Abstract. In this paper, we study the quotient of hypergeometric functions μα （r） in the theory of Ramanujan＇s generalized modular equation for α ∈（0, 1/2]. Several new inequalities are given for this and rela...Abstract. In this paper, we study the quotient of hypergeometric functions μα （r） in the theory of Ramanujan＇s generalized modular equation for α ∈（0, 1/2]. Several new inequalities are given for this and related functions. Our main results complement and generalize some known results in the literature.展开更多
Objective To explore the effect of heat-reinforcing acupuncture combined with Bobath rehabilita on training for the gross motor func on measurement（GMFM） in children with cerebral palsy. Methods Sixty cases of cereb...Objective To explore the effect of heat-reinforcing acupuncture combined with Bobath rehabilita on training for the gross motor func on measurement（GMFM） in children with cerebral palsy. Methods Sixty cases of cerebral palsy were randomized into a heat-reinforcing acupuncture combined with rehabilitation training group（group A） and a rehabilitation group（group B）,30 cases in each group. Rehabilitation training was applied in group B and heat-reinforcing acupuncture was added in group A. Jiāji（夹脊 EX-B 2）,Jiānyú（肩髃 LI 15）,Qūchí（曲池 LI 11）,Hégi（合谷 LI 4）,Yánglíngquán（阳陵泉 GB 34）,Yīnlíngquán（阴陵泉 SP 9）,Xuánzhōng（悬钟 GB 39）,Zúsānli（足三里 ST 36）,Sānyīnjiāo（三阴交 SP 6）,Chéngshān（承山 BL 57）,Tài chōng（太冲 LR 3）,Tàixī（太溪 KI 3） and Shénmén（神门 HT 4） were chosen in group A and the heat-reinforcing acupuncture was applied once a day. For scalp acupuncture,Biihuì（百会 GV 20）,Sìshéncōng（四神聪 EX-HN 1）,Zhìsānzhēn（智三针）,Nǎosānzhēn（脑三针）,Nièsānzhēn（颞三针） and motor area（运动区） were punctured without any manipulation,once every other day,3 months as a treatment course and 2 courses were needed. GMFM were selected to assess the children with cerebral palsy before treatment,a er 3 months treatment and a er 6 months treatment. Results The total eff ec ve rate in group A was 70.00%（21/30）,which is superior to that of 60.00%（24/30） in group B（P0.05）. In group A,the GMFM scores of decubitus position and turn-over of body,creeping and kneeling,sitting,standing,walking,running and jumping after6 months treatment were significantly improved compared with that before treatment and after 3 months treatment（all P0.05）. In group B,above indices a er 6 months treatment were significantly improved compared with those before treatment,the standing score after 6 months treatment was significantly improved compared with that a er 3 months treatment（P0.05）; the GMFM scores of creeping,kneeling,sitting,standing,walking,running and jumping after 6 months treatment in group A were more significantly improved than that in group B（all P0.05）. Conclusion The heat-reinforcing acupuncture combined with Bobath rehabilita on training has a be er eff ect than rehabilitation training on the GMFM scores of creeping and kneeling,si ng,standing,walking,running and jumping of children with cerebral palsy. It can be shown that the combination of heat-reinforcing acupuncture and Bobath rehabilita on training can improve the gross motor func on of children with cerebral palsy.展开更多
The paper approaches the problem of the command functions of galvanometer-based scanners （GS） that are necessary to produce the linear plus parabolic scanning function of the GS, which we have proved previously to p...The paper approaches the problem of the command functions of galvanometer-based scanners （GS） that are necessary to produce the linear plus parabolic scanning function of the GS, which we have proved previously to produce the highest possible duty cycle （i.e., time efficiency） of the device. We have completed this theoretical aspect （which contradicted what has been stated previously in the literature, where it has been considered that the linear plus sinusoidal scanning function was the best） with the experimental study of the most used scanning functions of the GSs （sawtooth, sinusoidal and triangular）, with applications in biomedical imaging, in particular in optical coherence tomography, demonstrating that the triangular function is always the best one to be applied, from both an optical and a mechanical point of view. In the present study the input voltage/command function which should be applied to the GS to produce the desired triangular scanning function （with controlled non-linearity for the fastest possible stop-and-turn portions） was determined analytically, in relationship with the active torque that drives the device. This command function is analyzed with regard to the specific, respectively required parameters of the GS： natural frequency and damping factor, respectively scan speed and amplitude. The modeling in an open loop control structure of the GS is finally discussed as a trade-off between using the highest possible duty cycle and minimizing the maximum peaks of the input voltage.展开更多
In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulati on of Erweikang at different doses and different time p...In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulati on of Erweikang at different doses and different time points was compared when n ormal saline and cyclophosphamide served as controls. The results showed that di fferent doses of Erweikang could effectively reverse the decreased induction lev els of NK, IL 2, γ IFN and the contents of TNF and IgG of the immunosu ppressive mice after administration of Erweikang for 7 to 14 days. It was sugges ted that compound polysaccharide Erweikang presents positive immune modulation i n dose and time dependent manners.展开更多
To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients （1...To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients （1-17 years old） who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 （range, 2-7） days after surgery for 10 （range, 7-23） days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients＇s clinical symptoms have no influences on neurofunctional outcomes.展开更多
With global integration going deeper,bilingualism has become a more social issue than a purely linguistic phenomenon.Over seas scholars have been studying in this field for a long time while in China,studies regarding...With global integration going deeper,bilingualism has become a more social issue than a purely linguistic phenomenon.Over seas scholars have been studying in this field for a long time while in China,studies regarding bilingualism are still in its early stages.This pa per provides a historic review on the definition,categorization as well as its cognitive functions.Although it is still a question whether bilin gualism is an advantage or disadvantage to human beings' especially children's cognitive ability,this paper has concluded that early studies showed more negative results while recent research has shifted to a more positive attitude.展开更多
Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction...Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.展开更多
When teaching neurology students about epilepsy,selecting appropriate antiseizure medications(ASMs)based on seizure type is a fundamental objective.Carbamazepine(CBZ),a widely used first-line ASM,is effective against ...When teaching neurology students about epilepsy,selecting appropriate antiseizure medications(ASMs)based on seizure type is a fundamental objective.Carbamazepine(CBZ),a widely used first-line ASM,is effective against focal seizures,generalized tonic-clonic seizures,and mixed seizure patterns[1].However,CBZ paradoxically aggravates absence seizures,as demonstrated by increased 36 Hz spike-and-wave discharges(SWDs)in both patients and animal models[2,3].While prior studies implicated altered GABAA receptor function in the thalamic ventrobasal complex[4],the precise mechanisms remained unclear.Recently,an inspiring study published on PNAS by Jang et al.from Stanford University has highlighted the thalamic reticular nucleus(RT)as the key brain region responsible for CBZ's aggravating effect on absence seizures[5].The combination of transgenic mouse models,optogenetics,and detailed electrophysiology in the original study provided exceptional precision in probing mechanistic insights,which greatly strengthens the conclusions.展开更多
We study a system(D)x’=F(t,x_t)of functional differential equations,together with a scalar equation(S)x’=-a(t)f(x)+b(t)g(x(t-h))as well as perturbed forms.A Liapunov functional is constructed which has a derivative ...We study a system(D)x’=F(t,x_t)of functional differential equations,together with a scalar equation(S)x’=-a(t)f(x)+b(t)g(x(t-h))as well as perturbed forms.A Liapunov functional is constructed which has a derivative of a nature that has been widely discussed in the literature. On the basis of this example we prove results for(D)on asymptotic stability and equi-boundedness.展开更多
Two types of activated carbon, namely, Filtrasorb 400 and Nuchar SA, were functionalized by quaternary ammonium salts （quats）, as to enhance perchlorate adsorption. Results showed that the adsorption of quats on Nuc...Two types of activated carbon, namely, Filtrasorb 400 and Nuchar SA, were functionalized by quaternary ammonium salts （quats）, as to enhance perchlorate adsorption. Results showed that the adsorption of quats on Nuchar SA increased with increase in chain length （hydrophobicity） of quats. Filtrasorb 400, however, had limited uptake of long-chain quats such as dodecyl- trimethylammonium and hexadecyltrimethylammoium （HDTMA）. Results indicated that perchlorate removal by the functionalized activated carbon was directly related to the chain length of the modifying quats. Perchlorate removal by functionalized activated carbon increased with increase in chain length of the modifying quats and became less pH-dependent. Modified Nuchar SA had higher overall perchlorate removal capacity than the modified Filtrasorb F400, but was more strongly affected by pH than Filtrasorb 400. Activated carbon treated with HDTMA exhibited the best perchlorate removal capacity among all quats studied. Results indicated that tailoring the activated carbon surface with HDTMA rendered the activated carbon surface positively charged, which resulted in substantial increase in perchlorate removal compared to unfunctionalized activated carbons.展开更多
The mechanism of the reaction of Ni^+ (~2D) with ethane in the gas-phase wasstudied by using density functional theory. Both the B3LYP and BLYP functionals with standardall-electron basis sets are used to give the det...The mechanism of the reaction of Ni^+ (~2D) with ethane in the gas-phase wasstudied by using density functional theory. Both the B3LYP and BLYP functionals with standardall-electron basis sets are used to give the detailed information of the potential energy surface(PES) of [Ni, C_2, H_6]^+. The mechanisms forming the products CH_4 and H_2 in the reaction of Ni^+with ethane are proposed. The reductive eliminations of CH_4 and H_2 are typicaladdition-elimination reactions. Each of the two reactions consists of two elementary steps; C―C orC―H bond activations to form inserted species followed by isomerizations to form product-likeintermediate. The rate determining steps for the elimination reactions of forming CH_4 and H_2 arethe isomerizations of the inserted species rather than C―C or C―H bond activations. Theelimination reaction of forming H_2 was found to be thermodynamically favored compared to that ofCH_4.展开更多
In this paper we consider infinite horizon backward doubly stochastic differential equations （BDS- DEs for short） coupled with forward stochastic differential equations, whose terminal functions are non-degenerate. ...In this paper we consider infinite horizon backward doubly stochastic differential equations （BDS- DEs for short） coupled with forward stochastic differential equations, whose terminal functions are non-degenerate. For such kind of BDSDEs, we study the existence and uniqueness of their solutions taking values in weighted Lp（dx）¤L2（dx）space （p _〉 2）, and obtain the stationary property for the solutions.展开更多
In this paper, we consider a nonlinear system of reaction diffusion equa- tions arising from mathematical neuroscience and two nonlinear scalar reaction diffusion equations under some assumptions on their coefficients...In this paper, we consider a nonlinear system of reaction diffusion equa- tions arising from mathematical neuroscience and two nonlinear scalar reaction diffusion equations under some assumptions on their coefficients. The main purpose is to couple together linearized stability criterion （the equivalence of the nonlinear stability, the linear stability and the spectral sta- bility of the standing pulse solutions） and Evans functions to accomplish the existence and instability of standing pulse solutions of the nonlinear system of reaction diffusion equations and the nonlinear scalar reaction diffusion equa- tions. The Evans functions for the standing pulse solutions are constructed explicitly.展开更多
目的探讨胰岛素强化疗法序贯司美格鲁肽治疗肥胖中青年T2DM患者的临床疗效及安全性。方法前瞻性选取2021年8月至2024年2月新乡医学院第一附属医院收治的120例肥胖中青年T2DM患者纳入研究,按随机数表法分为观察组和对照组各60例。两组患...目的探讨胰岛素强化疗法序贯司美格鲁肽治疗肥胖中青年T2DM患者的临床疗效及安全性。方法前瞻性选取2021年8月至2024年2月新乡医学院第一附属医院收治的120例肥胖中青年T2DM患者纳入研究,按随机数表法分为观察组和对照组各60例。两组患者均予以胰岛素泵强化降糖,待高血糖状态解除后,对照组序贯二甲双胍治疗,观察组于对照组基础上序贯司美格鲁肽治疗,治疗3个月。比较两组患者治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、葡萄糖目标范围内时间(TIR)、体质量指数(BMI)、内脏脂肪指数(VAI)、胰岛β细胞功能[胰岛素抵抗指数(HOMA-IR)、空腹C肽、餐后1 h C肽、胰岛素敏感性检测指数(QUICKI)]、血脂[总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血清内酯素(Visfatin)、网膜素-1(omentin-1)、趋化素(Chemerin),同时比较两组患者治疗期间的不良反应发生情况。结果治疗后,观察组患者的FBG、2 hPG、HbA1c、BMI、VAI分别为(5.34±0.71)mmoL/L、(9.00±0.84)mmoL/L、(5.76±0.51)%、(24.26±0.35)kg/m^(2)、3.15±0.71,明显低于对照组的(6.02±0.56)mmoL/L、(11.35±1.01)mmoL/L、(6.28±0.40)%、(26.00±0.49)kg/m^(2)、3.54±0.64,TIR为(95.00±1.52)%,明显高于对照组的(88.46±3.71)%,差异均有统计学意义(P<0.05);治疗后,观察组患者的HOMA-IR为2.16±0.32,明显低于对照组的2.65±0.40,空腹C肽、餐后1 h C肽、QUICKI分别为(3.85±0.27)ng/mL、(7.64±0.43)ng/mL、0.52±0.13,明显高于对照组的(3.02±0.46)ng/mL、(6.02±0.38)ng/mL、0.41±0.10,差异均有统计学意义(P<0.05);治疗后,观察组患者的总胆固醇、甘油三酯、LDL-C、Vaspin、chemerin分别为(3.25±0.42)mmoL/L、(1.77±0.25)mmoL/L、(1.89±0.42)mmoL/L、(70.92±4.68)ng/L、(45.84±4.90)ng/L,明显低于对照组的(3.90±0.53)mmoL/L、(2.08±0.34)mmoL/L、(2.21±0.36)mmoL/L、(75.00±5.15)ng/L、(51.03±5.66)ng/L,HDL-C、omentin-1分别为(1.27±0.11)mmoL/L、(218.45±16.63)pg/mL,明显高于对照组的(1.19±0.13)mmoL/L、(149.60±15.35)pg/mL,差异均有统计学意义(P<0.05);治疗期间两组患者的不良反应总发生率比较差异无统计学意义(P>0.05)。结论胰岛素强化疗法序贯司美格鲁肽治疗肥胖中青年T2DM可降低患者血糖,恢复胰岛β细胞功能,调节血脂,减轻体质量,且安全性较高。展开更多
基金Supported by the Zhejiang Provincial Natural Science Foundation of China(LQ17A010010)the National Natural Science Foundation of China(11171307,11671360)the Natural Science Foundation of the Department of Education of Zhejiang Province(Y201328799)
文摘Abstract. In this paper, we study the quotient of hypergeometric functions μα （r） in the theory of Ramanujan＇s generalized modular equation for α ∈（0, 1/2]. Several new inequalities are given for this and related functions. Our main results complement and generalize some known results in the literature.
基金Supported by a project from Bureau of Public Health of Shanghai:2008 L 029 A
文摘Objective To explore the effect of heat-reinforcing acupuncture combined with Bobath rehabilita on training for the gross motor func on measurement（GMFM） in children with cerebral palsy. Methods Sixty cases of cerebral palsy were randomized into a heat-reinforcing acupuncture combined with rehabilitation training group（group A） and a rehabilitation group（group B）,30 cases in each group. Rehabilitation training was applied in group B and heat-reinforcing acupuncture was added in group A. Jiāji（夹脊 EX-B 2）,Jiānyú（肩髃 LI 15）,Qūchí（曲池 LI 11）,Hégi（合谷 LI 4）,Yánglíngquán（阳陵泉 GB 34）,Yīnlíngquán（阴陵泉 SP 9）,Xuánzhōng（悬钟 GB 39）,Zúsānli（足三里 ST 36）,Sānyīnjiāo（三阴交 SP 6）,Chéngshān（承山 BL 57）,Tài chōng（太冲 LR 3）,Tàixī（太溪 KI 3） and Shénmén（神门 HT 4） were chosen in group A and the heat-reinforcing acupuncture was applied once a day. For scalp acupuncture,Biihuì（百会 GV 20）,Sìshéncōng（四神聪 EX-HN 1）,Zhìsānzhēn（智三针）,Nǎosānzhēn（脑三针）,Nièsānzhēn（颞三针） and motor area（运动区） were punctured without any manipulation,once every other day,3 months as a treatment course and 2 courses were needed. GMFM were selected to assess the children with cerebral palsy before treatment,a er 3 months treatment and a er 6 months treatment. Results The total eff ec ve rate in group A was 70.00%（21/30）,which is superior to that of 60.00%（24/30） in group B（P0.05）. In group A,the GMFM scores of decubitus position and turn-over of body,creeping and kneeling,sitting,standing,walking,running and jumping after6 months treatment were significantly improved compared with that before treatment and after 3 months treatment（all P0.05）. In group B,above indices a er 6 months treatment were significantly improved compared with those before treatment,the standing score after 6 months treatment was significantly improved compared with that a er 3 months treatment（P0.05）; the GMFM scores of creeping,kneeling,sitting,standing,walking,running and jumping after 6 months treatment in group A were more significantly improved than that in group B（all P0.05）. Conclusion The heat-reinforcing acupuncture combined with Bobath rehabilita on training has a be er eff ect than rehabilitation training on the GMFM scores of creeping and kneeling,si ng,standing,walking,running and jumping of children with cerebral palsy. It can be shown that the combination of heat-reinforcing acupuncture and Bobath rehabilita on training can improve the gross motor func on of children with cerebral palsy.
基金the support of the US Department of State through Fulbright Scholar Grant 474/2009
文摘The paper approaches the problem of the command functions of galvanometer-based scanners （GS） that are necessary to produce the linear plus parabolic scanning function of the GS, which we have proved previously to produce the highest possible duty cycle （i.e., time efficiency） of the device. We have completed this theoretical aspect （which contradicted what has been stated previously in the literature, where it has been considered that the linear plus sinusoidal scanning function was the best） with the experimental study of the most used scanning functions of the GSs （sawtooth, sinusoidal and triangular）, with applications in biomedical imaging, in particular in optical coherence tomography, demonstrating that the triangular function is always the best one to be applied, from both an optical and a mechanical point of view. In the present study the input voltage/command function which should be applied to the GS to produce the desired triangular scanning function （with controlled non-linearity for the fastest possible stop-and-turn portions） was determined analytically, in relationship with the active torque that drives the device. This command function is analyzed with regard to the specific, respectively required parameters of the GS： natural frequency and damping factor, respectively scan speed and amplitude. The modeling in an open loop control structure of the GS is finally discussed as a trade-off between using the highest possible duty cycle and minimizing the maximum peaks of the input voltage.
文摘In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulati on of Erweikang at different doses and different time points was compared when n ormal saline and cyclophosphamide served as controls. The results showed that di fferent doses of Erweikang could effectively reverse the decreased induction lev els of NK, IL 2, γ IFN and the contents of TNF and IgG of the immunosu ppressive mice after administration of Erweikang for 7 to 14 days. It was sugges ted that compound polysaccharide Erweikang presents positive immune modulation i n dose and time dependent manners.
文摘To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients （1-17 years old） who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 （range, 2-7） days after surgery for 10 （range, 7-23） days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients＇s clinical symptoms have no influences on neurofunctional outcomes.
文摘With global integration going deeper,bilingualism has become a more social issue than a purely linguistic phenomenon.Over seas scholars have been studying in this field for a long time while in China,studies regarding bilingualism are still in its early stages.This pa per provides a historic review on the definition,categorization as well as its cognitive functions.Although it is still a question whether bilin gualism is an advantage or disadvantage to human beings' especially children's cognitive ability,this paper has concluded that early studies showed more negative results while recent research has shifted to a more positive attitude.
文摘Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction.
基金Supported by National Natural Science Foundation of China （60474002, 60674041） and National High Technology Research and Development Program of China （863 Program） （2006AA04Z173）
基金supported by the National Natural Science Foundation of China(82173796)the Research Project of Zhejiang Chinese Medical University(2023JKZDZC04).
文摘When teaching neurology students about epilepsy,selecting appropriate antiseizure medications(ASMs)based on seizure type is a fundamental objective.Carbamazepine(CBZ),a widely used first-line ASM,is effective against focal seizures,generalized tonic-clonic seizures,and mixed seizure patterns[1].However,CBZ paradoxically aggravates absence seizures,as demonstrated by increased 36 Hz spike-and-wave discharges(SWDs)in both patients and animal models[2,3].While prior studies implicated altered GABAA receptor function in the thalamic ventrobasal complex[4],the precise mechanisms remained unclear.Recently,an inspiring study published on PNAS by Jang et al.from Stanford University has highlighted the thalamic reticular nucleus(RT)as the key brain region responsible for CBZ's aggravating effect on absence seizures[5].The combination of transgenic mouse models,optogenetics,and detailed electrophysiology in the original study provided exceptional precision in probing mechanistic insights,which greatly strengthens the conclusions.
基金Supported in part by NSF of China,Key Project # 19331060
文摘We study a system(D)x’=F(t,x_t)of functional differential equations,together with a scalar equation(S)x’=-a(t)f(x)+b(t)g(x(t-h))as well as perturbed forms.A Liapunov functional is constructed which has a derivative of a nature that has been widely discussed in the literature. On the basis of this example we prove results for(D)on asymptotic stability and equi-boundedness.
文摘Two types of activated carbon, namely, Filtrasorb 400 and Nuchar SA, were functionalized by quaternary ammonium salts （quats）, as to enhance perchlorate adsorption. Results showed that the adsorption of quats on Nuchar SA increased with increase in chain length （hydrophobicity） of quats. Filtrasorb 400, however, had limited uptake of long-chain quats such as dodecyl- trimethylammonium and hexadecyltrimethylammoium （HDTMA）. Results indicated that perchlorate removal by the functionalized activated carbon was directly related to the chain length of the modifying quats. Perchlorate removal by functionalized activated carbon increased with increase in chain length of the modifying quats and became less pH-dependent. Modified Nuchar SA had higher overall perchlorate removal capacity than the modified Filtrasorb F400, but was more strongly affected by pH than Filtrasorb 400. Activated carbon treated with HDTMA exhibited the best perchlorate removal capacity among all quats studied. Results indicated that tailoring the activated carbon surface with HDTMA rendered the activated carbon surface positively charged, which resulted in substantial increase in perchlorate removal compared to unfunctionalized activated carbons.
文摘The mechanism of the reaction of Ni^+ (~2D) with ethane in the gas-phase wasstudied by using density functional theory. Both the B3LYP and BLYP functionals with standardall-electron basis sets are used to give the detailed information of the potential energy surface(PES) of [Ni, C_2, H_6]^+. The mechanisms forming the products CH_4 and H_2 in the reaction of Ni^+with ethane are proposed. The reductive eliminations of CH_4 and H_2 are typicaladdition-elimination reactions. Each of the two reactions consists of two elementary steps; C―C orC―H bond activations to form inserted species followed by isomerizations to form product-likeintermediate. The rate determining steps for the elimination reactions of forming CH_4 and H_2 arethe isomerizations of the inserted species rather than C―C or C―H bond activations. Theelimination reaction of forming H_2 was found to be thermodynamically favored compared to that ofCH_4.
基金Supported in part by the National Natural Science Foundation of China under Grant No.11126081,11101090,11401212 and 11471079the Fundamental Research Funds for the Central Universities under Grant No.WM1014032
文摘In this paper we consider infinite horizon backward doubly stochastic differential equations （BDS- DEs for short） coupled with forward stochastic differential equations, whose terminal functions are non-degenerate. For such kind of BDSDEs, we study the existence and uniqueness of their solutions taking values in weighted Lp（dx）¤L2（dx）space （p _〉 2）, and obtain the stationary property for the solutions.
基金supported by a Faculty Research Grant of Lehigh University
文摘In this paper, we consider a nonlinear system of reaction diffusion equa- tions arising from mathematical neuroscience and two nonlinear scalar reaction diffusion equations under some assumptions on their coefficients. The main purpose is to couple together linearized stability criterion （the equivalence of the nonlinear stability, the linear stability and the spectral sta- bility of the standing pulse solutions） and Evans functions to accomplish the existence and instability of standing pulse solutions of the nonlinear system of reaction diffusion equations and the nonlinear scalar reaction diffusion equa- tions. The Evans functions for the standing pulse solutions are constructed explicitly.
文摘目的探讨胰岛素强化疗法序贯司美格鲁肽治疗肥胖中青年T2DM患者的临床疗效及安全性。方法前瞻性选取2021年8月至2024年2月新乡医学院第一附属医院收治的120例肥胖中青年T2DM患者纳入研究,按随机数表法分为观察组和对照组各60例。两组患者均予以胰岛素泵强化降糖,待高血糖状态解除后,对照组序贯二甲双胍治疗,观察组于对照组基础上序贯司美格鲁肽治疗,治疗3个月。比较两组患者治疗前后的空腹血糖(FBG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、葡萄糖目标范围内时间(TIR)、体质量指数(BMI)、内脏脂肪指数(VAI)、胰岛β细胞功能[胰岛素抵抗指数(HOMA-IR)、空腹C肽、餐后1 h C肽、胰岛素敏感性检测指数(QUICKI)]、血脂[总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血清内酯素(Visfatin)、网膜素-1(omentin-1)、趋化素(Chemerin),同时比较两组患者治疗期间的不良反应发生情况。结果治疗后,观察组患者的FBG、2 hPG、HbA1c、BMI、VAI分别为(5.34±0.71)mmoL/L、(9.00±0.84)mmoL/L、(5.76±0.51)%、(24.26±0.35)kg/m^(2)、3.15±0.71,明显低于对照组的(6.02±0.56)mmoL/L、(11.35±1.01)mmoL/L、(6.28±0.40)%、(26.00±0.49)kg/m^(2)、3.54±0.64,TIR为(95.00±1.52)%,明显高于对照组的(88.46±3.71)%,差异均有统计学意义(P<0.05);治疗后,观察组患者的HOMA-IR为2.16±0.32,明显低于对照组的2.65±0.40,空腹C肽、餐后1 h C肽、QUICKI分别为(3.85±0.27)ng/mL、(7.64±0.43)ng/mL、0.52±0.13,明显高于对照组的(3.02±0.46)ng/mL、(6.02±0.38)ng/mL、0.41±0.10,差异均有统计学意义(P<0.05);治疗后,观察组患者的总胆固醇、甘油三酯、LDL-C、Vaspin、chemerin分别为(3.25±0.42)mmoL/L、(1.77±0.25)mmoL/L、(1.89±0.42)mmoL/L、(70.92±4.68)ng/L、(45.84±4.90)ng/L,明显低于对照组的(3.90±0.53)mmoL/L、(2.08±0.34)mmoL/L、(2.21±0.36)mmoL/L、(75.00±5.15)ng/L、(51.03±5.66)ng/L,HDL-C、omentin-1分别为(1.27±0.11)mmoL/L、(218.45±16.63)pg/mL,明显高于对照组的(1.19±0.13)mmoL/L、(149.60±15.35)pg/mL,差异均有统计学意义(P<0.05);治疗期间两组患者的不良反应总发生率比较差异无统计学意义(P>0.05)。结论胰岛素强化疗法序贯司美格鲁肽治疗肥胖中青年T2DM可降低患者血糖,恢复胰岛β细胞功能,调节血脂,减轻体质量,且安全性较高。
