AIM: Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD ...AIM: Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD patients and controls in a Mexican population. METHODS: Twenty FD-Rome Ⅱ patients were matched by age and gender with 20 healthy controls. All underwent both drinking tests at a 15 mL/min rate, randomly, 7 d apart. Every 5 min within each test, four symptoms were evaluated (satiety, bloating, nausea and pain) by Likert scales. Maximum tolerated volume (MTV) was defined as the ingested volume when a score of 5 was reached for any symptom or when the test had to be stopped because the patients could not tolerate more volume. Sensitivity and specificity were analyzed. RESULTS: FD patients had higher symptom scores for both tests compared to controls (water: t= 4.1, P= 0.001 ＜0.01; Nutren(R): t= 5.2, P= 0.001＜0.01). The MTV forwater and Nutren(R) were significantly lower in FD (water: 1014±288 vs 1749±275 mL; t = 7.9, P = 0.001＜0.01;Nutren(R): 652±168 vs 1278±286 mL; t= 6.7, P = 0.001＜0.01). With the volume tolerated by the controls, the percentile 10 was determined as the lower limit fortolerance. Sensitivity and specificity were 0.90, 0.95 for water and 0.95, 0.95 for Nutren(R) tests.CONCLUSION: A drinking test with water or a nutritional beverage can discriminate between FD patients and healthy subjects in Mexico, with high sensitivity and specificity. These tests could be used as objective, noninvasive, and safe diagnostic approaches for FD patients.展开更多
为了研究广西铝矿主产区及非矿区老年人群认知能力与头发及饮水中铝元素之间的关系。我们采用简易精神状态调查表(mini-mental state examination,MMSE)及时钟绘图实验(clock drawing test,CDT)对≥60岁老年人群进行认知能力测定,用原...为了研究广西铝矿主产区及非矿区老年人群认知能力与头发及饮水中铝元素之间的关系。我们采用简易精神状态调查表(mini-mental state examination,MMSE)及时钟绘图实验(clock drawing test,CDT)对≥60岁老年人群进行认知能力测定,用原子吸收分光光度法检测头发及饮水中铝元素含量,并对头发及饮水中铝元素与老年认知能力之间的关系进行统计分析,评价铝元素对老年认知能力的影响。结果观察到,铝矿区内老年人头发及饮水中铝浓度显著高于非铝矿区老年人头发及饮水中铝的浓度,且铝矿区内老年人MMSE评分及CDT计分较非铝矿区老年人有显著的降低。提示高铝暴露可能是矿区内老年人认知能力降低,罹患老年性痴呆的危险环境因素之一。展开更多
文摘AIM: Recently, drinking load tests with water or nutritional beverages have been proposed as diagnostic tools for functional dyspepsia (FD), therefore we sought to reproduce if these tests can discriminate between FD patients and controls in a Mexican population. METHODS: Twenty FD-Rome Ⅱ patients were matched by age and gender with 20 healthy controls. All underwent both drinking tests at a 15 mL/min rate, randomly, 7 d apart. Every 5 min within each test, four symptoms were evaluated (satiety, bloating, nausea and pain) by Likert scales. Maximum tolerated volume (MTV) was defined as the ingested volume when a score of 5 was reached for any symptom or when the test had to be stopped because the patients could not tolerate more volume. Sensitivity and specificity were analyzed. RESULTS: FD patients had higher symptom scores for both tests compared to controls (water: t= 4.1, P= 0.001 ＜0.01; Nutren(R): t= 5.2, P= 0.001＜0.01). The MTV forwater and Nutren(R) were significantly lower in FD (water: 1014±288 vs 1749±275 mL; t = 7.9, P = 0.001＜0.01;Nutren(R): 652±168 vs 1278±286 mL; t= 6.7, P = 0.001＜0.01). With the volume tolerated by the controls, the percentile 10 was determined as the lower limit fortolerance. Sensitivity and specificity were 0.90, 0.95 for water and 0.95, 0.95 for Nutren(R) tests.CONCLUSION: A drinking test with water or a nutritional beverage can discriminate between FD patients and healthy subjects in Mexico, with high sensitivity and specificity. These tests could be used as objective, noninvasive, and safe diagnostic approaches for FD patients.
文摘为了研究广西铝矿主产区及非矿区老年人群认知能力与头发及饮水中铝元素之间的关系。我们采用简易精神状态调查表(mini-mental state examination,MMSE)及时钟绘图实验(clock drawing test,CDT)对≥60岁老年人群进行认知能力测定,用原子吸收分光光度法检测头发及饮水中铝元素含量,并对头发及饮水中铝元素与老年认知能力之间的关系进行统计分析,评价铝元素对老年认知能力的影响。结果观察到,铝矿区内老年人头发及饮水中铝浓度显著高于非铝矿区老年人头发及饮水中铝的浓度,且铝矿区内老年人MMSE评分及CDT计分较非铝矿区老年人有显著的降低。提示高铝暴露可能是矿区内老年人认知能力降低,罹患老年性痴呆的危险环境因素之一。
