Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the pr...Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the progression of the disease through susceptible,exposed,infected,and recovered populations.The focus is on simulating this model using the fractional Caputo derivative,allowing both qualitative and quantitative analyses of boundedness,positivity,and solution uniqueness.Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions,while Lyapunov functions establish the global stability of both disease-free and endemic equilibria.The study further examines the role of the Caputo operator by solving the generalized power-law kernel via a two-step Lagrange polynomial method.This approach offers practical advantages in handling additional data points in integral forms,though Newton polynomial-based schemes are generally more accurate and can outperform Lagrange-based Adams-Bashforth methods.Graphical simulations validate the proposed numerical approach for different fractional orders(ν)and illustrate the influence of model parameters on disease dynamics.Results indicate that increasing the fractional order accelerates the decline of Lassa fever in both human and rodent populations.Moreover,fractional-order modeling provides more nuanced insights than traditional integer-order models,suggesting potential improvements for medical intervention strategies.The study demonstrates that carefully chosen fractional orders can optimize convergence and enhance the predictive capacity of Lassa fever models,offering a promising direction for future research in epidemiological modeling.展开更多
Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ...Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.展开更多
Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In ...Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its ^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and ^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.展开更多
Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical eff...Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential.展开更多
In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizh...In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense.展开更多
Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin f...Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps process.The key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene glycol.The utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling up.In the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.展开更多
Pitch produced by the lique-faction of coal was divided into two frac-tions:soluble in toluene(TS)and insol-uble in toluene but soluble in pyridine(TI-PS),and their differences in molecu-lar structure and oxidation ac...Pitch produced by the lique-faction of coal was divided into two frac-tions:soluble in toluene(TS)and insol-uble in toluene but soluble in pyridine(TI-PS),and their differences in molecu-lar structure and oxidation activity were studied.Several different carbon materi-als were produced from them by oxida-tion in air(350℃,300 mL/min)fol-lowed by carbonization(1000℃ in Ar),and the effect of the cross-linked structure on their structure and sodium storage properties was investigated.The results showed that the two pitch fractions were obviously different after the air oxidation.The TS fraction with a low degree of condensation and abundant side chains had a stronger oxidation activity and thus introduced more cross-linked oxygen-containing functional groups C(O)―O which prevented carbon layer rearrangement during the carbonization.As a result,a disordered hard carbon with more defects was formed,which improved the electrochemical performance.Therefore,the carbon materials derived from TS(O-TS-1000)had an obvious disordered structure and a larger layer spacing,giving them better sodium storage perform-ance than those derived from the TI-PS fraction(O-TI-PS-1000).The specific capacity of O-TS-1000 was about 250 mAh/g at 20 mA/g,which was 1.67 times higher than that of O-TI-PS-1000(150 mAh/g).展开更多
In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):104...In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):1045-1049]and Monrad and Rootzén[Probab.Theory Related Fields,1995,101(2):173-192].展开更多
This article studies the existence and uniqueness of the mild solution of a family of control systems with a delay that are governed by the nonlinear fractional evolution differential equations in Banach spaces.Moreov...This article studies the existence and uniqueness of the mild solution of a family of control systems with a delay that are governed by the nonlinear fractional evolution differential equations in Banach spaces.Moreover,we establish the controllability of the considered system.To do so,first,we investigate the approximate controllability of the corresponding linear system.Subsequently,we prove the nonlinear system is approximately controllable if the corresponding linear system is approximately controllable.To reach the conclusions,the theory of resolvent operators,the Banach contraction mapping principle,and fixed point theorems are used.While concluding,some examples are given to demonstrate the efficacy of the proposed results.展开更多
Soil microorganisms and labile soil organic carbon(SOC)fractions are essential factors affecting greenhouse gas(GHG)emissions in paddy fields.However,the effects of labile SOC fractions and microorganisms on GHG emiss...Soil microorganisms and labile soil organic carbon(SOC)fractions are essential factors affecting greenhouse gas(GHG)emissions in paddy fields.However,the effects of labile SOC fractions and microorganisms on GHG emissions from flooding to drying after organic fertilizer replacing for chemical fertilizer remain unclear.Here,a long-term experiment was conducted with four treatments:chemical fertilization only(control),organic fertilizer substituting 25%of chemical N fertilizer(NM1),50%of chemical N fertilizer(NM2),and NM2combined with crop straw(NMS).GHG emissions were monitored,and soil samples were collected to determine labile SOC fractions and microorganisms.Results revealed the GHG emissions in the NM2 significantly increased by 196.88%from flooding to drying,mainly due to the higher CO_(2) emissions.The GHG emissions per kg of C input in NMS was the lowest with the value of 9.17.From flooding to drying,organic fertilizer application significantly increased the readily oxidizable organic carbon(ROC)contents and C lability;the NM2 and NMS dramatically increased the SOC and non-readily oxidizable organic carbon(NROC).The bacterial communities showed significant differences among different treatments in the flooding,while the significant difference was only found between the NMS and other treatments in the drying.From flooding to drying,changing soil moisture conditions causes C fractions and microbial communities to jointly affect carbon emissions,and the NMS promoted carbon sequestration and mitigated GHG emissions.Our findings highlight the importance of the labile SOC fractions and microorganisms linked to GHG emissions in paddy fields.展开更多
Stromal vascular fraction(SVF)is a complex mixture derived from adipose tissue,consisting of a variety of cells.Due to its potential for tissue repair,immunomod-ulation,and support of angiogenesis,SVF represents a pro...Stromal vascular fraction(SVF)is a complex mixture derived from adipose tissue,consisting of a variety of cells.Due to its potential for tissue repair,immunomod-ulation,and support of angiogenesis,SVF represents a promising frontier in regenerative medicine and offers potential therapy for a range of disease condi-tions.In this article,we delve into the mechanisms through which SVF exerts its effects and explore its potential applications in treating both male and female reproductive disorders,including erectile dysfunction,testicular injury,stress urinary incontinence and intrauterine adhesion.展开更多
Both fractional crystallization and fluid-melt-crystal interaction are involved in the formation of highly fractionated granites.This paper assessed those two processes using geochemistry of muscovite and tourmaline a...Both fractional crystallization and fluid-melt-crystal interaction are involved in the formation of highly fractionated granites.This paper assessed those two processes using geochemistry of muscovite and tourmaline and bulkrock chemistry of multi-phase Wangxianling granitoids,South China.Compositional variations suggest the coarse-grained muscovite granite is produced from fractional crystallization of the two-mica granite whereas the fine-grained muscovite granite represents a distinct magma pulse.Progressive fractionation of quartz,feldspar and biotite leads to elevated boron and aluminum content in melt which promoted muscovite and tourmaline to crystallize,which promotes two-mica granite evolving towards tourmaline-bearing muscovite granite.Fluid-melt-crystal interaction occurred at the magmatichydrothermal transitional stage and resulted in the textural and chemical zonings of tourmaline and muscovite in finegrained muscovite granite.The rims of both tourmaline and muscovite are characterized by the enrichment of fluid mobile elements such as Li,Mn,Cs and Zn and heavierδ^(11)B values of the tourmaline rims(-15.0‰to-13.6‰)compared to cores(-15.7‰to-14.3‰).Meanwhile,significant M-type REE tetrad effects(TE_(1,3)=1.07-1.18)and low K/Rb ratios(48-52)also correspond to fluid-melt-crystal interaction.This study shows zoned muscovite and tourmaline can be excellent tracers of fractional crystallization and late-stage fluid-melt-crystal interaction in highly evolved magmatic systems.展开更多
Prediction of production decline and evaluation of the adsorbed/free gas ratio are critical for determining the lifespan and production status of shale gas wells.Traditional production prediction methods have some sho...Prediction of production decline and evaluation of the adsorbed/free gas ratio are critical for determining the lifespan and production status of shale gas wells.Traditional production prediction methods have some shortcomings because of the low permeability and tightness of shale,complex gas flow behavior of multi-scale gas transport regions and multiple gas transport mechanism superpositions,and complex and variable production regimes of shale gas wells.Recent research has demonstrated the existence of a multi-stage isotope fractionation phenomenon during shale gas production,with the fractionation characteristics of each stage associated with the pore structure,gas in place(GIP),adsorption/desorption,and gas production process.This study presents a new approach for estimating shale gas well production and evaluating the adsorbed/free gas ratio throughout production using isotope fractionation techniques.A reservoir-scale carbon isotope fractionation(CIF)model applicable to the production process of shale gas wells was developed for the first time in this research.In contrast to the traditional model,this model improves production prediction accuracy by simultaneously fitting the gas production rate and δ^(13)C_(1) data and provides a new evaluation method of the adsorbed/free gas ratio during shale gas production.The results indicate that the diffusion and adsorption/desorption properties of rock,bottom-hole flowing pressure(BHP)of gas well,and multi-scale gas transport regions of the reservoir all affect isotope fractionation,with the diffusion and adsorption/desorption parameters of rock having the greatest effect on isotope fractionation being D∗/D,PL,VL,α,and others in that order.We effectively tested the universality of the four-stage isotope fractionation feature and revealed a unique isotope fractionation mechanism caused by the superimposed coupling of multi-scale gas transport regions during shale gas well production.Finally,we applied the established CIF model to a shale gas well in the Sichuan Basin,China,and calculated the estimated ultimate recovery(EUR)of the well to be 3.33×10^(8) m^(3);the adsorbed gas ratio during shale gas production was 1.65%,10.03%,and 23.44%in the first,fifth,and tenth years,respectively.The findings are significant for understanding the isotope fractionation mechanism during natural gas transport in complex systems and for formulating and optimizing unconventional natural gas development strategies.展开更多
A novel fractional elastoplastic constitutive model is proposed to accurately characterize the deformation of sandstone under true-triaxial stress states.This model is founded on the yield function and the fractional ...A novel fractional elastoplastic constitutive model is proposed to accurately characterize the deformation of sandstone under true-triaxial stress states.This model is founded on the yield function and the fractional flow rule.The yield function includes parameters that govern the evolution of yield surface,enabling an accurate description of three-dimensional stress states.The direction of plastic flow is governed by the two different fractional orders,which are functions of the plastic internal variable.Additionally,a detailed process is proposed for identifying the yield function parameters and fractional orders.Subsequently,the relationship between the fractional order and the direction of plastic flow in the meridian and deviatoric planes is examined,characterized by the dilation angle and the plastic deflection angle,respectively.The non-orthogonal flow rule,also referred to as the fractional flow rule,allows for a border range of plastic deflection and dilation angles compared to the orthogonal flow rule,thereby significantly enhancing its applicability.The validity and accuracy of proposed model are verified by comparing the analytical solution of the constitutive model with the experimental data.A comparison between the non-orthogonal flow rule and orthogonal flow rule is conducted in both the deviatoric and meridian planes.The further comparison of the stress-strain curves for the non-orthogonal and orthogonal flow rules demonstrates the superiority of the fractional constitutive model.展开更多
文摘Lassa Fever(LF)is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa,causing thousands of deaths annually.This study develops a dynamic model of Lassa virus transmission,capturing the progression of the disease through susceptible,exposed,infected,and recovered populations.The focus is on simulating this model using the fractional Caputo derivative,allowing both qualitative and quantitative analyses of boundedness,positivity,and solution uniqueness.Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions,while Lyapunov functions establish the global stability of both disease-free and endemic equilibria.The study further examines the role of the Caputo operator by solving the generalized power-law kernel via a two-step Lagrange polynomial method.This approach offers practical advantages in handling additional data points in integral forms,though Newton polynomial-based schemes are generally more accurate and can outperform Lagrange-based Adams-Bashforth methods.Graphical simulations validate the proposed numerical approach for different fractional orders(ν)and illustrate the influence of model parameters on disease dynamics.Results indicate that increasing the fractional order accelerates the decline of Lassa fever in both human and rodent populations.Moreover,fractional-order modeling provides more nuanced insights than traditional integer-order models,suggesting potential improvements for medical intervention strategies.The study demonstrates that carefully chosen fractional orders can optimize convergence and enhance the predictive capacity of Lassa fever models,offering a promising direction for future research in epidemiological modeling.
文摘Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.
基金financially supported by the National Natural Science Foundation of China (42477044,32171648 and U23A2017)the Hubei Provincial Science and Technology Program,China (2025AFD451 and 2022CFB030)。
文摘Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its ^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and ^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.
文摘Grifola frondosa(Maitake)is traditionally valued for its health benefits,with polysaccharides being key bioactive components.This paper investigates a specific subfraction,Fraction D(GFP-D),evaluating its clinical effects and mechanisms in immune enhancement,adjunctive anti-tumor activity,and regulation of glucose/lipid metabolism.Three clinical trials were conducted.In an immune study,120 healthy volunteers(CD4+T cell count 500–1000 cells/μL)received 150 mg/day GFP-D for 8 weeks,resulting in significant increases in CD4+T cells(from 632±95 to 812±108 cells/μL,28.5%increase,within the physiological activation range),CD4+/CD8+ratio,NK cell activity,IL-2,and IFN-γ(all P<0.001 vs.placebo).An anti-tumor study with 80 advanced cancer patients(stratified by age,tumor stage,and histotype)showed that adding 1000 mg/day GFP-D to chemotherapy improved objective response rate(52.5%vs.30.0%,P=0.036,95%CI:1.02–3.87),one-year progression-free survival(55.8%vs.33.3%,P=0.022),and preserved immune parameters versus chemotherapy alone.A metabolic study in 90 type 2 diabetes patients found that 400 mg/day GFP-D for 12 weeks significantly lowered fasting glucose,HbA1c,total cholesterol,triglycerides,and LDL-C,while raising HDL-C(from 1.0±0.2 to 1.2±0.2 mmol/L,20%increase,supported by increased AMPK phosphorylation).Mechanistically,immune enhancement involves macrophage/dendritic cell activation via Dectin-1/TLR4 receptors(confirmed by increased receptor expression and downstream signaling molecules),promoting cytokine-driven T/NK cell responses.Anti-tumor effects stem from immunomodulation,direct induction of cancer cell apoptosis(via mitochondrial/caspase pathways,verified by increased Bax/Bcl-2 ratio and caspase-3 activation),and angiogenesis inhibition by downregulating VEGF.Metabolic benefits are linked to AMPK pathway activation in liver/muscle(confirmed by increased p-AMPK/AMPK ratio),enhancing glucose uptake and inhibiting gluconeogenesis/lipogenesis,alongside modulation of gut microbiota(increased Bifidobacterium and Lactobacillus abundance).All trials reported no severe adverse events related to GFP-D;liver/kidney function parameters(ALT,AST,creatinine,urea nitrogen)remained within normal ranges throughout the intervention.Collectively,GFP-D emerges as a multi-functional bioactive agent with substantial therapeutic potential.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11961041,12261055)the Key Project of Natural Science Foundation of Gansu Province(Grant No.24JRRA222)the Foundation for Innovative Fundamental Research Group Project of Gansu Province(Grant No.25JRRA805).
文摘In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense.
基金supported by the Fundamental Research Funds for the Central Universities(QNTD202302)National Natural Science Foundation of China(22378024)the Foreign expert program(G2022109001L).
文摘Developing a cost-effective and environmentally friendly process for the production of valuable chemicals from abundant herbal biomass receives great attentions in recent years.Herein,taking advantage of the“lignin first”strategy,corn straw is converted to valuable chemicals including lignin monomers,furfural and 5-methoxymethylfurfural via a two steps process.The key of this research lies in the development of a green and low-cost catalytic process utilizing magnetic Raney Ni catalyst and high boiling point ethylene glycol.The utilization of neat ethylene glycol as the sole slovent under atmospheric conditions obviates the need for additional additives,thereby facilitating the entire process to be conducted in glass flasks and rendering it highly convenient for scaling up.In the initial step,depolymerization of corn straw lignin resulted in a monomer yield of 18.1 wt%.Subsequently,in a dimethyl carbonate system,the carbohydrate component underwent complete conversion in a one-pot process,yielding furfural and 5-methoxymethylfurfural as the primary products with an impressive yield of 47.7%.
文摘Pitch produced by the lique-faction of coal was divided into two frac-tions:soluble in toluene(TS)and insol-uble in toluene but soluble in pyridine(TI-PS),and their differences in molecu-lar structure and oxidation activity were studied.Several different carbon materi-als were produced from them by oxida-tion in air(350℃,300 mL/min)fol-lowed by carbonization(1000℃ in Ar),and the effect of the cross-linked structure on their structure and sodium storage properties was investigated.The results showed that the two pitch fractions were obviously different after the air oxidation.The TS fraction with a low degree of condensation and abundant side chains had a stronger oxidation activity and thus introduced more cross-linked oxygen-containing functional groups C(O)―O which prevented carbon layer rearrangement during the carbonization.As a result,a disordered hard carbon with more defects was formed,which improved the electrochemical performance.Therefore,the carbon materials derived from TS(O-TS-1000)had an obvious disordered structure and a larger layer spacing,giving them better sodium storage perform-ance than those derived from the TI-PS fraction(O-TI-PS-1000).The specific capacity of O-TS-1000 was about 250 mAh/g at 20 mA/g,which was 1.67 times higher than that of O-TI-PS-1000(150 mAh/g).
基金Supported by NSFC(Nos.11661025,12161024)Natural Science Foundation of Guangxi(Nos.2020GXNSFAA159118,2021GXNSFAA196045)+2 种基金Guangxi Science and Technology Project(No.Guike AD20297006)Training Program for 1000 Young and Middle-aged Cadre Teachers in Universities of GuangxiNational College Student's Innovation and Entrepreneurship Training Program(No.202110595049)。
文摘In this paper,we present local functional law of the iterated logarithm for Cs?rg?-Révész type increments of fractional Brownian motion.The results obtained extend works of Gantert[Ann.Probab.,1993,21(2):1045-1049]and Monrad and Rootzén[Probab.Theory Related Fields,1995,101(2):173-192].
文摘This article studies the existence and uniqueness of the mild solution of a family of control systems with a delay that are governed by the nonlinear fractional evolution differential equations in Banach spaces.Moreover,we establish the controllability of the considered system.To do so,first,we investigate the approximate controllability of the corresponding linear system.Subsequently,we prove the nonlinear system is approximately controllable if the corresponding linear system is approximately controllable.To reach the conclusions,the theory of resolvent operators,the Banach contraction mapping principle,and fixed point theorems are used.While concluding,some examples are given to demonstrate the efficacy of the proposed results.
基金the support of the National Natural Science Foundation of China(No.42107247)the National Key Research and Development Project(No.2022YFD1901605)+1 种基金the Natural Science Foundation of Sichuan Province(Nos.2025YFHZ0142 and 2024NSFSC0800)the Tobacco Science Foundation of Sichuan Province(No.SCYC202407)。
文摘Soil microorganisms and labile soil organic carbon(SOC)fractions are essential factors affecting greenhouse gas(GHG)emissions in paddy fields.However,the effects of labile SOC fractions and microorganisms on GHG emissions from flooding to drying after organic fertilizer replacing for chemical fertilizer remain unclear.Here,a long-term experiment was conducted with four treatments:chemical fertilization only(control),organic fertilizer substituting 25%of chemical N fertilizer(NM1),50%of chemical N fertilizer(NM2),and NM2combined with crop straw(NMS).GHG emissions were monitored,and soil samples were collected to determine labile SOC fractions and microorganisms.Results revealed the GHG emissions in the NM2 significantly increased by 196.88%from flooding to drying,mainly due to the higher CO_(2) emissions.The GHG emissions per kg of C input in NMS was the lowest with the value of 9.17.From flooding to drying,organic fertilizer application significantly increased the readily oxidizable organic carbon(ROC)contents and C lability;the NM2 and NMS dramatically increased the SOC and non-readily oxidizable organic carbon(NROC).The bacterial communities showed significant differences among different treatments in the flooding,while the significant difference was only found between the NMS and other treatments in the drying.From flooding to drying,changing soil moisture conditions causes C fractions and microbial communities to jointly affect carbon emissions,and the NMS promoted carbon sequestration and mitigated GHG emissions.Our findings highlight the importance of the labile SOC fractions and microorganisms linked to GHG emissions in paddy fields.
文摘Stromal vascular fraction(SVF)is a complex mixture derived from adipose tissue,consisting of a variety of cells.Due to its potential for tissue repair,immunomod-ulation,and support of angiogenesis,SVF represents a promising frontier in regenerative medicine and offers potential therapy for a range of disease condi-tions.In this article,we delve into the mechanisms through which SVF exerts its effects and explore its potential applications in treating both male and female reproductive disorders,including erectile dysfunction,testicular injury,stress urinary incontinence and intrauterine adhesion.
基金funded by the National Natural Science Foundation of China(Grant Nos.42072089 and 41530206)。
文摘Both fractional crystallization and fluid-melt-crystal interaction are involved in the formation of highly fractionated granites.This paper assessed those two processes using geochemistry of muscovite and tourmaline and bulkrock chemistry of multi-phase Wangxianling granitoids,South China.Compositional variations suggest the coarse-grained muscovite granite is produced from fractional crystallization of the two-mica granite whereas the fine-grained muscovite granite represents a distinct magma pulse.Progressive fractionation of quartz,feldspar and biotite leads to elevated boron and aluminum content in melt which promoted muscovite and tourmaline to crystallize,which promotes two-mica granite evolving towards tourmaline-bearing muscovite granite.Fluid-melt-crystal interaction occurred at the magmatichydrothermal transitional stage and resulted in the textural and chemical zonings of tourmaline and muscovite in finegrained muscovite granite.The rims of both tourmaline and muscovite are characterized by the enrichment of fluid mobile elements such as Li,Mn,Cs and Zn and heavierδ^(11)B values of the tourmaline rims(-15.0‰to-13.6‰)compared to cores(-15.7‰to-14.3‰).Meanwhile,significant M-type REE tetrad effects(TE_(1,3)=1.07-1.18)and low K/Rb ratios(48-52)also correspond to fluid-melt-crystal interaction.This study shows zoned muscovite and tourmaline can be excellent tracers of fractional crystallization and late-stage fluid-melt-crystal interaction in highly evolved magmatic systems.
基金supported by the Natural Science Foundation of China(Grant No.42302170)National Postdoctoral Innovative Talent Support Program(Grant No.BX20220062)+3 种基金CNPC Innovation Found(Grant No.2022DQ02-0104)National Science Foundation of Heilongjiang Province of China(Grant No.YQ2023D001)Postdoctoral Science Foundation of Heilongjiang Province of China(Grant No.LBH-Z22091)the Natural Science Foundation of Shandong Province(Grant No.ZR2022YQ30).
文摘Prediction of production decline and evaluation of the adsorbed/free gas ratio are critical for determining the lifespan and production status of shale gas wells.Traditional production prediction methods have some shortcomings because of the low permeability and tightness of shale,complex gas flow behavior of multi-scale gas transport regions and multiple gas transport mechanism superpositions,and complex and variable production regimes of shale gas wells.Recent research has demonstrated the existence of a multi-stage isotope fractionation phenomenon during shale gas production,with the fractionation characteristics of each stage associated with the pore structure,gas in place(GIP),adsorption/desorption,and gas production process.This study presents a new approach for estimating shale gas well production and evaluating the adsorbed/free gas ratio throughout production using isotope fractionation techniques.A reservoir-scale carbon isotope fractionation(CIF)model applicable to the production process of shale gas wells was developed for the first time in this research.In contrast to the traditional model,this model improves production prediction accuracy by simultaneously fitting the gas production rate and δ^(13)C_(1) data and provides a new evaluation method of the adsorbed/free gas ratio during shale gas production.The results indicate that the diffusion and adsorption/desorption properties of rock,bottom-hole flowing pressure(BHP)of gas well,and multi-scale gas transport regions of the reservoir all affect isotope fractionation,with the diffusion and adsorption/desorption parameters of rock having the greatest effect on isotope fractionation being D∗/D,PL,VL,α,and others in that order.We effectively tested the universality of the four-stage isotope fractionation feature and revealed a unique isotope fractionation mechanism caused by the superimposed coupling of multi-scale gas transport regions during shale gas well production.Finally,we applied the established CIF model to a shale gas well in the Sichuan Basin,China,and calculated the estimated ultimate recovery(EUR)of the well to be 3.33×10^(8) m^(3);the adsorbed gas ratio during shale gas production was 1.65%,10.03%,and 23.44%in the first,fifth,and tenth years,respectively.The findings are significant for understanding the isotope fractionation mechanism during natural gas transport in complex systems and for formulating and optimizing unconventional natural gas development strategies.
基金sponsored by the National Natural Science Foundation of China(Grant No.42141010).
文摘A novel fractional elastoplastic constitutive model is proposed to accurately characterize the deformation of sandstone under true-triaxial stress states.This model is founded on the yield function and the fractional flow rule.The yield function includes parameters that govern the evolution of yield surface,enabling an accurate description of three-dimensional stress states.The direction of plastic flow is governed by the two different fractional orders,which are functions of the plastic internal variable.Additionally,a detailed process is proposed for identifying the yield function parameters and fractional orders.Subsequently,the relationship between the fractional order and the direction of plastic flow in the meridian and deviatoric planes is examined,characterized by the dilation angle and the plastic deflection angle,respectively.The non-orthogonal flow rule,also referred to as the fractional flow rule,allows for a border range of plastic deflection and dilation angles compared to the orthogonal flow rule,thereby significantly enhancing its applicability.The validity and accuracy of proposed model are verified by comparing the analytical solution of the constitutive model with the experimental data.A comparison between the non-orthogonal flow rule and orthogonal flow rule is conducted in both the deviatoric and meridian planes.The further comparison of the stress-strain curves for the non-orthogonal and orthogonal flow rules demonstrates the superiority of the fractional constitutive model.
