Objective:The purpose of this article is to investigate the performance of Echinacea extract as a preservative and antimicrobial agent in a hydrating cream.Methods:The hydrating cream was prepared by mixing the oil an...Objective:The purpose of this article is to investigate the performance of Echinacea extract as a preservative and antimicrobial agent in a hydrating cream.Methods:The hydrating cream was prepared by mixing the oil and water phases at a temperature of 75±2℃.Then,physicochemical and microbial analyses were performed on the prepared cream using different devices.Results:For proper evaluation and a more detailed examination of the prepared cream,each experiment was performed three times(n≥3),and the average data are reported.The results of the prepared cream indicate that it has a high skin absorption capacity,and the Echinacea extract has given it antimicrobial properties.Other advantages of making this hydrating cream include high hydration to human skin,formulation stability,and a long-lasting effect without creating a two-phase state.Conclusion:Creams have been evaluated as a primary component of cosmetic products as topical preparations from time immemorial due to their ease of use and removal from the skin.In this article,we report the formulation of a hydrating cream using various ingredients.The results obtained from this article demonstrate that this extract can maintain its properties under accelerated stability conditions for 6 months.Also,the prepared cream can eliminate bacteria over 28 days in an effective antimicrobial preservative test.展开更多
Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of administration,targeted delivery and complete availability.Many excipients used in pharmaceutical f...Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of administration,targeted delivery and complete availability.Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery.These orphan excipients could enhance formulatability of highly lipophilic compounds.Additionally,they are safe in preclinical species when used below the LD50 values.However,when the excipients are used in formulating compounds with diverse physico-chemical properties,they pose challenges by modulating study results through their bioanalytical matrix effects.Excipients invariably present in study samples and not in the calibration curve standards cause over-/under-estimation of exposures.Thus,the mechanism by which excipients cause matrix effects and strategies to nullify these effects needs to be revisited.Furthermore,formulation excipients cause drug interactions by moderating the pathways of drug metabolizing enzymes and drug transport proteins.Although it is not possible to get rid of excipient driven interactions,it is always advised to be aware of these interactions and apply the knowledge to draw meaningful conclusions from study results.In this review,we will comprehensively discuss a)orphan excipients that have wider applications in preclinical formulations,b)bioanalytical matrix effects and possible approaches to mitigating these effects,and c)excipient driven drug interactions and strategies to alleviate the impacts of drug interactions.展开更多
With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug del...With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug delivery systems, transdermal patch can maintain stable and effective plasma concentration and therapeutic effect in vivo for a long time after skin dressing delivery, which provides a safe and effective drug-delivery way for the therapy and prevention of some chronic diseases and partial analgesia in a simple and convenient way. Veterinary drug transdermal preparations have been developed both at home and abroad, and satisfactory results have been achieved in the experimental application. Based on the study of veterinary transdermal patches at home and abroad, this paper systematically describes the development and characteristics of transdermal patches, the factors affecting skin permeation and the evaluation this type of preparations in veterinary drugs.展开更多
Nanoparticulate drug delivery systems(NDDS)have revolutionized modern medicine by significantly improving drug targeting,bioavailability,and therapeutic efficacy.Despite the clinical success of over 90 approved nanome...Nanoparticulate drug delivery systems(NDDS)have revolutionized modern medicine by significantly improving drug targeting,bioavailability,and therapeutic efficacy.Despite the clinical success of over 90 approved nanomedicines,the development of NDDS remains challenging due to the complexity of formulation design,optimization,and characterization processes.Artificial intelligence,particularly machine learning(ML),offers powerful data analytics and predictive capabilities that can address these challenges.This review systematically summarizes recent advances in ML applications across various NDDS formulations,including polymeric nanoparticles,lipid nanoparticles,liposomes,solid lipid nanoparticles,nanostructured lipid carriers,nanoemulsions,nanosuspensions,lipid-based hybrid NDDS,self-emulsifying drug delivery systems,niosomes,and nanocrystals.We also summarize how ML algorithms could help predict critical quality attributes of NDDS,such as particle size,shape,surface properties,drug encapsulation efficiency,drug loading efficiency,drug release behavior,and stability.Furthermore,we discuss existing challenges and prospects for the formulation development empowered by ML in NDDS.In conclusion,this review provides a comprehensive overview of the transformative potential of ML in improving the formulation development of nanomedicines,ultimately accelerating their clinical translation.展开更多
文摘Objective:The purpose of this article is to investigate the performance of Echinacea extract as a preservative and antimicrobial agent in a hydrating cream.Methods:The hydrating cream was prepared by mixing the oil and water phases at a temperature of 75±2℃.Then,physicochemical and microbial analyses were performed on the prepared cream using different devices.Results:For proper evaluation and a more detailed examination of the prepared cream,each experiment was performed three times(n≥3),and the average data are reported.The results of the prepared cream indicate that it has a high skin absorption capacity,and the Echinacea extract has given it antimicrobial properties.Other advantages of making this hydrating cream include high hydration to human skin,formulation stability,and a long-lasting effect without creating a two-phase state.Conclusion:Creams have been evaluated as a primary component of cosmetic products as topical preparations from time immemorial due to their ease of use and removal from the skin.In this article,we report the formulation of a hydrating cream using various ingredients.The results obtained from this article demonstrate that this extract can maintain its properties under accelerated stability conditions for 6 months.Also,the prepared cream can eliminate bacteria over 28 days in an effective antimicrobial preservative test.
文摘Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of administration,targeted delivery and complete availability.Many excipients used in pharmaceutical formulations are orphanized in preclinical drug discovery.These orphan excipients could enhance formulatability of highly lipophilic compounds.Additionally,they are safe in preclinical species when used below the LD50 values.However,when the excipients are used in formulating compounds with diverse physico-chemical properties,they pose challenges by modulating study results through their bioanalytical matrix effects.Excipients invariably present in study samples and not in the calibration curve standards cause over-/under-estimation of exposures.Thus,the mechanism by which excipients cause matrix effects and strategies to nullify these effects needs to be revisited.Furthermore,formulation excipients cause drug interactions by moderating the pathways of drug metabolizing enzymes and drug transport proteins.Although it is not possible to get rid of excipient driven interactions,it is always advised to be aware of these interactions and apply the knowledge to draw meaningful conclusions from study results.In this review,we will comprehensively discuss a)orphan excipients that have wider applications in preclinical formulations,b)bioanalytical matrix effects and possible approaches to mitigating these effects,and c)excipient driven drug interactions and strategies to alleviate the impacts of drug interactions.
基金Supported by the Program for Technology Research and Development and Its Demonstration and Popularization of Beijing Vocational College of Agriculture(XY-YF-15-08)~~
文摘With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug delivery systems, transdermal patch can maintain stable and effective plasma concentration and therapeutic effect in vivo for a long time after skin dressing delivery, which provides a safe and effective drug-delivery way for the therapy and prevention of some chronic diseases and partial analgesia in a simple and convenient way. Veterinary drug transdermal preparations have been developed both at home and abroad, and satisfactory results have been achieved in the experimental application. Based on the study of veterinary transdermal patches at home and abroad, this paper systematically describes the development and characteristics of transdermal patches, the factors affecting skin permeation and the evaluation this type of preparations in veterinary drugs.
基金supported by the National Natural Science Foundation of China(No.82104402)the Regulatory Science Research Project of the Guangdong-Hong Kong-Macao Greater Bay Area Center for Drug Evaluation and Inspection of National Medical Products Administration(No.GBA-JGKX-2507,China)+1 种基金Traditional Chinese Medicine Research Fund of Guangdong Provincial Bureau(No.202405061017183700,China)the Natural Science Foundation of Guangdong Province(No.2023A1515010720,China).
文摘Nanoparticulate drug delivery systems(NDDS)have revolutionized modern medicine by significantly improving drug targeting,bioavailability,and therapeutic efficacy.Despite the clinical success of over 90 approved nanomedicines,the development of NDDS remains challenging due to the complexity of formulation design,optimization,and characterization processes.Artificial intelligence,particularly machine learning(ML),offers powerful data analytics and predictive capabilities that can address these challenges.This review systematically summarizes recent advances in ML applications across various NDDS formulations,including polymeric nanoparticles,lipid nanoparticles,liposomes,solid lipid nanoparticles,nanostructured lipid carriers,nanoemulsions,nanosuspensions,lipid-based hybrid NDDS,self-emulsifying drug delivery systems,niosomes,and nanocrystals.We also summarize how ML algorithms could help predict critical quality attributes of NDDS,such as particle size,shape,surface properties,drug encapsulation efficiency,drug loading efficiency,drug release behavior,and stability.Furthermore,we discuss existing challenges and prospects for the formulation development empowered by ML in NDDS.In conclusion,this review provides a comprehensive overview of the transformative potential of ML in improving the formulation development of nanomedicines,ultimately accelerating their clinical translation.
