Background This study aimed to investigate the relationship between overall obesity,central obesity and brain volumes,as well as to determine the extent to which cardiometabolic and inflammatory measures act as mediat...Background This study aimed to investigate the relationship between overall obesity,central obesity and brain volumes,as well as to determine the extent to which cardiometabolic and inflammatory measures act as mediators in the association between body mass index(BMI),waist-hip ratio(WHR)and brain volumes.Methods In the context of counterfactual framework,mediation analysis was used to explore the potential mediation in which cardiometabolic and inflammatory measures may mediate the relationship between BMI,WHR,and brain volumes.Results Among 2413 community-dwelling participants,those with high BMI or WHR levels experienced an approximately brain ageing of 4 years.Especially,individuals with high WHR or BMI under the age of 65 exhibited white matter hyperintensity volume(WMHV)differences equivalent to around 5 years of ageing.Conversely,in the high-level WHR population over the age of 65,premature brain ageing in gray matter volume(GMV)exceeded 4.5 years.For GMV,more than 45%of the observed effect of WHR was mediated by glycaemic metabolism indicators.This proportion increases to 78.70%when blood pressure,triglyceride,leucocyte count,and neutrophil count are jointly considered with glycaemic metabolism indicators.Regarding WHR and BMI’s association with WMHV,cardiometabolic and inflammatory indicators,along with high-density lipoprotein cholesterol,mediated 35.50%and 20.20%of the respective effects.Conclusions Overall obesity and central obesity were associated with lower GMV and higher WMHV,a process that is partially mediated by the presence of cardiometabolic and inflammatory measures.展开更多
基金supported by National Key R&D Programme of China(No.2022YFC3602500,2022YFC3602505)National Natural Science Foundation of China(81971091)+3 种基金Outstanding Young Talents Project of Capital Medical University(A2105)Capital’s Funds for Health Improvement and Research(2020-1-2041)Key Science&Technologies R&D Programme of Lishui City(2019ZDYF18)Zhejiang Provincial Programme for the Cultivation of High-level Innovative Health talents and AstraZeneca Investment(China)Co.,Ltd.
文摘Background This study aimed to investigate the relationship between overall obesity,central obesity and brain volumes,as well as to determine the extent to which cardiometabolic and inflammatory measures act as mediators in the association between body mass index(BMI),waist-hip ratio(WHR)and brain volumes.Methods In the context of counterfactual framework,mediation analysis was used to explore the potential mediation in which cardiometabolic and inflammatory measures may mediate the relationship between BMI,WHR,and brain volumes.Results Among 2413 community-dwelling participants,those with high BMI or WHR levels experienced an approximately brain ageing of 4 years.Especially,individuals with high WHR or BMI under the age of 65 exhibited white matter hyperintensity volume(WMHV)differences equivalent to around 5 years of ageing.Conversely,in the high-level WHR population over the age of 65,premature brain ageing in gray matter volume(GMV)exceeded 4.5 years.For GMV,more than 45%of the observed effect of WHR was mediated by glycaemic metabolism indicators.This proportion increases to 78.70%when blood pressure,triglyceride,leucocyte count,and neutrophil count are jointly considered with glycaemic metabolism indicators.Regarding WHR and BMI’s association with WMHV,cardiometabolic and inflammatory indicators,along with high-density lipoprotein cholesterol,mediated 35.50%and 20.20%of the respective effects.Conclusions Overall obesity and central obesity were associated with lower GMV and higher WMHV,a process that is partially mediated by the presence of cardiometabolic and inflammatory measures.
