A new trinuclear nickel complex,[Ni3（pdc）3（2,2＇-bipy）3（H2O）2]·2H2O（H2pdc = pyridine 2,6-dicarboxylic acid,2,2＇-bipy = 2,2＇-bipyridine） has been hydrothermally synthesized and characterized by IR,elemen...A new trinuclear nickel complex,[Ni3（pdc）3（2,2＇-bipy）3（H2O）2]·2H2O（H2pdc = pyridine 2,6-dicarboxylic acid,2,2＇-bipy = 2,2＇-bipyridine） has been hydrothermally synthesized and characterized by IR,elemental analysis and X-ray diffraction methods.Crystal data for this complex：monoclinic,space group P21/n,a = 21.206（4）,b = 10.002（2）,c = 28.066（6）,β = 108.18（3）°,C51H41N9Ni3O16,Mr = 1212.06,V = 5.656（2） nm3,Dc = 1.423 g·cm-3,μ（MoKα） = 1.062 mm-1,Z = 4,F（000） = 2488,GOOF = 1.034,the final R = 0.0543 and wR = 0.1237 for 6149 observed reflections with Ⅰ 〉 2σ（Ⅰ）.In the complex,three nickel（Ⅱ） ions are bridged by the pyridine 2,6-dicarboxylic acid groups,and all nickel（Ⅱ） ions are seven-coordinated by nitrogen atoms of 2,2＇-bipyridine and pyridine 2,6-dicarboxylic acid and oxygen atoms from pyridine 2,6-dicarboxylic and water to adopt a severely distorted pentagonal bipyramidal geometry.The emission and excitation peaks of the complex in ethanol solutions are located at 336 and 316 nm,respectively.展开更多
Under the joint action of gypsum-salt rocks and faults,fluid evolution process is complicated in the northern Tuzimazha,Kuqa Depression,Tarim Basin.In the past,however,the oil and gas distribution rules in this area w...Under the joint action of gypsum-salt rocks and faults,fluid evolution process is complicated in the northern Tuzimazha,Kuqa Depression,Tarim Basin.In the past,however,the oil and gas distribution rules in this area were less studied,so the related understanding was insufficient.In this paper,the reservoirs in Well Block Tubei 1 were analyzed by means of fluid inclusion and quantitative grain fluorescence(QGF)techniques.Based on tectonic evolution history,burial history,thermal history and hydrocarbon generation history,the paleofluid evolution process in this area was reproduced.It is shown that the well block experienced hydrocarbon charge in two periods.The first period is the earlyemiddle stage(16-9 Ma)of Miocene Kangcun Fm(N_(1-2)k),when it was charged with oil,with the corresponding characteristics of yellow and whiteeyellow fluid inclusion fluorescence and the QGF Index higher than 4,indicating that there were paleo-oil reservoirs at the early stage of the reservoirs.And at the late stage,the fluids that were accumulated at the early stage escaped because the gypsum-salt rocks were cut by faults,and bitumen remained in the reservoirs.It is also the evidence for the escaping of the early charged oil that the total scanning fluorescence(TSF)of the hydrocarbon adsorbed to the surface of the current reservoirs is generally unimodal.The second period is the late stage(about 3 Ma)of Pliocene Kuqa Fm(N_(2)k),when the natural gas and light oil charging occurred.Correspondingly,there are two inclusions,i.e.black gaseous hydrocarbon inclusion and blue fluorescence inclusion located along the edge of the quartz grains.At this stage,the gypsum-salt caprocks deepened and their sealing capacity was recovered due to a strong plastic flow.Moreover,the trap was uplifted violently under the effect of Himalaya orogeny,and a large amount of natural gas and a little light oil were accumulated.展开更多
Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a t...Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a thera no stic nan oparticle (~24 nm size by dynamic light scatteri ng) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-Ⅱ) window and an an ti-ca ncer drug paclitaxel. Folic acid (FA) was conjugated to the nan oparticles to afford specific binding to molecular folate receptors on muri ne breast can cer 4T1 tumor cells. In vivo, the nan oparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0±2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-Ⅱ theranostic age nt developed.展开更多
In order to understand the structure-property correlation and explore the application of metal nanoclusters, it is important and intriguing to determine their crystal structure and obtain high-yield. At the same time,...In order to understand the structure-property correlation and explore the application of metal nanoclusters, it is important and intriguing to determine their crystal structure and obtain high-yield. At the same time, this is also a challenge in nanoscience and technology. Here, we report the highly efficient synthesis of Pt1Ag28 nanocluster via one-pot chemical wet method. The crystal structure of Pt1Ag28 nanocluster was determined by X-ray crystallography to be a face centered cubic (FCC) kernel. This novel structure is the structural isomerization of Pt1Ag28 nanocluster reported before. This phenomenon is first discovered in the synthesis of alloy nanoclusters. In addition, Pt1Ag28 nanocluster has high yield and exhibits potential optics in the near infrared (NIR) fluorescent imaging. The time-dependent density functional theory (TD-DFT) calculation implied that the optical property of Pt1Ag28 was sensitive to its structure. This work provides a simple method to synthesize alloy nanoclusters with structural isomerization.展开更多
基金Supported by the Science and Technology Fund of Hengyang Science and Technology Bureau (No. 2008KS035)the Construct Program of the Key Discipline in Hunan Province
文摘A new trinuclear nickel complex,[Ni3（pdc）3（2,2＇-bipy）3（H2O）2]·2H2O（H2pdc = pyridine 2,6-dicarboxylic acid,2,2＇-bipy = 2,2＇-bipyridine） has been hydrothermally synthesized and characterized by IR,elemental analysis and X-ray diffraction methods.Crystal data for this complex：monoclinic,space group P21/n,a = 21.206（4）,b = 10.002（2）,c = 28.066（6）,β = 108.18（3）°,C51H41N9Ni3O16,Mr = 1212.06,V = 5.656（2） nm3,Dc = 1.423 g·cm-3,μ（MoKα） = 1.062 mm-1,Z = 4,F（000） = 2488,GOOF = 1.034,the final R = 0.0543 and wR = 0.1237 for 6149 observed reflections with Ⅰ 〉 2σ（Ⅰ）.In the complex,three nickel（Ⅱ） ions are bridged by the pyridine 2,6-dicarboxylic acid groups,and all nickel（Ⅱ） ions are seven-coordinated by nitrogen atoms of 2,2＇-bipyridine and pyridine 2,6-dicarboxylic acid and oxygen atoms from pyridine 2,6-dicarboxylic and water to adopt a severely distorted pentagonal bipyramidal geometry.The emission and excitation peaks of the complex in ethanol solutions are located at 336 and 316 nm,respectively.
基金Project supported by National Major Oil and Gas Project(Grant No.2011ZX05003)CNPC Technological Development Project(Grant No.2014B-04)。
文摘Under the joint action of gypsum-salt rocks and faults,fluid evolution process is complicated in the northern Tuzimazha,Kuqa Depression,Tarim Basin.In the past,however,the oil and gas distribution rules in this area were less studied,so the related understanding was insufficient.In this paper,the reservoirs in Well Block Tubei 1 were analyzed by means of fluid inclusion and quantitative grain fluorescence(QGF)techniques.Based on tectonic evolution history,burial history,thermal history and hydrocarbon generation history,the paleofluid evolution process in this area was reproduced.It is shown that the well block experienced hydrocarbon charge in two periods.The first period is the earlyemiddle stage(16-9 Ma)of Miocene Kangcun Fm(N_(1-2)k),when it was charged with oil,with the corresponding characteristics of yellow and whiteeyellow fluid inclusion fluorescence and the QGF Index higher than 4,indicating that there were paleo-oil reservoirs at the early stage of the reservoirs.And at the late stage,the fluids that were accumulated at the early stage escaped because the gypsum-salt rocks were cut by faults,and bitumen remained in the reservoirs.It is also the evidence for the escaping of the early charged oil that the total scanning fluorescence(TSF)of the hydrocarbon adsorbed to the surface of the current reservoirs is generally unimodal.The second period is the late stage(about 3 Ma)of Pliocene Kuqa Fm(N_(2)k),when the natural gas and light oil charging occurred.Correspondingly,there are two inclusions,i.e.black gaseous hydrocarbon inclusion and blue fluorescence inclusion located along the edge of the quartz grains.At this stage,the gypsum-salt caprocks deepened and their sealing capacity was recovered due to a strong plastic flow.Moreover,the trap was uplifted violently under the effect of Himalaya orogeny,and a large amount of natural gas and a little light oil were accumulated.
文摘Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a thera no stic nan oparticle (~24 nm size by dynamic light scatteri ng) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-Ⅱ) window and an an ti-ca ncer drug paclitaxel. Folic acid (FA) was conjugated to the nan oparticles to afford specific binding to molecular folate receptors on muri ne breast can cer 4T1 tumor cells. In vivo, the nan oparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0±2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-Ⅱ theranostic age nt developed.
基金the National Natural Science Foundation of China (No. 21601178)the "Strategic Priority Research Program” of the Chinese Academy of Sciences (No. XDA09030103).
文摘In order to understand the structure-property correlation and explore the application of metal nanoclusters, it is important and intriguing to determine their crystal structure and obtain high-yield. At the same time, this is also a challenge in nanoscience and technology. Here, we report the highly efficient synthesis of Pt1Ag28 nanocluster via one-pot chemical wet method. The crystal structure of Pt1Ag28 nanocluster was determined by X-ray crystallography to be a face centered cubic (FCC) kernel. This novel structure is the structural isomerization of Pt1Ag28 nanocluster reported before. This phenomenon is first discovered in the synthesis of alloy nanoclusters. In addition, Pt1Ag28 nanocluster has high yield and exhibits potential optics in the near infrared (NIR) fluorescent imaging. The time-dependent density functional theory (TD-DFT) calculation implied that the optical property of Pt1Ag28 was sensitive to its structure. This work provides a simple method to synthesize alloy nanoclusters with structural isomerization.
