Background Prevalence of neurocognitive disorder with Lewy bodies （NCDLB） is low in Asian populations, which may partially refect its diagnostic diffculty. The Mayo Fluctuations Scale, a short questionnaire that ev...Background Prevalence of neurocognitive disorder with Lewy bodies （NCDLB） is low in Asian populations, which may partially refect its diagnostic diffculty. The Mayo Fluctuations Scale, a short questionnaire that evaluates cognitive fuctuation, has been shown to signifcantly differentiate NCDLB from Alzheimer＇s disease.Aim This study aimed to develop the Mayo Fluctuations Scale-Thai version and assess its validity to screen NCDLB in an elderly population.Methods The Mayo Fluctuations Scale was translated into Thai. The process involved back-translation, cross-cultural adaptation, feld testing of the prefnal version, as well as fnal adjustments. From all patients attending the Psychiatric and Memory Clinic at Ramathibodi Hospital, 135 patients accompanied by their primary caregivers were included. Caregivers were interviewed by research assistants using a four-item scale, and psychiatrists determined patients＇ diagnosis based on the diagnostic and statistical manual of mental disorders （DSM）-5 criteria. Evaluations performed by psychiatrists and research assistants were blinded.Results Seventeen participants had been diagnosed with major NCDLB. At a cut-off score of 2 or over, the Mayo Fluctuations Scale exhibited excellent performance to differentiate major NCDLB from other major neurocognitive disorders （NCDs）, with a sensitivity of 94.1% and a specifcity of 71.4%, and acceptable performance to differentiate mild NCDLB from other mild NCDs, with a sensitivity of 60% and a specifcity of 93.1%.Conclusion The Mayo Fluctuations Scale-Thai version is an excellent screening tool for major NCDLB and an acceptable tool that may be used with other additional tests for mild NCDLB. The tool is practical for use in memory and psychiatric clinics. Further validation studies in participants with other specifc clinical conditions are required.展开更多
Of the total area of the Yangtze Basin(1,280,000.square km.),400,000 sq,km.or one third lies in Szechwan.The river also receives within the province four of its eleven main tributaries:the Min,the Tou,the Kialing and ...Of the total area of the Yangtze Basin(1,280,000.square km.),400,000 sq,km.or one third lies in Szechwan.The river also receives within the province four of its eleven main tributaries:the Min,the Tou,the Kialing and the Ch'ien.In view or the absencd of railway transportation these rivers form the chieftrade routes besides the newly built highways in spite of the fact that they are often seriously hindered by local rapids and the wide scasonal fuctuations of water level.展开更多
Structural change in panel data is a widespread phenomena. This paper proposes a fluctuation test to detect a structural change at an unknown date in heterogeneous panel data models with or without common correlated e...Structural change in panel data is a widespread phenomena. This paper proposes a fluctuation test to detect a structural change at an unknown date in heterogeneous panel data models with or without common correlated effects. The asymptotic properties of the fluctuation statistics in two cases are developed under the null and local alternative hypothesis. Furthermore, the consistency of the change point estimator is proven. Monte Carlo simulation shows that the fluctuation test can control the probability of type I error in most cases, and the empirical power is high in case of small and moderate sample sizes. An application of the procedure to a real data is presented.展开更多
Background Dehydration of plant tissues caused by water stress affects the dynamics of the lateral cambium, the rate of cell division and differentiation in cell lumen size, wall thickness and wall chemical properties...Background Dehydration of plant tissues caused by water stress affects the dynamics of the lateral cambium, the rate of cell division and differentiation in cell lumen size, wall thickness and wall chemical properties. Based on evidence that ongoing climate change projects longer and more intense water stress conditions, forest dynam-ics and decline are predicted to be affected by increases in drought intensity and frequency. To verify the interaction of these phenomena, we described the modifications in the anatomy and mineral contents of annual growth rings of Araucaria araucana seedlings subjected to water stress treatments, using X-ray densitometry and X-ray fluores-cence techniques.Results Severe water stress conditions during the growing period produced narrower tree rings, with reduced cell lumen size(5–7 μm) and higher tracheid reinforcement factor values, but with lower wood density. Plants subjected to moderate water stress generated intra-annual density fluctuations coinciding with periods of decreased soil moisture. Under the precept that the essential nutrients play a relevant role in the functioning of trees, we found evidence of element allocation and concentration in response to drought. Calcium and phosphorus concentration increased significantly as stress becomes more severe, but with small differences between early- and latewood. On the contrary, potassium and sulfur presented lower values in the most stressed plants, and manganese had the lowest values only for moderate water stress. Finally, S/Ca and K/Ca molar ratios decreased, while Ca/Mn increased as stress becomes more severe.Conclusions Our findings suggested that A. araucana seedlings invested resources aimed at increasing structural components of the cell wall to prevent cavitation. This would maintain metabolism and cell growth even in unfavora-ble environmental conditions. Furthermore, the imbalance of manganese and calcium and their consequent ratio(Ca/Mn) could be linked to early adaptive signals to avoid dieback.展开更多
基金funded by a grant from the Faculty of MedicineRamathibodi Hospital,Mahidol University,Bangkok,Thailand
文摘Background Prevalence of neurocognitive disorder with Lewy bodies （NCDLB） is low in Asian populations, which may partially refect its diagnostic diffculty. The Mayo Fluctuations Scale, a short questionnaire that evaluates cognitive fuctuation, has been shown to signifcantly differentiate NCDLB from Alzheimer＇s disease.Aim This study aimed to develop the Mayo Fluctuations Scale-Thai version and assess its validity to screen NCDLB in an elderly population.Methods The Mayo Fluctuations Scale was translated into Thai. The process involved back-translation, cross-cultural adaptation, feld testing of the prefnal version, as well as fnal adjustments. From all patients attending the Psychiatric and Memory Clinic at Ramathibodi Hospital, 135 patients accompanied by their primary caregivers were included. Caregivers were interviewed by research assistants using a four-item scale, and psychiatrists determined patients＇ diagnosis based on the diagnostic and statistical manual of mental disorders （DSM）-5 criteria. Evaluations performed by psychiatrists and research assistants were blinded.Results Seventeen participants had been diagnosed with major NCDLB. At a cut-off score of 2 or over, the Mayo Fluctuations Scale exhibited excellent performance to differentiate major NCDLB from other major neurocognitive disorders （NCDs）, with a sensitivity of 94.1% and a specifcity of 71.4%, and acceptable performance to differentiate mild NCDLB from other mild NCDs, with a sensitivity of 60% and a specifcity of 93.1%.Conclusion The Mayo Fluctuations Scale-Thai version is an excellent screening tool for major NCDLB and an acceptable tool that may be used with other additional tests for mild NCDLB. The tool is practical for use in memory and psychiatric clinics. Further validation studies in participants with other specifc clinical conditions are required.
文摘Of the total area of the Yangtze Basin(1,280,000.square km.),400,000 sq,km.or one third lies in Szechwan.The river also receives within the province four of its eleven main tributaries:the Min,the Tou,the Kialing and the Ch'ien.In view or the absencd of railway transportation these rivers form the chieftrade routes besides the newly built highways in spite of the fact that they are often seriously hindered by local rapids and the wide scasonal fuctuations of water level.
基金supported by the National Natural Science Foundation of China under Grant Nos. 11801438,12161072 and 12171388the Natural Science Basic Research Plan in Shaanxi Province of China under Grant No. 2023-JC-YB-058the Innovation Capability Support Program of Shaanxi under Grant No. 2020PT-023。
文摘Structural change in panel data is a widespread phenomena. This paper proposes a fluctuation test to detect a structural change at an unknown date in heterogeneous panel data models with or without common correlated effects. The asymptotic properties of the fluctuation statistics in two cases are developed under the null and local alternative hypothesis. Furthermore, the consistency of the change point estimator is proven. Monte Carlo simulation shows that the fluctuation test can control the probability of type I error in most cases, and the empirical power is high in case of small and moderate sample sizes. An application of the procedure to a real data is presented.
基金supported by Consejo Nacional de Investigaciones Cientí‑fcas y Técnicas(CONICET,Argentina)through a doctoral fellowship to Sofía Papúand a project funded by the Agencia Nacional de Promoción Científca y Tecnológica(PICT-2679)and the program Bosques Andinos-HELVETAS Swiss IntercooperationThis research is a contribution to the NSF-FAPESP PIRE pro‑ject grants 2009/53951-7,2017/50085-3,2018/22914-8,2020/04608-7.
文摘Background Dehydration of plant tissues caused by water stress affects the dynamics of the lateral cambium, the rate of cell division and differentiation in cell lumen size, wall thickness and wall chemical properties. Based on evidence that ongoing climate change projects longer and more intense water stress conditions, forest dynam-ics and decline are predicted to be affected by increases in drought intensity and frequency. To verify the interaction of these phenomena, we described the modifications in the anatomy and mineral contents of annual growth rings of Araucaria araucana seedlings subjected to water stress treatments, using X-ray densitometry and X-ray fluores-cence techniques.Results Severe water stress conditions during the growing period produced narrower tree rings, with reduced cell lumen size(5–7 μm) and higher tracheid reinforcement factor values, but with lower wood density. Plants subjected to moderate water stress generated intra-annual density fluctuations coinciding with periods of decreased soil moisture. Under the precept that the essential nutrients play a relevant role in the functioning of trees, we found evidence of element allocation and concentration in response to drought. Calcium and phosphorus concentration increased significantly as stress becomes more severe, but with small differences between early- and latewood. On the contrary, potassium and sulfur presented lower values in the most stressed plants, and manganese had the lowest values only for moderate water stress. Finally, S/Ca and K/Ca molar ratios decreased, while Ca/Mn increased as stress becomes more severe.Conclusions Our findings suggested that A. araucana seedlings invested resources aimed at increasing structural components of the cell wall to prevent cavitation. This would maintain metabolism and cell growth even in unfavora-ble environmental conditions. Furthermore, the imbalance of manganese and calcium and their consequent ratio(Ca/Mn) could be linked to early adaptive signals to avoid dieback.
