BACKGROUND Arabic-speaking patients are underrepresented in orthopedic clinical studies,particularly in foot and ankle trauma research.The lack of validated Arabic language tools hinders their inclusion,creating a nee...BACKGROUND Arabic-speaking patients are underrepresented in orthopedic clinical studies,particularly in foot and ankle trauma research.The lack of validated Arabic language tools hinders their inclusion,creating a need for culturally and linguistically adapted instruments.The American Academy of Orthopedic Surgeons Foot and Ankle Outcomes Questionnaire(AAOS-FAOQ)is a widely used tool but has not been adapted for Arabic-speaking patients.AIM To translate,cross-culturally adapt,and validate the AAOS-FAOQ for Arabicspeaking patients with traumatic foot and ankle injuries.METHODS The cross-cultural adaptation followed established guidelines,involving forward and backward translations,expert review,and pre-testing.The final Arabic version was administered alongside the Arabic Short-Form 36(SF-36)to 100 patients for validity testing.Reliability was assessed through test-retest methods with 20 patients completing the questionnaire twice within 48 hours.Pearson correlation coefficients measured convergent and divergent validity with SF-36 subscales,while Cronbach's alpha and intraclass correlation coefficients(ICC)determined internal consistency and reliability.RESULTS Out of 100 patients,92 completed the first set of questionnaires.The Arabic AAOS-FAOQ showed strong correlations with the SF-36 subscales,particularly in physical function and bodily pain(r>0.6).Test-retest reliability was robust,with ICCs of 0.69 and 0.66 for the Global Foot and Ankle Scale and Shoe Comfort Scale,respectively.Cronbach's alpha for internal consistency ranged from 0.7 to 0.9.CONCLUSION The Arabic version of the AAOS-FAOQ demonstrated validity and reliability for use in Arabic-speaking patients with traumatic foot and ankle injuries.This adaptation will enhance the inclusion of this population in orthopedic clinical studies,improving the generalizability of research findings and patient care.展开更多
With the rapid adoption of artificial intelligence(AI)in domains such as power,transportation,and finance,the number of machine learning and deep learning models has grown exponentially.However,challenges such as dela...With the rapid adoption of artificial intelligence(AI)in domains such as power,transportation,and finance,the number of machine learning and deep learning models has grown exponentially.However,challenges such as delayed retraining,inconsistent version management,insufficient drift monitoring,and limited data security still hinder efficient and reliable model operations.To address these issues,this paper proposes the Intelligent Model Lifecycle Management Algorithm(IMLMA).The algorithm employs a dual-trigger mechanism based on both data volume thresholds and time intervals to automate retraining,and applies Bayesian optimization for adaptive hyperparameter tuning to improve performance.A multi-metric replacement strategy,incorporating MSE,MAE,and R2,ensures that new models replace existing ones only when performance improvements are guaranteed.A versioning and traceability database supports comparison and visualization,while real-time monitoring with stability analysis enables early warnings of latency and drift.Finally,hash-based integrity checks secure both model files and datasets.Experimental validation in a power metering operation scenario demonstrates that IMLMA reduces model update delays,enhances predictive accuracy and stability,and maintains low latency under high concurrency.This work provides a practical,reusable,and scalable solution for intelligent model lifecycle management,with broad applicability to complex systems such as smart grids.展开更多
Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with inc...Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.展开更多
The Chinese Pharmacopoeia 2020 edition was reviewed and approved by the National Medical Products Administration and the National Health Commission of the People’s Republic of China in July 2020.The current edition w...The Chinese Pharmacopoeia 2020 edition was reviewed and approved by the National Medical Products Administration and the National Health Commission of the People’s Republic of China in July 2020.The current edition was officially implemented on December 30,2020.The general chapters of the Chinese Pharmacopoeia discuss the general testing methods and guidelines,which are the common requirements and basis for the implementation of drug standards in the Chinese Pharmacopoeia.Owing to adherence to the principles of scientificity,versatility,operability,and sustainable development,there is an improvement in the general chapters of the 2020 edition over those of the previous editions.Further,the application of advanced and mature analytical techniques has expanded,the development of testing methods for exogenous pollutants in traditional Chinese medicines has been strengthened,and technical requirements are now better harmonized with international standards.The updated edition provides technical and methodological support to ensure safety,effectiveness,and control of pharmaceuticals in China and will play an important and active role in encouraging the application of advanced technologies,improving the quality control of medicines,and strengthening the means of drug regulation in China.This review provides a comprehensive introduction of the main features of and changes to the general chapters in the Chinese Pharmacopoeia 2020 edition and aims to provide reference for its correct understanding and accurate implementation.展开更多
Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the...Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the reorganization process and the regulator's intervention documented in U.S.Chapter 11 bankruptcy.We do this by further accommodating the fixed transaction costs on dividends to imitate the real-world procedure of dividend payments.Incorporating the fixed transaction costs transforms the targeting optimal dividend problem into an impulse control problem rather than a singular control problem,and hence computations and proofs that are distinct from[44]are needed.To account for the financial stress that is due to the more subtle concept of Chapter 11 bankruptcy,the surplus process after dividends is driven by a piece-wise spectrally negative Lévy process with endogenous regime switching.Some explicit expressions of the expected net present values under a double barrier dividend strategy,new to the literature,are established in terms of scale functions.With the help of these expressions,we are able to characterize the optimal strategy among the set of admissible double barrier dividend strategies.When the tail of the Lévy measure is log-convex,this optimal double barrier dividend strategy is then verified as the optimal dividend strategy,solving our optimal impulse control problem.展开更多
Fu Sheng Liu Ji is a collection of autobiographical essays written by Shen Fu and it occupies a rather important place in the notebook literature of the Qing Dynasty,which has also been widely translated and spread ab...Fu Sheng Liu Ji is a collection of autobiographical essays written by Shen Fu and it occupies a rather important place in the notebook literature of the Qing Dynasty,which has also been widely translated and spread abroad.So far,there have been four English translation versions.Based on the theory of creative treason,this paper analyzed Black’s English translation from the aspects of the choice of content and the restructure,culture and language.It has been found that,as a result of the translator’s conscious or unconscious creative treason,translations may have the effect of engaging readers of the target language,transmitting the culture of the source language and facilitating literary exchange,but they may also have caused misinterpretation by readers and the loss of Chinese cultural imagery.展开更多
Six Chapters of a Floating Life is an elegant autobiographical prose. The English version of Lin Yutang is honored as one of the classic translations. As the first translator to embrace"aestheticism"from the...Six Chapters of a Floating Life is an elegant autobiographical prose. The English version of Lin Yutang is honored as one of the classic translations. As the first translator to embrace"aestheticism"from the perspective of translation in Chinese history,Lin Yutang put for ward three standards for translation, namely,"fidelity, coherence and beauty", and proposed translation aesthetics in his article On Translation. By interpreting Lin's translation work of Six Chapters of a Floating Life from the aesthetic aspect,this paper analyzes Lin Yutang's standards for"aesthetic"translation, which refers to the beauty of sound, sense, conception, form and spirit, and also reveals his enlightening contribution to translation theory construction.展开更多
The structure of the irreducible collective spaces of the group Sp(12,R),which many-particle nuclear states are classified according to the chain Sp(12,R)⊃U(6)⊃SO(6)⊃SU_(pn)(3)⊗SO(2)⊃SO(3)of the proton-neutron symplec...The structure of the irreducible collective spaces of the group Sp(12,R),which many-particle nuclear states are classified according to the chain Sp(12,R)⊃U(6)⊃SO(6)⊃SU_(pn)(3)⊗SO(2)⊃SO(3)of the proton-neutron symplectic model(PNSM),is considered in detail.This chain of the PNSM was recently shown to correspond to a microscopic shell-model version of the Bohr-Mottelson collective model.The construction of the relevant shell-model representations of the Sp(12,R)group along this chain is considered for three nuclei with varying collective properties and from different mass regions.It is shown that the SU_(pn)(3)basis states of the Sp(12,R)representations belonging to the SO(6)irreps with seniorityυ≥υ0,withυ0 denoting the maximal seniority SO(6)irrep contained in the Sp(12,R)bandhead,are always Pauli allowed,but organized in a different way into different SO(6)shells.This is in contrast to the case of filling the levels of the standard three-dimensional harmonic oscillator and using the plethysm operation.Although the SU_(pn)(3)multiplets withinυ<υ0 are not all Pauli forbidden,it is safe to discard them.The results obtained in the present work are important for the practical application of the microscopic version of the Bohr-Mottelson collective model.展开更多
文摘BACKGROUND Arabic-speaking patients are underrepresented in orthopedic clinical studies,particularly in foot and ankle trauma research.The lack of validated Arabic language tools hinders their inclusion,creating a need for culturally and linguistically adapted instruments.The American Academy of Orthopedic Surgeons Foot and Ankle Outcomes Questionnaire(AAOS-FAOQ)is a widely used tool but has not been adapted for Arabic-speaking patients.AIM To translate,cross-culturally adapt,and validate the AAOS-FAOQ for Arabicspeaking patients with traumatic foot and ankle injuries.METHODS The cross-cultural adaptation followed established guidelines,involving forward and backward translations,expert review,and pre-testing.The final Arabic version was administered alongside the Arabic Short-Form 36(SF-36)to 100 patients for validity testing.Reliability was assessed through test-retest methods with 20 patients completing the questionnaire twice within 48 hours.Pearson correlation coefficients measured convergent and divergent validity with SF-36 subscales,while Cronbach's alpha and intraclass correlation coefficients(ICC)determined internal consistency and reliability.RESULTS Out of 100 patients,92 completed the first set of questionnaires.The Arabic AAOS-FAOQ showed strong correlations with the SF-36 subscales,particularly in physical function and bodily pain(r>0.6).Test-retest reliability was robust,with ICCs of 0.69 and 0.66 for the Global Foot and Ankle Scale and Shoe Comfort Scale,respectively.Cronbach's alpha for internal consistency ranged from 0.7 to 0.9.CONCLUSION The Arabic version of the AAOS-FAOQ demonstrated validity and reliability for use in Arabic-speaking patients with traumatic foot and ankle injuries.This adaptation will enhance the inclusion of this population in orthopedic clinical studies,improving the generalizability of research findings and patient care.
基金funded by Anhui NARI ZT Electric Co.,Ltd.,entitled“Research on the Shared Operation and Maintenance Service Model for Metering Equipment and Platform Development for the Modern Industrial Chain”(Grant No.524636250005).
文摘With the rapid adoption of artificial intelligence(AI)in domains such as power,transportation,and finance,the number of machine learning and deep learning models has grown exponentially.However,challenges such as delayed retraining,inconsistent version management,insufficient drift monitoring,and limited data security still hinder efficient and reliable model operations.To address these issues,this paper proposes the Intelligent Model Lifecycle Management Algorithm(IMLMA).The algorithm employs a dual-trigger mechanism based on both data volume thresholds and time intervals to automate retraining,and applies Bayesian optimization for adaptive hyperparameter tuning to improve performance.A multi-metric replacement strategy,incorporating MSE,MAE,and R2,ensures that new models replace existing ones only when performance improvements are guaranteed.A versioning and traceability database supports comparison and visualization,while real-time monitoring with stability analysis enables early warnings of latency and drift.Finally,hash-based integrity checks secure both model files and datasets.Experimental validation in a power metering operation scenario demonstrates that IMLMA reduces model update delays,enhances predictive accuracy and stability,and maintains low latency under high concurrency.This work provides a practical,reusable,and scalable solution for intelligent model lifecycle management,with broad applicability to complex systems such as smart grids.
基金supported by the National Natural Science Foundation of China(No.82373415)Beijing Xisike Clinical Oncology Research Foundation(No.Ytongshu2021/ms-0003)。
文摘Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.
基金financial support from the Chinese Pharmacopoeia Commission Drug Standard Promoting Funds and Comprehensive Reform of the Chinese Drug and Medical Device Review and Approval System Funds(2015e2020)。
文摘The Chinese Pharmacopoeia 2020 edition was reviewed and approved by the National Medical Products Administration and the National Health Commission of the People’s Republic of China in July 2020.The current edition was officially implemented on December 30,2020.The general chapters of the Chinese Pharmacopoeia discuss the general testing methods and guidelines,which are the common requirements and basis for the implementation of drug standards in the Chinese Pharmacopoeia.Owing to adherence to the principles of scientificity,versatility,operability,and sustainable development,there is an improvement in the general chapters of the 2020 edition over those of the previous editions.Further,the application of advanced and mature analytical techniques has expanded,the development of testing methods for exogenous pollutants in traditional Chinese medicines has been strengthened,and technical requirements are now better harmonized with international standards.The updated edition provides technical and methodological support to ensure safety,effectiveness,and control of pharmaceuticals in China and will play an important and active role in encouraging the application of advanced technologies,improving the quality control of medicines,and strengthening the means of drug regulation in China.This review provides a comprehensive introduction of the main features of and changes to the general chapters in the Chinese Pharmacopoeia 2020 edition and aims to provide reference for its correct understanding and accurate implementation.
基金the financial support from the National Natural Science Foundation of China(12171405 and 11661074)the Program for New Century Excellent Talents in Fujian Province University+2 种基金the financial support from the Characteristic&Preponderant Discipline of Key Construction Universities in Zhejiang Province(Zhejiang Gongshang University-Statistics)Collaborative Innovation Center of Statistical Data Engineering Technology&ApplicationDigital+Discipline Construction Project(SZJ2022B004)。
文摘Motivated by recent advances made in the study of dividend control and risk management problems involving the U.S.bankruptcy code,in this paper we follow[44]to revisit the De Finetti dividend control problem under the reorganization process and the regulator's intervention documented in U.S.Chapter 11 bankruptcy.We do this by further accommodating the fixed transaction costs on dividends to imitate the real-world procedure of dividend payments.Incorporating the fixed transaction costs transforms the targeting optimal dividend problem into an impulse control problem rather than a singular control problem,and hence computations and proofs that are distinct from[44]are needed.To account for the financial stress that is due to the more subtle concept of Chapter 11 bankruptcy,the surplus process after dividends is driven by a piece-wise spectrally negative Lévy process with endogenous regime switching.Some explicit expressions of the expected net present values under a double barrier dividend strategy,new to the literature,are established in terms of scale functions.With the help of these expressions,we are able to characterize the optimal strategy among the set of admissible double barrier dividend strategies.When the tail of the Lévy measure is log-convex,this optimal double barrier dividend strategy is then verified as the optimal dividend strategy,solving our optimal impulse control problem.
文摘Fu Sheng Liu Ji is a collection of autobiographical essays written by Shen Fu and it occupies a rather important place in the notebook literature of the Qing Dynasty,which has also been widely translated and spread abroad.So far,there have been four English translation versions.Based on the theory of creative treason,this paper analyzed Black’s English translation from the aspects of the choice of content and the restructure,culture and language.It has been found that,as a result of the translator’s conscious or unconscious creative treason,translations may have the effect of engaging readers of the target language,transmitting the culture of the source language and facilitating literary exchange,but they may also have caused misinterpretation by readers and the loss of Chinese cultural imagery.
文摘Six Chapters of a Floating Life is an elegant autobiographical prose. The English version of Lin Yutang is honored as one of the classic translations. As the first translator to embrace"aestheticism"from the perspective of translation in Chinese history,Lin Yutang put for ward three standards for translation, namely,"fidelity, coherence and beauty", and proposed translation aesthetics in his article On Translation. By interpreting Lin's translation work of Six Chapters of a Floating Life from the aesthetic aspect,this paper analyzes Lin Yutang's standards for"aesthetic"translation, which refers to the beauty of sound, sense, conception, form and spirit, and also reveals his enlightening contribution to translation theory construction.
文摘The structure of the irreducible collective spaces of the group Sp(12,R),which many-particle nuclear states are classified according to the chain Sp(12,R)⊃U(6)⊃SO(6)⊃SU_(pn)(3)⊗SO(2)⊃SO(3)of the proton-neutron symplectic model(PNSM),is considered in detail.This chain of the PNSM was recently shown to correspond to a microscopic shell-model version of the Bohr-Mottelson collective model.The construction of the relevant shell-model representations of the Sp(12,R)group along this chain is considered for three nuclei with varying collective properties and from different mass regions.It is shown that the SU_(pn)(3)basis states of the Sp(12,R)representations belonging to the SO(6)irreps with seniorityυ≥υ0,withυ0 denoting the maximal seniority SO(6)irrep contained in the Sp(12,R)bandhead,are always Pauli allowed,but organized in a different way into different SO(6)shells.This is in contrast to the case of filling the levels of the standard three-dimensional harmonic oscillator and using the plethysm operation.Although the SU_(pn)(3)multiplets withinυ<υ0 are not all Pauli forbidden,it is safe to discard them.The results obtained in the present work are important for the practical application of the microscopic version of the Bohr-Mottelson collective model.
