The free-surface vortex is a rotational flow phenomenon characterized by two-phase coupling,formed by the rupture of surface fluid in the final stage of discharge.It is a significant concept with broad applications in...The free-surface vortex is a rotational flow phenomenon characterized by two-phase coupling,formed by the rupture of surface fluid in the final stage of discharge.It is a significant concept with broad applications in engineering fields like metallurgy and hydraulics.The basic concepts and characteristics of free-surface vortices were introduced,and their hazards in various fields were discussed.The development of theoretical and numerical models over recent decades was reviewed,and the factors affecting vortex formation and existing suppression methods were outlined.Finally,the key challenges and focus areas on the study of free-surface vortex were summarized.With the ongoing advancements in computational fluid dynamics and experimental technology,research on free-surface vortices will become more in depth and precise.Additionally,interdisciplinary cooperation and technological innovation are expected to achieve precise control and optimal design of free-surface vortices,offering more efficient and sustainable solutions for metallurgy and related engineering fields.展开更多
Multiple suppression is an important element of marine seismic data processing.Intelligent suppression of multiples us-ing artificial intelligence reduces labor costs,minimizes dependence on unknown prior information,...Multiple suppression is an important element of marine seismic data processing.Intelligent suppression of multiples us-ing artificial intelligence reduces labor costs,minimizes dependence on unknown prior information,and improves data processing ef-ficiency.In this study,we propose an intelligent method for suppressing marine seismic multiples using deep learning approaches.The proposed method enables the intelligent suppression of free-surface-related multiples from seismic records.Initially,we construct a multi-category marine seismic multiple dataset through finite difference forward modeling under different boundary conditions.We use various models and data augmentation methods,including sample rotation,noise addition,and random channel omission.Then,we apply depthwise separable convolution to develop our deep learning Mobilenet-Unet model.The Mobilenet-Unet framework sig-nificantly reduces the number of operations required for multiple elimination without sacrificing model performance,ultimately reali-zing the optimal multiple suppression model.The trained Mobilenet-Unet is applied to the test set for verification.Moreover,to deter-mine its generalization ability,it is implemented to seismic records containing multiples generated by two marine geophysical models that were not included in the training process.The performance of Mobilenet-Unet is also compared with that of different network structures.The results indicate that,despite its small size,our proposed Mobilenet-Unet deep learning model can rapidly and effective-ly separate multiples in marine seismic data,possessing reasonable generalization ability.展开更多
The deep convolutional neural network U-net has been introduced into adaptive subtraction, which is a critical step in effectively suppressing seismic multiples. The U-net approach has higher precision than the tradit...The deep convolutional neural network U-net has been introduced into adaptive subtraction, which is a critical step in effectively suppressing seismic multiples. The U-net approach has higher precision than the traditional linear regression approach. However, the existing 2D U-net approach with 2D data windows can not deal with elaborate discrepancies between the actual and simulated multiples along the gather direction. It may lead to erroneous preservation of primaries or generate obvious vestigial multiples, especially in complex media. To further enhance the multiple suppression accuracy, we present an adaptive subtraction approach utilizing 3D U-net architecture, which can adaptively separate primaries and multiples utilizing 3D windows. The utilization of 3D windows allows for enhanced depiction of spatial continuity and anisotropy of seismic events along the gather direction in comparison to 2D windows. The 3D U-net approach with 3D windows can more effectively preserve the continuity of primaries and manage the complex disparities between the actual and simulated multiples. The proposed 3D U-net approach exhibits 1 dB improvement in the signal-to-noise ratio compared to the 2D U-net approach, as observed in the synthesis data section, and exhibits more outstanding performance in the preservation of primaries and removal of residual multiples in both synthesis and reality data sections. Moreover, to expedite network training in our proposed 3D U-net approach we employ the transfer learning (TL) strategy by utilizing the network parameters of 3D U-net estimated in the preceding data segment as the initial network parameters of 3D U-net for the subsequent data segment. In the reality data section, the 3D U-net approach incorporating TL reduces the computational expense by 70% compared to the one without TL.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte...BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.展开更多
In this research, we present a seismic trace interpolation method which uses seismic data with surface-related multiples. It is different from conventional seismic data interpolation using information transformation o...In this research, we present a seismic trace interpolation method which uses seismic data with surface-related multiples. It is different from conventional seismic data interpolation using information transformation or extrapolation of adjacent channels for reconstruction of missing seismic data. In this method there are two steps, first, we construct pseudo-primaries by cross-correlation of surface multiple data to extract the missing near- offset information in multiples, which are not displayed in the acquired seismic record. Second, we correct the pseudo-primaries by applying a Least-squares Matching Filter （LMF） and RMS amplitude correction method in time and space sliding windows. Then the corrected pseudo-primaries can be used to fill the data gaps. The method is easy to implement, without the need to separate multiples and primaries. It extracts the seismic information contained by multiples for filling missing traces. The method is suitable for seismic data with surfacerelated multiples.展开更多
With a target treated as the incompressible Tresca and Mohr-Coulomb material, by assuming that cavity expansion produces plastic-elastic and plastic-cracked-elastic response region, the decay function for the free-sur...With a target treated as the incompressible Tresca and Mohr-Coulomb material, by assuming that cavity expansion produces plastic-elastic and plastic-cracked-elastic response region, the decay function for the free-surface effect is constructed for metal and geological tar- gets, respectively. The forcing function for oblique penetration and perforation is obtained by multiplying the forcing function derived on the basis of infinite target assumption with the de- cay function. Then the projectile is modeled with an explicit transient dynamic finite element code and the target is represented by the forcing function as the pressure boundary condition. This methodology eliminates discretizing the target as well as the need for a complex contact algorithm and is implemented in ABAQUS explicit solver via the user subroutine VDLOAD. It is found that the free-surface effect must be considered in terms of the projectile deformation, residual velocity, projectile trajectory, ricochet limits and critical reverse velocity. The numerical predictions are in good agreement with the available experimental data if the free-surface effect is taken into account.展开更多
This paper investigates the hydrodynamic performance of a cylindrical-dual or rectangular-single pontoon floating breakwater using the numerical method and experimental study. The numerical simulation work is based on...This paper investigates the hydrodynamic performance of a cylindrical-dual or rectangular-single pontoon floating breakwater using the numerical method and experimental study. The numerical simulation work is based on the multi-physics computational fluid dynamics(CFD) code and an innovative full-structured dynamic grid method applied to update the three-degree-of-freedom(3-DOF) rigid structure motions. As a time-marching scheme, the trapezoid analogue integral method is used to update the time integration combined with remeshing at each time step.The application of full-structured mesh elements can prevent grids distortion or deformation caused by large-scale movement and improve the stability of calculation. In movable regions, each moving zone is specified with particular motion modes(sway, heave and roll). A series of experimental studies are carried out to validate the performance of the floating body and verify the accuracy of the proposed numerical model. The results are systematically assessed in terms of wave coefficients, mooring line forces, velocity streamlines and the 3-DOF motions of the floating breakwater. When compared with the wave coefficient solutions, excellent agreements are achieved between the computed and experimental data, except in the vicinity of resonant frequency. The velocity streamlines and wave profile movement in the fluid field can also be reproduced using this numerical model.展开更多
The attenuation of prestack internal multiples based on virtual seismic events is computationally costly and hinders seismic data processing. We propose a multiples attenuation method for poststack seismic data by app...The attenuation of prestack internal multiples based on virtual seismic events is computationally costly and hinders seismic data processing. We propose a multiples attenuation method for poststack seismic data by approximating conventional virtual events. The proposed method is iterative. The proposed method is tested using 2D synthetic and the field poststack seismic datasets. Compared with the conventional virtual events method, the proposed method does not require data regularization and offers higher computation efficiency. The method requires to know the travel time of the primary reflection waves. The results of the application to 2D field datasets suggest that the proposed method attenuates the internal multiples while highlighting the deep primaries.展开更多
Based on the complex dispersion relation for the two-dimensional free-surface waves generated by a moving body in the steady Oseen flows, the effect of viscosity on wavelength and wave amplitude was investigated by me...Based on the complex dispersion relation for the two-dimensional free-surface waves generated by a moving body in the steady Oseen flows, the effect of viscosity on wavelength and wave amplitude was investigated by means of an asymptotic method and a numerical analysis. A comparison between the asymptotic and numerical analysis for the viscous decay factor demonstrates the validity of the perturbation expansions for the wave profile. The numerical result shows that the wavelength of viscous wave is slightly elongated in comparison with that of inviscid wave.展开更多
Surface-related multiples frequently propagate into the subsurface and contain abundant information on small reflection angles.Compared with the conventional migration of primaries,migration of multiples offers comple...Surface-related multiples frequently propagate into the subsurface and contain abundant information on small reflection angles.Compared with the conventional migration of primaries,migration of multiples offers complementary illumination and a higher vertical resolution.However,crosstalk artifacts caused by unrelated multiples during reverse time migration(RTM)using multiples severely degrade the reliability and interpretation of the final migration images.Therefore,we proposed RTM using first-order receiver-side water-bottom-related multiples for eliminating crosstalk artifacts and enhancing vertical resolution.We first backward propagate the first-order receiver-side water-bottom-related multiples using a water-layer model,followed by saving the upper boundary wavefield.Then we produce the source wavefield using a seismic wavelet and the receiver wavefield by back-extrapolating the saved boundary.Finally,the cross-correlation imaging condition is applied to generate the final image.This method transforms the receiver-side multiples into primaries,followed by the conventional migration processing procedures.Numerical examples using synthetic datasets demonstrate that our method significantly enhances the imaging quality by eliminating crosstalk artifacts and improving the resolution.展开更多
In marine seismic exploration,especially in deep-water and hard ocean-bottom cases,free-surface multiples are strongly developed.Compared with primary waves,the wider illumination aperture of the multiples is benefici...In marine seismic exploration,especially in deep-water and hard ocean-bottom cases,free-surface multiples are strongly developed.Compared with primary waves,the wider illumination aperture of the multiples is beneficial for high-resolution seismic imaging.In this study,by introducing a new compound source composed of primaries and free-surface multiples and by ignoring internal multiples,we derive a new linearized forward problem(free-surface-multiple prediction model)under a weak-scattering assumption(i.e.,first-order Born approximation).On the basis of the new linearized problem,we propose a joint inversion-imaging method by simultaneously using the primaries and free-surface multiples under the general framework of least square inversion.To eliminate the crosstalk artifacts introduced by the cross-correlation of multiples with different orders,we prove that the crosstalk artifacts can be gradually eliminated during the inversion if a proper step length is selected.Synthetic-andfield-data tests demonstrate the effectiveness of the proposed method.展开更多
In practical seismic exploration, internal multiples generated when the wave impedance of medium is strong, and seismic records are recorded. The method of virtual event repress internal multiples is to move scattered...In practical seismic exploration, internal multiples generated when the wave impedance of medium is strong, and seismic records are recorded. The method of virtual event repress internal multiples is to move scattered points from underground to the surface, similar to the method of the surface-related multiple elimination (SRME). The method of SRME belongs to the prediction-subtraction approaches to eliminate internal multiples, prediction method is based on building a brand new way of seismic wave propagation (virtual reflection and virtual event), so that it has forward and backward wave propagation, and through convolution with significant wave to predict the internal multiples. Due to required data needing field information of full-wave, the authors use Seislet transform interpolating the missing data to ensure the premise of internal multiples prediction. The test data show that the above method has achieved good results.展开更多
A rotating stopper-rod technique was proposed to suppress the formation of free-surface vortex in the tundish.The large eddy simulation model coupled with volume of fluid model was developed to study the steel–slag–...A rotating stopper-rod technique was proposed to suppress the formation of free-surface vortex in the tundish.The large eddy simulation model coupled with volume of fluid model was developed to study the steel–slag–gas three-phase flow behavior.The critical slag entrapment height of the free-surface vortex and mass of residual steel were predicted at different rotating speeds(30,60,90 and 120 r/min)of the rotating stopper-rod.The numerical model was verified by water model experiment.The results showed that by rotating the stopper-rod in the opposite direction of the vortex above the submerged entry nozzle,the formation of vortex can be effectively disturbed and the critical height of the free-surface vortex can be reduced.Particularly for the 2nd strand,when the rotating speeds are 30,60,90 and 120 r/min,the critical height of the free-surface vortex above the 2nd strand is 7.3,4.7,6.3 and 7.4 cm,respectively.A reasonable rotating speed should be 60 r/min,which can reduce about 2 tons of residual steel.Other rotating speeds just can reduce about 1.6 tons of residual steel.展开更多
A doublet integral equation is formulated for the two-dimensional dissipative potential flow around a hydrofoil submerged below a free-water surface. The free-water surface is assumed to involve energy dissipation, an...A doublet integral equation is formulated for the two-dimensional dissipative potential flow around a hydrofoil submerged below a free-water surface. The free-water surface is assumed to involve energy dissipation, and thus it is the source of damping. A doublet panel method is developed from incorporation of the dissipative Green function approach and the doublet distributions on the hydrofoil surface. Numerical computations are implemented, and the derived numerical results are in good agreement with analytic solutions and experimental measurements.展开更多
A new three-dimensional fundamental solution to the Stokes flow was proposed by transforming the solid harmonic functions in Lamb's solution into expressions in terms Of the oblate spheroidal coordinates. These fu...A new three-dimensional fundamental solution to the Stokes flow was proposed by transforming the solid harmonic functions in Lamb's solution into expressions in terms Of the oblate spheroidal coordinates. These fundamental solutions are advantageous in treating flows past an arbitrary number of arbitrarily positioned and oriented oblate spheroids. The least squares technique was adopted herein so that the convergence difficulties often encountered in solving three-dimensional problems were completely avoided. The examples demonstrate that present approach is highly accurate, consistently stable and computationally efficient. The oblate spheroid may be used to model a variety of particle shapes between a circular disk and a sphere. For the first time, the effect of various geometric factors on the forces and torques exerted on two oblate spheroids were systematically studied by using the proposed fundamental solutions. The generality of this approach was illustrated by two problems of three spheroids.展开更多
Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple rol...Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.展开更多
The Hartree-Fock equation is non-linear and has, in principle, multiple solutions. The ωth HF extreme and its associated virtual spin-orbitals furnish an orthogonal base Bω of the full configuration interaction spac...The Hartree-Fock equation is non-linear and has, in principle, multiple solutions. The ωth HF extreme and its associated virtual spin-orbitals furnish an orthogonal base Bω of the full configuration interaction space. Although all Bω bases generate the same CI space, the corresponding configurations of each Bω base have distinct quantum-mechanical information contents. In previous works, we have introduced a multi-reference configuration interaction method, based on the multiple extremes of the Hartree-Fock problem. This method was applied to calculate the permanent electrical dipole and quadrupole moments of some small molecules using minimal and double, triple and polarized double-zeta bases. In all cases were possible, using a reduced number of configurations, to obtain dipole and quadrupole moments in close agreement with the experimental values and energies without compromising the energy of the state function. These results show the positive effect of the use of the multi-reference Hartree-Fock bases that allowed a better extraction of quantum mechanical information from the several Bω bases. But to extend these ideas for larger systems and atomic bases, it is necessary to develop criteria to build the multireference Hartree-Fock bases. In this project, we are beginning a study of the non-uniform distribution of quantum-mechanical information content of the Bω bases, searching identify the factors that allowed obtain the good results cited展开更多
The theoretical relationship between water injection multiple(i.e.injected pore volume)and water saturation is inferred from theoretical concepts of reservoir engineering.A mathematical model based on core displacemen...The theoretical relationship between water injection multiple(i.e.injected pore volume)and water saturation is inferred from theoretical concepts of reservoir engineering.A mathematical model based on core displacement tests is established for the entire injection process that satisfies both initial displacement and extreme displacement,simultaneously.The results show that prior to the flooding,the water injection multiple has a linear relationship with the water saturation,and the utilization rate of the injected water is the highest.As water breakthrough at the production end,the water-cut increases,and the injection multiple increases exponentially while the utilization efficiency of the injected water gradually decreases.When the injection multiple approaches infinity,the utilization efficiency of the injected water gradually decreases to 0,by which time the water-cut at the production end is always 1.At this time,the water saturation no longer changes,and the water flooding recovery rate reaches its limit.Based on the experimental test data,a mathematical model of the entire process of injection multiple and water saturation is established,which has high fitting accuracy that can predict the injection multiple in the different stages of development of a mature oil reservoir.The dynamically changing index of the injection water utilization efficiency in reservoir development by reactive water flooding can be obtained through reasonable transformation of the mathematical model.This is of great significance in guiding evaluations of the effects of reservoir development and formulating countermeasures.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52474339)Anhui Province Outstanding Research and Innovation Team in Higher Education Institutions(Grant No.2022AH010024).
文摘The free-surface vortex is a rotational flow phenomenon characterized by two-phase coupling,formed by the rupture of surface fluid in the final stage of discharge.It is a significant concept with broad applications in engineering fields like metallurgy and hydraulics.The basic concepts and characteristics of free-surface vortices were introduced,and their hazards in various fields were discussed.The development of theoretical and numerical models over recent decades was reviewed,and the factors affecting vortex formation and existing suppression methods were outlined.Finally,the key challenges and focus areas on the study of free-surface vortex were summarized.With the ongoing advancements in computational fluid dynamics and experimental technology,research on free-surface vortices will become more in depth and precise.Additionally,interdisciplinary cooperation and technological innovation are expected to achieve precise control and optimal design of free-surface vortices,offering more efficient and sustainable solutions for metallurgy and related engineering fields.
基金supported by the Key Laboratory of Ma-rine Mineral Resources,Ministry of Natural Resources,Guangzhou(No.KLMMR-2022-G09)the Guangzhou Ba-sic Research Program-Basic and Basic Applied Research Project(No.2023A04J0917)the PI Project of South-ern Marine Science and Engineering Guangdong Labora-tory(Guangzhou)(No.GML2020GD0802).
文摘Multiple suppression is an important element of marine seismic data processing.Intelligent suppression of multiples us-ing artificial intelligence reduces labor costs,minimizes dependence on unknown prior information,and improves data processing ef-ficiency.In this study,we propose an intelligent method for suppressing marine seismic multiples using deep learning approaches.The proposed method enables the intelligent suppression of free-surface-related multiples from seismic records.Initially,we construct a multi-category marine seismic multiple dataset through finite difference forward modeling under different boundary conditions.We use various models and data augmentation methods,including sample rotation,noise addition,and random channel omission.Then,we apply depthwise separable convolution to develop our deep learning Mobilenet-Unet model.The Mobilenet-Unet framework sig-nificantly reduces the number of operations required for multiple elimination without sacrificing model performance,ultimately reali-zing the optimal multiple suppression model.The trained Mobilenet-Unet is applied to the test set for verification.Moreover,to deter-mine its generalization ability,it is implemented to seismic records containing multiples generated by two marine geophysical models that were not included in the training process.The performance of Mobilenet-Unet is also compared with that of different network structures.The results indicate that,despite its small size,our proposed Mobilenet-Unet deep learning model can rapidly and effective-ly separate multiples in marine seismic data,possessing reasonable generalization ability.
基金supported by National Natural Science Foundation of China(42364008,41804110)in part by Guizhou Provincial Basic Research Program(Natural Science)(ZK[2022]060)+1 种基金in part by China Postdoctoral Science Foundation(2022M723127)in part by Youth Innovation Team Project of Shandong Provincial Education Department(2022KJ141).
文摘The deep convolutional neural network U-net has been introduced into adaptive subtraction, which is a critical step in effectively suppressing seismic multiples. The U-net approach has higher precision than the traditional linear regression approach. However, the existing 2D U-net approach with 2D data windows can not deal with elaborate discrepancies between the actual and simulated multiples along the gather direction. It may lead to erroneous preservation of primaries or generate obvious vestigial multiples, especially in complex media. To further enhance the multiple suppression accuracy, we present an adaptive subtraction approach utilizing 3D U-net architecture, which can adaptively separate primaries and multiples utilizing 3D windows. The utilization of 3D windows allows for enhanced depiction of spatial continuity and anisotropy of seismic events along the gather direction in comparison to 2D windows. The 3D U-net approach with 3D windows can more effectively preserve the continuity of primaries and manage the complex disparities between the actual and simulated multiples. The proposed 3D U-net approach exhibits 1 dB improvement in the signal-to-noise ratio compared to the 2D U-net approach, as observed in the synthesis data section, and exhibits more outstanding performance in the preservation of primaries and removal of residual multiples in both synthesis and reality data sections. Moreover, to expedite network training in our proposed 3D U-net approach we employ the transfer learning (TL) strategy by utilizing the network parameters of 3D U-net estimated in the preceding data segment as the initial network parameters of 3D U-net for the subsequent data segment. In the reality data section, the 3D U-net approach incorporating TL reduces the computational expense by 70% compared to the one without TL.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
基金Supported by Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2023MSXM060.
文摘BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.
基金sponsored by:the National Basic Research Program of China (973 Program) (2007CB209605)the National Natural Science Foundation of China (40974073)the National Hi-tech Research and Development Program of China (863 Program) (2009AA06Z206)
文摘In this research, we present a seismic trace interpolation method which uses seismic data with surface-related multiples. It is different from conventional seismic data interpolation using information transformation or extrapolation of adjacent channels for reconstruction of missing seismic data. In this method there are two steps, first, we construct pseudo-primaries by cross-correlation of surface multiple data to extract the missing near- offset information in multiples, which are not displayed in the acquired seismic record. Second, we correct the pseudo-primaries by applying a Least-squares Matching Filter （LMF） and RMS amplitude correction method in time and space sliding windows. Then the corrected pseudo-primaries can be used to fill the data gaps. The method is easy to implement, without the need to separate multiples and primaries. It extracts the seismic information contained by multiples for filling missing traces. The method is suitable for seismic data with surfacerelated multiples.
基金Project supported by the National Natural Science Foundations of China(Nos.51321064,51178461 and 51378015)
文摘With a target treated as the incompressible Tresca and Mohr-Coulomb material, by assuming that cavity expansion produces plastic-elastic and plastic-cracked-elastic response region, the decay function for the free-surface effect is constructed for metal and geological tar- gets, respectively. The forcing function for oblique penetration and perforation is obtained by multiplying the forcing function derived on the basis of infinite target assumption with the de- cay function. Then the projectile is modeled with an explicit transient dynamic finite element code and the target is represented by the forcing function as the pressure boundary condition. This methodology eliminates discretizing the target as well as the need for a complex contact algorithm and is implemented in ABAQUS explicit solver via the user subroutine VDLOAD. It is found that the free-surface effect must be considered in terms of the projectile deformation, residual velocity, projectile trajectory, ricochet limits and critical reverse velocity. The numerical predictions are in good agreement with the available experimental data if the free-surface effect is taken into account.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51579122,51609109,and 51622902)the Natural Science Found of Jiangsu Province(Grant No.BK20160556)+1 种基金the University Natural Science Research Project of Jiangsu Province(Grant No.16kjb70003)the Key Lab Foundation for Advanced Manufacturing Technology of Jiangsu Province(Grant No.CJ1506)
文摘This paper investigates the hydrodynamic performance of a cylindrical-dual or rectangular-single pontoon floating breakwater using the numerical method and experimental study. The numerical simulation work is based on the multi-physics computational fluid dynamics(CFD) code and an innovative full-structured dynamic grid method applied to update the three-degree-of-freedom(3-DOF) rigid structure motions. As a time-marching scheme, the trapezoid analogue integral method is used to update the time integration combined with remeshing at each time step.The application of full-structured mesh elements can prevent grids distortion or deformation caused by large-scale movement and improve the stability of calculation. In movable regions, each moving zone is specified with particular motion modes(sway, heave and roll). A series of experimental studies are carried out to validate the performance of the floating body and verify the accuracy of the proposed numerical model. The results are systematically assessed in terms of wave coefficients, mooring line forces, velocity streamlines and the 3-DOF motions of the floating breakwater. When compared with the wave coefficient solutions, excellent agreements are achieved between the computed and experimental data, except in the vicinity of resonant frequency. The velocity streamlines and wave profile movement in the fluid field can also be reproduced using this numerical model.
基金supported by the National Natural Science Foundation of China(No.41674122)National Science and Technology Major Project of China(No.2016ZX05004003)National Basic Research Program of China(No.2013CB228602)
文摘The attenuation of prestack internal multiples based on virtual seismic events is computationally costly and hinders seismic data processing. We propose a multiples attenuation method for poststack seismic data by approximating conventional virtual events. The proposed method is iterative. The proposed method is tested using 2D synthetic and the field poststack seismic datasets. Compared with the conventional virtual events method, the proposed method does not require data regularization and offers higher computation efficiency. The method requires to know the travel time of the primary reflection waves. The results of the application to 2D field datasets suggest that the proposed method attenuates the internal multiples while highlighting the deep primaries.
文摘Based on the complex dispersion relation for the two-dimensional free-surface waves generated by a moving body in the steady Oseen flows, the effect of viscosity on wavelength and wave amplitude was investigated by means of an asymptotic method and a numerical analysis. A comparison between the asymptotic and numerical analysis for the viscous decay factor demonstrates the validity of the perturbation expansions for the wave profile. The numerical result shows that the wavelength of viscous wave is slightly elongated in comparison with that of inviscid wave.
基金partially funded by the National Natural Science Foundation of China(Grant No.41730425)the Special Fund of the Institute of Geophysics,China Earthquake Administration(Grant No.DQJB20K42)the Institute of Geology and Geophysics,Chinese Academy of Sciences Project(Grant No.IGGCAS-2019031)。
文摘Surface-related multiples frequently propagate into the subsurface and contain abundant information on small reflection angles.Compared with the conventional migration of primaries,migration of multiples offers complementary illumination and a higher vertical resolution.However,crosstalk artifacts caused by unrelated multiples during reverse time migration(RTM)using multiples severely degrade the reliability and interpretation of the final migration images.Therefore,we proposed RTM using first-order receiver-side water-bottom-related multiples for eliminating crosstalk artifacts and enhancing vertical resolution.We first backward propagate the first-order receiver-side water-bottom-related multiples using a water-layer model,followed by saving the upper boundary wavefield.Then we produce the source wavefield using a seismic wavelet and the receiver wavefield by back-extrapolating the saved boundary.Finally,the cross-correlation imaging condition is applied to generate the final image.This method transforms the receiver-side multiples into primaries,followed by the conventional migration processing procedures.Numerical examples using synthetic datasets demonstrate that our method significantly enhances the imaging quality by eliminating crosstalk artifacts and improving the resolution.
基金the sponsors of the WPI group for their financial supportfinancially supported by the National Key R&D Program of China (Grant Number: 2018YFA0702503, 2019YFC0312004)+2 种基金National Natural Science Foundation of China (Grant Number: 41774126)Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) (ZJW-2019-04)National Science and Technology Major Project of China (Grant Number: 2016ZX05024-001, 2016ZX05006-002)。
文摘In marine seismic exploration,especially in deep-water and hard ocean-bottom cases,free-surface multiples are strongly developed.Compared with primary waves,the wider illumination aperture of the multiples is beneficial for high-resolution seismic imaging.In this study,by introducing a new compound source composed of primaries and free-surface multiples and by ignoring internal multiples,we derive a new linearized forward problem(free-surface-multiple prediction model)under a weak-scattering assumption(i.e.,first-order Born approximation).On the basis of the new linearized problem,we propose a joint inversion-imaging method by simultaneously using the primaries and free-surface multiples under the general framework of least square inversion.To eliminate the crosstalk artifacts introduced by the cross-correlation of multiples with different orders,we prove that the crosstalk artifacts can be gradually eliminated during the inversion if a proper step length is selected.Synthetic-andfield-data tests demonstrate the effectiveness of the proposed method.
基金Supported by the National Natural Science Foundation of China(40974054,41174080)the National Basic Research Program of China(973 Program)(2009CB219301)+1 种基金the National Innovation Research Project for Exploration and Development of Oil Shale(OSP-02,OSR-02)the National Public Benefit Scientific Research Foundation of China(201011078)
文摘In practical seismic exploration, internal multiples generated when the wave impedance of medium is strong, and seismic records are recorded. The method of virtual event repress internal multiples is to move scattered points from underground to the surface, similar to the method of the surface-related multiple elimination (SRME). The method of SRME belongs to the prediction-subtraction approaches to eliminate internal multiples, prediction method is based on building a brand new way of seismic wave propagation (virtual reflection and virtual event), so that it has forward and backward wave propagation, and through convolution with significant wave to predict the internal multiples. Due to required data needing field information of full-wave, the authors use Seislet transform interpolating the missing data to ensure the premise of internal multiples prediction. The test data show that the above method has achieved good results.
基金the National Natural Science Foundation of China(52004191)the China Postdoctoral Science Foundation(2022M711120)+1 种基金the Science and Technology Research Project of Education Department of Hubei Province(B2022020)Besides,the numerical calculation is supported by High-Performance Computing Center of Wuhan University of Science and Technology.
文摘A rotating stopper-rod technique was proposed to suppress the formation of free-surface vortex in the tundish.The large eddy simulation model coupled with volume of fluid model was developed to study the steel–slag–gas three-phase flow behavior.The critical slag entrapment height of the free-surface vortex and mass of residual steel were predicted at different rotating speeds(30,60,90 and 120 r/min)of the rotating stopper-rod.The numerical model was verified by water model experiment.The results showed that by rotating the stopper-rod in the opposite direction of the vortex above the submerged entry nozzle,the formation of vortex can be effectively disturbed and the critical height of the free-surface vortex can be reduced.Particularly for the 2nd strand,when the rotating speeds are 30,60,90 and 120 r/min,the critical height of the free-surface vortex above the 2nd strand is 7.3,4.7,6.3 and 7.4 cm,respectively.A reasonable rotating speed should be 60 r/min,which can reduce about 2 tons of residual steel.Other rotating speeds just can reduce about 1.6 tons of residual steel.
文摘A doublet integral equation is formulated for the two-dimensional dissipative potential flow around a hydrofoil submerged below a free-water surface. The free-water surface is assumed to involve energy dissipation, and thus it is the source of damping. A doublet panel method is developed from incorporation of the dissipative Green function approach and the doublet distributions on the hydrofoil surface. Numerical computations are implemented, and the derived numerical results are in good agreement with analytic solutions and experimental measurements.
文摘A new three-dimensional fundamental solution to the Stokes flow was proposed by transforming the solid harmonic functions in Lamb's solution into expressions in terms Of the oblate spheroidal coordinates. These fundamental solutions are advantageous in treating flows past an arbitrary number of arbitrarily positioned and oriented oblate spheroids. The least squares technique was adopted herein so that the convergence difficulties often encountered in solving three-dimensional problems were completely avoided. The examples demonstrate that present approach is highly accurate, consistently stable and computationally efficient. The oblate spheroid may be used to model a variety of particle shapes between a circular disk and a sphere. For the first time, the effect of various geometric factors on the forces and torques exerted on two oblate spheroids were systematically studied by using the proposed fundamental solutions. The generality of this approach was illustrated by two problems of three spheroids.
基金supported by the National Natural Science Foundation of China,Nos.82060219,82271234the Natural Science Foundation of Jiangxi Province,Nos.20212ACB216009,20212BAB216048+1 种基金Jiangxi Province Thousands of Plans,No.jxsq2019201023Youth Team Project of the Second Affiliated Hospital of Nanchang University,No.2019YNTD12003(all to FH)。
文摘Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.
文摘The Hartree-Fock equation is non-linear and has, in principle, multiple solutions. The ωth HF extreme and its associated virtual spin-orbitals furnish an orthogonal base Bω of the full configuration interaction space. Although all Bω bases generate the same CI space, the corresponding configurations of each Bω base have distinct quantum-mechanical information contents. In previous works, we have introduced a multi-reference configuration interaction method, based on the multiple extremes of the Hartree-Fock problem. This method was applied to calculate the permanent electrical dipole and quadrupole moments of some small molecules using minimal and double, triple and polarized double-zeta bases. In all cases were possible, using a reduced number of configurations, to obtain dipole and quadrupole moments in close agreement with the experimental values and energies without compromising the energy of the state function. These results show the positive effect of the use of the multi-reference Hartree-Fock bases that allowed a better extraction of quantum mechanical information from the several Bω bases. But to extend these ideas for larger systems and atomic bases, it is necessary to develop criteria to build the multireference Hartree-Fock bases. In this project, we are beginning a study of the non-uniform distribution of quantum-mechanical information content of the Bω bases, searching identify the factors that allowed obtain the good results cited
文摘The theoretical relationship between water injection multiple(i.e.injected pore volume)and water saturation is inferred from theoretical concepts of reservoir engineering.A mathematical model based on core displacement tests is established for the entire injection process that satisfies both initial displacement and extreme displacement,simultaneously.The results show that prior to the flooding,the water injection multiple has a linear relationship with the water saturation,and the utilization rate of the injected water is the highest.As water breakthrough at the production end,the water-cut increases,and the injection multiple increases exponentially while the utilization efficiency of the injected water gradually decreases.When the injection multiple approaches infinity,the utilization efficiency of the injected water gradually decreases to 0,by which time the water-cut at the production end is always 1.At this time,the water saturation no longer changes,and the water flooding recovery rate reaches its limit.Based on the experimental test data,a mathematical model of the entire process of injection multiple and water saturation is established,which has high fitting accuracy that can predict the injection multiple in the different stages of development of a mature oil reservoir.The dynamically changing index of the injection water utilization efficiency in reservoir development by reactive water flooding can be obtained through reasonable transformation of the mathematical model.This is of great significance in guiding evaluations of the effects of reservoir development and formulating countermeasures.
