Recurrent pregnancy loss(RPL)affects 2%-5%of couples attempting to conceive.It is a highly heterogenous condition attributed to several factors including endocrine dysfunction,auto immune disorders,thrombophilia,genet...Recurrent pregnancy loss(RPL)affects 2%-5%of couples attempting to conceive.It is a highly heterogenous condition attributed to several factors including endocrine dysfunction,auto immune disorders,thrombophilia,genetic abnormalities,infectious diseases,uterine anomalies,sperm DNA fragmentation,and epigenetics.Among genetic causes,chromosomal abnormalities are the most frequent etiological factor of early miscarriage,accounting for 50%–60%of first trimester abortions.Numerical or structural chromosomal changes may result in spontaneous miscarriages.These anomalies arise as a result of chromosomal translocation,non-disjunction,or mutations[1].Transmission of parental chromosomal abnormalities may be one of the chances for a recurrence of miscarriage in the first trimester of pregnancy,albeit the cause is unknown[2,3].展开更多
文摘Recurrent pregnancy loss(RPL)affects 2%-5%of couples attempting to conceive.It is a highly heterogenous condition attributed to several factors including endocrine dysfunction,auto immune disorders,thrombophilia,genetic abnormalities,infectious diseases,uterine anomalies,sperm DNA fragmentation,and epigenetics.Among genetic causes,chromosomal abnormalities are the most frequent etiological factor of early miscarriage,accounting for 50%–60%of first trimester abortions.Numerical or structural chromosomal changes may result in spontaneous miscarriages.These anomalies arise as a result of chromosomal translocation,non-disjunction,or mutations[1].Transmission of parental chromosomal abnormalities may be one of the chances for a recurrence of miscarriage in the first trimester of pregnancy,albeit the cause is unknown[2,3].
