Objective: To study the coumarin from the seeds oil leavings of Xanthoceras sorbifolia.Methods: The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and...Objective: To study the coumarin from the seeds oil leavings of Xanthoceras sorbifolia.Methods: The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by spectral and chemical methods. The cytotoxicity of the new compound against 10 selected human cancer cell lines was assayed.Results: Five comarins were isolated and identified as fraxetin-7-O-β-D-[6'-(3"–hydroxyl–3"-methylglutaryl)] glucopyranoside(1), fraxoside(2), fraxetin(3), scopoline(4), and esculetin(5), respectively.Conclusion: Compound 1 is a new compound. Unfortunately, this compound exhibited no cytotoxicity with tested cell lines.展开更多
基金financially supported by the Natural Science Foundation of Liaoning Province(No.2015020720)Teaching Reform Project of Jinzhou Medical University(No.YA2016044)Student Innovation Training Program of Jinzhou Medical University(No.201710160000082)
文摘Objective: To study the coumarin from the seeds oil leavings of Xanthoceras sorbifolia.Methods: The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by spectral and chemical methods. The cytotoxicity of the new compound against 10 selected human cancer cell lines was assayed.Results: Five comarins were isolated and identified as fraxetin-7-O-β-D-[6'-(3"–hydroxyl–3"-methylglutaryl)] glucopyranoside(1), fraxoside(2), fraxetin(3), scopoline(4), and esculetin(5), respectively.Conclusion: Compound 1 is a new compound. Unfortunately, this compound exhibited no cytotoxicity with tested cell lines.
