to satisfy the standards of N-60 to N-120, more copper plates were added as needed, and the first and second half-value layers were calculated to enable comparisons of the facility’s X-ray system quality with the N-60 to N-120 quality values. Next, we used a medical X-ray system to measure the leakage dose and calculate the time constant of the survey meter. The functionality of the meter was then checked and compared with the energy characteristics of the meter. The experimental results showed that it was possible to use a medical X-ray system to reproduce the N-60 to N-120 radiation quality values and to calculate the time constant from the measured results, assuming actual leakage dosimetry for that radiation quality. We also found that the calibration factor was equivalent to that of the energy characteristics of the survey meter.
