Idioms,collocations,and formulaic phrases are three factors playing the important role in the second language acquisition(SLA).This essay firstly deals with the definitions of these concepts,then it illustrates the im...Idioms,collocations,and formulaic phrases are three factors playing the important role in the second language acquisition(SLA).This essay firstly deals with the definitions of these concepts,then it illustrates the importance of them to SLA on two perspectives—idioms,collocations,and formulaic phrases respectively and they regarded as a whole.Therefore,in this way,the essay may lead to the answer the question“How are idioms,collocations,and formulaic phrases important to SLA?”展开更多
This study was conducted to explore the individual uses of formulaic sequence(FS)frequency and their effects on complexity,accuracy,and fluency(CAF)in academic writing.Data was collected from the conclusion sections o...This study was conducted to explore the individual uses of formulaic sequence(FS)frequency and their effects on complexity,accuracy,and fluency(CAF)in academic writing.Data was collected from the conclusion sections of a self-compiled corpus of 30 L2 master’s theses.Statistical analysis revealed several notable conclusions.1)Student writers tend to make repetitive use of particular FSs in single texts.2)FS use has a significant frequency effect on fluency,and the high-frequency group slightly outperforms the low-frequency group.3)FS use has a certain frequency effect on accuracy,and the high-frequency group demonstrates the strongest correlation between FS frequency and accuracy.4)FS use has a significant frequency effect on lexical complexity,and the low-frequency group slightly outperforms the high-frequency group.In the low-frequency group,FS use has a significant frequency effect on syntactic complexity as well.Finally,5)The results support Skehan’s trade-off effect,a competition between CAF,which,to a certain degree,is affected by individual uses of FS frequency.The low-frequency group displays a greater trade-off effect than the high-frequency group.展开更多
Language plays an important role in interpersonal communication, among which the importance of formulaic language shall never be under-estimated. Reflected in not only the language of individual language users but als...Language plays an important role in interpersonal communication, among which the importance of formulaic language shall never be under-estimated. Reflected in not only the language of individual language users but also language community, formulaic language could help establish and maintain human relationships. Meanwhile, interpersonal function is the most important one among the three metafunctions of language. The present paper aims to find the interface between functional grammar and the study of formulaic language, and consequently the significance of formulaic language in the realization of interoersonal function.展开更多
This study explored the distribution of three types of English formulaic language, which involves four categories in L1 Chinese L2 English learners’ speaking performance. In addition, it investigated the relationship...This study explored the distribution of three types of English formulaic language, which involves four categories in L1 Chinese L2 English learners’ speaking performance. In addition, it investigated the relationship between the English learners’ use of formulaic language and their spoken English fluency. A CCA(canonical correlation analysis) was conducted to examine the correlations between two sets of fluency variables(dependent variables) and linguistic variables of English formulaic language use(independent variables). The fluency variable set consists of:(1)temporal indices such as SR(speech rate), AR(articulation rate), MLR(mean length of run), and PTR(phonation time ratio);(2) linguistic variables of English formulaic language like F2 R(twoword formulaic sequences/run ratio, B3 R(three-word lexical bundles/run ratio), and B4 R(fourword lexical bundles/run ratio). These are calculated according to the frequency of the English formulaic language in the speech samples of the participants(n = 86) across three academic levels.The results indicate that the learners’ spoken English fluency is highly related to their use of English formulaic language. Its limitations and future research directions are also discussed.展开更多
This paper discusses the role of formulaic language in the teaching of English as a foreign language,and in particular in the decoding of the spoken production of native speakers(NSs).
This paper argues for the need of the reappraisal of the formulaic aspect of language in second language acquisition by drawing insights from recent development in applied linguistics, psycholinguistics and corpus lin...This paper argues for the need of the reappraisal of the formulaic aspect of language in second language acquisition by drawing insights from recent development in applied linguistics, psycholinguistics and corpus linguistics. This library study begins by reviewing the dual-nature view of language in relation to formulaic aspect of language. Then, a brief survey of evidence from corpus linguistics is provided to demonstrate the formulaicity of language. What follows is the discussion of rehearsal and implicit learning vis-a-vis memory from the perspective of psycholinguistics. After that, the role of formulaic language in second language acquisition is examined by taking stock of empirical findings that have accumulated in this area. Finally, by way of conclusion, how the formulaicity of language can shed light on second/foreign language teaching theory is illustrated.展开更多
A controversial issue in the field of Second Language spoken English acquisition is which one plays a more important role, the formulaic speech or the creative rules? And researchers have long kept different opinions ...A controversial issue in the field of Second Language spoken English acquisition is which one plays a more important role, the formulaic speech or the creative rules? And researchers have long kept different opinions about the definition of formulaic speech. The present paper discusses the definition of formulaic speech, describes relevant empirical studies and summarizes some roles of formulaic speech from our own experiments, hoping to provide some insights for second language spoken English teaching and learning.展开更多
This corpus-based study cmploys statistical analysis to compare the use of non-compositional formulaic sequences by high proficiency Chinese learners and native students.The top 5 overused and underused patterns by Ch...This corpus-based study cmploys statistical analysis to compare the use of non-compositional formulaic sequences by high proficiency Chinese learners and native students.The top 5 overused and underused patterns by Chinese users are identified.Features of their usage point to a lack of register awareness as well as linguistic resources,while showing individual differences.展开更多
Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas. The basic ideas include utilizing properly the △-operator and Stirling num...Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas. The basic ideas include utilizing properly the △-operator and Stirling numbers for some series transformations. A variety of classic formulas and remarkable identities are shown to be the members of the classes.展开更多
This study investigated the relationship between situation-bound utterances （SBUs thereafter） and formulaic competence, focusing on the acquisition of three subcategories of SBUs among early intermediate and early a...This study investigated the relationship between situation-bound utterances （SBUs thereafter） and formulaic competence, focusing on the acquisition of three subcategories of SBUs among early intermediate and early advanced Chinese learners of English as a foreign language （EFL）. A group of native English speakers also participated in this study to provide baseline data. One-way ANOVA analysis and post hoc tests confirmed that linguistic competence usually preceded formulaic competence for EFL learners. The findings also showed no statistically significant difference existing between the three groups of participants in the use of plain SBUs, and this could be attributed to the low degree of cultural-embeddedness and high semantic transparency of plain SBUs. It was further argued that a threshold has to be reached for EFL learners to go through a movement from rules to wholes.展开更多
Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi...Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.展开更多
Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.Howev...Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.However,the widened hydraulic excitation frequency may satisfy the blade resonance due to the time variation in the velocity and angle of attack of the ocean current,even resulting in blade fatigue and destructively interfering with grid stability.A key parameter that determines the resonance amplitude of the blade is the hydrodynamic damping ratio(HDR).However,HDR is difficult to obtain due to the complex fluid-structure interaction(FSI).Therefore,a literature review was conducted on the hydrodynamic damping characteristics of blade-like structures.The experimental and simulation methods used to identify and obtain the HDR quantitatively were described,placing emphasis on the experimental processes and simulation setups.Moreover,the accuracy and efficiency of different simulation methods were compared,and the modal work approach was recommended.The effects of key typical parameters,including flow velocity,angle of attack,gap,rotational speed,and cavitation,on the HDR were then summarized,and the suggestions on operating conditions were presented from the perspective of increasing the HDR.Subsequently,considering multiple flow parameters,several theoretical derivations and semi-empirical prediction formulas for HDR were introduced,and the accuracy and application were discussed.Based on the shortcomings of the existing research,the direction of future research was finally determined.The current work offers a clear understanding of the HDR of blade-like structures,which could improve the evaluation accuracy of flow-induced vibration in the design stage.展开更多
Objective The study of medicine formulas is a core component of traditional Chinese medicine(TCM),yet traditional learning methods often lack interactivity and contextual understanding,making it challenging for beginn...Objective The study of medicine formulas is a core component of traditional Chinese medicine(TCM),yet traditional learning methods often lack interactivity and contextual understanding,making it challenging for beginners to grasp the intricate composition rules of formulas.To address this gap,we introduce Formula-S,a situated visualization method for TCM formula learning in augmented reality(AR)and evaluate its performance.This study aims to evaluate the effectiveness of Formula-S in enhancing TCM formula learning for beginners by comparing it with traditional text-based formula learning and web-based visualization.Methods Formula-S is an interactive AR tool designed for TCM formula learning,featuring three modes(3D,Web,and Table).The dataset included TCM formulas and herb properties extracted from authoritative references,including textbook and the SymMap database.In Formula-S,the hierarchical visualization of the formulas as herbal medicine compositions,is linked to the multidimensional herb attribute visualization and embedded in the real world,where real herb samples are presented.To evaluate its effectiveness,a controlled study(n=30)was conducted.Participants who had no formal TCM knowledge were tasked with herbal medicine identification,formula composition,and recognition.In the study,participants interacted with the AR tool through HoloLens 2.Data were collected on both task performance(accuracy and response time)and user experience,with a focus on task efficiency,accuracy,and user preference across the different learning modes.Results The situated visualization method of Formula-S had comparable accuracy to other methods but shorter response time for herbal formula learning tasks.Regarding user experience,our new approach demonstrated the highest system usability and lowest task load,effectively reducing cognitive load and allowing users to complete tasks with greater ease and efficiency.Participants reported that Formula-S enhanced their learning experience through its intuitive interface and immersive AR environment,suggesting this approach offers usability advantages for TCM education.Conclusions The situated visualization method in Formula-S offers more efficient and accurate searching capabilities compared to traditional and web-based methods.Additionally,it provides superior contextual understanding of TCM formulas,making it a promising new solution for TCM learning.展开更多
The overall heat transfer coefficient(OHTC)of rock fractures is a fundamental parameter for characterizing the heat transfer behavior of rock fractures in hot dry rock(HDR)geothermal mining.Although a number of practi...The overall heat transfer coefficient(OHTC)of rock fractures is a fundamental parameter for characterizing the heat transfer behavior of rock fractures in hot dry rock(HDR)geothermal mining.Although a number of practical formulae for heat transfer coefficients have been developed in the literature,there is still no widely accepted analytical solution.This paper constructs highly accurate analytical solutions for the temperatures of the inner fracture wall and the fluid.Then they are employed to develop new definition-based formulae(formula A and its simplification formula B)of the OHTC,which are well validated by the experimental and numerical simulation results.An empirical correlation formula of heat transfer coefficient is proposed based on the definition-based formulae which can be directly used in the numerical simulations of heat transfer in rock fractures.A site-scale application example of numerical simulation also demonstrates the effectiveness of the empirical correlation formula.展开更多
This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal o...This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of Gastroenterology.The study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and autophagy.This editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.展开更多
Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of treatment.Nevertheless,the specific mechanism of action of SXLJF remains unclear.Methods:The mou...Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of treatment.Nevertheless,the specific mechanism of action of SXLJF remains unclear.Methods:The mouse model of insomnia was established by intraperitoneal injection of para-chlorophenylalanine.Forty-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive days.The open field test and pentobarbital-induced sleeping test were conducted.LC-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating insomnia.Finally,key targets were validated using RT-qPCR.Results:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep duration.Metabolomics and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of SXLJF.Specifically,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,respectively.RT-qPCR results supported the role of TH in the mechanism of SXLJF in treating insomnia.Conclusion:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.展开更多
OBJECTIVE To explore the mechanism of action of Qihuang Zhuyu formula(QHZYF)in improving depression after myocardial infarction(MI),with a focus on revealing its regulatory effect on the inflammatory response of the h...OBJECTIVE To explore the mechanism of action of Qihuang Zhuyu formula(QHZYF)in improving depression after myocardial infarction(MI),with a focus on revealing its regulatory effect on the inflammatory response of the heart and brain.METHODS The active ingredients of QHZYF and the action targets for intervening in depression after MI were analyzed by using ultra-performance liquid chromatography-high-resolution mass spectrometry(UPLC-Q-TOF/MS)combined with network pharmacology and molecular docking.A rat model of depression after MI was established by ligation of the left anterior descending coronary artery combined with chronic restraint stress.Echocardiography was used to evaluate cardiac function,hematoxylin-eosin(HE)and Masson staining were used to evaluate myocardial injury,behavioral tests were used to detect melancholic behaviors,Nissl staining was used to evaluate hippocampal neuron injury.Western blot detection of tumor necrosis factor receptor 2(TNFR2),phosphatidylinositol-3-kinase(PI3K),phosphorylated seronine protein kinase(p-AKT),seronine protein kinase(AKT),tumor necrosis factor receptor 1(TNFR1),phosphorylated nuclear factorκB(p-NF-κB),and nuclear factorκB(NF-κB)in cardiac and hippocampal tissues was conducted.The levels of serum IL-6 and IL-10 were detected by enzyme-linked immunosorbent assay(ELISA),and the expression of TNFR1 and TNFR2 was detected by immunohistochemical technique(IHC).In vitro experiments,co-culture of rat cardiomyocyte line H9C2 cells and rat adrenal pheochromocytoma cell line with high differentiation PC12 cells was conducted,TNFR1 inhibitor(H398)and TNFR2 agonist(C-6His)were administered for intervention,and the expression of TNFR2,PI3K,p-AKT,AKT,TNFR1,NF-κB,p-NF-κB was detected by Western blot.Observe the apoptosis of cells by TUNEL staining,ELISA was used to detect the levels of IL-6 and IL-10 in the cell supernatant.RESULTS Network pharmacological analysis indicates that the TNF signaling pathway was a key target for the treatment of depression after MI with the QHZYF.In vivo experiments have confirmed that the intervention of QHZYF could significantly improve the cardiac function,myocardial tissue and hippocampal neuron structure damage of depressed rats after MI,and improve their depression-like behaviors.At the molecular level,the high-dose group of QHZYF significantly upregulated TNFR2,p-AKT/AKT,and IL-10 in cardiac and hippocampal tissues(P<0.01),and downregulated TNFR1,p-NF-κB/NF-κB and IL-6(P<0.01).In vitro experiments showed that the drug-containing serum of QHZYF significantly upregulated the expression of TNFR2,p-AKT/AKT and IL-10 in H9C2 and PC12 cells(P<0.01),downregulated the expression of TNFR1,p-NF-κB/NF-κB and IL-6(P<0.01),and significantly inhibited cell apoptosis(P<0.01).Furthermore,experiments on the combined application of H398 or C-6His further confirmed that its protective and anti-inflammatory effects were mediated by regulating the TNFR2/PI3K/AKT and TNFR1/NF-κB pathways.CONCLUSION QHZYF improves the homeostasis of heart and brain inflammation by regulating the TNF pathway,and ameliorates myocardial injury and depressive state in depressed rats after MI.展开更多
文摘Idioms,collocations,and formulaic phrases are three factors playing the important role in the second language acquisition(SLA).This essay firstly deals with the definitions of these concepts,then it illustrates the importance of them to SLA on two perspectives—idioms,collocations,and formulaic phrases respectively and they regarded as a whole.Therefore,in this way,the essay may lead to the answer the question“How are idioms,collocations,and formulaic phrases important to SLA?”
基金This project was supported by China National Social Science Funding(No.18BYY107).
文摘This study was conducted to explore the individual uses of formulaic sequence(FS)frequency and their effects on complexity,accuracy,and fluency(CAF)in academic writing.Data was collected from the conclusion sections of a self-compiled corpus of 30 L2 master’s theses.Statistical analysis revealed several notable conclusions.1)Student writers tend to make repetitive use of particular FSs in single texts.2)FS use has a significant frequency effect on fluency,and the high-frequency group slightly outperforms the low-frequency group.3)FS use has a certain frequency effect on accuracy,and the high-frequency group demonstrates the strongest correlation between FS frequency and accuracy.4)FS use has a significant frequency effect on lexical complexity,and the low-frequency group slightly outperforms the high-frequency group.In the low-frequency group,FS use has a significant frequency effect on syntactic complexity as well.Finally,5)The results support Skehan’s trade-off effect,a competition between CAF,which,to a certain degree,is affected by individual uses of FS frequency.The low-frequency group displays a greater trade-off effect than the high-frequency group.
文摘Language plays an important role in interpersonal communication, among which the importance of formulaic language shall never be under-estimated. Reflected in not only the language of individual language users but also language community, formulaic language could help establish and maintain human relationships. Meanwhile, interpersonal function is the most important one among the three metafunctions of language. The present paper aims to find the interface between functional grammar and the study of formulaic language, and consequently the significance of formulaic language in the realization of interoersonal function.
文摘This study explored the distribution of three types of English formulaic language, which involves four categories in L1 Chinese L2 English learners’ speaking performance. In addition, it investigated the relationship between the English learners’ use of formulaic language and their spoken English fluency. A CCA(canonical correlation analysis) was conducted to examine the correlations between two sets of fluency variables(dependent variables) and linguistic variables of English formulaic language use(independent variables). The fluency variable set consists of:(1)temporal indices such as SR(speech rate), AR(articulation rate), MLR(mean length of run), and PTR(phonation time ratio);(2) linguistic variables of English formulaic language like F2 R(twoword formulaic sequences/run ratio, B3 R(three-word lexical bundles/run ratio), and B4 R(fourword lexical bundles/run ratio). These are calculated according to the frequency of the English formulaic language in the speech samples of the participants(n = 86) across three academic levels.The results indicate that the learners’ spoken English fluency is highly related to their use of English formulaic language. Its limitations and future research directions are also discussed.
文摘This paper discusses the role of formulaic language in the teaching of English as a foreign language,and in particular in the decoding of the spoken production of native speakers(NSs).
文摘This paper argues for the need of the reappraisal of the formulaic aspect of language in second language acquisition by drawing insights from recent development in applied linguistics, psycholinguistics and corpus linguistics. This library study begins by reviewing the dual-nature view of language in relation to formulaic aspect of language. Then, a brief survey of evidence from corpus linguistics is provided to demonstrate the formulaicity of language. What follows is the discussion of rehearsal and implicit learning vis-a-vis memory from the perspective of psycholinguistics. After that, the role of formulaic language in second language acquisition is examined by taking stock of empirical findings that have accumulated in this area. Finally, by way of conclusion, how the formulaicity of language can shed light on second/foreign language teaching theory is illustrated.
文摘A controversial issue in the field of Second Language spoken English acquisition is which one plays a more important role, the formulaic speech or the creative rules? And researchers have long kept different opinions about the definition of formulaic speech. The present paper discusses the definition of formulaic speech, describes relevant empirical studies and summarizes some roles of formulaic speech from our own experiments, hoping to provide some insights for second language spoken English teaching and learning.
文摘This corpus-based study cmploys statistical analysis to compare the use of non-compositional formulaic sequences by high proficiency Chinese learners and native students.The top 5 overused and underused patterns by Chinese users are identified.Features of their usage point to a lack of register awareness as well as linguistic resources,while showing individual differences.
文摘Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas. The basic ideas include utilizing properly the △-operator and Stirling numbers for some series transformations. A variety of classic formulas and remarkable identities are shown to be the members of the classes.
基金supported by National Social Science Fund of China(Grant No.15BYY100)the China Scholarship Council~~
文摘This study investigated the relationship between situation-bound utterances （SBUs thereafter） and formulaic competence, focusing on the acquisition of three subcategories of SBUs among early intermediate and early advanced Chinese learners of English as a foreign language （EFL）. A group of native English speakers also participated in this study to provide baseline data. One-way ANOVA analysis and post hoc tests confirmed that linguistic competence usually preceded formulaic competence for EFL learners. The findings also showed no statistically significant difference existing between the three groups of participants in the use of plain SBUs, and this could be attributed to the low degree of cultural-embeddedness and high semantic transparency of plain SBUs. It was further argued that a threshold has to be reached for EFL learners to go through a movement from rules to wholes.
基金supported by the National Key Research and Development Project(2022YFC3400700)the City-School Cooperation Project of the Fuyang Science and Technology Special Fund undertaken by Fuyang Normal University(SXHZ2020007)+1 种基金the Basic Research Program of Shenzhen Municipal Government(JCYJ20200109114242138)the Special Commissioner for Rural Science and Technology of Guangdong Province(KTP20210345).
文摘Background Meat originating from the spent hen is an important source of poultry meat production;however,multiple factors cause the decline in the meat quality of spent hens.Chinese herbs have been widely used as medi-cine for a long time to prevent diseases and as nutrient supplements to improve the product quality.This experi-ment explored the effects of adding 1.0%Chinese herbal formula(CHF,including 0.30%Leonurus japonicus Houtt.,0.20%Salvia miltiorrhiza Bge.,0.25%Ligustrum lucidum Ait.,and 0.25%Taraxacum mongolicum Hand.-Mazz.)for 120 d to the spent hens’diet through metabolomics,network pharmacology,and microbiome strategies.Results The results indicated that CHF supplementation improved the meat quality by reducing drip loss(P<0.05),b*value(P=0.058),and shear force(P=0.099)and increasing cooked meat percentage(P=0.054)and dry matter(P<0.05)of breast muscle.The addition of CHF improved the nutritional value of breast muscle by increasing(P<0.05)the content of C18:2n-6,n-6/n-3 polyunsaturated fatty acids(PUFA),total PUFA,PUFA-to-saturated fatty acids(SFA)ratio,and hypocholesterolemic-to-hypercholesterolemic ratio,and tending to increase serine content(P=0.069).The targeted metabolomics analysis revealed that the biosynthesis of SFA,linoleic acid metabolism,fatty acid degradation,fatty acid elongation,and fatty acid biosynthesis pathways were enriched by CHF supplementation.Furthermore,the network pharmacology analysis indicated that CHF was closely associated with oxidative stress and lipid metabo-lism.The CHF supplementation increased the glutathione peroxidase level(P<0.05)and upregulated gene expres-sion related to the Nrf2 pathway(including HO-1,P<0.05;Nrf2,P=0.098;CAT,P=0.060;GPX1,P=0.063;and SOD2,P=0.052)and lipid metabolism(including PPARγ,P<0.05;SREBP1,P=0.059;and CPT1A,P=0.058).Additionally,CHF supplementation increased Firmicutes and decreased Bacteroidetes,Spirochaetes,and Synergistetes abundances(P<0.05),which may contribute to better meat quality.Conclusions Our results suggest that CHF supplementation improved the quality and nutritional value of meat,which will provide a theoretical basis for the utilization of CHF as a feed additive in spent hens’diets.
基金Supported by the National Natural Science Foundation of China(Nos.52222904 and 52309117)China Postdoctoral Science Foundation(Nos.2022TQ0168 and 2023M731895).
文摘Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.However,the widened hydraulic excitation frequency may satisfy the blade resonance due to the time variation in the velocity and angle of attack of the ocean current,even resulting in blade fatigue and destructively interfering with grid stability.A key parameter that determines the resonance amplitude of the blade is the hydrodynamic damping ratio(HDR).However,HDR is difficult to obtain due to the complex fluid-structure interaction(FSI).Therefore,a literature review was conducted on the hydrodynamic damping characteristics of blade-like structures.The experimental and simulation methods used to identify and obtain the HDR quantitatively were described,placing emphasis on the experimental processes and simulation setups.Moreover,the accuracy and efficiency of different simulation methods were compared,and the modal work approach was recommended.The effects of key typical parameters,including flow velocity,angle of attack,gap,rotational speed,and cavitation,on the HDR were then summarized,and the suggestions on operating conditions were presented from the perspective of increasing the HDR.Subsequently,considering multiple flow parameters,several theoretical derivations and semi-empirical prediction formulas for HDR were introduced,and the accuracy and application were discussed.Based on the shortcomings of the existing research,the direction of future research was finally determined.The current work offers a clear understanding of the HDR of blade-like structures,which could improve the evaluation accuracy of flow-induced vibration in the design stage.
文摘Objective The study of medicine formulas is a core component of traditional Chinese medicine(TCM),yet traditional learning methods often lack interactivity and contextual understanding,making it challenging for beginners to grasp the intricate composition rules of formulas.To address this gap,we introduce Formula-S,a situated visualization method for TCM formula learning in augmented reality(AR)and evaluate its performance.This study aims to evaluate the effectiveness of Formula-S in enhancing TCM formula learning for beginners by comparing it with traditional text-based formula learning and web-based visualization.Methods Formula-S is an interactive AR tool designed for TCM formula learning,featuring three modes(3D,Web,and Table).The dataset included TCM formulas and herb properties extracted from authoritative references,including textbook and the SymMap database.In Formula-S,the hierarchical visualization of the formulas as herbal medicine compositions,is linked to the multidimensional herb attribute visualization and embedded in the real world,where real herb samples are presented.To evaluate its effectiveness,a controlled study(n=30)was conducted.Participants who had no formal TCM knowledge were tasked with herbal medicine identification,formula composition,and recognition.In the study,participants interacted with the AR tool through HoloLens 2.Data were collected on both task performance(accuracy and response time)and user experience,with a focus on task efficiency,accuracy,and user preference across the different learning modes.Results The situated visualization method of Formula-S had comparable accuracy to other methods but shorter response time for herbal formula learning tasks.Regarding user experience,our new approach demonstrated the highest system usability and lowest task load,effectively reducing cognitive load and allowing users to complete tasks with greater ease and efficiency.Participants reported that Formula-S enhanced their learning experience through its intuitive interface and immersive AR environment,suggesting this approach offers usability advantages for TCM education.Conclusions The situated visualization method in Formula-S offers more efficient and accurate searching capabilities compared to traditional and web-based methods.Additionally,it provides superior contextual understanding of TCM formulas,making it a promising new solution for TCM learning.
基金support of this work by the National Natural Science Foundation of China (Grant Nos.41972316 and 41672252).
文摘The overall heat transfer coefficient(OHTC)of rock fractures is a fundamental parameter for characterizing the heat transfer behavior of rock fractures in hot dry rock(HDR)geothermal mining.Although a number of practical formulae for heat transfer coefficients have been developed in the literature,there is still no widely accepted analytical solution.This paper constructs highly accurate analytical solutions for the temperatures of the inner fracture wall and the fluid.Then they are employed to develop new definition-based formulae(formula A and its simplification formula B)of the OHTC,which are well validated by the experimental and numerical simulation results.An empirical correlation formula of heat transfer coefficient is proposed based on the definition-based formulae which can be directly used in the numerical simulations of heat transfer in rock fractures.A site-scale application example of numerical simulation also demonstrates the effectiveness of the empirical correlation formula.
文摘This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of Gastroenterology.The study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and autophagy.This editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.
基金Science Foundation of Hunan Province(2021JJ40510)General Guidance Project of Hunan Health Commission(202203074169)+1 种基金Clinical Medical Technology Innovation Guidance Project of Hunan Province(2021SK51901)and Key Guiding Projects of Hunan Health Commission(20201918)for supporting this study.
文摘Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of treatment.Nevertheless,the specific mechanism of action of SXLJF remains unclear.Methods:The mouse model of insomnia was established by intraperitoneal injection of para-chlorophenylalanine.Forty-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive days.The open field test and pentobarbital-induced sleeping test were conducted.LC-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating insomnia.Finally,key targets were validated using RT-qPCR.Results:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep duration.Metabolomics and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of SXLJF.Specifically,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,respectively.RT-qPCR results supported the role of TH in the mechanism of SXLJF in treating insomnia.Conclusion:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.
文摘OBJECTIVE To explore the mechanism of action of Qihuang Zhuyu formula(QHZYF)in improving depression after myocardial infarction(MI),with a focus on revealing its regulatory effect on the inflammatory response of the heart and brain.METHODS The active ingredients of QHZYF and the action targets for intervening in depression after MI were analyzed by using ultra-performance liquid chromatography-high-resolution mass spectrometry(UPLC-Q-TOF/MS)combined with network pharmacology and molecular docking.A rat model of depression after MI was established by ligation of the left anterior descending coronary artery combined with chronic restraint stress.Echocardiography was used to evaluate cardiac function,hematoxylin-eosin(HE)and Masson staining were used to evaluate myocardial injury,behavioral tests were used to detect melancholic behaviors,Nissl staining was used to evaluate hippocampal neuron injury.Western blot detection of tumor necrosis factor receptor 2(TNFR2),phosphatidylinositol-3-kinase(PI3K),phosphorylated seronine protein kinase(p-AKT),seronine protein kinase(AKT),tumor necrosis factor receptor 1(TNFR1),phosphorylated nuclear factorκB(p-NF-κB),and nuclear factorκB(NF-κB)in cardiac and hippocampal tissues was conducted.The levels of serum IL-6 and IL-10 were detected by enzyme-linked immunosorbent assay(ELISA),and the expression of TNFR1 and TNFR2 was detected by immunohistochemical technique(IHC).In vitro experiments,co-culture of rat cardiomyocyte line H9C2 cells and rat adrenal pheochromocytoma cell line with high differentiation PC12 cells was conducted,TNFR1 inhibitor(H398)and TNFR2 agonist(C-6His)were administered for intervention,and the expression of TNFR2,PI3K,p-AKT,AKT,TNFR1,NF-κB,p-NF-κB was detected by Western blot.Observe the apoptosis of cells by TUNEL staining,ELISA was used to detect the levels of IL-6 and IL-10 in the cell supernatant.RESULTS Network pharmacological analysis indicates that the TNF signaling pathway was a key target for the treatment of depression after MI with the QHZYF.In vivo experiments have confirmed that the intervention of QHZYF could significantly improve the cardiac function,myocardial tissue and hippocampal neuron structure damage of depressed rats after MI,and improve their depression-like behaviors.At the molecular level,the high-dose group of QHZYF significantly upregulated TNFR2,p-AKT/AKT,and IL-10 in cardiac and hippocampal tissues(P<0.01),and downregulated TNFR1,p-NF-κB/NF-κB and IL-6(P<0.01).In vitro experiments showed that the drug-containing serum of QHZYF significantly upregulated the expression of TNFR2,p-AKT/AKT and IL-10 in H9C2 and PC12 cells(P<0.01),downregulated the expression of TNFR1,p-NF-κB/NF-κB and IL-6(P<0.01),and significantly inhibited cell apoptosis(P<0.01).Furthermore,experiments on the combined application of H398 or C-6His further confirmed that its protective and anti-inflammatory effects were mediated by regulating the TNFR2/PI3K/AKT and TNFR1/NF-κB pathways.CONCLUSION QHZYF improves the homeostasis of heart and brain inflammation by regulating the TNF pathway,and ameliorates myocardial injury and depressive state in depressed rats after MI.
