AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resec...AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer.展开更多
In the conventional differential quadrature （DQ） method the functional values along a mesh line are used to approximate derivatives and its application is limited to regular regions. In this paper, a local different...In the conventional differential quadrature （DQ） method the functional values along a mesh line are used to approximate derivatives and its application is limited to regular regions. In this paper, a local differential quadrature （LDQ） method was developed by using irregular distributed nodes, where any spatial derivative at a nodal point is approximated by a linear weighted sum of the functional values of nodes in the local physical domain. The weighting coefficients in the new approach are determined by the quadrature rule with the aid of nodal interpolation. Since the proposed method directly approximates the derivative, it can be consistently well applied to linear and nonlinear problems and the mesh-free feature is still kept. Numerical examples are provided to validate the LDQ method.展开更多
目的探讨腋窝淋巴结外软组织受累对三阴性乳腺癌(triple-negative breast cancer,TNBC)患者预后的影响。方法回顾性收集2017年1月至2019年1月期间南阳市中心医院收治的TNBC伴腋窝淋巴结转移患者,分析并比较腋窝淋巴结外软组织阳性和阴性...目的探讨腋窝淋巴结外软组织受累对三阴性乳腺癌(triple-negative breast cancer,TNBC)患者预后的影响。方法回顾性收集2017年1月至2019年1月期间南阳市中心医院收治的TNBC伴腋窝淋巴结转移患者,分析并比较腋窝淋巴结外软组织阳性和阴性TNBC患者的临床病理特征和预后情况并分析影响预后的因素。结果共纳入216例TNBC伴腋窝淋巴结转移患者,其中腋窝淋巴结外软组织阴性者123例、阳性者93例。相较于腋窝淋巴结外软组织阴性者,其阳性患者中组织学分级更高者(Ⅲ级)、淋巴结转移数目更多者(>10枚)、原发肿瘤直径更大者(>5 cm)占比更高(P<0.05)。多因素分析结果显示,淋巴结转移数目多(>10枚)是影响TNBC患者总生存期和无病生存期缩短的风险因素(P<0.05),腋窝淋巴结外软组织阳性是影响TNBC患者无病生存期缩短的风险因素(P<0.05),组织学分级高(Ⅲ级)和人类表皮生长因子受体2低表达是影响TNBC患者总生存期缩短的风险因素(P<0.05)。腋窝淋巴结外软组织阳性TNBC患者的5年累积无病生存率低于阴性患者且差异有统计学意义(70.2%比83.3%,χ^(2)=6.934,P=0.008),而二者的5年累积总生存率比较差异无统计学意义(75.3%比82.1%,χ^(2)=1.969,P=0.161)。结论从本研究结果看,TNBC患者中腋窝淋巴结外软组织阳性患者预后更差,尤其需多关注组织学分级Ⅲ级、淋巴结转移数目>10枚及人类表皮生长因子受体2低表达患者。展开更多
文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer.
文摘In the conventional differential quadrature （DQ） method the functional values along a mesh line are used to approximate derivatives and its application is limited to regular regions. In this paper, a local differential quadrature （LDQ） method was developed by using irregular distributed nodes, where any spatial derivative at a nodal point is approximated by a linear weighted sum of the functional values of nodes in the local physical domain. The weighting coefficients in the new approach are determined by the quadrature rule with the aid of nodal interpolation. Since the proposed method directly approximates the derivative, it can be consistently well applied to linear and nonlinear problems and the mesh-free feature is still kept. Numerical examples are provided to validate the LDQ method.
文摘目的探讨腋窝淋巴结外软组织受累对三阴性乳腺癌(triple-negative breast cancer,TNBC)患者预后的影响。方法回顾性收集2017年1月至2019年1月期间南阳市中心医院收治的TNBC伴腋窝淋巴结转移患者,分析并比较腋窝淋巴结外软组织阳性和阴性TNBC患者的临床病理特征和预后情况并分析影响预后的因素。结果共纳入216例TNBC伴腋窝淋巴结转移患者,其中腋窝淋巴结外软组织阴性者123例、阳性者93例。相较于腋窝淋巴结外软组织阴性者,其阳性患者中组织学分级更高者(Ⅲ级)、淋巴结转移数目更多者(>10枚)、原发肿瘤直径更大者(>5 cm)占比更高(P<0.05)。多因素分析结果显示,淋巴结转移数目多(>10枚)是影响TNBC患者总生存期和无病生存期缩短的风险因素(P<0.05),腋窝淋巴结外软组织阳性是影响TNBC患者无病生存期缩短的风险因素(P<0.05),组织学分级高(Ⅲ级)和人类表皮生长因子受体2低表达是影响TNBC患者总生存期缩短的风险因素(P<0.05)。腋窝淋巴结外软组织阳性TNBC患者的5年累积无病生存率低于阴性患者且差异有统计学意义(70.2%比83.3%,χ^(2)=6.934,P=0.008),而二者的5年累积总生存率比较差异无统计学意义(75.3%比82.1%,χ^(2)=1.969,P=0.161)。结论从本研究结果看,TNBC患者中腋窝淋巴结外软组织阳性患者预后更差,尤其需多关注组织学分级Ⅲ级、淋巴结转移数目>10枚及人类表皮生长因子受体2低表达患者。
