随着电子封装微型化、多功能化的发展,三维封装已成为封装技术的主要发展方向,叠层CSP封装具有封装密度高、互连性能好等特性,是实现三维封装的重要技术。针对超薄芯片传统叠层CSP封装过程中容易产生圆片翘曲、金线键合过程中容易出现O...随着电子封装微型化、多功能化的发展,三维封装已成为封装技术的主要发展方向,叠层CSP封装具有封装密度高、互连性能好等特性,是实现三维封装的重要技术。针对超薄芯片传统叠层CSP封装过程中容易产生圆片翘曲、金线键合过程中容易出现OBOP不良、以及线弧(wire loop)的CPK值达不到工艺要求等问题,文中简要介绍了芯片减薄方法对圆片翘曲的影响,利用有限元(FEA)的方法进行芯片减薄后对悬空功能芯片金线键合(Wirebond)的影响进行分析,Film on Wire(FOW)的贴片(Die Attach)方法在解决悬空功能芯片金线键合中的应用,以及FOW贴片方式对叠层CSP封装流程的简化。采用FOW贴片技术可以达到30%的成本节约,具有很好的经济效益。展开更多
Dual Synthetic Jets (DSJ) can directly affect the development of spray through the complex vortex structure. The mechanism of flow control on spray and its thermal management application are studied by combining exper...Dual Synthetic Jets (DSJ) can directly affect the development of spray through the complex vortex structure. The mechanism of flow control on spray and its thermal management application are studied by combining experiment and simulation. The spray characteristics under different injection angles are studied, and the results show that the angle should be controlled in the range of 45°–60°, so that sufficient momentum transfer can be obtained, and meanwhile spray impingement area narrowing can be avoided. The spray characteristics under flow control of DSJ with different Reynolds numbers are studied, and the results show that Reynolds number should be controlled in the range of 2859–3574, so that strong particle streamwise acceleration and wall film disturbing can be achieved. In addition, the DSJ kinetic energy is utilized more efficiently. On the basis of previous research, this paper proposes a novel active heat pipe based on spray controlled by DSJ. The space occupancy has been reduced by more than 60%. Even in a sealed state, the active heat pipe is able to cool a hot surface with heat flux of 22.2 kW/m^(2) from 111℃ to 57℃ only in 20 s. The noise of DSJ is reduced from 85 dB to 60 dB, which is expected to promote the practical application of DSJ in thermal management.展开更多
Triple-negative bresst canær(TNBC)metastscis is particularly severe due to its aggressive nsture,leading to rapid disease progresion and significantly reduced survival rates.Rujifang(RJF),a traditional Chinese fo...Triple-negative bresst canær(TNBC)metastscis is particularly severe due to its aggressive nsture,leading to rapid disease progresion and significantly reduced survival rates.Rujifang(RJF),a traditional Chinese formula,has demonstrated potential anti-tumor effects and theability to inhibit TNBC metastasis.However,the efects af varying R.IF dors remain undear.This study utilized Laser-based in vino fow cytometry(IVFC)to monitor circulating tumor cells(CTCs)and evaluate the efficacy of R.IF at different doses.The results indicated that R.IF at the high dose inhibited both the number af CTC:and the formaton of metatatic foci more eflectively compared to the lower dose.TUNEL assays revealed that R.IF trentment promotes apoptosis of tumor cells,with a more pronounced effect observed at the higher dose.Immuno-fluorescence experiments demonstrated that administering a higher dose of R.IF suppreses theеxprescion of Kindlin-1 more effectively in the tumor microenvironment.Although higher doses showed enhanced efficacy,they might also lesd to an increase in side efects.These findings underscore the promise and challenges of using R.IF at high doses for anti-tumor therspy.They highlight the criticnl importance of optimizing the dose of R.JP in the treatment of TNBC and provide valuable insights for its dinical application.展开更多
In this paper,a composite numerical scheme is proposed to solve the threedimensional Darcy-Forchheimer miscible displacement problem with positive semi-definite assumptions.A mixed finite element is used for the fow e...In this paper,a composite numerical scheme is proposed to solve the threedimensional Darcy-Forchheimer miscible displacement problem with positive semi-definite assumptions.A mixed finite element is used for the fow equation.The velocity and pressure are computed simultaneously.The accuracy of velocity is improved one order.The concentration equation is solved by using mixed finite element,multi-step difference and upwind approximation.A multi-step method is used to approximate time derivative for improving the accuracy.The upwind approximation and an expanded mixed finite element are adopted to solve the convection and diffusion,respectively.The composite method could compute the diffusion flux and its gradient.It possibly becomes an eficient tool for solving convection-dominated diffusion problems.Firstly,the conservation of mass holds.Secondly,the multi-step method has high accuracy.Thirdly,the upwind approximation could avoid numerical dispersion.Using numerical analysis of a priori estimates and special techniques of differential equations,we give an error estimates for a positive definite problem.Numerical experiments illustrate its computational efficiency and feasibility of application.展开更多
This is a survey of the results in[14]regarding the isoperimetric problem in the Riemannian manifold.We consider a mean curvature type flow in the Riemannian manifold endowed with a non-trivial conformal vector field,...This is a survey of the results in[14]regarding the isoperimetric problem in the Riemannian manifold.We consider a mean curvature type flow in the Riemannian manifold endowed with a non-trivial conformal vector field,which was firstly introduced by Guan and Li[8]in space forms.This flow preserves the volume of the bounded domain enclosed by a star-shaped hypersurface and decreases the area of hypersurface under certain conditions.We will prove the long time existence and convergence of the flow.As a result,the isoperimetric inequality for such a domain is established.展开更多
In this paper,the L_(p)chord Minkowski problem is concerned.Based on the results shown in[20],we obtain a new existence result of solutions to this problem in terms of smooth measures by using a nonlocal Gauss curvatu...In this paper,the L_(p)chord Minkowski problem is concerned.Based on the results shown in[20],we obtain a new existence result of solutions to this problem in terms of smooth measures by using a nonlocal Gauss curvature flow for p>−n with p≠0.展开更多
文摘随着电子封装微型化、多功能化的发展,三维封装已成为封装技术的主要发展方向,叠层CSP封装具有封装密度高、互连性能好等特性,是实现三维封装的重要技术。针对超薄芯片传统叠层CSP封装过程中容易产生圆片翘曲、金线键合过程中容易出现OBOP不良、以及线弧(wire loop)的CPK值达不到工艺要求等问题,文中简要介绍了芯片减薄方法对圆片翘曲的影响,利用有限元(FEA)的方法进行芯片减薄后对悬空功能芯片金线键合(Wirebond)的影响进行分析,Film on Wire(FOW)的贴片(Die Attach)方法在解决悬空功能芯片金线键合中的应用,以及FOW贴片方式对叠层CSP封装流程的简化。采用FOW贴片技术可以达到30%的成本节约,具有很好的经济效益。
基金supported by the National Natural Science Foundation of China(Nos.U2341202,12402333).
文摘Dual Synthetic Jets (DSJ) can directly affect the development of spray through the complex vortex structure. The mechanism of flow control on spray and its thermal management application are studied by combining experiment and simulation. The spray characteristics under different injection angles are studied, and the results show that the angle should be controlled in the range of 45°–60°, so that sufficient momentum transfer can be obtained, and meanwhile spray impingement area narrowing can be avoided. The spray characteristics under flow control of DSJ with different Reynolds numbers are studied, and the results show that Reynolds number should be controlled in the range of 2859–3574, so that strong particle streamwise acceleration and wall film disturbing can be achieved. In addition, the DSJ kinetic energy is utilized more efficiently. On the basis of previous research, this paper proposes a novel active heat pipe based on spray controlled by DSJ. The space occupancy has been reduced by more than 60%. Even in a sealed state, the active heat pipe is able to cool a hot surface with heat flux of 22.2 kW/m^(2) from 111℃ to 57℃ only in 20 s. The noise of DSJ is reduced from 85 dB to 60 dB, which is expected to promote the practical application of DSJ in thermal management.
基金supported by the National Key Re-search and Development Program of China(2021YFF0502900,2019YFC1604604)the grant of Peak Climbing Project of Foshan Hospital of Tra-ditional Chinese Medicine,Traditional Chinese Medicine Bureat of Guangdong Province Project(No.20213018)+2 种基金the Special Fund for Research on National Major Research Instruuments of China(Grant No.62027824)Scientific Research Fund of Education Department of Yunnan Province(2023Y0619)Biomedical Projects of Yun-nan Key Science and Technology Program(202302AA310046).
文摘Triple-negative bresst canær(TNBC)metastscis is particularly severe due to its aggressive nsture,leading to rapid disease progresion and significantly reduced survival rates.Rujifang(RJF),a traditional Chinese formula,has demonstrated potential anti-tumor effects and theability to inhibit TNBC metastasis.However,the efects af varying R.IF dors remain undear.This study utilized Laser-based in vino fow cytometry(IVFC)to monitor circulating tumor cells(CTCs)and evaluate the efficacy of R.IF at different doses.The results indicated that R.IF at the high dose inhibited both the number af CTC:and the formaton of metatatic foci more eflectively compared to the lower dose.TUNEL assays revealed that R.IF trentment promotes apoptosis of tumor cells,with a more pronounced effect observed at the higher dose.Immuno-fluorescence experiments demonstrated that administering a higher dose of R.IF suppreses theеxprescion of Kindlin-1 more effectively in the tumor microenvironment.Although higher doses showed enhanced efficacy,they might also lesd to an increase in side efects.These findings underscore the promise and challenges of using R.IF at high doses for anti-tumor therspy.They highlight the criticnl importance of optimizing the dose of R.JP in the treatment of TNBC and provide valuable insights for its dinical application.
基金supported by the Natural Science Foundation of Shandong Province(ZR2021MA019)the National Natural Science Foundation of China(11871312)。
文摘In this paper,a composite numerical scheme is proposed to solve the threedimensional Darcy-Forchheimer miscible displacement problem with positive semi-definite assumptions.A mixed finite element is used for the fow equation.The velocity and pressure are computed simultaneously.The accuracy of velocity is improved one order.The concentration equation is solved by using mixed finite element,multi-step difference and upwind approximation.A multi-step method is used to approximate time derivative for improving the accuracy.The upwind approximation and an expanded mixed finite element are adopted to solve the convection and diffusion,respectively.The composite method could compute the diffusion flux and its gradient.It possibly becomes an eficient tool for solving convection-dominated diffusion problems.Firstly,the conservation of mass holds.Secondly,the multi-step method has high accuracy.Thirdly,the upwind approximation could avoid numerical dispersion.Using numerical analysis of a priori estimates and special techniques of differential equations,we give an error estimates for a positive definite problem.Numerical experiments illustrate its computational efficiency and feasibility of application.
文摘This is a survey of the results in[14]regarding the isoperimetric problem in the Riemannian manifold.We consider a mean curvature type flow in the Riemannian manifold endowed with a non-trivial conformal vector field,which was firstly introduced by Guan and Li[8]in space forms.This flow preserves the volume of the bounded domain enclosed by a star-shaped hypersurface and decreases the area of hypersurface under certain conditions.We will prove the long time existence and convergence of the flow.As a result,the isoperimetric inequality for such a domain is established.
基金supported by the National Natural Science Foundation of China(12171144,12231006,12122106).
文摘In this paper,the L_(p)chord Minkowski problem is concerned.Based on the results shown in[20],we obtain a new existence result of solutions to this problem in terms of smooth measures by using a nonlocal Gauss curvature flow for p>−n with p≠0.
