Background Iron deficiency anemia(IDA)ranks among the most prevalent nutritional disorders,particularly affecting adolescents and women of reproductive age.An estimated 2 billion individuals worldwide suffer from iron...Background Iron deficiency anemia(IDA)ranks among the most prevalent nutritional disorders,particularly affecting adolescents and women of reproductive age.An estimated 2 billion individuals worldwide suffer from iron deficiency.Globally,iron deficiency is responsible for around 50%of all anemia cases and contributes to approximately 841,000 deaths each year.Objective This study aims to evaluate the effect of Unani formulation for treating IDA in reproductive age group women.Methods This clinical trial was a single-blind,randomized,standard-controlled study involving 30 women aged 18 to 45 years,all of whom completed the trial.Participants were randomized between two groups of 15 each using block randomization,receiving either 20 mL Sharbat Anar Shireen(juice of Punica granatum Linn.)(test group)or elemental iron 100 mg(control group)once daily after food with water for 30 days.The primary outcomes were evaluated using the Fatigue Severity Scale,Grading of Pallor,and the Exercise Capacity Evaluation Questionnaire,assessed at baseline and at fortnightly follow-ups.The secondary outcome included changes in haemoglobin percentage,measured before and after treatment.An additional follow-up was conducted one-month post-treatment to assess sustained effects.Safety assessments were evaluated through routine clinical evaluations and monitoring of adverse effects.Results This study demonstrated the significant effect of Sharbat Anar Shireen(P.granatum),a Unani formulation in improving both subjective and objective parameters.After one month of treatment,both groups demonstrated statistically significant improvements(P<0.001)in the Fatigue Severity Scale,Pallor Grading,and Exercise Capacity Evaluation Questionnaire at every assessment point.Intergroup analysis exhibited no significant differences(P>0.05),except for enhanced exercise capacity and reduced fatigue,which showed a statistically significant improvement in the test group compared to the control group(P<0.05).Objective parameters,including haemoglobin percentage,significantly improved in both groups after treatment(P<0.001)with intergroup analysis revealed a statistically significant difference(P<0.005).Conclusion This RCT demonstrated that Sharbat Anar Shireen(P.granatum)is a safe and effective intervention for iron deficiency anemia.Both groups exhibited significant improvements(P<0.001),with the test group exhibiting greater efficacy in reducing fatigue and improving haemoglobin levels(P<0.005).Further clinical studies are warranted to confirm these findings.展开更多
文摘Background Iron deficiency anemia(IDA)ranks among the most prevalent nutritional disorders,particularly affecting adolescents and women of reproductive age.An estimated 2 billion individuals worldwide suffer from iron deficiency.Globally,iron deficiency is responsible for around 50%of all anemia cases and contributes to approximately 841,000 deaths each year.Objective This study aims to evaluate the effect of Unani formulation for treating IDA in reproductive age group women.Methods This clinical trial was a single-blind,randomized,standard-controlled study involving 30 women aged 18 to 45 years,all of whom completed the trial.Participants were randomized between two groups of 15 each using block randomization,receiving either 20 mL Sharbat Anar Shireen(juice of Punica granatum Linn.)(test group)or elemental iron 100 mg(control group)once daily after food with water for 30 days.The primary outcomes were evaluated using the Fatigue Severity Scale,Grading of Pallor,and the Exercise Capacity Evaluation Questionnaire,assessed at baseline and at fortnightly follow-ups.The secondary outcome included changes in haemoglobin percentage,measured before and after treatment.An additional follow-up was conducted one-month post-treatment to assess sustained effects.Safety assessments were evaluated through routine clinical evaluations and monitoring of adverse effects.Results This study demonstrated the significant effect of Sharbat Anar Shireen(P.granatum),a Unani formulation in improving both subjective and objective parameters.After one month of treatment,both groups demonstrated statistically significant improvements(P<0.001)in the Fatigue Severity Scale,Pallor Grading,and Exercise Capacity Evaluation Questionnaire at every assessment point.Intergroup analysis exhibited no significant differences(P>0.05),except for enhanced exercise capacity and reduced fatigue,which showed a statistically significant improvement in the test group compared to the control group(P<0.05).Objective parameters,including haemoglobin percentage,significantly improved in both groups after treatment(P<0.001)with intergroup analysis revealed a statistically significant difference(P<0.005).Conclusion This RCT demonstrated that Sharbat Anar Shireen(P.granatum)is a safe and effective intervention for iron deficiency anemia.Both groups exhibited significant improvements(P<0.001),with the test group exhibiting greater efficacy in reducing fatigue and improving haemoglobin levels(P<0.005).Further clinical studies are warranted to confirm these findings.
