AIM:To assess visual outcomes and satisfaction of a non-diffractive extended depth of focus(EDOF)intraocular lens(IOL)in individuals with ocular hypertension(OHT)and well-controlled mild glaucoma undergoing cataract s...AIM:To assess visual outcomes and satisfaction of a non-diffractive extended depth of focus(EDOF)intraocular lens(IOL)in individuals with ocular hypertension(OHT)and well-controlled mild glaucoma undergoing cataract surgery.METHODS:An investigator-initiated,single-center,prospective,interventional,noncomparative study conducted in Montreal,Canada.The study enrolled 31 patients(55 eyes)with OHT or mild glaucoma who received a non-diffractive EDOF IOL(Acrysof IQ Vivity).Participants underwent sequential cataract surgery with the Vivity IOL.Follow-up evaluations occurred at 1d,1,and 3mo postoperatively,assessing uncorrected distance,intermediate,and near visual acuity.Questionnaires(QUVID:Questionnaire for visual disturbances and IOLSAT:Intraocular lens satisfaction)were administered pre and post-operatively to measure visual disturbances and spectacle independence in various lighting.Safety parameters included intraocular pressure(IOP),glaucoma medications,spherical equivalence,mean deviation and pattern standard deviation or square root of lost variance on Octopus visual field.RESULTS:At 1 and 3mo postoperatively,significant improvements were observed in uncorrected distance and intermediate visual acuity.Spectacle independence was enhanced for distance and intermediate vision,especially in bright light settings.Spectacle-free intermediate vision was improved even in dim lighting.Visual disturbances,particularly glare symptoms,were reduced,and there was a notable decrease in IOP and glaucoma medication burden at 3mo.There was more hazy vision postoperatively with no impact on visual acuity and visual satisfaction.CONCLUSION:The non-diffractive EDOF lens improves distance and intermediate spectacle-free visual function in patients with OHT and well-controlled glaucoma.The findings highlight significant improvements in visual acuity,reduced glare,enhanced spectacle independence,and improved visual performance in different lighting conditions.展开更多
Optical-resolution photoacoustic microscopy(OR-PAM)has rapidly developed and is capable of characterizing optical absorption properties of biological tissue with high contrast and high resolution(micrometer-scale late...Optical-resolution photoacoustic microscopy(OR-PAM)has rapidly developed and is capable of characterizing optical absorption properties of biological tissue with high contrast and high resolution(micrometer-scale lateral resolution).However,the conventional excitation source of rapidly diverging Gaussian beam imposes limitations on the depth of focus(DOF)in OR-PAM,which in turn affects the depth-resolving ability and detection sensitivity.Here,we proposed a flexible DOF,depth-invariant resolution photoacoustic microscopy(FDIR-PAM)with nondiffraction of Airy beams.The spatial light modulator was incorporated into the optical pathway of the excitation source with matched switching phase patterns,achieving the flexibly adjustable modulation parameters of the Airy beam.We conducted experiments on phantoms and intravital tissue to validate the effectiveness of the proposed approach for high sensitivity and highresolution characterization of variable topology of tissue,offering a promising DOF of 926μm with an invariant lateral resolution of 3.2μm,which is more than 17-fold larger compared to the Gaussian beam.In addition,FDIR-PAM successfully revealed clear individual zebrafish larvae and the pigment pattern of adult zebrafishes,as well as fine morphology of cerebral vasculature in a large depth range with high resolution,which has reached an evident resolving capability improvement of 62%mean value compared with the Gaussian beam.展开更多
<strong>Purpose:</strong> To clinically evaluate a new extended depth of focus intraocular lens (ISOPURE, PhysIOL) with optic design modification based on a unique polynomial concept to improve intermediat...<strong>Purpose:</strong> To clinically evaluate a new extended depth of focus intraocular lens (ISOPURE, PhysIOL) with optic design modification based on a unique polynomial concept to improve intermediate vision while keeping the quality of distance vision equal to a monofocal lens. <strong>Methods:</strong> 18 patients (11 female, 7 male, mean age of 69.4 years) with bilateral cataract and regular corneal astigmatism ≤ 1.0 D underwent bilateral cataract surgery with ISOPURE implantation. Patients were followed for up to 6 months. Measured parameters were uncorrected (UDVA) and corrected distance visual acuity (CDVA), uncorrected (UIVA) and distance-corrected intermediate visual acuity at 80 cm and 66 cm (DCI80VA, DCI66VA) subjective refraction, defocus curve, tolerance of cylinder induction, and contrast sensitivity. The data from all implanted eyes (all-eyes) and a subset only including the first eye implanted for each patient were analysed. <strong>Results:</strong> The mean manifest refraction spherical equivalent (MRSE) decreased from 1.05 D pre-operatively to ?0.15 D at the 4 - 6 month assessment, with 80.6% of eyes within ±0.50 D of emmetropia. At the final follow-up, mean (SD) monocular CDVA was ?0.06 (0.04) logMAR, DCI80VA was 0.18 (0.08) logMAR and DCI66VA was 0.27 (0.13) logMAR. Despite a cylinder induction of ?0.50 D, uncorrected distance visual acuity of 0.02 logMAR was still achieved. <strong>Conclusion:</strong> The ISOPURE intraocular lens provides excellent distance corrected visual acuity for far and intermediate distances along with high contrast sensitivity and good tolerance of residual refractive cylinder.展开更多
In this paper, we discuss the influence of ratio of minor to major axis on the propagation property and focusing performance of a plasmonic lens with variant periodic concentric elliptical slits illuminating under a G...In this paper, we discuss the influence of ratio of minor to major axis on the propagation property and focusing performance of a plasmonic lens with variant periodic concentric elliptical slits illuminating under a Gaussian beam. In order to analyse the influence theoretically, a finite-difference time-domain （FDTD） numerical algorithm is adopted for the computational numerical calculation and the design of the plasmonic structure. The structure is flanked with penetrated slits through a 200-nm metal film （Au） which is coated on a quartz substrate. Tunability of focusing capability of the plasmonic lenses is studied by tailoring the ratio. Our calculation results demonstrate that the ratio of the elliptical slits greatly affects the focusing capability of the lense. The plasmonic lenses with concentric elliptical slits illuminating under a Gaussian beam have ultra-elongated depth of focus. These results are very encouraging for the future study of the plasmonic lens-based applications.展开更多
Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-wa...Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-way wave equation migration. However, its imaging quality depends on the initial beam parameters, which can make the beam width increase and wave-front spread with the propagation of the central ray, resulting in poor migration accuracy at depth, especially for exploration areas with complex geological structures. To address this problem, we present an adaptive focused beam method for shot-domain prestack depth migration. Using the infor- mation of the input smooth velocity field, we first derive an adaptive focused parameter, which makes a seismic beam focused along the whole central ray to enhance the wave- field construction accuracy in both the shallow and deep regions. Then we introduce this parameter into the GBM, which not only improves imaging quality of deep reflectors but also makes the shallow small-scale geological struc- tures well-defined. As well, using the amplitude-preserved extrapolation operator and deconvolution imaging condi- tion, the concept of amplitude-preserved imaging has been included in our method. Typical numerical examples and the field data processing results demonstrate the validity and adaptability of our method.展开更多
文摘AIM:To assess visual outcomes and satisfaction of a non-diffractive extended depth of focus(EDOF)intraocular lens(IOL)in individuals with ocular hypertension(OHT)and well-controlled mild glaucoma undergoing cataract surgery.METHODS:An investigator-initiated,single-center,prospective,interventional,noncomparative study conducted in Montreal,Canada.The study enrolled 31 patients(55 eyes)with OHT or mild glaucoma who received a non-diffractive EDOF IOL(Acrysof IQ Vivity).Participants underwent sequential cataract surgery with the Vivity IOL.Follow-up evaluations occurred at 1d,1,and 3mo postoperatively,assessing uncorrected distance,intermediate,and near visual acuity.Questionnaires(QUVID:Questionnaire for visual disturbances and IOLSAT:Intraocular lens satisfaction)were administered pre and post-operatively to measure visual disturbances and spectacle independence in various lighting.Safety parameters included intraocular pressure(IOP),glaucoma medications,spherical equivalence,mean deviation and pattern standard deviation or square root of lost variance on Octopus visual field.RESULTS:At 1 and 3mo postoperatively,significant improvements were observed in uncorrected distance and intermediate visual acuity.Spectacle independence was enhanced for distance and intermediate vision,especially in bright light settings.Spectacle-free intermediate vision was improved even in dim lighting.Visual disturbances,particularly glare symptoms,were reduced,and there was a notable decrease in IOP and glaucoma medication burden at 3mo.There was more hazy vision postoperatively with no impact on visual acuity and visual satisfaction.CONCLUSION:The non-diffractive EDOF lens improves distance and intermediate spectacle-free visual function in patients with OHT and well-controlled glaucoma.The findings highlight significant improvements in visual acuity,reduced glare,enhanced spectacle independence,and improved visual performance in different lighting conditions.
基金supported by the National Natural Science Foundation of China(Grant Nos.62105255 and 62275210)the Xidian University Specially Funded Project for Interdisciplinary Exploration(Grant No.TZJH2024043)+1 种基金the Key Research and Development Program of Shaanxi Province(Grant No.2023-YBSF-293)the National Young Talent Program and Shaanxi Young Top-notch Talent Program,and the Fundamental Research Funds for CentralUniversities(Grant No.ZYTS23187).
文摘Optical-resolution photoacoustic microscopy(OR-PAM)has rapidly developed and is capable of characterizing optical absorption properties of biological tissue with high contrast and high resolution(micrometer-scale lateral resolution).However,the conventional excitation source of rapidly diverging Gaussian beam imposes limitations on the depth of focus(DOF)in OR-PAM,which in turn affects the depth-resolving ability and detection sensitivity.Here,we proposed a flexible DOF,depth-invariant resolution photoacoustic microscopy(FDIR-PAM)with nondiffraction of Airy beams.The spatial light modulator was incorporated into the optical pathway of the excitation source with matched switching phase patterns,achieving the flexibly adjustable modulation parameters of the Airy beam.We conducted experiments on phantoms and intravital tissue to validate the effectiveness of the proposed approach for high sensitivity and highresolution characterization of variable topology of tissue,offering a promising DOF of 926μm with an invariant lateral resolution of 3.2μm,which is more than 17-fold larger compared to the Gaussian beam.In addition,FDIR-PAM successfully revealed clear individual zebrafish larvae and the pigment pattern of adult zebrafishes,as well as fine morphology of cerebral vasculature in a large depth range with high resolution,which has reached an evident resolving capability improvement of 62%mean value compared with the Gaussian beam.
文摘<strong>Purpose:</strong> To clinically evaluate a new extended depth of focus intraocular lens (ISOPURE, PhysIOL) with optic design modification based on a unique polynomial concept to improve intermediate vision while keeping the quality of distance vision equal to a monofocal lens. <strong>Methods:</strong> 18 patients (11 female, 7 male, mean age of 69.4 years) with bilateral cataract and regular corneal astigmatism ≤ 1.0 D underwent bilateral cataract surgery with ISOPURE implantation. Patients were followed for up to 6 months. Measured parameters were uncorrected (UDVA) and corrected distance visual acuity (CDVA), uncorrected (UIVA) and distance-corrected intermediate visual acuity at 80 cm and 66 cm (DCI80VA, DCI66VA) subjective refraction, defocus curve, tolerance of cylinder induction, and contrast sensitivity. The data from all implanted eyes (all-eyes) and a subset only including the first eye implanted for each patient were analysed. <strong>Results:</strong> The mean manifest refraction spherical equivalent (MRSE) decreased from 1.05 D pre-operatively to ?0.15 D at the 4 - 6 month assessment, with 80.6% of eyes within ±0.50 D of emmetropia. At the final follow-up, mean (SD) monocular CDVA was ?0.06 (0.04) logMAR, DCI80VA was 0.18 (0.08) logMAR and DCI66VA was 0.27 (0.13) logMAR. Despite a cylinder induction of ?0.50 D, uncorrected distance visual acuity of 0.02 logMAR was still achieved. <strong>Conclusion:</strong> The ISOPURE intraocular lens provides excellent distance corrected visual acuity for far and intermediate distances along with high contrast sensitivity and good tolerance of residual refractive cylinder.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11079014 and 61077010)
文摘In this paper, we discuss the influence of ratio of minor to major axis on the propagation property and focusing performance of a plasmonic lens with variant periodic concentric elliptical slits illuminating under a Gaussian beam. In order to analyse the influence theoretically, a finite-difference time-domain （FDTD） numerical algorithm is adopted for the computational numerical calculation and the design of the plasmonic structure. The structure is flanked with penetrated slits through a 200-nm metal film （Au） which is coated on a quartz substrate. Tunability of focusing capability of the plasmonic lenses is studied by tailoring the ratio. Our calculation results demonstrate that the ratio of the elliptical slits greatly affects the focusing capability of the lense. The plasmonic lenses with concentric elliptical slits illuminating under a Gaussian beam have ultra-elongated depth of focus. These results are very encouraging for the future study of the plasmonic lens-based applications.
文摘Gaussian beam migration （GBM） is an effec- tive and robust depth seismic imaging method, which overcomes the disadvantage of Kirchhoff migration in imaging multiple arrivals and has no steep-dip limitation of one-way wave equation migration. However, its imaging quality depends on the initial beam parameters, which can make the beam width increase and wave-front spread with the propagation of the central ray, resulting in poor migration accuracy at depth, especially for exploration areas with complex geological structures. To address this problem, we present an adaptive focused beam method for shot-domain prestack depth migration. Using the infor- mation of the input smooth velocity field, we first derive an adaptive focused parameter, which makes a seismic beam focused along the whole central ray to enhance the wave- field construction accuracy in both the shallow and deep regions. Then we introduce this parameter into the GBM, which not only improves imaging quality of deep reflectors but also makes the shallow small-scale geological struc- tures well-defined. As well, using the amplitude-preserved extrapolation operator and deconvolution imaging condi- tion, the concept of amplitude-preserved imaging has been included in our method. Typical numerical examples and the field data processing results demonstrate the validity and adaptability of our method.
