Our research reveals the critical role of the suprachiasmatic nucleus(SCN)vasoactive intestinal peptide(VIP)neurons in mediating light-induced transient forgetting.Acute exposure to bright light selectively impairs tr...Our research reveals the critical role of the suprachiasmatic nucleus(SCN)vasoactive intestinal peptide(VIP)neurons in mediating light-induced transient forgetting.Acute exposure to bright light selectively impairs trace fear memory by activating VIP neurons in the SCN,as demonstrated by increased c-Fos expression and Ca2+recording.This effect can be replicated and reversed through optogenetic and chemogenetic manipulations of SCN VIP neurons.Furthermore,we identify the SCN→PVT(paraventricular nucleus of the thalamus)VIP neuronal circuitry as essential in this process.These findings establish a novel role for SCN VIP neurons in modulating memory accessibility in response to environmental light cues,extending their known function beyond circadian regulation and revealing a mechanism for transient forgetting.展开更多
Vaccination is critical for controlling infectious diseases,but negative vaccination information can lead to vaccine hesitancy.To study how the interplay between information diffusion and disease transmission impacts ...Vaccination is critical for controlling infectious diseases,but negative vaccination information can lead to vaccine hesitancy.To study how the interplay between information diffusion and disease transmission impacts vaccination and epidemic spread,we propose a novel two-layer multiplex network model that integrates an unaware-acceptant-negative-unaware(UANU)information diffusion model with a susceptible-vaccinated-exposed-infected-susceptible(SVEIS)epidemiological framework.This model includes individual exposure and vaccination statuses,time-varying forgetting probabilities,and information conversion thresholds.Through the microscopic Markov chain approach(MMCA),we derive dynamic transition equations and the epidemic threshold expression,validated by Monte Carlo simulations.Using MMCA equations,we predict vaccination densities and analyze parameter effects on vaccination,disease transmission,and the epidemic threshold.Our findings suggest that promoting positive information,curbing the spread of negative information,enhancing vaccine effectiveness,and promptly identifying asymptomatic carriers can significantly increase vaccination rates,reduce epidemic spread,and raise the epidemic threshold.展开更多
基金supported by grants from the National Natural Science Foundation of China(32021002 and 31900724)the STI2030-Major Projects(2022ZD0204900)the Tsinghua-Peking Joint Center for Life Sciences.
文摘Our research reveals the critical role of the suprachiasmatic nucleus(SCN)vasoactive intestinal peptide(VIP)neurons in mediating light-induced transient forgetting.Acute exposure to bright light selectively impairs trace fear memory by activating VIP neurons in the SCN,as demonstrated by increased c-Fos expression and Ca2+recording.This effect can be replicated and reversed through optogenetic and chemogenetic manipulations of SCN VIP neurons.Furthermore,we identify the SCN→PVT(paraventricular nucleus of the thalamus)VIP neuronal circuitry as essential in this process.These findings establish a novel role for SCN VIP neurons in modulating memory accessibility in response to environmental light cues,extending their known function beyond circadian regulation and revealing a mechanism for transient forgetting.
基金supported by the National Social Science Foundation of China(Grant Nos.21BGL217 and 22CGL050)the Philosophy and Social Science Fund of Education Department of Jiangsu Province(Grant No.2020SJA2346).
文摘Vaccination is critical for controlling infectious diseases,but negative vaccination information can lead to vaccine hesitancy.To study how the interplay between information diffusion and disease transmission impacts vaccination and epidemic spread,we propose a novel two-layer multiplex network model that integrates an unaware-acceptant-negative-unaware(UANU)information diffusion model with a susceptible-vaccinated-exposed-infected-susceptible(SVEIS)epidemiological framework.This model includes individual exposure and vaccination statuses,time-varying forgetting probabilities,and information conversion thresholds.Through the microscopic Markov chain approach(MMCA),we derive dynamic transition equations and the epidemic threshold expression,validated by Monte Carlo simulations.Using MMCA equations,we predict vaccination densities and analyze parameter effects on vaccination,disease transmission,and the epidemic threshold.Our findings suggest that promoting positive information,curbing the spread of negative information,enhancing vaccine effectiveness,and promptly identifying asymptomatic carriers can significantly increase vaccination rates,reduce epidemic spread,and raise the epidemic threshold.
