Idioms,collocations,and formulaic phrases are three factors playing the important role in the second language acquisition(SLA).This essay firstly deals with the definitions of these concepts,then it illustrates the im...Idioms,collocations,and formulaic phrases are three factors playing the important role in the second language acquisition(SLA).This essay firstly deals with the definitions of these concepts,then it illustrates the importance of them to SLA on two perspectives—idioms,collocations,and formulaic phrases respectively and they regarded as a whole.Therefore,in this way,the essay may lead to the answer the question“How are idioms,collocations,and formulaic phrases important to SLA?”展开更多
This study was conducted to explore the individual uses of formulaic sequence(FS)frequency and their effects on complexity,accuracy,and fluency(CAF)in academic writing.Data was collected from the conclusion sections o...This study was conducted to explore the individual uses of formulaic sequence(FS)frequency and their effects on complexity,accuracy,and fluency(CAF)in academic writing.Data was collected from the conclusion sections of a self-compiled corpus of 30 L2 master’s theses.Statistical analysis revealed several notable conclusions.1)Student writers tend to make repetitive use of particular FSs in single texts.2)FS use has a significant frequency effect on fluency,and the high-frequency group slightly outperforms the low-frequency group.3)FS use has a certain frequency effect on accuracy,and the high-frequency group demonstrates the strongest correlation between FS frequency and accuracy.4)FS use has a significant frequency effect on lexical complexity,and the low-frequency group slightly outperforms the high-frequency group.In the low-frequency group,FS use has a significant frequency effect on syntactic complexity as well.Finally,5)The results support Skehan’s trade-off effect,a competition between CAF,which,to a certain degree,is affected by individual uses of FS frequency.The low-frequency group displays a greater trade-off effect than the high-frequency group.展开更多
Language plays an important role in interpersonal communication, among which the importance of formulaic language shall never be under-estimated. Reflected in not only the language of individual language users but als...Language plays an important role in interpersonal communication, among which the importance of formulaic language shall never be under-estimated. Reflected in not only the language of individual language users but also language community, formulaic language could help establish and maintain human relationships. Meanwhile, interpersonal function is the most important one among the three metafunctions of language. The present paper aims to find the interface between functional grammar and the study of formulaic language, and consequently the significance of formulaic language in the realization of interoersonal function.展开更多
This study explored the distribution of three types of English formulaic language, which involves four categories in L1 Chinese L2 English learners’ speaking performance. In addition, it investigated the relationship...This study explored the distribution of three types of English formulaic language, which involves four categories in L1 Chinese L2 English learners’ speaking performance. In addition, it investigated the relationship between the English learners’ use of formulaic language and their spoken English fluency. A CCA(canonical correlation analysis) was conducted to examine the correlations between two sets of fluency variables(dependent variables) and linguistic variables of English formulaic language use(independent variables). The fluency variable set consists of:(1)temporal indices such as SR(speech rate), AR(articulation rate), MLR(mean length of run), and PTR(phonation time ratio);(2) linguistic variables of English formulaic language like F2 R(twoword formulaic sequences/run ratio, B3 R(three-word lexical bundles/run ratio), and B4 R(fourword lexical bundles/run ratio). These are calculated according to the frequency of the English formulaic language in the speech samples of the participants(n = 86) across three academic levels.The results indicate that the learners’ spoken English fluency is highly related to their use of English formulaic language. Its limitations and future research directions are also discussed.展开更多
This paper discusses the role of formulaic language in the teaching of English as a foreign language,and in particular in the decoding of the spoken production of native speakers(NSs).
This paper argues for the need of the reappraisal of the formulaic aspect of language in second language acquisition by drawing insights from recent development in applied linguistics, psycholinguistics and corpus lin...This paper argues for the need of the reappraisal of the formulaic aspect of language in second language acquisition by drawing insights from recent development in applied linguistics, psycholinguistics and corpus linguistics. This library study begins by reviewing the dual-nature view of language in relation to formulaic aspect of language. Then, a brief survey of evidence from corpus linguistics is provided to demonstrate the formulaicity of language. What follows is the discussion of rehearsal and implicit learning vis-a-vis memory from the perspective of psycholinguistics. After that, the role of formulaic language in second language acquisition is examined by taking stock of empirical findings that have accumulated in this area. Finally, by way of conclusion, how the formulaicity of language can shed light on second/foreign language teaching theory is illustrated.展开更多
A controversial issue in the field of Second Language spoken English acquisition is which one plays a more important role, the formulaic speech or the creative rules? And researchers have long kept different opinions ...A controversial issue in the field of Second Language spoken English acquisition is which one plays a more important role, the formulaic speech or the creative rules? And researchers have long kept different opinions about the definition of formulaic speech. The present paper discusses the definition of formulaic speech, describes relevant empirical studies and summarizes some roles of formulaic speech from our own experiments, hoping to provide some insights for second language spoken English teaching and learning.展开更多
This corpus-based study cmploys statistical analysis to compare the use of non-compositional formulaic sequences by high proficiency Chinese learners and native students.The top 5 overused and underused patterns by Ch...This corpus-based study cmploys statistical analysis to compare the use of non-compositional formulaic sequences by high proficiency Chinese learners and native students.The top 5 overused and underused patterns by Chinese users are identified.Features of their usage point to a lack of register awareness as well as linguistic resources,while showing individual differences.展开更多
Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas. The basic ideas include utilizing properly the △-operator and Stirling num...Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas. The basic ideas include utilizing properly the △-operator and Stirling numbers for some series transformations. A variety of classic formulas and remarkable identities are shown to be the members of the classes.展开更多
The ability of folk singers to master and perform a large repertoire of ballads fundamentally relies on oral formulas.Taking Shoubo Zhang,a folk singer from Shanxi Province,as a case study,this research applies oral f...The ability of folk singers to master and perform a large repertoire of ballads fundamentally relies on oral formulas.Taking Shoubo Zhang,a folk singer from Shanxi Province,as a case study,this research applies oral formula theory to analyzehis oral performances.The analysis shows that his performances depend on a system of formulas composed of metrical units andnarrative elements.Furthermore,the study finds that the singer’s performance ability manifests as a dynamic generativecapability,enabling flexible transitions within individual ballads as well as between different ballads through the use of formulas.Based on this,the paper extends this mechanism to the phenomenon of poetry generation in the Book of Songs,arguing for theuniversality of formulaic transitions as an intrinsic law of oral tradition.展开更多
This study investigated the relationship between situation-bound utterances （SBUs thereafter） and formulaic competence, focusing on the acquisition of three subcategories of SBUs among early intermediate and early a...This study investigated the relationship between situation-bound utterances （SBUs thereafter） and formulaic competence, focusing on the acquisition of three subcategories of SBUs among early intermediate and early advanced Chinese learners of English as a foreign language （EFL）. A group of native English speakers also participated in this study to provide baseline data. One-way ANOVA analysis and post hoc tests confirmed that linguistic competence usually preceded formulaic competence for EFL learners. The findings also showed no statistically significant difference existing between the three groups of participants in the use of plain SBUs, and this could be attributed to the low degree of cultural-embeddedness and high semantic transparency of plain SBUs. It was further argued that a threshold has to be reached for EFL learners to go through a movement from rules to wholes.展开更多
In this paper,we study the generalized Dedekind Rademacher sums considered by Hall,Wilson and Zagier.We establish a new formula for the products of two Bernoulli functions by using Parseval's formula,Hurwitz's...In this paper,we study the generalized Dedekind Rademacher sums considered by Hall,Wilson and Zagier.We establish a new formula for the products of two Bernoulli functions by using Parseval's formula,Hurwitz's formula and Lerch's functional equation.As applications of the result,some well-known reciprocity formulas are deduced as special cases.展开更多
In the references[4,11,12],the authors gave some modular forms overΓ^(0)(2).In this note,we proceed with the study of cancellation formulas relating to the modular forms.
Chronic heart failure(CHF)impairs cognitive function.Xijiaqi Formula(XJQ),a traditional Chinese medicine(TCM)used clinically to treat CHF,demonstrates potential for improving cognition in CHF patients.However,its prec...Chronic heart failure(CHF)impairs cognitive function.Xijiaqi Formula(XJQ),a traditional Chinese medicine(TCM)used clinically to treat CHF,demonstrates potential for improving cognition in CHF patients.However,its precise mechanism in treating post-CHF cognitive dysfunction remains unclear.This study systematically investigates XJQ’s effects on post-CHF cognitive dysfunction and the underlying mechanisms.The components of XJQ were identified through liquid chromatography-mass spectrometry.CHF was induced in rats via ligation of the left anterior descending coronary artery,followed by six weeks of XJQ treatment.Cardiac function was evaluated through echocardiography and hemodynamic parameters,while cognitive function was assessed using Morris water maze(MWM)and open field tests(OFT).XJQ treatment enhanced both cardiac and cognitive functions in CHF rats.Network pharmacology identified 12 core active components of XJQ and indicated its effect on cognitive dysfunction involved regulating synapses,inflammation,and phosphodiesterase 4(PDE4)-dependent cyclic adenosine monophosphate(cAMP)signaling.XJQ inhibited microglial and astrocyte activation,decreased proinflammatory cytokines,and mitigated neuronal damage.Notably,XJQ promoted synaptic repair and dendritic growth by downregulating PDE4 and upregulating cAMP,protein kinase A(PKA),cAMP-response element binding protein(CREB),brain-derived neurotrophic factor(BDNF),PSD95,and synapsin I levels.Molecular docking and Bio-layer interferometry assays confirmed direct binding of quercetin,kaempferol,isorhamnetin,and darutoside to PDE4.In conclusion,XJQ alleviates neuroinflammation and enhances synaptic plasticity to improve cognitive dysfunction in CHF rats via the PDE4/cAMP/PKA/CREB signaling pathway.These findings provide valuable insight into the heart-brain axis.展开更多
Background:Hua-Yi-Jie-Du formula(HYJD)is a traditional Chinese medicine that has proven effective against viral pneumonia and was extensively used during the COVID-19 pandemic.This study investigates how HYJD influenc...Background:Hua-Yi-Jie-Du formula(HYJD)is a traditional Chinese medicine that has proven effective against viral pneumonia and was extensively used during the COVID-19 pandemic.This study investigates how HYJD influences group 2 innate lymphoid cell(ILC2)and nucleotide oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation in a mouse model of viral pneumonia.Methods:A mouse model of viral pneumonia was established through the administration of polyinosinic-polycytidylic acid(poly(I:C))via nasal drops.Histopathological analysis of lung tissue was conducted,alongside enzyme-linked immunosorbent assay to quantify cytokine levels in serum and bronchoalveolar lavage fluid(BALF).Flow cytometry was employed to detect ILC2 cells in lung tissue and spleen,while immunofluorescence techniques were utilized to visualize ILC2 cells in lung tissue.Transcriptomic sequencing was performed,and the results were validated using qRT-PCR and western blot analysis.Results:HYJD significantly ameliorated inflammatory infiltration in lung tissue,decreased mucus protein secretion,and reduced the serum levels of inflammatory cytokines interleukin(IL)-1β,IL-6,and tumor necrosis factor-alpha(TNF-α).Additionally,it lowered the expression of cytokines IL-4,IL-5,IL-13,IL-25,thymic stromal lymphopoietin(TSLP),and IL-33 in BALF,and reduced the differentiation of ILC2 cells in both lung tissue and spleen.Transcriptomic analysis and experimental validation revealed that HYJD downregulated the expression of NLRP3 related genes and proteins within the NOD-like receptor signaling pathway.Conclusion:The mechanism by which HYJD intervenes in acute lung injury associated with viral pneumonia may involve the reduction of ILC2 cells differentiation and the inhibition of NLRP3 activation.展开更多
BACKGROUND Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels,which significantly impair their quality of life.The current treatments have certain limitations.In traditional Chi...BACKGROUND Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels,which significantly impair their quality of life.The current treatments have certain limitations.In traditional Chinese medicine,liver-soothing formulas are commonly prescribed for mood-related disorders,but their overall efficacy in perimenopausal anxiety and depression remains uncertain and requires verification through meta-analysis.AIM To provide evidence-based support for clinical decision-making and research,a meta-analysis was conducted to evaluate the effectiveness of liver-soothing formulas in treating perimenopausal anxiety and depression.METHODS Relevant studies published up to April 2025 were retrieved from ClinicalTrials.gov,PubMed,Web of Science,EMBASE,and the Cochrane Library.Eligible studies were screened according to predefined inclusion and exclusion criteria.Data were extracted and analyzed using the Stata 12.0 software.RESULTS After searching and screening,12 articles involving 1798 patients(922 in the treatment group and 876 in the control group)were included in the analysis.Meta-analysis showed that the standardized scores for anxiety[standardized mean difference(SMD)=-0.71,95%confidence interval(95%CI):-1.06 to-0.36]and depression(SMD=-0.67,95%CI:-1.06 to-0.27)of the treatment group were lower than those of the control group.Subgroup analysis results revealed that for anxiety,liver-soothing formulas used alone(SMD=-0.34,95%CI:-0.50 to-0.18)or in combination(SMD=-0.88,95%CI:-1.43 to-0.34)both significantly reduced scores compared with the control group.For depression,monotherapy of liversoothing formulas showed no significant statistical difference between the treatment and control groups(SMD=-0.47,95%CI:-1.11 to 0.17),whereas combination therapy produced significantly lower standardized scale scores in the treatment group than in the control group,with a statistically significant difference(SMD=-0.83,95%CI:-1.39 to-0.28).Regarding Greene scores,no statistically significant difference was observed with monotherapy(SMD=0.87,95%CI:-0.32 to 2.06),whereas combination therapy had significantly lower Greene scores(SMD=-0.24,95%CI:-0.44 to-0.04).No statistically significant difference was found between the groups in the occurrence of adverse reactions(odds ratio=0.90,95%CI:0.57-1.43).However,liver-soothing formulas did not affect estrogen levels in perimenopausal women.CONCLUSION Compared with placebo,conventional Western medicine,or other interventions,the monotherapy of liver-soothing formulas demonstrates superior efficacy in treating perimenopausal anxiety.When used as an adjuvant,they exert a synergistic effect in alleviating negative emotions and improving overall perimenopausal symptoms.展开更多
文摘Idioms,collocations,and formulaic phrases are three factors playing the important role in the second language acquisition(SLA).This essay firstly deals with the definitions of these concepts,then it illustrates the importance of them to SLA on two perspectives—idioms,collocations,and formulaic phrases respectively and they regarded as a whole.Therefore,in this way,the essay may lead to the answer the question“How are idioms,collocations,and formulaic phrases important to SLA?”
基金This project was supported by China National Social Science Funding(No.18BYY107).
文摘This study was conducted to explore the individual uses of formulaic sequence(FS)frequency and their effects on complexity,accuracy,and fluency(CAF)in academic writing.Data was collected from the conclusion sections of a self-compiled corpus of 30 L2 master’s theses.Statistical analysis revealed several notable conclusions.1)Student writers tend to make repetitive use of particular FSs in single texts.2)FS use has a significant frequency effect on fluency,and the high-frequency group slightly outperforms the low-frequency group.3)FS use has a certain frequency effect on accuracy,and the high-frequency group demonstrates the strongest correlation between FS frequency and accuracy.4)FS use has a significant frequency effect on lexical complexity,and the low-frequency group slightly outperforms the high-frequency group.In the low-frequency group,FS use has a significant frequency effect on syntactic complexity as well.Finally,5)The results support Skehan’s trade-off effect,a competition between CAF,which,to a certain degree,is affected by individual uses of FS frequency.The low-frequency group displays a greater trade-off effect than the high-frequency group.
文摘Language plays an important role in interpersonal communication, among which the importance of formulaic language shall never be under-estimated. Reflected in not only the language of individual language users but also language community, formulaic language could help establish and maintain human relationships. Meanwhile, interpersonal function is the most important one among the three metafunctions of language. The present paper aims to find the interface between functional grammar and the study of formulaic language, and consequently the significance of formulaic language in the realization of interoersonal function.
文摘This study explored the distribution of three types of English formulaic language, which involves four categories in L1 Chinese L2 English learners’ speaking performance. In addition, it investigated the relationship between the English learners’ use of formulaic language and their spoken English fluency. A CCA(canonical correlation analysis) was conducted to examine the correlations between two sets of fluency variables(dependent variables) and linguistic variables of English formulaic language use(independent variables). The fluency variable set consists of:(1)temporal indices such as SR(speech rate), AR(articulation rate), MLR(mean length of run), and PTR(phonation time ratio);(2) linguistic variables of English formulaic language like F2 R(twoword formulaic sequences/run ratio, B3 R(three-word lexical bundles/run ratio), and B4 R(fourword lexical bundles/run ratio). These are calculated according to the frequency of the English formulaic language in the speech samples of the participants(n = 86) across three academic levels.The results indicate that the learners’ spoken English fluency is highly related to their use of English formulaic language. Its limitations and future research directions are also discussed.
文摘This paper discusses the role of formulaic language in the teaching of English as a foreign language,and in particular in the decoding of the spoken production of native speakers(NSs).
文摘This paper argues for the need of the reappraisal of the formulaic aspect of language in second language acquisition by drawing insights from recent development in applied linguistics, psycholinguistics and corpus linguistics. This library study begins by reviewing the dual-nature view of language in relation to formulaic aspect of language. Then, a brief survey of evidence from corpus linguistics is provided to demonstrate the formulaicity of language. What follows is the discussion of rehearsal and implicit learning vis-a-vis memory from the perspective of psycholinguistics. After that, the role of formulaic language in second language acquisition is examined by taking stock of empirical findings that have accumulated in this area. Finally, by way of conclusion, how the formulaicity of language can shed light on second/foreign language teaching theory is illustrated.
文摘A controversial issue in the field of Second Language spoken English acquisition is which one plays a more important role, the formulaic speech or the creative rules? And researchers have long kept different opinions about the definition of formulaic speech. The present paper discusses the definition of formulaic speech, describes relevant empirical studies and summarizes some roles of formulaic speech from our own experiments, hoping to provide some insights for second language spoken English teaching and learning.
文摘This corpus-based study cmploys statistical analysis to compare the use of non-compositional formulaic sequences by high proficiency Chinese learners and native students.The top 5 overused and underused patterns by Chinese users are identified.Features of their usage point to a lack of register awareness as well as linguistic resources,while showing individual differences.
文摘Here introduced and studied are two formulaic classes consisting of various combinatorial algebraic identities and series summation formulas. The basic ideas include utilizing properly the △-operator and Stirling numbers for some series transformations. A variety of classic formulas and remarkable identities are shown to be the members of the classes.
基金supported by the following projects:Teaching Reform Project,Northwest Minzu University:Exploring the Practical Teaching Reform of“Great Ideological and Political Courses”on Strengthening the Awareness of the Chinese National Community—A Study of the Concept of the Chinese National Community,Key Graduate Education and Teaching Reform Project,Northwest Minzu University:Exploring Practical Approaches for Strengthening Graduate Students’Awareness of the Chinese National Community,Dialogue of Civilizations:Lessons from the Mutual Learning of Civilizations in the Chinese Edition of“Introduction to World Ethnic Groups”,(2025-GMJ-197)。
文摘The ability of folk singers to master and perform a large repertoire of ballads fundamentally relies on oral formulas.Taking Shoubo Zhang,a folk singer from Shanxi Province,as a case study,this research applies oral formula theory to analyzehis oral performances.The analysis shows that his performances depend on a system of formulas composed of metrical units andnarrative elements.Furthermore,the study finds that the singer’s performance ability manifests as a dynamic generativecapability,enabling flexible transitions within individual ballads as well as between different ballads through the use of formulas.Based on this,the paper extends this mechanism to the phenomenon of poetry generation in the Book of Songs,arguing for theuniversality of formulaic transitions as an intrinsic law of oral tradition.
基金supported by National Social Science Fund of China(Grant No.15BYY100)the China Scholarship Council~~
文摘This study investigated the relationship between situation-bound utterances （SBUs thereafter） and formulaic competence, focusing on the acquisition of three subcategories of SBUs among early intermediate and early advanced Chinese learners of English as a foreign language （EFL）. A group of native English speakers also participated in this study to provide baseline data. One-way ANOVA analysis and post hoc tests confirmed that linguistic competence usually preceded formulaic competence for EFL learners. The findings also showed no statistically significant difference existing between the three groups of participants in the use of plain SBUs, and this could be attributed to the low degree of cultural-embeddedness and high semantic transparency of plain SBUs. It was further argued that a threshold has to be reached for EFL learners to go through a movement from rules to wholes.
基金Supported by the Natural Science Foundation of Sichuan Province(No.2023NSFSC0065)。
文摘In this paper,we study the generalized Dedekind Rademacher sums considered by Hall,Wilson and Zagier.We establish a new formula for the products of two Bernoulli functions by using Parseval's formula,Hurwitz's formula and Lerch's functional equation.As applications of the result,some well-known reciprocity formulas are deduced as special cases.
文摘In the references[4,11,12],the authors gave some modular forms overΓ^(0)(2).In this note,we proceed with the study of cancellation formulas relating to the modular forms.
基金supported by the National Natural Science Foundation of China(Nos.82430116 and 82574622)the Special Fund of Central Committee High Level Chinese Medicine Hospital(Nos.DZMG-LJRC-0014,DZMG-ZJXY-23013)+1 种基金Chinese Medicine Inheritance and Innovation“Thousand Million”Talents Project(Qihuang Project 2021)Qihuang Scholarsthe Medical and Health Industry Development Project of Tongzhou District(2023).
文摘Chronic heart failure(CHF)impairs cognitive function.Xijiaqi Formula(XJQ),a traditional Chinese medicine(TCM)used clinically to treat CHF,demonstrates potential for improving cognition in CHF patients.However,its precise mechanism in treating post-CHF cognitive dysfunction remains unclear.This study systematically investigates XJQ’s effects on post-CHF cognitive dysfunction and the underlying mechanisms.The components of XJQ were identified through liquid chromatography-mass spectrometry.CHF was induced in rats via ligation of the left anterior descending coronary artery,followed by six weeks of XJQ treatment.Cardiac function was evaluated through echocardiography and hemodynamic parameters,while cognitive function was assessed using Morris water maze(MWM)and open field tests(OFT).XJQ treatment enhanced both cardiac and cognitive functions in CHF rats.Network pharmacology identified 12 core active components of XJQ and indicated its effect on cognitive dysfunction involved regulating synapses,inflammation,and phosphodiesterase 4(PDE4)-dependent cyclic adenosine monophosphate(cAMP)signaling.XJQ inhibited microglial and astrocyte activation,decreased proinflammatory cytokines,and mitigated neuronal damage.Notably,XJQ promoted synaptic repair and dendritic growth by downregulating PDE4 and upregulating cAMP,protein kinase A(PKA),cAMP-response element binding protein(CREB),brain-derived neurotrophic factor(BDNF),PSD95,and synapsin I levels.Molecular docking and Bio-layer interferometry assays confirmed direct binding of quercetin,kaempferol,isorhamnetin,and darutoside to PDE4.In conclusion,XJQ alleviates neuroinflammation and enhances synaptic plasticity to improve cognitive dysfunction in CHF rats via the PDE4/cAMP/PKA/CREB signaling pathway.These findings provide valuable insight into the heart-brain axis.
基金supported by Yunnan Provincial Major Science and Technology Special Program(No.202402AA310035)Yunnan Key Laboratory of Dai and Yi Medicines(Yunnan University of Chinese Medicine)(No.2024JS2404)Research Foundation of Chuxiong Medical College(No.2024YYXM38).
文摘Background:Hua-Yi-Jie-Du formula(HYJD)is a traditional Chinese medicine that has proven effective against viral pneumonia and was extensively used during the COVID-19 pandemic.This study investigates how HYJD influences group 2 innate lymphoid cell(ILC2)and nucleotide oligomerization domain(NOD)-like receptor protein 3(NLRP3)inflammasome activation in a mouse model of viral pneumonia.Methods:A mouse model of viral pneumonia was established through the administration of polyinosinic-polycytidylic acid(poly(I:C))via nasal drops.Histopathological analysis of lung tissue was conducted,alongside enzyme-linked immunosorbent assay to quantify cytokine levels in serum and bronchoalveolar lavage fluid(BALF).Flow cytometry was employed to detect ILC2 cells in lung tissue and spleen,while immunofluorescence techniques were utilized to visualize ILC2 cells in lung tissue.Transcriptomic sequencing was performed,and the results were validated using qRT-PCR and western blot analysis.Results:HYJD significantly ameliorated inflammatory infiltration in lung tissue,decreased mucus protein secretion,and reduced the serum levels of inflammatory cytokines interleukin(IL)-1β,IL-6,and tumor necrosis factor-alpha(TNF-α).Additionally,it lowered the expression of cytokines IL-4,IL-5,IL-13,IL-25,thymic stromal lymphopoietin(TSLP),and IL-33 in BALF,and reduced the differentiation of ILC2 cells in both lung tissue and spleen.Transcriptomic analysis and experimental validation revealed that HYJD downregulated the expression of NLRP3 related genes and proteins within the NOD-like receptor signaling pathway.Conclusion:The mechanism by which HYJD intervenes in acute lung injury associated with viral pneumonia may involve the reduction of ILC2 cells differentiation and the inhibition of NLRP3 activation.
文摘BACKGROUND Perimenopausal women are prone to anxiety and depression due to fluctuating hormone levels,which significantly impair their quality of life.The current treatments have certain limitations.In traditional Chinese medicine,liver-soothing formulas are commonly prescribed for mood-related disorders,but their overall efficacy in perimenopausal anxiety and depression remains uncertain and requires verification through meta-analysis.AIM To provide evidence-based support for clinical decision-making and research,a meta-analysis was conducted to evaluate the effectiveness of liver-soothing formulas in treating perimenopausal anxiety and depression.METHODS Relevant studies published up to April 2025 were retrieved from ClinicalTrials.gov,PubMed,Web of Science,EMBASE,and the Cochrane Library.Eligible studies were screened according to predefined inclusion and exclusion criteria.Data were extracted and analyzed using the Stata 12.0 software.RESULTS After searching and screening,12 articles involving 1798 patients(922 in the treatment group and 876 in the control group)were included in the analysis.Meta-analysis showed that the standardized scores for anxiety[standardized mean difference(SMD)=-0.71,95%confidence interval(95%CI):-1.06 to-0.36]and depression(SMD=-0.67,95%CI:-1.06 to-0.27)of the treatment group were lower than those of the control group.Subgroup analysis results revealed that for anxiety,liver-soothing formulas used alone(SMD=-0.34,95%CI:-0.50 to-0.18)or in combination(SMD=-0.88,95%CI:-1.43 to-0.34)both significantly reduced scores compared with the control group.For depression,monotherapy of liversoothing formulas showed no significant statistical difference between the treatment and control groups(SMD=-0.47,95%CI:-1.11 to 0.17),whereas combination therapy produced significantly lower standardized scale scores in the treatment group than in the control group,with a statistically significant difference(SMD=-0.83,95%CI:-1.39 to-0.28).Regarding Greene scores,no statistically significant difference was observed with monotherapy(SMD=0.87,95%CI:-0.32 to 2.06),whereas combination therapy had significantly lower Greene scores(SMD=-0.24,95%CI:-0.44 to-0.04).No statistically significant difference was found between the groups in the occurrence of adverse reactions(odds ratio=0.90,95%CI:0.57-1.43).However,liver-soothing formulas did not affect estrogen levels in perimenopausal women.CONCLUSION Compared with placebo,conventional Western medicine,or other interventions,the monotherapy of liver-soothing formulas demonstrates superior efficacy in treating perimenopausal anxiety.When used as an adjuvant,they exert a synergistic effect in alleviating negative emotions and improving overall perimenopausal symptoms.
