Spectrin domains,characterized by a distinctive triple helix structure,are crucial in physiological processes,particularly in maintaining membrane shape and crosslinking cytoskeletons.Previous research on the 16th dom...Spectrin domains,characterized by a distinctive triple helix structure,are crucial in physiological processes,particularly in maintaining membrane shape and crosslinking cytoskeletons.Previous research on the 16th domain of a-spectrin repeats(R16)has yielded conflicting results:bulk experiments showed an unfolding rate approximately two orders of magnitude faster than the zero-force result extrapolated from single-molecule force spectroscopy experiments using atomic force microscopy(AFM).To address this discrepancy,we investigated the folding and unfolding rates of R16 across a broader range of forces using magnetic tweezers(MT).Our findings reveal that AFM results at higher forces cannot be directly extrapolated to the low-force regime due to a nonlinear relationship between force and the logarithm of the unfolding rate.We demonstrated that two-dimensional model,structural-elastic model,and two-pathway model can all effectively explain the experimental data when they capture the core physics of the short unfolding distance at low forces.Our study provides a more comprehensive understanding of the unfolding dynamics of the spectrin domain,resolves previous contradictory experimental results,and highlights the common basis of different theoretical models.展开更多
Morphing aircraft are designed to adaptively adjust their shape for changing flight missions,which enables them to improve their flight performance significantly for future applications.The folding wingtips represent ...Morphing aircraft are designed to adaptively adjust their shape for changing flight missions,which enables them to improve their flight performance significantly for future applications.The folding wingtips represent a key research aspect for morphing aircraft,since they can lead to potential improvements in flight range,maneuverability,load alleviation and airport compatibility.This paper proposes a hinge mechanism design for folding wingtips based on the shape memory alloy torsion tube,aiming to achieve successful folding using the actuation effect of the shape memory alloy.The proposed design employs a shape memory alloy torsion tube as the actuator for the active folding of the wingtip,which is motivated by the characteristics of the tube,enabling a simplified structure for the integration with high energy density.Through numerical simulation and testing of the folding wingtip structure,the concept is verified,which shows its potential as an actuator for folding wingtips.展开更多
Two types of bound states in continuum(BICs),symmetry-protected and Brillouin zone folding driven,are identified in hollow Si nanorod arrays.By modulating the direction and distance of the air holes from the center of...Two types of bound states in continuum(BICs),symmetry-protected and Brillouin zone folding driven,are identified in hollow Si nanorod arrays.By modulating the direction and distance of the air holes from the center of the nanorods,it is possible to achieve either a single quasi-BIC or three quasi-BICs.The transmission spectra exhibit ultra-narrow lines,and the quasi-BICs demonstrate ultra-high Q factors.Additionally,efficient third-harmonic generation occurs at low pump intensities.The results indicate that the proposed nanostructures of two types of BICs with a flexible modulation hold great potential applications for nonlinear photonic devices.展开更多
The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulu...The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.展开更多
Bistable Deployable Composite Boom(Bi-DCB)can achieve bistable function by storing and releasing strain energy,which has a good application prospect in space field.For example,it serves as the main support section of ...Bistable Deployable Composite Boom(Bi-DCB)can achieve bistable function by storing and releasing strain energy,which has a good application prospect in space field.For example,it serves as the main support section of deployable structures(e.g.,solar arrays and antennas).This paper investigates folding stable state of Bi-DCB through the analytical method.Based on Archimedes’helix and energy principle,an analytical model for predicting folding stable state of Bi-DCB was presented.The failure index of Bi-DCB in folding stable state were analyzed using the Tsai-Hill criterion and the maximum stress criterion.Then,a 2400 mm long Bi-DCB was fabricated using autoclave method.The prediction results of the proposed model were compared with experiments and results of two other analytical models.It is shown that the proposed model shows good prediction accuracy.Finally,the effect of geometric parameters on folding stable state of Bi-DCB was further investigated with the aid of the proposed model.展开更多
Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic materials.Here,a new rational strategy of anion-directed fold-ing a flexi...Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic materials.Here,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been developed.Electron-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)cation.Three complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,respectively.In contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and 3.An intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.展开更多
Folding of molecules is an essential process in nature,and various molecular machines achieve their chemical and mechanical function via controlled folding of molecular conformations.The electric field offers a unique...Folding of molecules is an essential process in nature,and various molecular machines achieve their chemical and mechanical function via controlled folding of molecular conformations.The electric field offers a unique strategy to drive the folding of molecular conformation and to control charge transport through single molecules but remains unexplored.The single-molecule break junction technique provides access to detect the conformational changes via the monitoring of single-molecule conductance,and the electric field between two metal electrodes with nanoscale spacing can provide an extremely strong to achieve in-situ control and detection of molecular folding at the single-molecule level.Here,we use the electric field to control the single-molecule folding using the scanning tunneling microscope break junction(STM-BJ)technique.The electric fields induced folding could lead to a∼1400%conductance change of the single-molecule junctions,and the folding/unfolding process can be in-situ switched at the scale of milliseconds.DFT calculations suggest the conformational control originates from the electric fieldinduced charge injection,and the formation of homoconjugated conformation with the overlapped orbitals.This work provides the first demonstration of electric field-driven molecular folding,which is essential for the understanding of molecular machines in nature and for the design of artificial molecular machines.展开更多
Flasher origami pattern has been widely utilized to improve the stowage efficiency of deployable structures.Nevertheless,flasher origami cannot be folded fully flat,and they still have great potential for optimization...Flasher origami pattern has been widely utilized to improve the stowage efficiency of deployable structures.Nevertheless,flasher origami cannot be folded fully flat,and they still have great potential for optimization in terms of storage volume and folding creases.In this paper,a flat foldable equiangular spiral folding pattern inspired by the sunflower disk is introduced.Then,a parametric design method for this equiangular spiral crease diagram is introduced in detail.Subsequently,a kinematic model of the equiangular spiral folding pattern is established based on the kinematic equivalence between rigid origami and spherical linkages.A simulation of the developed model demonstrates that the equiangular spiral folding pattern can be folded flat.Using the folded ratio as an evaluation index,the calculated results and experiments show that the equiangular spiral crease pattern can yield fewer creases and improve stowage efficiency in comparison to flasher origami pattern.Equiangular spiral folding pattern can save a considerable amount of space and provide a new approach to spatially deployable structures.展开更多
Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spec...Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated outputs.In this case,a multipath NYFR architecture with a step-sampling rate for the different paths is proposed.The different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these grids.Thus,high-precision parameter estimation is performed by utilizing the NYFR characteristics.Compared with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm probability.Comparative simulation experiments verify the effectiveness of the proposed architecture in this paper.展开更多
The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of the...The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of their unique familial,sporadic,and transmissible etiologies,all caused by a single agent:misfolded conformations of PrP.展开更多
Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D measurements.The algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measure...Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D measurements.The algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measurements is pivotal in the imaging process.Early approaches painstakingly designed networks to directly map compressive measurements to HSIs,resulting in the lack of interpretability without exploiting the imaging priors.While some recent works have introduced the deep unfolding framework for explainable reconstruction,the performance of these methods is still limited by the weak information transmission between iterative stages.In this paper,we propose a Memory-Augmented deep Unfolding Network,termed MAUN,for explainable and accurate HSI reconstruction.Specifically,MAUN implements a novel CNN scheme to facilitate a better extrapolation step of the fast iterative shrinkage-thresholding algorithm,introducing an extra momentum incorporation step for each iteration to alleviate the information loss.Moreover,to exploit the high correlation of intermediate images from neighboring iterations,we customize a cross-stage transformer(CSFormer)as the deep denoiser to simultaneously capture self-similarity from both in-stage and cross-stage features,which is the first attempt to model the long-distance dependencies between iteration stages.Extensive experiments demonstrate that the proposed MAUN is superior to other state-of-the-art methods both visually and metrically.Our code is publicly available at https://github.com/HuQ1an/MAUN.展开更多
Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dep...Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dependent folding and unfolding rates of both protein L(PLWT) and its Y47W mutant(PLY47W) where the mutation point is not at the force-bearing β-strands. The measurements were conducted within a force range of 3–120 pN. Notably, the unfolding rates of both PLWT and PWY47W exhibit distinct force sensitivities below 50 pN and above 60 pN, implying a two-barrier free energy landscape. Both PLWT and PLY47W share the same force-dependent folding rate and the same transition barriers,but the unfolding rate of PLY47W is faster than that of PLWT. Our finding demonstrates that the residue outside of the force-bearing region will also affect the force-induced unfolding dynamics.展开更多
A CMOS folding and interpolating analog-to-digital converter (ADC) for embedded application is described.The circuit is fully compatible with standard digital CMOS technology.A modified folding block implemented witho...A CMOS folding and interpolating analog-to-digital converter (ADC) for embedded application is described.The circuit is fully compatible with standard digital CMOS technology.A modified folding block implemented without resistor contributes to a small chip area.At the input stage,offset averaging reduces the input capacitance and the distributed track-and-hold circuits are proposed to improve signal-to-noise-plus-distortion ratio.The 200Ms/s 8bit ADC with 177mW total power consumption at 3.3V power supply is realized in standard digital 0.18μm 3.3V CMOS technology.展开更多
[Background]Traveling-wave tubes(TWTs)are widely applied in radar,imaging,and military systems owing to their excellent amplification characteristics.Miniaturization and integration are critical to the future of TWTs,...[Background]Traveling-wave tubes(TWTs)are widely applied in radar,imaging,and military systems owing to their excellent amplification characteristics.Miniaturization and integration are critical to the future of TWTs,with multi-channel slow-wave structures(SWSs)forming the foundation for their realization in high-power vacuum electronic devices.[Purpose]To provide design insights for multi-channel TWTs and simultaneously enhance their output power,a W-band folded-waveguide TWT with dual electron beams and H-plane power combining was proposed.[Methods]Three-dimensional electromagnetic simulations in CST were conducted to verify the highfrequency characteristics,electric field distribution,and amplification performance of the proposed SWS,thereby confirming the validity of the design.[Results]Results indicate that the designed TWT achieves a transmission bandwidth of 10 GHz.With an electron beam voltage of 17.9 kV and a current of 0.35 A,the output power reaches 450 W at 94 GHz,corresponding to an efficiency of 7.18%and a gain of 23.5 dB.Moreover,under fixed beam voltage and current,the TWT delivers over 200 W output power across 91–99 GHz,with a 3 dB bandwidth of 91–98.5 GHz.The particle voltage distribution after modulation further validates the mode analysis.[Conclusions]These results demonstrate the feasibility of compact dual-beam power-combining structures and provide useful guidance for the design of future multi-channel TWTs.展开更多
A duxianqin musician needs only a single string stretched across an elongated(细长的)soundboard and a feather⁃shaped rod to deliver a diverse repertoire,whether pop or classical,Chinese or Western.In his Zen⁃style stu...A duxianqin musician needs only a single string stretched across an elongated(细长的)soundboard and a feather⁃shaped rod to deliver a diverse repertoire,whether pop or classical,Chinese or Western.In his Zen⁃style studio adorned with folding screens,Wei Qingbing,39,sits on a bamboo mat and plucks(弹拨)the string of his duxianqin with his right hand,while his left hand slides across the rod to adjust the pitch and add vibrato.展开更多
This paper introduces an innovative approach to the deployment of folding wings on cruise missiles,aiming to overcome the issues associated with explosive devices.The proposed solution involves employing NiTi shape me...This paper introduces an innovative approach to the deployment of folding wings on cruise missiles,aiming to overcome the issues associated with explosive devices.The proposed solution involves employing NiTi shape memory wires for a nonexplosive self-deploying wing mechanism.The fundamental concept of the design revolves around the utilization of NiTi wires,which contract upon electric heating.This contraction action severs the shear pin,consequently releasing the folded wings.The operational performance of the NiTi wire is thoroughly examined through a series of electro-thermo-mechanical tests,offering valuable insights for selecting the appropriate wire material.Moreover,the mechanical dynamics involved in the self-deploying process are elucidated through finite element simulations.The simulations highlight that the thermally-induced phase transformation within the NiTi wires generates substantial actuation forces,exceeding 700 N,and strokes of over 6 mm.These forces are deemed sufficient for breaking the aluminum shear pin and effecting wing deployment.The proposed mechanism’s practical viability is substantiated through prototype tests,which conclusively establish the superiority of the nonexplosive self-deploying wing mechanism when compared to conventional methods.The experimental outcomes underscore the mechanism’s capability to markedly reduce overload stress while remaining compliant with the designated requirements and constraints.展开更多
This study explored how the human cortical folding pattern composed of convex gyri and concave sulci afected single-subject morphological brain networks,which are becoming an important method for studying the human br...This study explored how the human cortical folding pattern composed of convex gyri and concave sulci afected single-subject morphological brain networks,which are becoming an important method for studying the human brain connectome.We found that gyri-gyri networks exhibited higher morphological similarity,lower small-world parameters,and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness-and gyrifcation index-based networks,while opposite patterns were observed for fractal dimension-based networks.Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions signifcantly explained inter-individual variance in Cognition and Motor domains for fractal dimension-and sulcal depth-based networks.Finally,the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-,fractal dimension-,and gyrifcation index-based networks.Taken together,these fndings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.展开更多
The spatial constraints of aircraft have accelerated the development of multi-wing deployable mechanisms.These systems enable the rapid,sub-second deployment of multiple folding wings,which generate high-energy impact...The spatial constraints of aircraft have accelerated the development of multi-wing deployable mechanisms.These systems enable the rapid,sub-second deployment of multiple folding wings,which generate high-energy impacts upon locking-resulting in oscillations that can adversely affect aerodynamic performance.Despite their importance,the transient dynamic characteristics during deployment and locking remain insufficiently explored.This study presents an integrated dynamic model for a single-actuator,multi-wing deployable mechanism that accounts for joint clearances,component elasticity,and locking collisions.This model is used to analyze the influence of transient driving on the motion errors of multiple folding wings,the locking oscillation amplitude,and the complete stabilization time.Results indicate that as the driving force and transient deployment speed increase,all dynamic performance characteristics are notably affected.Specifically,raising the transient driving force from 3000 to 7000 N leads to a maximum increase of 60.8%in oscillation amplitude and 78.4%in stabilization time.By comparing the results of the prototype experiment with the theoretical model,it is found that the errors of the maximum locking oscillation amplitude and the complete stabilization time for the three groups of folding wings are all within the acceptable range,which verifies the theoretical model.These findings advance the theoretical understanding of transient deployment dynamics and locking oscillations in high-speed deployable mechanisms.展开更多
Using periodic refractive index perturbations,the Brillouin zone is folded,transforming the guided modes in a metasurface into guided resonances with arbitrarily high quality-factors.The incorporation of phase change ...Using periodic refractive index perturbations,the Brillouin zone is folded,transforming the guided modes in a metasurface into guided resonances with arbitrarily high quality-factors.The incorporation of phase change materials within the metasurface enables dynamic modulation of the guided modes.The system’s symmetry ensures a polarization-independent response under normal incidence.Furthermore,the metasurface exhibits excellent sensing performance,demonstrating its potential for advanced photonic applications.展开更多
基金supported by the National Natural Science Foun-dation of China(Grant Nos.12174322,12474200,32271367,and 12204389)111 Project(B16029)Research Grant from Wenzhou Institute.
文摘Spectrin domains,characterized by a distinctive triple helix structure,are crucial in physiological processes,particularly in maintaining membrane shape and crosslinking cytoskeletons.Previous research on the 16th domain of a-spectrin repeats(R16)has yielded conflicting results:bulk experiments showed an unfolding rate approximately two orders of magnitude faster than the zero-force result extrapolated from single-molecule force spectroscopy experiments using atomic force microscopy(AFM).To address this discrepancy,we investigated the folding and unfolding rates of R16 across a broader range of forces using magnetic tweezers(MT).Our findings reveal that AFM results at higher forces cannot be directly extrapolated to the low-force regime due to a nonlinear relationship between force and the logarithm of the unfolding rate.We demonstrated that two-dimensional model,structural-elastic model,and two-pathway model can all effectively explain the experimental data when they capture the core physics of the short unfolding distance at low forces.Our study provides a more comprehensive understanding of the unfolding dynamics of the spectrin domain,resolves previous contradictory experimental results,and highlights the common basis of different theoretical models.
基金supported by the National Natural Science Foundation of China(No.52305262)the Aeronautical Science Foundation of China(No.20230015052002)the Fundamental Research Funds for the Central Universities(No.NT2024001)。
文摘Morphing aircraft are designed to adaptively adjust their shape for changing flight missions,which enables them to improve their flight performance significantly for future applications.The folding wingtips represent a key research aspect for morphing aircraft,since they can lead to potential improvements in flight range,maneuverability,load alleviation and airport compatibility.This paper proposes a hinge mechanism design for folding wingtips based on the shape memory alloy torsion tube,aiming to achieve successful folding using the actuation effect of the shape memory alloy.The proposed design employs a shape memory alloy torsion tube as the actuator for the active folding of the wingtip,which is motivated by the characteristics of the tube,enabling a simplified structure for the integration with high energy density.Through numerical simulation and testing of the folding wingtip structure,the concept is verified,which shows its potential as an actuator for folding wingtips.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12174228 and 12274271)。
文摘Two types of bound states in continuum(BICs),symmetry-protected and Brillouin zone folding driven,are identified in hollow Si nanorod arrays.By modulating the direction and distance of the air holes from the center of the nanorods,it is possible to achieve either a single quasi-BIC or three quasi-BICs.The transmission spectra exhibit ultra-narrow lines,and the quasi-BICs demonstrate ultra-high Q factors.Additionally,efficient third-harmonic generation occurs at low pump intensities.The results indicate that the proposed nanostructures of two types of BICs with a flexible modulation hold great potential applications for nonlinear photonic devices.
基金This work was supported by the National Natural Science Foundation of China(No.82071762)the Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100)the 2021 Capacity Building of Shanghai Universities(No.21010503600),China。
文摘The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.
基金supported by the National Natural Science Foundation of China(No.52275231)the National Defense Basic Scientific Research Program of China(No.JCKY2019205C002).
文摘Bistable Deployable Composite Boom(Bi-DCB)can achieve bistable function by storing and releasing strain energy,which has a good application prospect in space field.For example,it serves as the main support section of deployable structures(e.g.,solar arrays and antennas).This paper investigates folding stable state of Bi-DCB through the analytical method.Based on Archimedes’helix and energy principle,an analytical model for predicting folding stable state of Bi-DCB was presented.The failure index of Bi-DCB in folding stable state were analyzed using the Tsai-Hill criterion and the maximum stress criterion.Then,a 2400 mm long Bi-DCB was fabricated using autoclave method.The prediction results of the proposed model were compared with experiments and results of two other analytical models.It is shown that the proposed model shows good prediction accuracy.Finally,the effect of geometric parameters on folding stable state of Bi-DCB was further investigated with the aid of the proposed model.
基金supported by National Natural Science Foundation of China(No.92261109)Natural Science Foundation of Fujian Province(No.2020J05080)+3 种基金Project Funded by China Postdoctoral Science Foundation(No.2023M733496)Natural Science Foundation of Xiamen(No.3502Z20206080)Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China(No.2021ZR110)Recruitment Program of Global Youth Experts,Youth Innovation Promotion Association CAS(No.2021302).
文摘Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic materials.Here,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been developed.Electron-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)cation.Three complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,respectively.In contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and 3.An intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.
基金the National Natural Science Foundation of China(Nos.22250003 and 22205084)National Key R&D Program of China(No.2017YFA0204902).
文摘Folding of molecules is an essential process in nature,and various molecular machines achieve their chemical and mechanical function via controlled folding of molecular conformations.The electric field offers a unique strategy to drive the folding of molecular conformation and to control charge transport through single molecules but remains unexplored.The single-molecule break junction technique provides access to detect the conformational changes via the monitoring of single-molecule conductance,and the electric field between two metal electrodes with nanoscale spacing can provide an extremely strong to achieve in-situ control and detection of molecular folding at the single-molecule level.Here,we use the electric field to control the single-molecule folding using the scanning tunneling microscope break junction(STM-BJ)technique.The electric fields induced folding could lead to a∼1400%conductance change of the single-molecule junctions,and the folding/unfolding process can be in-situ switched at the scale of milliseconds.DFT calculations suggest the conformational control originates from the electric fieldinduced charge injection,and the formation of homoconjugated conformation with the overlapped orbitals.This work provides the first demonstration of electric field-driven molecular folding,which is essential for the understanding of molecular machines in nature and for the design of artificial molecular machines.
基金supported in part by National Key R&D Program of China(Grant No.2018YFB1304600)CAS Interdisciplinary Innovation Team(Grant No.JCTD-2018-11)the Natural Science Foundation of China(Grant No.51775541).
文摘Flasher origami pattern has been widely utilized to improve the stowage efficiency of deployable structures.Nevertheless,flasher origami cannot be folded fully flat,and they still have great potential for optimization in terms of storage volume and folding creases.In this paper,a flat foldable equiangular spiral folding pattern inspired by the sunflower disk is introduced.Then,a parametric design method for this equiangular spiral crease diagram is introduced in detail.Subsequently,a kinematic model of the equiangular spiral folding pattern is established based on the kinematic equivalence between rigid origami and spherical linkages.A simulation of the developed model demonstrates that the equiangular spiral folding pattern can be folded flat.Using the folded ratio as an evaluation index,the calculated results and experiments show that the equiangular spiral crease pattern can yield fewer creases and improve stowage efficiency in comparison to flasher origami pattern.Equiangular spiral folding pattern can save a considerable amount of space and provide a new approach to spatially deployable structures.
基金supported by the Key Projects of the 2022 National Defense Science and Technology Foundation Strengthening Plan 173 (Grant No.2022-173ZD-010)the Equipment PreResearch Foundation of The State Key Laboratory (Grant No.6142101200204)。
文摘Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical systems.The Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated outputs.In this case,a multipath NYFR architecture with a step-sampling rate for the different paths is proposed.The different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these grids.Thus,high-precision parameter estimation is performed by utilizing the NYFR characteristics.Compared with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm probability.Comparative simulation experiments verify the effectiveness of the proposed architecture in this paper.
基金supported by the NIH grant7R21 NS09662 7-02 to PFFthe Winston and Maxine Wallin Neuroscience Discovery Fund award CON000000083928 to PFF and AC。
文摘The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of their unique familial,sporadic,and transmissible etiologies,all caused by a single agent:misfolded conformations of PrP.
基金supported by the National Natural Science Foundation of China(62276192)。
文摘Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D measurements.The algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measurements is pivotal in the imaging process.Early approaches painstakingly designed networks to directly map compressive measurements to HSIs,resulting in the lack of interpretability without exploiting the imaging priors.While some recent works have introduced the deep unfolding framework for explainable reconstruction,the performance of these methods is still limited by the weak information transmission between iterative stages.In this paper,we propose a Memory-Augmented deep Unfolding Network,termed MAUN,for explainable and accurate HSI reconstruction.Specifically,MAUN implements a novel CNN scheme to facilitate a better extrapolation step of the fast iterative shrinkage-thresholding algorithm,introducing an extra momentum incorporation step for each iteration to alleviate the information loss.Moreover,to exploit the high correlation of intermediate images from neighboring iterations,we customize a cross-stage transformer(CSFormer)as the deep denoiser to simultaneously capture self-similarity from both in-stage and cross-stage features,which is the first attempt to model the long-distance dependencies between iteration stages.Extensive experiments demonstrate that the proposed MAUN is superior to other state-of-the-art methods both visually and metrically.Our code is publicly available at https://github.com/HuQ1an/MAUN.
基金supported by the National Natural Science Foundation of China(Grant Nos.12174322 to HC and 12204124 to ZG)111 Project(Grant No.B16029)+1 种基金the Graduate Scientific Research Foundation of Wenzhou University(Grant No.3162023003034 to JH)research grant from Wenzhou Institute。
文摘Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dependent folding and unfolding rates of both protein L(PLWT) and its Y47W mutant(PLY47W) where the mutation point is not at the force-bearing β-strands. The measurements were conducted within a force range of 3–120 pN. Notably, the unfolding rates of both PLWT and PWY47W exhibit distinct force sensitivities below 50 pN and above 60 pN, implying a two-barrier free energy landscape. Both PLWT and PLY47W share the same force-dependent folding rate and the same transition barriers,but the unfolding rate of PLY47W is faster than that of PLWT. Our finding demonstrates that the residue outside of the force-bearing region will also affect the force-induced unfolding dynamics.
文摘A CMOS folding and interpolating analog-to-digital converter (ADC) for embedded application is described.The circuit is fully compatible with standard digital CMOS technology.A modified folding block implemented without resistor contributes to a small chip area.At the input stage,offset averaging reduces the input capacitance and the distributed track-and-hold circuits are proposed to improve signal-to-noise-plus-distortion ratio.The 200Ms/s 8bit ADC with 177mW total power consumption at 3.3V power supply is realized in standard digital 0.18μm 3.3V CMOS technology.
基金National Key Research and Development Program of China(2022YFF0707602)National Natural Science Foundation of China(62471097,62471115,62471101)National Natural Science Foundation of Sichuan(2025ZNSFSC0537)。
文摘[Background]Traveling-wave tubes(TWTs)are widely applied in radar,imaging,and military systems owing to their excellent amplification characteristics.Miniaturization and integration are critical to the future of TWTs,with multi-channel slow-wave structures(SWSs)forming the foundation for their realization in high-power vacuum electronic devices.[Purpose]To provide design insights for multi-channel TWTs and simultaneously enhance their output power,a W-band folded-waveguide TWT with dual electron beams and H-plane power combining was proposed.[Methods]Three-dimensional electromagnetic simulations in CST were conducted to verify the highfrequency characteristics,electric field distribution,and amplification performance of the proposed SWS,thereby confirming the validity of the design.[Results]Results indicate that the designed TWT achieves a transmission bandwidth of 10 GHz.With an electron beam voltage of 17.9 kV and a current of 0.35 A,the output power reaches 450 W at 94 GHz,corresponding to an efficiency of 7.18%and a gain of 23.5 dB.Moreover,under fixed beam voltage and current,the TWT delivers over 200 W output power across 91–99 GHz,with a 3 dB bandwidth of 91–98.5 GHz.The particle voltage distribution after modulation further validates the mode analysis.[Conclusions]These results demonstrate the feasibility of compact dual-beam power-combining structures and provide useful guidance for the design of future multi-channel TWTs.
文摘A duxianqin musician needs only a single string stretched across an elongated(细长的)soundboard and a feather⁃shaped rod to deliver a diverse repertoire,whether pop or classical,Chinese or Western.In his Zen⁃style studio adorned with folding screens,Wei Qingbing,39,sits on a bamboo mat and plucks(弹拨)the string of his duxianqin with his right hand,while his left hand slides across the rod to adjust the pitch and add vibrato.
基金Supported by National Natural Science Foundation of China(Grant No.12372156).
文摘This paper introduces an innovative approach to the deployment of folding wings on cruise missiles,aiming to overcome the issues associated with explosive devices.The proposed solution involves employing NiTi shape memory wires for a nonexplosive self-deploying wing mechanism.The fundamental concept of the design revolves around the utilization of NiTi wires,which contract upon electric heating.This contraction action severs the shear pin,consequently releasing the folded wings.The operational performance of the NiTi wire is thoroughly examined through a series of electro-thermo-mechanical tests,offering valuable insights for selecting the appropriate wire material.Moreover,the mechanical dynamics involved in the self-deploying process are elucidated through finite element simulations.The simulations highlight that the thermally-induced phase transformation within the NiTi wires generates substantial actuation forces,exceeding 700 N,and strokes of over 6 mm.These forces are deemed sufficient for breaking the aluminum shear pin and effecting wing deployment.The proposed mechanism’s practical viability is substantiated through prototype tests,which conclusively establish the superiority of the nonexplosive self-deploying wing mechanism when compared to conventional methods.The experimental outcomes underscore the mechanism’s capability to markedly reduce overload stress while remaining compliant with the designated requirements and constraints.
基金supported by the STI 2030-Major Projects(2021ZD0200500)the National Social Science Foundation of China(20&ZD296)Key Realm R&D Program of Guangdong Province(2019B030335001).
文摘This study explored how the human cortical folding pattern composed of convex gyri and concave sulci afected single-subject morphological brain networks,which are becoming an important method for studying the human brain connectome.We found that gyri-gyri networks exhibited higher morphological similarity,lower small-world parameters,and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness-and gyrifcation index-based networks,while opposite patterns were observed for fractal dimension-based networks.Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions signifcantly explained inter-individual variance in Cognition and Motor domains for fractal dimension-and sulcal depth-based networks.Finally,the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-,fractal dimension-,and gyrifcation index-based networks.Taken together,these fndings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.
基金Supported by National Natural Science Foundation of China(Grant Nos.52192634,92471202,52105013,U2341237,T2388101).
文摘The spatial constraints of aircraft have accelerated the development of multi-wing deployable mechanisms.These systems enable the rapid,sub-second deployment of multiple folding wings,which generate high-energy impacts upon locking-resulting in oscillations that can adversely affect aerodynamic performance.Despite their importance,the transient dynamic characteristics during deployment and locking remain insufficiently explored.This study presents an integrated dynamic model for a single-actuator,multi-wing deployable mechanism that accounts for joint clearances,component elasticity,and locking collisions.This model is used to analyze the influence of transient driving on the motion errors of multiple folding wings,the locking oscillation amplitude,and the complete stabilization time.Results indicate that as the driving force and transient deployment speed increase,all dynamic performance characteristics are notably affected.Specifically,raising the transient driving force from 3000 to 7000 N leads to a maximum increase of 60.8%in oscillation amplitude and 78.4%in stabilization time.By comparing the results of the prototype experiment with the theoretical model,it is found that the errors of the maximum locking oscillation amplitude and the complete stabilization time for the three groups of folding wings are all within the acceptable range,which verifies the theoretical model.These findings advance the theoretical understanding of transient deployment dynamics and locking oscillations in high-speed deployable mechanisms.
基金supported by the National Natural Science Foundation of China(Grant No.12347101).
文摘Using periodic refractive index perturbations,the Brillouin zone is folded,transforming the guided modes in a metasurface into guided resonances with arbitrarily high quality-factors.The incorporation of phase change materials within the metasurface enables dynamic modulation of the guided modes.The system’s symmetry ensures a polarization-independent response under normal incidence.Furthermore,the metasurface exhibits excellent sensing performance,demonstrating its potential for advanced photonic applications.
