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A Generalized Frontogenesis Function and Its Application 被引量:16
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作者 YANG Shuai GAO Shouting LU Chungu 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2014年第5期1065-1078,共14页
With the definition of generalized potential temperature, a new generalized frontogenesis function, which is expressed as the Lagrangian change rate of the magnitude of the horizontal generalized potential temperature... With the definition of generalized potential temperature, a new generalized frontogenesis function, which is expressed as the Lagrangian change rate of the magnitude of the horizontal generalized potential temperature gradient, is derived. Such a frontogenesis function is more appropriate for a real moist atmosphere because it can reflect frontogenesis processes, in which the atmosphere in a frontal zone is typically characterized by neither completely dry nor uniform saturation. Furthermore, by derivation, the expression of generalized frontogenesis function includes both temperature and humidity gradients, which is different from and superior to the traditional frontogenesis function in moist processes, which also uses equivalent potential temperature. Diagnostic studies of real cases are performed and show that the generalized frontogenesis function in non- uniformly saturated moist atmosphere indeed provides a useful tool for frontogenesis, compared to using the traditional frontogenesis function. The new frontogenesis function can be used in situations involving either a strong temperature or moisture gradient and is closely correlated with precipitation. 展开更多
关键词 frontogenesis diagnostic analysis case study
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抗肿瘤药物伴随诊断试剂临床试验设计探究及案例分析
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作者 徐超 方丽 +1 位作者 李冉 吕允凤 《中国药事》 CAS 2024年第1期66-70,共5页
目的:系统阐述我国伴随诊断试剂临床试验设计原则,为相关伴随诊断试剂产品临床试验提供参考。方法:基于不同伴随诊断试剂的开发模式,介绍我国与抗肿瘤药物同步开发的原研伴随诊断试剂及非原研伴随诊断试剂的临床试验设计,结合相关产品... 目的:系统阐述我国伴随诊断试剂临床试验设计原则,为相关伴随诊断试剂产品临床试验提供参考。方法:基于不同伴随诊断试剂的开发模式,介绍我国与抗肿瘤药物同步开发的原研伴随诊断试剂及非原研伴随诊断试剂的临床试验设计,结合相关产品技术审评过程中的考虑,深入分析伴随诊断试剂临床试验设计的科学性与合理性。结果与结论:伴随诊断试剂在抗肿瘤药物临床应用中具有非常重要的作用,伴随诊断试剂的临床试验与抗肿瘤药物的临床试验息息相关,该类产品临床试验有多种设计类型,临床试验主要研究者应结合产品开发模式、产品检测的标志物等具体情况,选择合适的临床试验设计,能够更加科学合理地评价产品临床意义,促进产品尽快上市。 展开更多
关键词 伴随诊断试剂 开发模式 临床试验设计 桥接试验 案例分析
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