Good writing is about making good choice of a thesis statement. A thesis statement is not only our source of writing but also our limit and measure. Based on the structure and function of a thesis statement, three cri...Good writing is about making good choice of a thesis statement. A thesis statement is not only our source of writing but also our limit and measure. Based on the structure and function of a thesis statement, three critical thesis statement formulating strategies are suggested. The thesis statement formulating strategies are targeted as the critical points in this paper because thesis statement formulating strategies can provide a learner with possibilities of selecting clear and concise thesis statements for writing purposes. These strategies ensure a learner to write effectively in English.展开更多
CAS 132-2006 formulation background and work courses
Flat panel display technology is maturing alongside the development of science and technology. The prices of flat panel display TV sets are becoming lower ... CAS 132-2006 formulation background and work courses
Flat panel display technology is maturing alongside the development of science and technology. The prices of flat panel display TV sets are becoming lower and lower. Flat panel display TV sets have begun entering the mainstream and are now the first choice of some consumers when making new TV purchases.Display TV Set Installation Service Point Explanation and AnalysisRepair, Retreat and Change Duty Stipulations. Peculiar use conditions, usage environments, and the practical circumstances of user consumption service requirements, etc., were also taken into account on the basis of extensive investigation, testing, and verification.……展开更多
Objective： To study which items need the formulation of national standards and which standards should be first formulated. Methods： Apply the method of the questionnaire survey to collect data, and the statistical a...Objective： To study which items need the formulation of national standards and which standards should be first formulated. Methods： Apply the method of the questionnaire survey to collect data, and the statistical analysis adopt the frequency and weighted average method. Results： Propose the items of acupuncture and moxibustion which need the urgent formulation of standards and the sequence in the formulation of standard items. Conclusion： Provid important bases for the follow-up report of national standard items and avoid temporary formulation of standards without plan .展开更多
In response to the malnutrition problem affecting children in Congo Brazzaville, we made three cooking-type infant flours from <i>Treculia obovoidea</i>, <i>Terminalia catappa </i>L. almonds an...In response to the malnutrition problem affecting children in Congo Brazzaville, we made three cooking-type infant flours from <i>Treculia obovoidea</i>, <i>Terminalia catappa </i>L. almonds and <i>Ipomoea batatas</i> L. leaves. The nutritional quality of the three infant flours we developed indicates 11.07% - 12.47% protein content, 9.92% - 14.87% fat content, 58.85% - 68.06% carbohydrate content, 1.50% - 2.18% ash and an energy intake varying between 399.84 and 439.37 Kcal. Functionally, our prepared flours have a water absorption capacity between 219.05 and 317.86 mL/g, an oil absorption capacity of 0.19 mL/g, a water solubility index varying from 29.66 - 41.03 and a swelling capacity of 250% - 320%.展开更多
Change is a word synonymous with China. Since inaugurating its reform campaign 29 years ago, the nation has seen countless examples of change, from the social, economic, political and cultural perspectives. Many of th...Change is a word synonymous with China. Since inaugurating its reform campaign 29 years ago, the nation has seen countless examples of change, from the social, economic, political and cultural perspectives. Many of these changes have been dramatic and have spawned social problems and related disputes. The 21st Century Business Herald, a leading Chinese financial news- paper, recently convened a group of eminent scholars specializing in social sciences to discuss the challenges facing China's further reform and the trend of its social development. Professor Zhou Weimin, Editor in Chief of Study Times, Yang Fengchun, Dean of the E-Government Research Center of Peking University, Professor Mao Shoulong, Faculty Director of the Department of Public Administration of the Renmin University of China, and Professor Zhen Xiaoying at the Central Institute of Socialism, give their opinions in the following excerpts:展开更多
In recent years,the application scenarios of electrical and electronic products have become increasingly diverse worldwide.The impact of climatic environmental tests on the performance of related products has attracte...In recent years,the application scenarios of electrical and electronic products have become increasingly diverse worldwide.The impact of climatic environmental tests on the performance of related products has attracted much attention,and formulating scientific and reasonable environmental test plans has become an important step to ensure product quality and reliability.展开更多
In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratifi...In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratification,prevention,intervention,and management framework for hypertension tailored to the unique characteristics of the Chinese population.Over the past two decades,these guidelines have been widely implemented in clinical practice across China and have played a significant role in the management of hypertension and chronic diseases,the development of grassroots guidelines,the formulation of clinical pathways,and the implementation of health insurance policies.展开更多
OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a mor...OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.展开更多
Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,stressed that we should adhere to the“two integrations”(namely,integrating the basic tenets of Marxism with China’s specific realit...Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,stressed that we should adhere to the“two integrations”(namely,integrating the basic tenets of Marxism with China’s specific realities and fine traditional culture),root ourselves in Chinese soil,carry forward the Chinese cultural heritage,and strengthen the academic foundation.We should accelerate the building of an independent knowledge system for Chinese philosophy and social sciences,and formulate original concepts and develop systems of academic discipline,research and discourse,drawing on China’s rich experience of advancing human rights.In the face of changes of a magnitude not seen in a century,in the historic process of advancing the great rejuvenation of the Chinese nation on all fronts through Chinese modernization,we should and must strengthen our theoretical self-consciousness and confidence in the path of Chinese modernization.We need to enhance human rights research,develop the human rights theoretical system and paradigm that are based on Chinese realities and express Chinese voice,and an independent Chinese knowledge system for human rights.展开更多
Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affec...Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use.展开更多
This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized ...This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized via the esterification of phytosterol and oleic acid,whose structure was characterized using Fourier-transform infrared spectroscopy(FTIR)and mass spectrometry(MS).Its liquid crystalline behavior was confirmed via the polarized optical microscopy(POM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),wide-angle X-ray scattering(WAXS),and small-angle X-ray scattering(SAXS).UV absorption tests were conducted to assess the UV-blocking performance of the oleic acid sterol ester liquid crystals.To improve the stability of its liquid crystalline structure,the oleic acid sterol ester was encapsulated into microcapsules through the emulsion polymerization.SPF measurements were performed on the sunscreen formulations containing liquid crystal microcapsules.The oleic acid sterol ester displayed cholesteric liquid crystalline behavior and strong UVA absorption,which indicates its suitability as a natural UV absorber.Microencapsulation further enhanced its stability and UV-blocking properties.SPF testing showed that the formulations with microcapsules achieved an SPF value of 7.01,which surpasses the nano titanium dioxide(SPF=6.23)and significantly outperform the unencapsulated liquid crystal formulations(SPF=2.65).This study highlights the potential of microencapsulated oleic acid sterol ester as a novel UV absorber in the sunscreen formulations,offers the enhanced stability and effective UV protection,and showcases its application potential in the innovative cosmetic products.展开更多
Plant biofertilization involves introducing compounds containing living mi-croorganisms into the coating medium to sustainably enhance plant production and soil health. This is a complex process that undergoes multipl...Plant biofertilization involves introducing compounds containing living mi-croorganisms into the coating medium to sustainably enhance plant production and soil health. This is a complex process that undergoes multiple stages of development before yielding a final product. The final biofertilizer is used by legumes-protein-rich crops in symbiosis with rhizobia to enable biological nitrogen fixation increasing natural soil fertility. This study aims to determine the optimal formulation of a rhizobial biofertilizer to improve the performance of soybean (Glycine max L. cv. Docko). To this end, soybean seeds obtained from IRAD were coated with different formulations derived from locally sourced materials. Palm kernel oil was used as an adhesive in one group, while corn powder served as an adhesive in another. The coated seeds were then sown in the field. The results indicate that the combination of pigeon pea powder + sugarcane molasses, with palm kernel oil as an adhesive, produced the best nodulation (nitrogen fixation). This formulation also led to significant improvements in growth (+350%) and total nitrogen content (+1100%) compared to the bacterial broth inoculum control (B0) (P ≤ 0.01). These findings represent a significant advancement in improving nitrogen-fixing bacterial inoculants and enhancing soil fertility for the sustainable cultivation of soybeans in this tropical soil.展开更多
This research is an experimental study aimed at identifying and determining the physico-mechanical properties of various granular materials used in current concretes based on local aggregates (sands, gravels) from dif...This research is an experimental study aimed at identifying and determining the physico-mechanical properties of various granular materials used in current concretes based on local aggregates (sands, gravels) from different quarries, highlighting their intrinsic properties. The aim was also to test their specific influence on the cementitious matrix of hardened concrete. Several laboratory tests were conducted on samples from Brazzaville and Pointe-Noire. To develop a variety of concrete formulations meeting rheological criteria (deformability, bleeding, segregation) and create an optimal concrete formulation approach considering its microstructural and compacting matrix, a good granular distribution was planned, using two types of sand (rolled and crushed). This involved correcting the rolled sand with variable proportions (30% to 50%) of crushed sand. The results from the eight concrete formulations studied, using the Dreux-Gorisse method, showed that six formulations produced the expected results. Compressive strengths at 28 days ranged from 25 to 36.75 MPa. As a result, formulation 3 appears to be the best, with a mechanical strength of 36.75 MPa at 28 days, compared to formulation 1 (33.75 MPa), formulation 4 (27.25 MPa), and formulation 2 (26.65 MPa) for the Brazzaville locality. For the Pointe-Noire locality, formulation 8 was judged the best, with a characteristic mechanical strength of 29.70 MPa at 28 days, followed by formulation 7 (27.30 MPa), formulation 5 (22.80 MPa), and formulation 6 (18.30 MPa). In summary, the concretes formulated with raw sand showed better results than those with improved sands. The same was true for concrete formulations using rolled sand and gravel.展开更多
BACKGROUND Mesalamine is the recommended first-line treatment for inducing and maintaining remission in mild-to-moderate ulcerative colitis(UC).However,adherence in real-world settings is frequently suboptimal.Encoura...BACKGROUND Mesalamine is the recommended first-line treatment for inducing and maintaining remission in mild-to-moderate ulcerative colitis(UC).However,adherence in real-world settings is frequently suboptimal.Encouraging collaborative patient-provider relationships may foster better adherence and patient outcomes.AIM To quantify the association between patient participation in treatment decisionmaking and adherence to oral mesalamine in UC.METHODS We conducted a 12-month,prospective,non-interventional cohort study at 113 gastroenterology practices in Germany.Eligible patients were aged≥18 years,had a confirmed UC diagnosis,had no prior mesalamine treatment,and provided informed consent.At the first visit,we collected data on demographics,clinical characteristics,patient preference for mesalamine formulation(tablets or granules),and disease knowledge.Self-reported adherence and disease activity were assessed at all visits.Correlation analyses and logistic regression were used to examine associations between adherence and various factors.RESULTS Of the 605 consecutively screened patients,520 were included in the study.The median age was 41 years(range:18-91),with a male-to-female ratio of 1.1:1.0.Approximately 75%of patients reported good adherence at each study visit.In correlation analyses,patient participation in treatment decision-making was significantly associated with better adherence across all visits(P=0.04).In the regression analysis at 12 months,this association was evident among patients who both preferred and received prolonged-release mesalamine granules(odds ratio=2.73,P=0.001).Patients reporting good adherence also experienced significant improvements in disease activity over 12 months(P<0.001).CONCLUSION Facilitating patient participation in treatment decisions and accommodating medication preferences may improve adherence to mesalamine.This may require additional effort but has the potential to improve long-term management of UC.展开更多
Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy ...Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties.This review consolidates scientific efforts to elucidate how LNP’s physicochemical attributes influence their in vivo fate,emphasizing particle size and shape,surface electric potential and ligand-binding chemistry.By examining the interplay between LNPs and biological barriers across various administration routes,this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects.Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.展开更多
Background:Luliconazole is an imidazole antifungal drug mainly used to treat dermatophytic infections including tinea pedis,tinea cruris,and tinea corporis.Objective:The purpose of this research was to synthesize a tr...Background:Luliconazole is an imidazole antifungal drug mainly used to treat dermatophytic infections including tinea pedis,tinea cruris,and tinea corporis.Objective:The purpose of this research was to synthesize a transferosomal gel incorporating luliconazole for external applications.Materials and methods:The preparation method employed thin film hydration to prepare transferosomes loaded with luliconazole with lecithin and tween 80 at different concentrations.The transferosomes formed were characterized in terms of particle size and entrapment efficiency.Finally,the prepared transferosomes were applied in a carbopol gel base and characterized for drug content,pH,spreadability,viscosity,in vitro release profile,and antifungal studies.Results:The synthesized luliconazole transferosomes had high entrapment efficiency of 74.45%,and 92.75%,with particle size ranging between 60 and 200 nm.The shape of the transferosomes was established using scanning electron microscopy;the results depicted spherical-shaped vesicles.The in vitro release study also suggested that the entrapment efficiency influences in vitro release where there is a negative relationship between the two.The gel formulation revealed a good antifungal effect.Conclusion:The luliconazole transferosomal gel exhibited a sustained release profile of the drug and thus may lessen the number of applications required,thereby enhancing patient compliance.展开更多
This work focuses on the formulation of a dietary cold sauce,mayonnaise,which combines the therapeutic properties of two basic ingredients:PSO(Pumpkin Seed Oil)and quail egg,both of which are renowned for their high f...This work focuses on the formulation of a dietary cold sauce,mayonnaise,which combines the therapeutic properties of two basic ingredients:PSO(Pumpkin Seed Oil)and quail egg,both of which are renowned for their high functional properties.PSO is essentially made up of unsaturated fatty acids(50%to 65%)including linoleic acid,from the omega 6 family,oleic acid(20%to 50%),a monounsaturated fatty acid(omega 9),cucurbitin,phytosterols,tri-terpenes and vitamin E(3.5 mg%).The nutritional,fatty acid,vitamin and mineral compositions of the mayonnaise compared with the ingredients,the physico-chemical characteristics of the quail egg,the PSO and the tasting of the mayonnaise were determined and gave results in terms of variable contents which are recorded in Tables 2-8.The results obtained were satisfactory.Mayonnaise,a semi-solid emulsion of oil in water with viscoelastic properties due to the network formed by lipoproteins adsorbed around neighbouring drops of oil,was prepared using the ratio of quail egg and PSO 1/4.This study may offer an alternative way of making dietary sauces.展开更多
The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these s...The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these shortcomings.However,its efficacy against PWD remains uncertain.This study evaluated the translocation of fluopyram dust within tree tissues,soil and water degradation,and its effective control against PWD.Nursery tests showed effective prevention;field tests showed dust absorption and translocation into pine tissues.Thirty days following application,residual concentrations in soil were low at 0.09 mg kg^(−1);no detectable residues were found in water samples.Three years after applying fluopyram,its effectiveness increased to approximately 87%.Based on this study,fluopyram had a half-life of 346 d with persistence lasting up to three years.This provides valuable insight for managing PWD through dust applications.展开更多
Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and poten...Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and potential mechanisms of FHF for treating vaginitis,and reveal its pharmacological activities against vaginitis.Results:A total of 12 anti-inflammatory components in FHF and 584 pharmacological targets were identified.Furthermore,1427 vaginitis-associated targets were identified,and 184 intersection targets between FHF and vaginitis were constructed for network analysis.Gene Ontology and pathway analysis revealed that the therapeutical targets of FHF against vaginitis are involved in modulating inflammatory stress,enhancing immunoregulation,reconstructing the microenvironment,and suppressing cell damage.Molecular docking analysis further suggested the possible direct binding of the bioactive compounds of FHF(fumarine)to the core targets,including AKT Serine/Threonine Kinase 1(AKT1),Signal Transducer and Activator of Transcription 3(STAT3),and nuclear factor-kappaB(NF-κB).Experimental validation found that FHF-treated vaginitis rats exhibited reduced intracellular AKT1,STAT3,and NF-κB protein expressions.Conclusion:Overall,we identified the bioactive compounds and pharmacological mechanisms of FHF against vaginitis,thus offering a theoretical fundament for exploring FHF for treating vaginitis in the future.展开更多
A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order t...A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order to reduce the use of chemical spices in the preparation of different dishes. The Design of Experiments (DOE) methodology was used for the formulation of the spices and their physicochemical, nutritional and sensory characteristics were evaluated by standardized and standard methods. The results obtained showed lipid contents (g/100 g DM) ranging from 10.41 ± 0.26 to 15.64 ± 0.68, total sugars from 4.39 ± 0.32 to 5.46 ± 0.31, protein from 3.65 ± 0.17 to 12.04 ± 0.35 and ash from 5.83 ± 0.01 to 7.02 ± 0.01. The polyphenol content ranged from 9.09 ± 1.60 to 11.33 ± 0.90, and the flavonoid content ranged from 0.65 ± 0.03 to 1.08 ± 0.13. The sensory analysis carried out showed that the spices have generally satisfactory organoleptic characteristics. These results constitute new information in the diet of populations and are an alternative to the chemical spices used in their cooking.展开更多
文摘Good writing is about making good choice of a thesis statement. A thesis statement is not only our source of writing but also our limit and measure. Based on the structure and function of a thesis statement, three critical thesis statement formulating strategies are suggested. The thesis statement formulating strategies are targeted as the critical points in this paper because thesis statement formulating strategies can provide a learner with possibilities of selecting clear and concise thesis statements for writing purposes. These strategies ensure a learner to write effectively in English.
文摘 CAS 132-2006 formulation background and work courses
Flat panel display technology is maturing alongside the development of science and technology. The prices of flat panel display TV sets are becoming lower and lower. Flat panel display TV sets have begun entering the mainstream and are now the first choice of some consumers when making new TV purchases.Display TV Set Installation Service Point Explanation and AnalysisRepair, Retreat and Change Duty Stipulations. Peculiar use conditions, usage environments, and the practical circumstances of user consumption service requirements, etc., were also taken into account on the basis of extensive investigation, testing, and verification.……
基金TCM project supported by the National Program of Science and Technology Development (2006BA121B01)
文摘Objective： To study which items need the formulation of national standards and which standards should be first formulated. Methods： Apply the method of the questionnaire survey to collect data, and the statistical analysis adopt the frequency and weighted average method. Results： Propose the items of acupuncture and moxibustion which need the urgent formulation of standards and the sequence in the formulation of standard items. Conclusion： Provid important bases for the follow-up report of national standard items and avoid temporary formulation of standards without plan .
文摘In response to the malnutrition problem affecting children in Congo Brazzaville, we made three cooking-type infant flours from <i>Treculia obovoidea</i>, <i>Terminalia catappa </i>L. almonds and <i>Ipomoea batatas</i> L. leaves. The nutritional quality of the three infant flours we developed indicates 11.07% - 12.47% protein content, 9.92% - 14.87% fat content, 58.85% - 68.06% carbohydrate content, 1.50% - 2.18% ash and an energy intake varying between 399.84 and 439.37 Kcal. Functionally, our prepared flours have a water absorption capacity between 219.05 and 317.86 mL/g, an oil absorption capacity of 0.19 mL/g, a water solubility index varying from 29.66 - 41.03 and a swelling capacity of 250% - 320%.
文摘Change is a word synonymous with China. Since inaugurating its reform campaign 29 years ago, the nation has seen countless examples of change, from the social, economic, political and cultural perspectives. Many of these changes have been dramatic and have spawned social problems and related disputes. The 21st Century Business Herald, a leading Chinese financial news- paper, recently convened a group of eminent scholars specializing in social sciences to discuss the challenges facing China's further reform and the trend of its social development. Professor Zhou Weimin, Editor in Chief of Study Times, Yang Fengchun, Dean of the E-Government Research Center of Peking University, Professor Mao Shoulong, Faculty Director of the Department of Public Administration of the Renmin University of China, and Professor Zhen Xiaoying at the Central Institute of Socialism, give their opinions in the following excerpts:
文摘In recent years,the application scenarios of electrical and electronic products have become increasingly diverse worldwide.The impact of climatic environmental tests on the performance of related products has attracted much attention,and formulating scientific and reasonable environmental test plans has become an important step to ensure product quality and reliability.
文摘In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratification,prevention,intervention,and management framework for hypertension tailored to the unique characteristics of the Chinese population.Over the past two decades,these guidelines have been widely implemented in clinical practice across China and have played a significant role in the management of hypertension and chronic diseases,the development of grassroots guidelines,the formulation of clinical pathways,and the implementation of health insurance policies.
基金National Key Research and Development Project:Clinical Evaluation of the Interventional Techniques for Abdominal Obesity(No.2019YFC1710102)。
文摘OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.
文摘Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,stressed that we should adhere to the“two integrations”(namely,integrating the basic tenets of Marxism with China’s specific realities and fine traditional culture),root ourselves in Chinese soil,carry forward the Chinese cultural heritage,and strengthen the academic foundation.We should accelerate the building of an independent knowledge system for Chinese philosophy and social sciences,and formulate original concepts and develop systems of academic discipline,research and discourse,drawing on China’s rich experience of advancing human rights.In the face of changes of a magnitude not seen in a century,in the historic process of advancing the great rejuvenation of the Chinese nation on all fronts through Chinese modernization,we should and must strengthen our theoretical self-consciousness and confidence in the path of Chinese modernization.We need to enhance human rights research,develop the human rights theoretical system and paradigm that are based on Chinese realities and express Chinese voice,and an independent Chinese knowledge system for human rights.
基金Supported by National Science and Technology Major Project,No.2024ZD0521002The Innovation Team Project of Traditional Chinese Medicine of Liaoning Province,No.LNZYYCXTD-CCCX-003+1 种基金General Program of the National Natural Science Foundation of China,No.82074296Construction Project of Inheritance Studios of Famous Chinese Medicine Experts in China,No.[2022]No.75.
文摘Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use.
文摘This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized via the esterification of phytosterol and oleic acid,whose structure was characterized using Fourier-transform infrared spectroscopy(FTIR)and mass spectrometry(MS).Its liquid crystalline behavior was confirmed via the polarized optical microscopy(POM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),wide-angle X-ray scattering(WAXS),and small-angle X-ray scattering(SAXS).UV absorption tests were conducted to assess the UV-blocking performance of the oleic acid sterol ester liquid crystals.To improve the stability of its liquid crystalline structure,the oleic acid sterol ester was encapsulated into microcapsules through the emulsion polymerization.SPF measurements were performed on the sunscreen formulations containing liquid crystal microcapsules.The oleic acid sterol ester displayed cholesteric liquid crystalline behavior and strong UVA absorption,which indicates its suitability as a natural UV absorber.Microencapsulation further enhanced its stability and UV-blocking properties.SPF testing showed that the formulations with microcapsules achieved an SPF value of 7.01,which surpasses the nano titanium dioxide(SPF=6.23)and significantly outperform the unencapsulated liquid crystal formulations(SPF=2.65).This study highlights the potential of microencapsulated oleic acid sterol ester as a novel UV absorber in the sunscreen formulations,offers the enhanced stability and effective UV protection,and showcases its application potential in the innovative cosmetic products.
文摘Plant biofertilization involves introducing compounds containing living mi-croorganisms into the coating medium to sustainably enhance plant production and soil health. This is a complex process that undergoes multiple stages of development before yielding a final product. The final biofertilizer is used by legumes-protein-rich crops in symbiosis with rhizobia to enable biological nitrogen fixation increasing natural soil fertility. This study aims to determine the optimal formulation of a rhizobial biofertilizer to improve the performance of soybean (Glycine max L. cv. Docko). To this end, soybean seeds obtained from IRAD were coated with different formulations derived from locally sourced materials. Palm kernel oil was used as an adhesive in one group, while corn powder served as an adhesive in another. The coated seeds were then sown in the field. The results indicate that the combination of pigeon pea powder + sugarcane molasses, with palm kernel oil as an adhesive, produced the best nodulation (nitrogen fixation). This formulation also led to significant improvements in growth (+350%) and total nitrogen content (+1100%) compared to the bacterial broth inoculum control (B0) (P ≤ 0.01). These findings represent a significant advancement in improving nitrogen-fixing bacterial inoculants and enhancing soil fertility for the sustainable cultivation of soybeans in this tropical soil.
文摘This research is an experimental study aimed at identifying and determining the physico-mechanical properties of various granular materials used in current concretes based on local aggregates (sands, gravels) from different quarries, highlighting their intrinsic properties. The aim was also to test their specific influence on the cementitious matrix of hardened concrete. Several laboratory tests were conducted on samples from Brazzaville and Pointe-Noire. To develop a variety of concrete formulations meeting rheological criteria (deformability, bleeding, segregation) and create an optimal concrete formulation approach considering its microstructural and compacting matrix, a good granular distribution was planned, using two types of sand (rolled and crushed). This involved correcting the rolled sand with variable proportions (30% to 50%) of crushed sand. The results from the eight concrete formulations studied, using the Dreux-Gorisse method, showed that six formulations produced the expected results. Compressive strengths at 28 days ranged from 25 to 36.75 MPa. As a result, formulation 3 appears to be the best, with a mechanical strength of 36.75 MPa at 28 days, compared to formulation 1 (33.75 MPa), formulation 4 (27.25 MPa), and formulation 2 (26.65 MPa) for the Brazzaville locality. For the Pointe-Noire locality, formulation 8 was judged the best, with a characteristic mechanical strength of 29.70 MPa at 28 days, followed by formulation 7 (27.30 MPa), formulation 5 (22.80 MPa), and formulation 6 (18.30 MPa). In summary, the concretes formulated with raw sand showed better results than those with improved sands. The same was true for concrete formulations using rolled sand and gravel.
文摘BACKGROUND Mesalamine is the recommended first-line treatment for inducing and maintaining remission in mild-to-moderate ulcerative colitis(UC).However,adherence in real-world settings is frequently suboptimal.Encouraging collaborative patient-provider relationships may foster better adherence and patient outcomes.AIM To quantify the association between patient participation in treatment decisionmaking and adherence to oral mesalamine in UC.METHODS We conducted a 12-month,prospective,non-interventional cohort study at 113 gastroenterology practices in Germany.Eligible patients were aged≥18 years,had a confirmed UC diagnosis,had no prior mesalamine treatment,and provided informed consent.At the first visit,we collected data on demographics,clinical characteristics,patient preference for mesalamine formulation(tablets or granules),and disease knowledge.Self-reported adherence and disease activity were assessed at all visits.Correlation analyses and logistic regression were used to examine associations between adherence and various factors.RESULTS Of the 605 consecutively screened patients,520 were included in the study.The median age was 41 years(range:18-91),with a male-to-female ratio of 1.1:1.0.Approximately 75%of patients reported good adherence at each study visit.In correlation analyses,patient participation in treatment decision-making was significantly associated with better adherence across all visits(P=0.04).In the regression analysis at 12 months,this association was evident among patients who both preferred and received prolonged-release mesalamine granules(odds ratio=2.73,P=0.001).Patients reporting good adherence also experienced significant improvements in disease activity over 12 months(P<0.001).CONCLUSION Facilitating patient participation in treatment decisions and accommodating medication preferences may improve adherence to mesalamine.This may require additional effort but has the potential to improve long-term management of UC.
文摘Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties.This review consolidates scientific efforts to elucidate how LNP’s physicochemical attributes influence their in vivo fate,emphasizing particle size and shape,surface electric potential and ligand-binding chemistry.By examining the interplay between LNPs and biological barriers across various administration routes,this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects.Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.
文摘Background:Luliconazole is an imidazole antifungal drug mainly used to treat dermatophytic infections including tinea pedis,tinea cruris,and tinea corporis.Objective:The purpose of this research was to synthesize a transferosomal gel incorporating luliconazole for external applications.Materials and methods:The preparation method employed thin film hydration to prepare transferosomes loaded with luliconazole with lecithin and tween 80 at different concentrations.The transferosomes formed were characterized in terms of particle size and entrapment efficiency.Finally,the prepared transferosomes were applied in a carbopol gel base and characterized for drug content,pH,spreadability,viscosity,in vitro release profile,and antifungal studies.Results:The synthesized luliconazole transferosomes had high entrapment efficiency of 74.45%,and 92.75%,with particle size ranging between 60 and 200 nm.The shape of the transferosomes was established using scanning electron microscopy;the results depicted spherical-shaped vesicles.The in vitro release study also suggested that the entrapment efficiency influences in vitro release where there is a negative relationship between the two.The gel formulation revealed a good antifungal effect.Conclusion:The luliconazole transferosomal gel exhibited a sustained release profile of the drug and thus may lessen the number of applications required,thereby enhancing patient compliance.
文摘This work focuses on the formulation of a dietary cold sauce,mayonnaise,which combines the therapeutic properties of two basic ingredients:PSO(Pumpkin Seed Oil)and quail egg,both of which are renowned for their high functional properties.PSO is essentially made up of unsaturated fatty acids(50%to 65%)including linoleic acid,from the omega 6 family,oleic acid(20%to 50%),a monounsaturated fatty acid(omega 9),cucurbitin,phytosterols,tri-terpenes and vitamin E(3.5 mg%).The nutritional,fatty acid,vitamin and mineral compositions of the mayonnaise compared with the ingredients,the physico-chemical characteristics of the quail egg,the PSO and the tasting of the mayonnaise were determined and gave results in terms of variable contents which are recorded in Tables 2-8.The results obtained were satisfactory.Mayonnaise,a semi-solid emulsion of oil in water with viscoelastic properties due to the network formed by lipoproteins adsorbed around neighbouring drops of oil,was prepared using the ratio of quail egg and PSO 1/4.This study may offer an alternative way of making dietary sauces.
基金supported by grants from the National Key R&D Program of China(grant number 2021YFD1400900)the National Natural Science Foundation of China(grant numbers U1905201,32171805)+6 种基金the Forestry Key Program of Science and Technology in Fujian Province(grant number 2021FKJ03)the Natural Science Foundation of Fujian Province,China(grant number 2021J01056)the Forestry Programs of Science and Technology in Fujian Province[grant number Mincaizhi(2020)601]the Science and Technology Program of Fujian Province(grant number 2018N5002)the Forestry Science Research Project of Fujian Forestry Department[grant number Minlinke(2017)03]the National Major Emergency Science and Technology Program of China(grant number ZD202001)the Forestry Peak Discipline Construction Project of Fujian Agriculture and Forestry University(grant numbers 72202200205,71201800720).
文摘The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these shortcomings.However,its efficacy against PWD remains uncertain.This study evaluated the translocation of fluopyram dust within tree tissues,soil and water degradation,and its effective control against PWD.Nursery tests showed effective prevention;field tests showed dust absorption and translocation into pine tissues.Thirty days following application,residual concentrations in soil were low at 0.09 mg kg^(−1);no detectable residues were found in water samples.Three years after applying fluopyram,its effectiveness increased to approximately 87%.Based on this study,fluopyram had a half-life of 346 d with persistence lasting up to three years.This provides valuable insight for managing PWD through dust applications.
文摘Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and potential mechanisms of FHF for treating vaginitis,and reveal its pharmacological activities against vaginitis.Results:A total of 12 anti-inflammatory components in FHF and 584 pharmacological targets were identified.Furthermore,1427 vaginitis-associated targets were identified,and 184 intersection targets between FHF and vaginitis were constructed for network analysis.Gene Ontology and pathway analysis revealed that the therapeutical targets of FHF against vaginitis are involved in modulating inflammatory stress,enhancing immunoregulation,reconstructing the microenvironment,and suppressing cell damage.Molecular docking analysis further suggested the possible direct binding of the bioactive compounds of FHF(fumarine)to the core targets,including AKT Serine/Threonine Kinase 1(AKT1),Signal Transducer and Activator of Transcription 3(STAT3),and nuclear factor-kappaB(NF-κB).Experimental validation found that FHF-treated vaginitis rats exhibited reduced intracellular AKT1,STAT3,and NF-κB protein expressions.Conclusion:Overall,we identified the bioactive compounds and pharmacological mechanisms of FHF against vaginitis,thus offering a theoretical fundament for exploring FHF for treating vaginitis in the future.
文摘A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order to reduce the use of chemical spices in the preparation of different dishes. The Design of Experiments (DOE) methodology was used for the formulation of the spices and their physicochemical, nutritional and sensory characteristics were evaluated by standardized and standard methods. The results obtained showed lipid contents (g/100 g DM) ranging from 10.41 ± 0.26 to 15.64 ± 0.68, total sugars from 4.39 ± 0.32 to 5.46 ± 0.31, protein from 3.65 ± 0.17 to 12.04 ± 0.35 and ash from 5.83 ± 0.01 to 7.02 ± 0.01. The polyphenol content ranged from 9.09 ± 1.60 to 11.33 ± 0.90, and the flavonoid content ranged from 0.65 ± 0.03 to 1.08 ± 0.13. The sensory analysis carried out showed that the spices have generally satisfactory organoleptic characteristics. These results constitute new information in the diet of populations and are an alternative to the chemical spices used in their cooking.
