Parkinson’s disease(PD),the second most common neurodegenerative neurological disease,is characterized by dopaminergic neuron loss in the substantia nigra(SN)and Lewy body formation.Subthalamic nucleus deep brain sti...Parkinson’s disease(PD),the second most common neurodegenerative neurological disease,is characterized by dopaminergic neuron loss in the substantia nigra(SN)and Lewy body formation.Subthalamic nucleus deep brain stimulation(STN-DBS)effectively treats motor symptoms like tremor and dyskinesia in PD.In addition to its acute effect on the motor symptom networks,there is an ongoing debate on a potential disease-modifying neuroplastic or even neuroprotective effect of chronic STN-DBS,and the underlying mechanisms remain elusive.Plasticity-associated factors,such as brain-derived neurotrophic factor(BDNF)and its receptor tropomyosin receptor kinase B(TrkB),can play important roles in retuning neural networks.Dopamine deficiency in PD striatum causes reduced sensitivity of dopamine receptor D1-expressing medium spiny neurons(dMSNs)to BDNF,leading to intracellular TrkB clustering.This highlights a mechanism relevant to PD pathogenesis and treatment[1].展开更多
基金financed by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Project-ID 424778381-TRR 295(A01 to J.V.,A05 to M.S.,A06 to C.W.I.)C.W.I.received additional funding from the Interdisciplinary Center for Clinical Research(IZKF)at the University of Wurzburg(S-506,N-362)and from the VERUM foundation.
文摘Parkinson’s disease(PD),the second most common neurodegenerative neurological disease,is characterized by dopaminergic neuron loss in the substantia nigra(SN)and Lewy body formation.Subthalamic nucleus deep brain stimulation(STN-DBS)effectively treats motor symptoms like tremor and dyskinesia in PD.In addition to its acute effect on the motor symptom networks,there is an ongoing debate on a potential disease-modifying neuroplastic or even neuroprotective effect of chronic STN-DBS,and the underlying mechanisms remain elusive.Plasticity-associated factors,such as brain-derived neurotrophic factor(BDNF)and its receptor tropomyosin receptor kinase B(TrkB),can play important roles in retuning neural networks.Dopamine deficiency in PD striatum causes reduced sensitivity of dopamine receptor D1-expressing medium spiny neurons(dMSNs)to BDNF,leading to intracellular TrkB clustering.This highlights a mechanism relevant to PD pathogenesis and treatment[1].
