Large birefringence is important and indispensable for laser technology to meet the application demands.However,it is still a challenge to obtain optical materials with large birefringence that can extend the commerci...Large birefringence is important and indispensable for laser technology to meet the application demands.However,it is still a challenge to obtain optical materials with large birefringence that can extend the commercial birefringent crystals.Herein,we present a birefringence screening and analysis system to explore high-performance optical materials by introducing multiple functional chromophores.Using the high-throughput screening methodology,optical materials with one or two functional chromophores were explored.In particular,the chalcohalides Hg_(3)AsQ_(4)X(Q=S or Se;X=Cl,Br,or I)with multiple functional chromophores were screened out using the density functional theory and high-throughput screening method.The results show that Hg_(3)AsQ_(4)X(Q=S or Se;X=Cl,Br,or I)have an extremely large birefringence(Δn:0.391-0.493 at 1064 nm),two times that of the commercial birefringent crystal CaCO_(3)(0.172 at 1064 nm).And novel birefringent material motifs activated by the synergism of the d10 cation Hg^(2+),the layer of lone pair electrons of As3+cation,and the mixed anions Q^(2-)/X-(Q=S or Se;X=Cl,Br,or I)were found.展开更多
Introduction In English teaching, the first task for teachers should be teaching students with clear information about the language they are learning. The presentation stage is the best way to reach this goal. In this...Introduction In English teaching, the first task for teachers should be teaching students with clear information about the language they are learning. The presentation stage is the best way to reach this goal. In this essay, we analyze the importance of this stage. How it is different from the traditional methods -grammatical explanation and translations methods- and its advantages.展开更多
Gene therapy,a revolutionary approach to treating genetic disorders,aims to introduce functional genes into cells to correct genetic defects.Liposomes,artificial lipid vesicles,have emerged as promising nonviral vecto...Gene therapy,a revolutionary approach to treating genetic disorders,aims to introduce functional genes into cells to correct genetic defects.Liposomes,artificial lipid vesicles,have emerged as promising nonviral vectors for gene delivery.Owing to their biocompatibility,versatility,and ability to encapsulate various therapeutic molecules,liposomes are ideal candidates for gene therapy.This review explores the principles of liposome-based gene therapy,including composition,mechanisms of action,and applications.We discuss the challenges and limitations of liposome-mediated gene delivery and ongoing research efforts to improve their efficacy and safety.In conclusion,liposomes offer a promising avenue for developing effective and safe gene therapies for various genetic diseases.展开更多
基金supported by the National Natural Science Foundation of China(11774414 and 61835014)Key Research Program of Frontier Sciences,CAS(ZDBS-LY-SLH035)+1 种基金Tianshan Innovation Team Program(2018D14001)the Western Light Foundation of CAS(Y92S191301),Fujian Institute of Innovation,CAS.
文摘Large birefringence is important and indispensable for laser technology to meet the application demands.However,it is still a challenge to obtain optical materials with large birefringence that can extend the commercial birefringent crystals.Herein,we present a birefringence screening and analysis system to explore high-performance optical materials by introducing multiple functional chromophores.Using the high-throughput screening methodology,optical materials with one or two functional chromophores were explored.In particular,the chalcohalides Hg_(3)AsQ_(4)X(Q=S or Se;X=Cl,Br,or I)with multiple functional chromophores were screened out using the density functional theory and high-throughput screening method.The results show that Hg_(3)AsQ_(4)X(Q=S or Se;X=Cl,Br,or I)have an extremely large birefringence(Δn:0.391-0.493 at 1064 nm),two times that of the commercial birefringent crystal CaCO_(3)(0.172 at 1064 nm).And novel birefringent material motifs activated by the synergism of the d10 cation Hg^(2+),the layer of lone pair electrons of As3+cation,and the mixed anions Q^(2-)/X-(Q=S or Se;X=Cl,Br,or I)were found.
文摘Introduction In English teaching, the first task for teachers should be teaching students with clear information about the language they are learning. The presentation stage is the best way to reach this goal. In this essay, we analyze the importance of this stage. How it is different from the traditional methods -grammatical explanation and translations methods- and its advantages.
基金supported by the SEEDgrant(2023/0298)sanctioned by GITAM(deemed tobe University),Vishakhapatnam,Andhra Pradesh。
文摘Gene therapy,a revolutionary approach to treating genetic disorders,aims to introduce functional genes into cells to correct genetic defects.Liposomes,artificial lipid vesicles,have emerged as promising nonviral vectors for gene delivery.Owing to their biocompatibility,versatility,and ability to encapsulate various therapeutic molecules,liposomes are ideal candidates for gene therapy.This review explores the principles of liposome-based gene therapy,including composition,mechanisms of action,and applications.We discuss the challenges and limitations of liposome-mediated gene delivery and ongoing research efforts to improve their efficacy and safety.In conclusion,liposomes offer a promising avenue for developing effective and safe gene therapies for various genetic diseases.
