In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the max...In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the maximum distance of any pair of nodes in the support domain.The proposed method is verified and shows good performance.The results are stable and accurate with any number of nodes and an arbitrary nodal distribution.Notably,the support domain should be large enough to obtain accurate results.This method is then applied for transient analysis of curved shell structures made from functionally graded materials with complex geometries.Through several numerical examples,the accuracy of the proposed approach is demonstrated and discussed.Additionally,the influence of various factors on the dynamic behavior of the structures,including the power-law index,different materials,loading conditions,and geometrical parameters of the structures,was investigated.展开更多
In 2019,China had over 13.14 million dementia cases,with incidence rates of(56.47–207.08)/100,000[1].Early cognitive impairment—a key dementia symptom—reduces quality of life,increases care dependence,and lowers su...In 2019,China had over 13.14 million dementia cases,with incidence rates of(56.47–207.08)/100,000[1].Early cognitive impairment—a key dementia symptom—reduces quality of life,increases care dependence,and lowers survival in older adults[2].A decline in physical function can also be observed in older adults with increasing age.Grip strength has been shown to be a marker of overall physiological function in older adults.展开更多
Triboelectric nanogenerators(TENGs)offer a selfsustaining power solution for marine regions abundant in resources but constrained by energy availability.Since their pioneering use in wave energy harvesting in 2014,nea...Triboelectric nanogenerators(TENGs)offer a selfsustaining power solution for marine regions abundant in resources but constrained by energy availability.Since their pioneering use in wave energy harvesting in 2014,nearly a decade of advancements has yielded nearly thousands of research articles in this domain.Researchers have developed various TENG device structures with diverse functionalities to facilitate their commercial deployment.Nonetheless,there is a gap in comprehensive summaries and performance evaluations of TENG structural designs.This paper delineates six innovative structural designs,focusing on enhancing internal device output and adapting to external environments:high space utilization,hybrid generator,mechanical gain,broadband response,multi-directional operation,and hybrid energy-harvesting systems.We summarize the prevailing trends in device structure design identified by the research community.Furthermore,we conduct a meticulous comparison of the electrical performance of these devices under motorized,simulated wave,and real marine conditions,while also assessing their sustainability in terms of device durability and mechanical robustness.In conclusion,the paper outlines future research avenues and discusses the obstacles encountered in the TENG field.This review aims to offer valuable perspectives for ongoing research and to advance the progress and application of TENG technology.展开更多
BACKGROUND Psychological comorbidities,such as anxiety and depression,in patients with chronic ankle instability(CAI)may impede ankle function improvement,although the precise nature of this association warrants furth...BACKGROUND Psychological comorbidities,such as anxiety and depression,in patients with chronic ankle instability(CAI)may impede ankle function improvement,although the precise nature of this association warrants further investigation.AIM To analyze the correlation of anxiety and depression with ankle function in patients with CAI and discussing the risk factors.METHODS This study included 116 patients with CAI,who were admitted to our hospital from July 2022 to July 2024.Anxiety and depression states of patients were assessed with the self-rating anxiety scale(SAS)and self-rating depression scale(SDS),respectively,and their ankle joint function was assessed with the anklehindfoot function score of the American Orthopedic Foot and Ankle Society.Further,the ankle function of patients with CAI with different anxiety and depression states was discussed.Furthermore,the Pearson correlation coefficient was used to analyze the correlation of anxiety and depression with ankle joint function in such patients.Univariate and multivariate analyses were conducted to investigate the factors affecting ankle joint function in patients with CAI.RESULTS Among the 116 patients with CAI,97,13,5,and 1 cases demonstrated none,mild,moderate,and severe anxiety,whereas 95,15,6,and 0 cases showed none,mild,moderate,and severe depression,respectively.The average ankle joint function score was 74.82±6.93 points.The ankle joint function in patients with CAI presented a significant downward tendency as the degree of anxiety and depression increased.Correlation analysis revealed that both the SAS and SDS scores of patients with CAI were significantly negatively correlated with the ankle joint function score.Univariate and multivariate analyses indicated that the risk factors affecting patients’ankle joint function included early functional rehabilitation,visual analog scale,and SDS.CONCLUSION A substantial number of patients with CAI suffer from anxiety and depression,and these negative emotions,to a certain extent,harm the smooth rehabilitation of ankle joint function.展开更多
Functional networks(FNs)hold significant promise in understanding brain function.Independent component analysis(ICA)has been applied in estimating FNs from functional magnetic resonance imaging(fMRI).However,determini...Functional networks(FNs)hold significant promise in understanding brain function.Independent component analysis(ICA)has been applied in estimating FNs from functional magnetic resonance imaging(fMRI).However,determining an optimal model order for ICA remains challenging,leading to criticism about the reliability of FN estimation.Here,we propose a SMART(splitting-merging assisted reliable)ICA method that automatically extracts reliable FNs by clustering independent components(ICs)obtained from multi-model-order ICA using a simplified graph while providing linkages among FNs deduced from different-model orders.We extend SMART ICA to multi-subject fMRI analysis,validating its effectiveness using simulated and real fMRI data.Based on simulated data,the method accurately estimates both group-common and group-unique components and demonstrates robustness to parameters.Using two age-matched cohorts of resting fMRI data comprising 1,950 healthy subjects,the resulting reliable group-level FNs are greatly similar between the two cohorts,and interestingly the subject-specific FNs show progressive changes while age increases.Furthermore,both small-scale and large-scale brain FN templates are provided as benchmarks for future studies.Taken together,SMART ICA can automatically obtain reliable FNs in analyzing multi-subject fMRI data,while also providing linkages between different FNs.展开更多
Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides minin...Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides mining was slow due to lack of reference genome and protein sequence data.In this study,we illustrated full-length transcriptome sequencing to interpret the proteome of CGS meat and obtain 10703 coding DNA sequences.By functional annotation and amino acid composition analysis,we have discovered various genes related to signal transduction,and 16 genes related to longevity.We have also found vast variety of functional peptides through protein coding sequence(CDS)analysis by comparing the data obtained with the functional peptide database.Val-Pro-Ile predicted by the CDS analysis was released from the CGS meat through enzymatic hydrolysis,suggesting that our approach is reliable.This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat,thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.展开更多
Given the significant potential of multi-directional functionally graded materials(MFGMs)for customizable performance,it is crucial to develop versatile material models to enhance design optimization in engineering ap...Given the significant potential of multi-directional functionally graded materials(MFGMs)for customizable performance,it is crucial to develop versatile material models to enhance design optimization in engineering applications.This paper introduces a material model for an MFGM plate described by trigonometric functions,equipped with four parameters to control diverse material distributions effectively.The bending and vibration analysis of MFGM rectangular and cutout plates is carried out utilizing isogeometric analysis,which is based on a novel third-order shear deformation theory(TSDT)to account for transverse shear deformation.The present TSDT,founded on rigorous kinematics of displacements,is demonstrated to surpass other preceding theories.It is derived from an elasticity formulation,rather than relying on the hypothesis of displacements.The effectiveness of the proposed method is verified by comparing its numerical results with those of other methods reported in the relevant literature.Numerical results indicate that the structure,boundary conditions,and gradient parameters of the MFGM plate significantly influence its deflection,stress,and vibration frequency.As the periodic parameter exceeds four,the model complexity increases,causing result fluctuations.Additionally,MFGM cutout plates,when clamped on all sides,display almost identical first four vibration frequencies.展开更多
A Monte Carlo experiment was done to create a statistically significant test table for selecting EOF modes whose signals are above the noise level. Numerical analysis showed that it is feasible to choose a shorter dat...A Monte Carlo experiment was done to create a statistically significant test table for selecting EOF modes whose signals are above the noise level. Numerical analysis showed that it is feasible to choose a shorter data set between temporal and spatial dimensions for conducting an EOF analysis, and thus simplify calculation of the covariance matrix and solution of its eigenvalues and eigenvectors. The experiment showed that the dominant EOF modes remained the same. This approach is more computationally efficient, reducing both computing time and computer memory requirement, while still retaining the dominant signal.展开更多
The stable sub-angstrom resolution of the aberration-corrected scanning transmission electron microscope(ACSTEM)makes it an advanced and practical characterization technique for all materials.Owing to the prosperous a...The stable sub-angstrom resolution of the aberration-corrected scanning transmission electron microscope(ACSTEM)makes it an advanced and practical characterization technique for all materials.Owing to the prosperous advancement in computational technology,specialized software and programs have emerged as potent facilitators across the entirety of electron microscopy characterization process.Utilizing advanced image processing algorithms promotes the rectification of image distortions,concurrently elevating the overall image quality to superior standards.Extracting high-resolution,pixel-level discrete information and converting it into atomic-scale,followed by performing statistical calculations on the physical matters of interest through quantitative analysis,represent an effective strategy to maximize the value of electron microscope images.The efficacious utilization of quantitative analysis of electron microscope images has become a progressively prominent consideration for materials scientists and electron microscopy researchers.This article offers a concise overview of the pivotal procedures in quantitative analysis and summarizes the computational methodologies involved from three perspectives:contrast,lattice and strain,as well as atomic displacements and polarization.It further elaborates on practical applications of these methods in electronic functional materials,notably in piezoelectrics/ferroelectrics and thermoelectrics.It emphasizes the indispensable role of quantitative analysis in fundamental theoretical research,elucidating the structure–property correlations in high-performance systems,and guiding synthesis strategies.展开更多
To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable...To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable rate observed in China. As a behavioural addiction, NSSI poses a significant suicide risk,and is emerging as a major mental health problem among adolescents.To unravel this puzzle,the four-function model(FFM)distinguishes between interpersonal and intrapersonal functions,as well as positive and negative reinforcement functions,proving relatively comprehensive among various theoretical models.展开更多
For a general normed vector space,a special optimal value function called a maximal time function is considered.This covers the farthest distance function as a special case,and has a close relationship with the smalle...For a general normed vector space,a special optimal value function called a maximal time function is considered.This covers the farthest distance function as a special case,and has a close relationship with the smallest enclosing ball problem.Some properties of the maximal time function are proven,including the convexity,the lower semicontinuity,and the exact characterizations of its subdifferential formulas.展开更多
The selection and scaling of ground motion records is considered a primary and essential task in performing structural analysis and design.Conventional methods involve using ground motion models and a conditional spec...The selection and scaling of ground motion records is considered a primary and essential task in performing structural analysis and design.Conventional methods involve using ground motion models and a conditional spectrum to select ground motion records based on the target spectrum.This research demonstrates the influence of adopting different weighted factors for various period ranges during matching selected ground motions with the target hazard spectrum.The event data from the Next Generation Attenuation West 2(NGA-West 2)database is used as the basis for ground motion selection,and hazard de-aggregation is conducted to estimate the event parameters of interest,which are then used to construct the target intensity measure(IM).The target IMs are then used to select ground motion records with different weighted vector-valued objective functions.The weights are altered to account for the relative importance of IM in accordance with the structural analysis application of steel moment resisting frame(SMRF)buildings.Instead of an ordinary objective function for the matching spectrum,a novel model is introduced and compared with the conventional cost function.The results indicate that when applying the new cost function for ground motion selection,it places higher demands on structures compared to the conventional cost function.Moreover,submitting more weights to the first-mode period of structures increases engineering demand parameters.Findings demonstrate that weight factors allocated to different period ranges can successfully account for period elongation and higher mode effects.展开更多
Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent years.Bamboo fibers ar...Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent years.Bamboo fibers are renowned for their good mechanical properties,abundance,and short cycle growth.As beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic foundation.Three different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the thickness.The elastic properties of the composite are determined with the law of mixture.Employing Hamilton’s principle,the governing equations of motion are obtained.The generalized differential quadrature method(GDQM)is then applied to the equations to obtain the results.The achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam change.Furthermore,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber distribution.Eventually,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.展开更多
The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the ...The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the SCF complex and degraded by the 26S protease accounts for the bulk of the available self-incompatibility studies.In this study,15 ClSKP1s from the‘Xiangshui'lemon genome and ubiquitome exist in the same SKP1 conserved domain(CD)as SKP1s in other species.The q PCR results showed that SKP1-6 and SKP1-14 have tissue expression patterns specific for expression in pollen.In addition,SKP1-6 and SKP1-14 in the stigma,style and ovary were significantly upregulated after self-pollination compared to those after cross-pollination.A subcellular location showed that SKP1-6 and SKP1-14 were located in the nucleus.In addition,yeast two-hybrid(Y2H)assays,bimolecular fluorescence complementation(BiFC)and luciferase complementation imaging(LCI)assays showed that SKP1-6 interacted with F-box1,F-box33,F-box34,F-box17,F-box19,Cullin1-2 and 26S proteasome subunit 4 homolog A(26S PS4HA).SKP1-14 interacted with F-box17,F-box19,F-box35,Cullin1-2 and 26S PS4HA.The interaction of Cullin1-2 and the F-box with SKP1 as a bridge was verified by a yeast three-hybrid experiment.The ability of S3-RNase to inhibit pollen and pollen tube growth and development was assessed using in vitro pollen co-culture experiments with recombinant S3-RNase proteins.Overall,this study provides important experimental evidence and theoretical basis for understanding the mechanism of self-incompatibility in plants by revealing the key role of the SCF complex in‘Xiangshui'lemon,which is bridged by ClSKP1-6,in self-incompatibility.The results of this study are of great significance for the future indepth exploration of the molecular mechanism of the SCF complex and its wide application in the self-incompatibility of plants.展开更多
Purpose: This study focused on maintaining and improving the walking function of late-stage older individuals while longitudinally tracking the effects of regular exercise programs in a day-care service specialized fo...Purpose: This study focused on maintaining and improving the walking function of late-stage older individuals while longitudinally tracking the effects of regular exercise programs in a day-care service specialized for preventive care over 5 years, using detailed gait function measurements with an accelerometer-based system. Methods: Seventy individuals (17 male and 53 female) of a daycare service in Tokyo participated in a weekly exercise program, meeting 1 - 2 times. The average age of the participants at the start of the program was 81.4 years. Gait function, including gait speed, stride length, root mean square (RMS) of acceleration, gait cycle time and its standard deviation, and left-right difference in stance time, was evaluated every 6 months. Results: Gait speed and stride length improved considerably within six months of starting the exercise program, confirming an initial improvement in gait function. This suggests that regular exercise programs can maintain or improve gait function even age groups that predictably have a gradual decline in gait ability due to enhanced age. In the long term, many indicators tended to approach baseline values. However, the exercise program seemingly counteracts age-related changes in gait function and maintains a certain level of function. Conclusions: While a decline in gait ability with aging is inevitable, establishing appropriate exercise habits in late-stage older individuals may contribute to long-term maintenance of gait function.展开更多
In this paper, the isogeometric analysis (IGA) is employed to develop an acoustic radiation model for a double plate-acoustic cavity coupling system, with a focus on analyzing the sound transmission loss (STL). The fu...In this paper, the isogeometric analysis (IGA) is employed to develop an acoustic radiation model for a double plate-acoustic cavity coupling system, with a focus on analyzing the sound transmission loss (STL). The functionally graded (FG) plate exhibits a different material properties in-plane, and the power-law rule is adopted as the governing principle for material mixing. To validate the harmonic response and demonstrate the accuracy and convergence of the isogeometric modeling, ANASYS is utilized to compare with numerical examples. A plane wave serves as the acoustic excitation, and the Rayleigh integral is applied to discretize the radiated plate. The STL results are compared with the literature, confirming the reliability of the coupling system. Finally, the investigation is conducted to study impact of cavity depth and power-law parameter on the STL.展开更多
Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network lev...Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.展开更多
This paper demonstrates that the spatial distribution of the ionospheric TEC over the Indian region can be reconstructed with appreciable accuracy using minimal numbers of empirical orthogonal functions as a basis.The...This paper demonstrates that the spatial distribution of the ionospheric TEC over the Indian region can be reconstructed with appreciable accuracy using minimal numbers of empirical orthogonal functions as a basis.These basis functions were derived using the Singular Value Decomposition of a matrix composed of pragmatic vertical Total Electron Content(VTEC)values collected across varied ionospheric conditions and measured over the region of interest.The reconstruction was achieved by linearly combining the appropriately chosen significant bases with corresponding weight factors.The reconstruction accuracy of the algorithm was found to be better than 4 TECU(TECU=1016electrons/m2)for more than 99.9%of the time when tested over the complete year of 2016 with only eight basis vectors.The containment factor,defined here,indicates the goodness of the chosen bases in representing the arbitrary VTEC distributions and is found to remain typically high,aiding in improved algorithm performance.The performance,however,was found to be sensitive to the seasons and geomagnetic conditions.Deteriorated performance was observed when tested for the St.Patrick's Day storm data.The deterioration was attributed to the structural alteration of the ionospheric plasma density and the presence of atypical modes during the storm.The results ascertain the prospect of a faithful representation of the spatial distribution of the ionospheric VTEC using limited parametric variables,which may find utility in navigation,radar,and various other applications.展开更多
基金Ho Chi Minh City University of Technology (HCMUT), VNU-HCM for supporting this study
文摘In this study,an improved integrated radial basis function with nonuniform shape parameter is introduced.The proposed shape parameter varies in each support domain and is defined byθ=1/d_(max),where d_(max)is the maximum distance of any pair of nodes in the support domain.The proposed method is verified and shows good performance.The results are stable and accurate with any number of nodes and an arbitrary nodal distribution.Notably,the support domain should be large enough to obtain accurate results.This method is then applied for transient analysis of curved shell structures made from functionally graded materials with complex geometries.Through several numerical examples,the accuracy of the proposed approach is demonstrated and discussed.Additionally,the influence of various factors on the dynamic behavior of the structures,including the power-law index,different materials,loading conditions,and geometrical parameters of the structures,was investigated.
基金supported by the Shanghai New Three-year Action Plan for Public Health(Grant No.GWV-10.1-XK16)the US National Institute on Aging(RO1-AGO34479).
文摘In 2019,China had over 13.14 million dementia cases,with incidence rates of(56.47–207.08)/100,000[1].Early cognitive impairment—a key dementia symptom—reduces quality of life,increases care dependence,and lowers survival in older adults[2].A decline in physical function can also be observed in older adults with increasing age.Grip strength has been shown to be a marker of overall physiological function in older adults.
基金supported by the National Key R&D Project from Ministry of Science and Technology,China(2021YFA1201603)National Natural Science Foundation of China(52073032 and 52192611)the Fundamental Research Funds for the Central Universities.
文摘Triboelectric nanogenerators(TENGs)offer a selfsustaining power solution for marine regions abundant in resources but constrained by energy availability.Since their pioneering use in wave energy harvesting in 2014,nearly a decade of advancements has yielded nearly thousands of research articles in this domain.Researchers have developed various TENG device structures with diverse functionalities to facilitate their commercial deployment.Nonetheless,there is a gap in comprehensive summaries and performance evaluations of TENG structural designs.This paper delineates six innovative structural designs,focusing on enhancing internal device output and adapting to external environments:high space utilization,hybrid generator,mechanical gain,broadband response,multi-directional operation,and hybrid energy-harvesting systems.We summarize the prevailing trends in device structure design identified by the research community.Furthermore,we conduct a meticulous comparison of the electrical performance of these devices under motorized,simulated wave,and real marine conditions,while also assessing their sustainability in terms of device durability and mechanical robustness.In conclusion,the paper outlines future research avenues and discusses the obstacles encountered in the TENG field.This review aims to offer valuable perspectives for ongoing research and to advance the progress and application of TENG technology.
文摘BACKGROUND Psychological comorbidities,such as anxiety and depression,in patients with chronic ankle instability(CAI)may impede ankle function improvement,although the precise nature of this association warrants further investigation.AIM To analyze the correlation of anxiety and depression with ankle function in patients with CAI and discussing the risk factors.METHODS This study included 116 patients with CAI,who were admitted to our hospital from July 2022 to July 2024.Anxiety and depression states of patients were assessed with the self-rating anxiety scale(SAS)and self-rating depression scale(SDS),respectively,and their ankle joint function was assessed with the anklehindfoot function score of the American Orthopedic Foot and Ankle Society.Further,the ankle function of patients with CAI with different anxiety and depression states was discussed.Furthermore,the Pearson correlation coefficient was used to analyze the correlation of anxiety and depression with ankle joint function in such patients.Univariate and multivariate analyses were conducted to investigate the factors affecting ankle joint function in patients with CAI.RESULTS Among the 116 patients with CAI,97,13,5,and 1 cases demonstrated none,mild,moderate,and severe anxiety,whereas 95,15,6,and 0 cases showed none,mild,moderate,and severe depression,respectively.The average ankle joint function score was 74.82±6.93 points.The ankle joint function in patients with CAI presented a significant downward tendency as the degree of anxiety and depression increased.Correlation analysis revealed that both the SAS and SDS scores of patients with CAI were significantly negatively correlated with the ankle joint function score.Univariate and multivariate analyses indicated that the risk factors affecting patients’ankle joint function included early functional rehabilitation,visual analog scale,and SDS.CONCLUSION A substantial number of patients with CAI suffer from anxiety and depression,and these negative emotions,to a certain extent,harm the smooth rehabilitation of ankle joint function.
基金supported by the National Natural Science Foundation of China(62076157 and 61703253)the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20210033)the National Institutes of Health(R01MH123610 and R01EB006841).
文摘Functional networks(FNs)hold significant promise in understanding brain function.Independent component analysis(ICA)has been applied in estimating FNs from functional magnetic resonance imaging(fMRI).However,determining an optimal model order for ICA remains challenging,leading to criticism about the reliability of FN estimation.Here,we propose a SMART(splitting-merging assisted reliable)ICA method that automatically extracts reliable FNs by clustering independent components(ICs)obtained from multi-model-order ICA using a simplified graph while providing linkages among FNs deduced from different-model orders.We extend SMART ICA to multi-subject fMRI analysis,validating its effectiveness using simulated and real fMRI data.Based on simulated data,the method accurately estimates both group-common and group-unique components and demonstrates robustness to parameters.Using two age-matched cohorts of resting fMRI data comprising 1,950 healthy subjects,the resulting reliable group-level FNs are greatly similar between the two cohorts,and interestingly the subject-specific FNs show progressive changes while age increases.Furthermore,both small-scale and large-scale brain FN templates are provided as benchmarks for future studies.Taken together,SMART ICA can automatically obtain reliable FNs in analyzing multi-subject fMRI data,while also providing linkages between different FNs.
基金funded by Shenzhen Science and Technology Innovation Commission(KCXFZ20201221173207022)。
文摘Andrias davidianus(Chinese giant salamander,CGS)is the largest and oldest extant amphibian species in the world and is a source of prospective functional food in China.However,the progress of functional peptides mining was slow due to lack of reference genome and protein sequence data.In this study,we illustrated full-length transcriptome sequencing to interpret the proteome of CGS meat and obtain 10703 coding DNA sequences.By functional annotation and amino acid composition analysis,we have discovered various genes related to signal transduction,and 16 genes related to longevity.We have also found vast variety of functional peptides through protein coding sequence(CDS)analysis by comparing the data obtained with the functional peptide database.Val-Pro-Ile predicted by the CDS analysis was released from the CGS meat through enzymatic hydrolysis,suggesting that our approach is reliable.This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat,thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.
基金supported by the Guangdong Major Project of Basic and Applied Basic Research(2021B0301030001)the National Key Research and Development Program of China(2021YFA0716304)+3 种基金the project supported by the Space Utilization System of China Manned Space Engineering(KJZ-YY-WCL03)the National Key Laboratory Foundation of Science and Technology on Materials under Shock and Impact(6142902210109)Independent Innovation Projects of the Hubei Longzhong Laboratory(2022ZZ-32)the National Natural Science Foundation of China(Nos.11902232,51972246,and 51521001).
文摘Given the significant potential of multi-directional functionally graded materials(MFGMs)for customizable performance,it is crucial to develop versatile material models to enhance design optimization in engineering applications.This paper introduces a material model for an MFGM plate described by trigonometric functions,equipped with four parameters to control diverse material distributions effectively.The bending and vibration analysis of MFGM rectangular and cutout plates is carried out utilizing isogeometric analysis,which is based on a novel third-order shear deformation theory(TSDT)to account for transverse shear deformation.The present TSDT,founded on rigorous kinematics of displacements,is demonstrated to surpass other preceding theories.It is derived from an elasticity formulation,rather than relying on the hypothesis of displacements.The effectiveness of the proposed method is verified by comparing its numerical results with those of other methods reported in the relevant literature.Numerical results indicate that the structure,boundary conditions,and gradient parameters of the MFGM plate significantly influence its deflection,stress,and vibration frequency.As the periodic parameter exceeds four,the model complexity increases,causing result fluctuations.Additionally,MFGM cutout plates,when clamped on all sides,display almost identical first four vibration frequencies.
文摘A Monte Carlo experiment was done to create a statistically significant test table for selecting EOF modes whose signals are above the noise level. Numerical analysis showed that it is feasible to choose a shorter data set between temporal and spatial dimensions for conducting an EOF analysis, and thus simplify calculation of the covariance matrix and solution of its eigenvalues and eigenvectors. The experiment showed that the dominant EOF modes remained the same. This approach is more computationally efficient, reducing both computing time and computer memory requirement, while still retaining the dominant signal.
基金Project supported by the financial support from the National Key R&D Program of China(Grant No.2021YFB3201100)the National Natural Science Foundation of China(Grant No.52172128)the Top Young Talents Programme of Xi’an Jiaotong University.
文摘The stable sub-angstrom resolution of the aberration-corrected scanning transmission electron microscope(ACSTEM)makes it an advanced and practical characterization technique for all materials.Owing to the prosperous advancement in computational technology,specialized software and programs have emerged as potent facilitators across the entirety of electron microscopy characterization process.Utilizing advanced image processing algorithms promotes the rectification of image distortions,concurrently elevating the overall image quality to superior standards.Extracting high-resolution,pixel-level discrete information and converting it into atomic-scale,followed by performing statistical calculations on the physical matters of interest through quantitative analysis,represent an effective strategy to maximize the value of electron microscope images.The efficacious utilization of quantitative analysis of electron microscope images has become a progressively prominent consideration for materials scientists and electron microscopy researchers.This article offers a concise overview of the pivotal procedures in quantitative analysis and summarizes the computational methodologies involved from three perspectives:contrast,lattice and strain,as well as atomic displacements and polarization.It further elaborates on practical applications of these methods in electronic functional materials,notably in piezoelectrics/ferroelectrics and thermoelectrics.It emphasizes the indispensable role of quantitative analysis in fundamental theoretical research,elucidating the structure–property correlations in high-performance systems,and guiding synthesis strategies.
文摘To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable rate observed in China. As a behavioural addiction, NSSI poses a significant suicide risk,and is emerging as a major mental health problem among adolescents.To unravel this puzzle,the four-function model(FFM)distinguishes between interpersonal and intrapersonal functions,as well as positive and negative reinforcement functions,proving relatively comprehensive among various theoretical models.
基金supported by the National Natural Science Foundation of China(11201324)the Fok Ying Tuny Education Foundation(141114)the Sichuan Technology Program(2022ZYD0011,2022NFSC1852).
文摘For a general normed vector space,a special optimal value function called a maximal time function is considered.This covers the farthest distance function as a special case,and has a close relationship with the smallest enclosing ball problem.Some properties of the maximal time function are proven,including the convexity,the lower semicontinuity,and the exact characterizations of its subdifferential formulas.
基金financial support from Teesside University to support the Ph.D. program of the first author.
文摘The selection and scaling of ground motion records is considered a primary and essential task in performing structural analysis and design.Conventional methods involve using ground motion models and a conditional spectrum to select ground motion records based on the target spectrum.This research demonstrates the influence of adopting different weighted factors for various period ranges during matching selected ground motions with the target hazard spectrum.The event data from the Next Generation Attenuation West 2(NGA-West 2)database is used as the basis for ground motion selection,and hazard de-aggregation is conducted to estimate the event parameters of interest,which are then used to construct the target intensity measure(IM).The target IMs are then used to select ground motion records with different weighted vector-valued objective functions.The weights are altered to account for the relative importance of IM in accordance with the structural analysis application of steel moment resisting frame(SMRF)buildings.Instead of an ordinary objective function for the matching spectrum,a novel model is introduced and compared with the conventional cost function.The results indicate that when applying the new cost function for ground motion selection,it places higher demands on structures compared to the conventional cost function.Moreover,submitting more weights to the first-mode period of structures increases engineering demand parameters.Findings demonstrate that weight factors allocated to different period ranges can successfully account for period elongation and higher mode effects.
文摘Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent years.Bamboo fibers are renowned for their good mechanical properties,abundance,and short cycle growth.As beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic foundation.Three different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the thickness.The elastic properties of the composite are determined with the law of mixture.Employing Hamilton’s principle,the governing equations of motion are obtained.The generalized differential quadrature method(GDQM)is then applied to the equations to obtain the results.The achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam change.Furthermore,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber distribution.Eventually,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.
基金supported by grants from the National Natural Science Foundation of China(Grant No.31960585)Science and Technology Major Project of Guangxi(Grant No.Guike AA22068092)+1 种基金Guangxi Science and Technology Vanguard Special Action Project(Grant No.202204)State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(Grant Nos.SKLCUSA-a201906,SKLCU-SA-c201901)。
文摘The SKP1 gene is an important component of the SCF(SKP1-Cullin1-F-box)complex and serves as a bridge connecting the F-box and Cullin1genes(F-box-SKP1-Cullin1).The pattern of S-RNase being ubiquitously labelled by the SCF complex and degraded by the 26S protease accounts for the bulk of the available self-incompatibility studies.In this study,15 ClSKP1s from the‘Xiangshui'lemon genome and ubiquitome exist in the same SKP1 conserved domain(CD)as SKP1s in other species.The q PCR results showed that SKP1-6 and SKP1-14 have tissue expression patterns specific for expression in pollen.In addition,SKP1-6 and SKP1-14 in the stigma,style and ovary were significantly upregulated after self-pollination compared to those after cross-pollination.A subcellular location showed that SKP1-6 and SKP1-14 were located in the nucleus.In addition,yeast two-hybrid(Y2H)assays,bimolecular fluorescence complementation(BiFC)and luciferase complementation imaging(LCI)assays showed that SKP1-6 interacted with F-box1,F-box33,F-box34,F-box17,F-box19,Cullin1-2 and 26S proteasome subunit 4 homolog A(26S PS4HA).SKP1-14 interacted with F-box17,F-box19,F-box35,Cullin1-2 and 26S PS4HA.The interaction of Cullin1-2 and the F-box with SKP1 as a bridge was verified by a yeast three-hybrid experiment.The ability of S3-RNase to inhibit pollen and pollen tube growth and development was assessed using in vitro pollen co-culture experiments with recombinant S3-RNase proteins.Overall,this study provides important experimental evidence and theoretical basis for understanding the mechanism of self-incompatibility in plants by revealing the key role of the SCF complex in‘Xiangshui'lemon,which is bridged by ClSKP1-6,in self-incompatibility.The results of this study are of great significance for the future indepth exploration of the molecular mechanism of the SCF complex and its wide application in the self-incompatibility of plants.
文摘Purpose: This study focused on maintaining and improving the walking function of late-stage older individuals while longitudinally tracking the effects of regular exercise programs in a day-care service specialized for preventive care over 5 years, using detailed gait function measurements with an accelerometer-based system. Methods: Seventy individuals (17 male and 53 female) of a daycare service in Tokyo participated in a weekly exercise program, meeting 1 - 2 times. The average age of the participants at the start of the program was 81.4 years. Gait function, including gait speed, stride length, root mean square (RMS) of acceleration, gait cycle time and its standard deviation, and left-right difference in stance time, was evaluated every 6 months. Results: Gait speed and stride length improved considerably within six months of starting the exercise program, confirming an initial improvement in gait function. This suggests that regular exercise programs can maintain or improve gait function even age groups that predictably have a gradual decline in gait ability due to enhanced age. In the long term, many indicators tended to approach baseline values. However, the exercise program seemingly counteracts age-related changes in gait function and maintains a certain level of function. Conclusions: While a decline in gait ability with aging is inevitable, establishing appropriate exercise habits in late-stage older individuals may contribute to long-term maintenance of gait function.
文摘In this paper, the isogeometric analysis (IGA) is employed to develop an acoustic radiation model for a double plate-acoustic cavity coupling system, with a focus on analyzing the sound transmission loss (STL). The functionally graded (FG) plate exhibits a different material properties in-plane, and the power-law rule is adopted as the governing principle for material mixing. To validate the harmonic response and demonstrate the accuracy and convergence of the isogeometric modeling, ANASYS is utilized to compare with numerical examples. A plane wave serves as the acoustic excitation, and the Rayleigh integral is applied to discretize the radiated plate. The STL results are compared with the literature, confirming the reliability of the coupling system. Finally, the investigation is conducted to study impact of cavity depth and power-law parameter on the STL.
基金supported by the National Natural Science Foundation of China,Nos.81871836(to MZ),82172554(to XH),and 81802249(to XH),81902301(to JW)the National Key R&D Program of China,Nos.2018YFC2001600(to JX)and 2018YFC2001604(to JX)+3 种基金Shanghai Rising Star Program,No.19QA1409000(to MZ)Shanghai Municipal Commission of Health and Family Planning,No.2018YQ02(to MZ)Shanghai Youth Top Talent Development PlanShanghai“Rising Stars of Medical Talent”Youth Development Program,No.RY411.19.01.10(to XH)。
文摘Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.
文摘This paper demonstrates that the spatial distribution of the ionospheric TEC over the Indian region can be reconstructed with appreciable accuracy using minimal numbers of empirical orthogonal functions as a basis.These basis functions were derived using the Singular Value Decomposition of a matrix composed of pragmatic vertical Total Electron Content(VTEC)values collected across varied ionospheric conditions and measured over the region of interest.The reconstruction was achieved by linearly combining the appropriately chosen significant bases with corresponding weight factors.The reconstruction accuracy of the algorithm was found to be better than 4 TECU(TECU=1016electrons/m2)for more than 99.9%of the time when tested over the complete year of 2016 with only eight basis vectors.The containment factor,defined here,indicates the goodness of the chosen bases in representing the arbitrary VTEC distributions and is found to remain typically high,aiding in improved algorithm performance.The performance,however,was found to be sensitive to the seasons and geomagnetic conditions.Deteriorated performance was observed when tested for the St.Patrick's Day storm data.The deterioration was attributed to the structural alteration of the ionospheric plasma density and the presence of atypical modes during the storm.The results ascertain the prospect of a faithful representation of the spatial distribution of the ionospheric VTEC using limited parametric variables,which may find utility in navigation,radar,and various other applications.
