Age-related Ecto-Nicotinamide Adenine Dinucleotide Oxidase Disulfide Thiol Exchangers 3 (ENOX3) or age-related NADH oxidases (arNOX) are expressed at the cell surface as five members of the TM-9 superfamily, initially...Age-related Ecto-Nicotinamide Adenine Dinucleotide Oxidase Disulfide Thiol Exchangers 3 (ENOX3) or age-related NADH oxidases (arNOX) are expressed at the cell surface as five members of the TM-9 superfamily, initially membrane anchored, all functionally similar, with the N-termini exposed at the cell’s exterior. ECTO-NOXes are cell surface proteins with both time-keeping CoQH2 [NAD(P)H] oxidase and protein disulfidethiol interchange activities. They are designated as ECTO-NOX proteins because of their localization on the outer surface of the plasma membrane and to distinguish them from the phox-NOXes of host defense. A ca. 30 kDa N-terminal fragment is cleaved and accumulates in body fluids (serum, saliva, urine, perspiration). arNOXes appear around age 30 and increase steadily thereafter. Reduced quinones, i.e., reduced coenzyme Q, of the plasma membrane are natural substrates. NAD(P)H is oxidized as an artificial substrate. In one phase of the arNOX cycle electrons are transferred to oxygen to generate superoxide. Substrates for the shed forms of arNOX appear to be proteins of body fluids. Circulating lipoproteins and skin matrix proteins emerge as potentially important health-related targets. Through oxidation of collagen, elastin and other proteins of the skin matrix, arNOXes are major contributors to skin aging through tyrosine and thiol oxidation and subsequent cross linking. The main destructive action of arNOX, however, may be to directly oxidize circulating lipoproteins. arNOX in the blood is structured as an integral component of the LDL particle through site-specific binding. As such, arNOXes are implicated as major risk factors for cardiovascular disease due to specific oxidation of LDLs. The superoxide produced and its conversion to hydrogen peroxide would be one part of the potentially destructive properties by contribution to lipid oxidation. Inhibition of arNOX proteins provides a rational basis for anti-aging interventions and their elimination as a major risk factor of atherogenesis.展开更多
Low-permeability dense reservoirs,including micro-fractured reservoirs,are commonly characterized by high content of clay substances,high original water saturation,high sensitivity to invasive fluids,high capillary pr...Low-permeability dense reservoirs,including micro-fractured reservoirs,are commonly characterized by high content of clay substances,high original water saturation,high sensitivity to invasive fluids,high capillary pressure,complicated structure and anisotropic,high flow-resistance and micro pore throats etc,.Generally they also have lots of natural micro fractures,probably leading to stress sensibility.Main damaging factors in such reservoirs are water-sensibility and water-blocking caused by invasive fluids during drilling and production operations.Once damaged,formation permeability can rarely recovered.Numerous studies have shown that damaging extent of water-blocking ranges from 70% to 90%.Main damaging mechanisms and influencing factors of water-blocking were systematically analyzed.Also some feasible precaution or treating approaches of water-blocking were put forward.In a laboratory setting,a new multi-functional drilling fluid composed mainly of amphion polymer,sulfonation polymer,high effectively preventive water-blocking surfactants,ideal packing temporary bridging agents(TBA) and film-forming agents,etc.,were developed.New low-damage drilling fluids has many advantages,such as good rheological properties,excellent effectiveness of water-blocking prevention,good temporary plugging effect,low filtration and ultra-low permeability(API filtration≤5 mL,HTHP filtration≤10 mL,mud cake frictional coefficient≤0.14,permeability recovery>81%),can efficiently prevent or minimize damage,preserve natural formation and enhance comprehensive development-investment effect in TUHA Jurassic dense sandstone reservoir formation with low-permeability,the only one developing integrated condense gas field.Some references can be provided to similar reservoir formations.展开更多
Healthcare workers (HCWs) who are employed in traditional health care workplaces face a serious danger that may threaten their life;it is their exposure to blood and body fluids (BBF). In Lebanon, the introduction of ...Healthcare workers (HCWs) who are employed in traditional health care workplaces face a serious danger that may threaten their life;it is their exposure to blood and body fluids (BBF). In Lebanon, the introduction of a hospital accreditation system has put a particular emphasis on staff safety, and on the evaluation of professional practice (EPP) programs. Methods: A cross-sectional survey was conducted amongst 277 HCWs working in 4 general hospitals in South Lebanon. Objective: 1) describe the prevalence and the risk factors for occupational exposure to BBF among HCWs;2) evaluate knowledge, attitude, and practices of HCW concerning blood-borne pathogens and adherence to universal safety precautions. Results: The mean age of the respondents was 32.14 years (SD = 10.33), 57.4% were females. 43.3% of HCWs expressed that they use gloves all the time for every activeity of care. 67.1% were aware that needles should not be recapped after use;registered nurses and nursing students were more aware than physicians and nursing assistants (nurse) in this subject. 30% of HCWs declared having had at least one occupational exposure to BBF;62.7% of all accidental exposure was reported to the department responsible for managing exposures. Percutaneous injuries were the most frequently reported. Vaccination coverage was 88.4% for hepatitis B, and 48.4% against influenza. The source patient was tested in 43.4% of reported BBF exposures. Accidental exposure to BBF was more frequent in older people (OR = 3.42;p = 0.03) and the more experienced. Subjects working in intensive care unit ward reported more exposure to BBF (OR = 3;p = 0.04). Participants incurring exposure to BBF resorted to different measures after the injury suggesting a lack of a uniform policy for post-exposure prophylaxis. Conclusion: Exposure to BBF represents an important and frequently preventable occupational hazard for HCWs in Lebanon that requires continuous EPP of HCWs, and a comprehensive approach for prevention and management.展开更多
In this paper, we investigate a(3+1)-dimensional generalized variable-coefficient Kadomtsev–Petviashvili equation, which can describe the nonlinear phenomena in fluids or plasmas. Painlev′e analysis is performed for...In this paper, we investigate a(3+1)-dimensional generalized variable-coefficient Kadomtsev–Petviashvili equation, which can describe the nonlinear phenomena in fluids or plasmas. Painlev′e analysis is performed for us to study the integrability, and we find that the equation is not completely integrable. By virtue of the binary Bell polynomials,bilinear form and soliton solutions are obtained, and B¨acklund transformation in the binary-Bell-polynomial form and bilinear form are derived. Soliton collisions are graphically discussed: the solitons keep their original shapes unchanged after the collision except for the phase shifts. Variable coefficients are seen to affect the motion of solitons: when the variable coefficients are chosen as the constants, solitons keep their directions unchanged during the collision; with the variable coefficients as the functions of the temporal coordinate, the one soliton changes its direction.展开更多
Tractor hydraulic fluids are tested to maximize their performance levels and to ensure manufacturer′s standards are met.Common tractor hydraulic fluid tests include: Gear Wear Protection,Brake Chatter Reduction,Wet-C...Tractor hydraulic fluids are tested to maximize their performance levels and to ensure manufacturer′s standards are met.Common tractor hydraulic fluid tests include: Gear Wear Protection,Brake Chatter Reduction,Wet-Clutch Capacity,and Pump Performance tests.These tests are run by Southwest Research Institute,in the U.S.A.,for tractors built by John Deere and Case-New Holland.This paper details current methods for evaluating tractor hydraulic fluids.The tests that are described utilize full size equipment and were developed by the tractor′s original equipment manufacturers(OEMs).展开更多
The well preserved eclogitic rocks of the Tso Morari dome in eastern Ladakh, northwest Himalaya, provide information relevant to the exhumation of high pressure/low temperature rocks, and the early stage of the Himala...The well preserved eclogitic rocks of the Tso Morari dome in eastern Ladakh, northwest Himalaya, provide information relevant to the exhumation of high pressure/low temperature rocks, and the early stage of the Himalayan orogeny. The Tso Morari unit outcrops south of the Indus suture zone (Fig.1). The eclogitic dome is underlined on its eastern part by the Zildat normal fault where serpentinite lenses and partially hydrated peridotites are abundant. The close association of the high pressure rocks and serpentinites suggests a possible role of serpentinites in the exhumation of ultrahigh\|pressure rocks. To evaluate this possibility, geochemical analyses were carried out on the serpentinites closely associated with the Tso Morari eclogites.展开更多
The metallogenic environment of the Irtysh gold belt in Xinjiang is studied in detail.The metallogenic geological background,metallogenic conditions and ore-controlling factors of the gold deposits in eastern,central ...The metallogenic environment of the Irtysh gold belt in Xinjiang is studied in detail.The metallogenic geological background,metallogenic conditions and ore-controlling factors of the gold deposits in eastern,central and western regions of the metallogenic belt are compared.The metallogenic structure of the Irtysh tectonic belt has the characteristics of diverging to the west and converging to the east.Composite ore controlling by ductile shearing and magmatic activity in Irtysh gold belt result in zoned and segmented distribution of gold mineralization.Through the fluid inclusion research and H-O-S isotope analysis,the evolution regularity of gold ore-forming fluids in the region was analyzed.Synchrotron radiation X-ray fluorescence was used to analysis the concentration of metal elements in a single fluid inclusion,explaining the occurrence and migration process of Au in hydrothermal fluid.The source of ore forming minerals in western gold deposit is more closely related to magmatic activity,and the structural metamorphism of eastern gold deposit has greater influence on mineralization.Metallogenic fluids of gold deposits are characterized by metamorphic water(and magmatic water)in the early stage and mixed with meteoric water in the late stage.And the metallogenic elements are enriched in CO2 rich fluid.The Au is mainly activated,migrated and enriched with the mixed fluid of magmatic hydrothermal,metamorphic hydrothermal and atmospheric precipitation in the medium-low temperature,shallow to medium-deep environment.展开更多
AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers.METHODS:DNA was extracted from undiluted pancreatic and bi...AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers.METHODS:DNA was extracted from undiluted pancreatic and biliary fluids.As a surrogate for a genomewide hypomethylation assay,levels of long interspersed nuclear element-1(LINE-1) methylation were analyzed using bisulfite pyrosequencing.CpG island hypermethylation of 10 tumor-associated genes,aryl-hydrocarbon receptor repressor,adenomatous polyposis coli,calcium channel,voltage dependent,T type α1G subunit,insulin-like growth factor 2,O-6-methyl-guanine-DNA methyltransferase,neurogenin 1,CDKN2A,runt-related transcription factor 3(RUNX3),secreted frizzled-related protein 1,and ubiquitin carboxyl-terminal esterase L1(UCHL1),was analyzed using MethyLight.To examine the role of CpG methylation and histone deacetylation in the silencing of UCHL1,human gallbladder carcinoma cell lines and pancreatic carcinoma cell lines were treated with 2 or 5 μmol/L 5-AZA-dC for 72 h or 100 nmol/L Trichostatin A for 24 h.After the treatment,UCHL1 expression was analyzed by real-time reverse transcription-polymerase chain reaction.RESULTS:Pancreatobiliary cancers exhibited significantly lower LINE-1 methylation levels in pancreatic and biliary fluids than did noncancerous pancreatobiliary disease(58.7% ± 4.3% vs 61.7% ± 2.2%,P = 0.027;53.8% ± 6.6% vs 57.5% ± 1.7%,P = 0.007);however,LINE-1 hypomethylation was more evident in pancreatic cancer tissues than in pancreatic fluids(45.4% ± 5.5% vs 58.7% ± 4.3%,P < 0.001).CpG island hypermethylation of tumor-associated genes was detected at various frequencies,but it was not correlated with LINE-1 hypomethylation.Hypermethylation of the UCHL1 gene was cancer-specific and most frequently detected in pancreatic(67%) or biliary(70%) fluids from patients with pancreatobiliary cancer.As a single marker,hypermethylation of the UCHL1 gene in pancreatic and biliary fluids was most useful for the detection of pancreatic and pancreatobiliary cancers,respectively(100% specificity).Hypermethylation of the UCHL1 and RUNX3 genes in pancreatic and biliary fluids was the most useful combined marker for pancreatic(87% sensitivity and 100% specificity) and pancreatobiliary(97% sensitivity and 100% specificity) cancers.Treatment with a demethylating agent,5-AZA-2'-deoxycytidine,restored UCHL1 expression in pancreatobiliary cancer cell lines.CONCLUSION:Our results suggest that hypermethylation of UCHL1 and RUNX3 in pancreatobiliary fluid might be useful for the diagnosis of pancreatobiliary cancers.展开更多
These experimental investigations are designed to study shock wave characteristics and spray structure. Supersonic liq- uid jets injected into ambient fields are empirically studied using projectile impacts in a two-s...These experimental investigations are designed to study shock wave characteristics and spray structure. Supersonic liq- uid jets injected into ambient fields are empirically studied using projectile impacts in a two-stage light gas gun. This study looks primarily at the design of the nozzle assembly, the tip velocity of the high speed jet, the structure of the spray jet and the shock wave generation process. The supersonic liquid jets were visualized using an ultra high-speed camera and the schlieren system for visualization to quantitatively analyze the shock wave angle. The experimental re- sults with straight cone nozzle types and various non-Newtonian fluid viscosities are presented in this paper. The effects of nozzle geometry on the jet behavior are described. The characteristics of the shock wave generation and spray jet structure were found to be significantly related to the nozzle geometry. The expansion gases accelerated the projectile, which had a mass of 6 grams, from 250 m/s. As a result, it was found that the maximum jet velocity appeared in the liquid jet with high viscosity properties. Supersonic liquid jets, which occurred at the leading edge the shock waves and the compression waves in front of the jets, were observed. Also, the shock waves significantly affected the atomization process for each spray droplet.展开更多
The present pagination reports both Brownian diffusion and thermophoresis aspects subject to magneto hydrodynamic Williamson fluid model.Assuming the flow is unsteady and blood is treated as Williamson fluid over a we...The present pagination reports both Brownian diffusion and thermophoresis aspects subject to magneto hydrodynamic Williamson fluid model.Assuming the flow is unsteady and blood is treated as Williamson fluid over a wedge with radiation.The governing equations are transformed into ordinary differential equations by using similarity variables.The analytical solutions of the transformed governing equations are obtained by using the RK 4th order method along with shooting technique solver.The effects of various physical parameters such as Hartmann number,local Weissenberg number,radiation parameter,unsteadiness parameter,Prandtl number,Lewis number,Brownian diffusion,thermophoresis,wedge angle parameter,moving wedge parameter,on velocity,temperature,concentration,skin friction,heat transfer rate and mass transfer rate have been discussed in detail.The velocity and temperature profile deprives for larger We and an opposite trend is observed for concentration.The radiation parameter is propositional to temperature and a counter behaviour is observed for Pr.展开更多
The flow behavior of gravity-driven falling film of non-conductive high viscosity polymer fluids on an industrial-scale vertical wavy wall was investigated in terms of film thickness and residence time distribution by...The flow behavior of gravity-driven falling film of non-conductive high viscosity polymer fluids on an industrial-scale vertical wavy wall was investigated in terms of film thickness and residence time distribution by numerical simulation and experiment.Falling film flow of high viscosity fluids was found to be steady on a vertical wavy wall in the presence of the large film thickness.The comparison between numerical simulation and experiment for the film thickness both in crest and trough of wavy wall showed good agreement.The simulation results of average residence time of falling film flow with different viscous fluids were also consistent with the experimental results.This work provides the initial insights of how to evaluate and optimize the falling film flow system of polymer fluid.展开更多
Modern processing technology is calling the scientific understanding of dynamic processes,where the science of complex fluids plays a central role.We summarize our recent efforts using the generic approaches of multi-...Modern processing technology is calling the scientific understanding of dynamic processes,where the science of complex fluids plays a central role.We summarize our recent efforts using the generic approaches of multi-scale physics of complex fluids on apparently irrelevant processes,i.e.the mixing of polymer blends,the processing of thermoplastic(TP) toughened thermosetting(TS) composites using phase separation of TP in TS,as well as the enhanced oil recovery using polymer soft gel.It is emphasized that the thorough physical understanding in multi-scales of time and space through the joint efforts of experiment and theory in each scale is the key issue for the modeling of various processes.展开更多
The reservoir landslide is typically characterized by high-speed movement of a particle-fluid mixture,and its flow and deposit mechanisms are complex.This paper presents the mechanism of submerged granular column coll...The reservoir landslide is typically characterized by high-speed movement of a particle-fluid mixture,and its flow and deposit mechanisms are complex.This paper presents the mechanism of submerged granular column collapse under different densities ambient fluids based on coupled computational fluid dynamics and discrete element method(CFD-DEM)analysis.Important fluid-particle interaction forces,such as the drag force and the buoyancy,are considered by exchanging interaction forces between the CFD and DEM computations.We focus on the flow and deposit characteristics of submerged granular column collapse,namely the runout distance,the tail end height,the particle velocity,the energy,and deposit morphology,which are analyzed qualitatively and quantitatively.The change in fluid field caused by submerged granular column collapse and the formation of eddies are also discussed.A relatively dense fluid can significantly hinder the motion of granular flow,but can improve the conversion efficiency of kinetic energy from the vertical to the horizontal direction.Moreover,the eddies caused by fluid turbulence erode the surface of the granular pile,which is especially marked in a high-density fluid.The findings can provide vital theoretical support for the flow and deposit characteristics of granular flow under fluid and offer insights for the study of reservoir landslides.展开更多
Conversion and capture of carbon pollutants based on carbon dioxide to valuable green oil-field chemicals are target all over the world for controlling the global warming.The present article used new room temperature ...Conversion and capture of carbon pollutants based on carbon dioxide to valuable green oil-field chemicals are target all over the world for controlling the global warming.The present article used new room temperature amphiphilic imidazolium ionic liquids with superior surface activity in the aqueous solutions to convert carbon dioxide gas to superior amphiphilic calcium carbonate nanoparticles.In this respect,tetra-cationic ionic liquids 2-(4-dodecyldimethylamino)phenyl)-1,3-bis(3-dodecyldimethylammnonio)propyl)bromide-1-H-imidazol-3-ium acetate and 2-(4-hexyldimethylamino)phenyl)-1,3-bis(3-hexcyldimethylammnonio)propyl)bromide-1 H-imidazol-3-ium acetate were prepared.Their chemical structures,thermal as well as their carbon dioxide absorption/desorption characteristicswere evaluated.Theywere used as solvent and capping agent to synthesize calcium carbonate nanoparticles with controlled crystalline lattice,sizes,thermal properties and spherical surface morphologies.The prepared calcium carbonate nanoparticles were used as additives for the commercial water based drilling mud to improve their filter lose and rheology.The data confirm that the lower concentrations of 2-(4-dodecyldimethylamino)phenyl)-1,3-bis(3-dodecyldimethylammnonio)propyl)bromide-1-H-imidazol-3-ium acetate achieved lower seawater filter lose and improved viscosities.展开更多
The purpose of this study is to explore the effects of working fluid on conventional combined cycle integrated with pressurized solid oxide fuel cell (SOFC) and waste heat recovery organic Rankine cycle (ORC) for stat...The purpose of this study is to explore the effects of working fluid on conventional combined cycle integrated with pressurized solid oxide fuel cell (SOFC) and waste heat recovery organic Rankine cycle (ORC) for stationary utility power generation. The mathematical model of a natural gas fueled design configuration is developed in Matlab and Simulink and simulated with 14 working fluids. The effluent gases of SOFC undergo combustion in the combustion chamber and it is utilized in the gas turbine, steam turbine cycle and ORC. The model is compared with those found in literature and the parametric studies of temperature, flow rate, fuel utilization factor and exhaust gas on the system efficiency are examined. Results revealed that working fluids show a closely related behavior in efficiency at low pressure ratio and high flow fraction, fuel utilization, and temperature. R-123 was found to perform the best among 14 working fluids studied, yielding a system energy efficiency of 70% in the combined cycle integrated with SOFC and ORC.展开更多
0 INTRODUCTION Sulfur(S)and carbon(C)are essential volatile elements in both interior and surficial systems of the Earth.The cycling of S and C in subduction zones plays a fundamental role in modulating global S-C flu...0 INTRODUCTION Sulfur(S)and carbon(C)are essential volatile elements in both interior and surficial systems of the Earth.The cycling of S and C in subduction zones plays a fundamental role in modulating global S-C fluxes and exerts a significant influence on the climate evolution,mantle's redox budget,and ore deposit formation(Bekaert et al.,2021).展开更多
We present a theoretical analysis for fully developed convective beat transfer in a circular tube for power law fluids by assuming that the thermal diffusivity is a function of temperature gradient. The analytical eol...We present a theoretical analysis for fully developed convective beat transfer in a circular tube for power law fluids by assuming that the thermal diffusivity is a function of temperature gradient. The analytical eolution is obtained and the heat transfer behaviour is investigated under a constant heat flux boundary condition. It is shown that the Nusselt number strongly depends on the value of power law index n. The Nusselt number sharply decreases in the range of 0 〈 n 〈 0.1. However, for n 〉 0.5, the Nusselt number decreases monotonically with the increasing n, and for n 〉 20, the values of Nusselt number approach a constant.展开更多
The hear transfer mechanism and the constitutive models for energy boundary layer in power law fluids were investigated.Two energy transfer constitutive equations models were proposed based on the assumption of simila...The hear transfer mechanism and the constitutive models for energy boundary layer in power law fluids were investigated.Two energy transfer constitutive equations models were proposed based on the assumption of similarity of velocity field momentum diffusion and temperature field heat transfer.The governing systems of partial different equations were transformed into ordinary differential equations respectively by using the similarity transformation group.One model was assumed that Prandtl number is a constant,and the other model was assumed that viscosity diffusion is analogous to thermal diffusion.The solutions were presented analytically and numerically by using the Runge-Kutta formulas and shooting technique and the associated transfer characteristics were discussed.展开更多
The Sichuan-Yunnan-Guizhou(SYG)metallogenic province of southwest China is one of the most important Zn-Pb ore zones in China,with^200 Mt ZnPb ores at mean grades of 10 wt.%Zn and 5 wt.%Pb.The source and mechanism of ...The Sichuan-Yunnan-Guizhou(SYG)metallogenic province of southwest China is one of the most important Zn-Pb ore zones in China,with^200 Mt ZnPb ores at mean grades of 10 wt.%Zn and 5 wt.%Pb.The source and mechanism of the regional Zn-Pb mineralization remain controversial despite many investigations that have been conducted.The Wusihe Zn-Pb deposit is a representative large-scale Zn-Pb deposit in the northern SYG,which mainly occurs in the Dengying Formation and yields Zn-Pb resources of^3.7 Mt.In this paper,Zn and S isotopes,and Fe and Cd contents of sphalerite from the Wusihe deposit were investigated in an attempt to constrain the controls on Zn and S isotopic variations,the potential sources of ore-forming components,and the possible mineralization mechanisms.Both theδ66Zn andδ34S values in sphalerite from the Wusihe deposit increase systematically from the bottom to the top of the strata-bound orebodies.Such spatial evolution inδ66Zn andδ34S values of sphalerite can be attributed to isotopic Rayleigh fractionation during sphalerite precipitation with temperature variations.The strong correlations between the Zn-S isotopic compositions and Fe-Cd concentrations in sphalerite suggest that their variations were dominated by a similar mechanism.However,the Rayleigh fractionation mechanism cannot explain the spatial variations of Fe and Cd concentrations of sphalerite in this deposit.It is noted that the bottom and top sphalerites from the strata-bound orebodies document contrasting Zn and S isotopic compositions which correspond to the Zn and S isotopic characteristics of basement rocks and host rocks,respectively.Therefore,the mixing of two-source fluids with distinct Zn-S isotopic signatures was responsible for the spatial variations of Zn-S isotopic compositions of sphalerite from the Wusihe deposit.The fluids from basement rocks are characterized by relatively lighter Zn(~0.2‰)and S(~5‰)isotopic compositions while the fluids from host rocks are marked by relatively heavier Zn(~0.6‰)and S(~15‰)isotopic compositions.展开更多
On the basis of the free volume theory and activation energy concept,a fundamental equation whichtakes into account the effects of temperature and pressure has been developed.By introducing differentexpressions for th...On the basis of the free volume theory and activation energy concept,a fundamental equation whichtakes into account the effects of temperature and pressure has been developed.By introducing differentexpressions for the free volume and activation energy,several equations for fluid diffusion coefficients were derivedaccordingly.With the van der Waals free volume and intermal energy formula,a three-parameter model for fluiddiffusion coeffficients at moderate pressure was obtained.The grand average absolute deviation percent of 345data points (44 systems)for self-and infinite dilute inter-diffusivities is 2.32,against the results of the model ofCohen and Turnbull,4.13.In particular,by means of the modified Carnahan-Starling free volume equation,afour-parameter model with average abosolute deviation percent 2.64(30 systems,644 data points)for theestimation of dense fluid inter-and self-diffusivities at high pressures and in supercritical conditions was derived.The derived model is superior to the method of展开更多
文摘Age-related Ecto-Nicotinamide Adenine Dinucleotide Oxidase Disulfide Thiol Exchangers 3 (ENOX3) or age-related NADH oxidases (arNOX) are expressed at the cell surface as five members of the TM-9 superfamily, initially membrane anchored, all functionally similar, with the N-termini exposed at the cell’s exterior. ECTO-NOXes are cell surface proteins with both time-keeping CoQH2 [NAD(P)H] oxidase and protein disulfidethiol interchange activities. They are designated as ECTO-NOX proteins because of their localization on the outer surface of the plasma membrane and to distinguish them from the phox-NOXes of host defense. A ca. 30 kDa N-terminal fragment is cleaved and accumulates in body fluids (serum, saliva, urine, perspiration). arNOXes appear around age 30 and increase steadily thereafter. Reduced quinones, i.e., reduced coenzyme Q, of the plasma membrane are natural substrates. NAD(P)H is oxidized as an artificial substrate. In one phase of the arNOX cycle electrons are transferred to oxygen to generate superoxide. Substrates for the shed forms of arNOX appear to be proteins of body fluids. Circulating lipoproteins and skin matrix proteins emerge as potentially important health-related targets. Through oxidation of collagen, elastin and other proteins of the skin matrix, arNOXes are major contributors to skin aging through tyrosine and thiol oxidation and subsequent cross linking. The main destructive action of arNOX, however, may be to directly oxidize circulating lipoproteins. arNOX in the blood is structured as an integral component of the LDL particle through site-specific binding. As such, arNOXes are implicated as major risk factors for cardiovascular disease due to specific oxidation of LDLs. The superoxide produced and its conversion to hydrogen peroxide would be one part of the potentially destructive properties by contribution to lipid oxidation. Inhibition of arNOX proteins provides a rational basis for anti-aging interventions and their elimination as a major risk factor of atherogenesis.
基金Project(50574061) supported by the National Natural Science Foundation of China
文摘Low-permeability dense reservoirs,including micro-fractured reservoirs,are commonly characterized by high content of clay substances,high original water saturation,high sensitivity to invasive fluids,high capillary pressure,complicated structure and anisotropic,high flow-resistance and micro pore throats etc,.Generally they also have lots of natural micro fractures,probably leading to stress sensibility.Main damaging factors in such reservoirs are water-sensibility and water-blocking caused by invasive fluids during drilling and production operations.Once damaged,formation permeability can rarely recovered.Numerous studies have shown that damaging extent of water-blocking ranges from 70% to 90%.Main damaging mechanisms and influencing factors of water-blocking were systematically analyzed.Also some feasible precaution or treating approaches of water-blocking were put forward.In a laboratory setting,a new multi-functional drilling fluid composed mainly of amphion polymer,sulfonation polymer,high effectively preventive water-blocking surfactants,ideal packing temporary bridging agents(TBA) and film-forming agents,etc.,were developed.New low-damage drilling fluids has many advantages,such as good rheological properties,excellent effectiveness of water-blocking prevention,good temporary plugging effect,low filtration and ultra-low permeability(API filtration≤5 mL,HTHP filtration≤10 mL,mud cake frictional coefficient≤0.14,permeability recovery>81%),can efficiently prevent or minimize damage,preserve natural formation and enhance comprehensive development-investment effect in TUHA Jurassic dense sandstone reservoir formation with low-permeability,the only one developing integrated condense gas field.Some references can be provided to similar reservoir formations.
文摘Healthcare workers (HCWs) who are employed in traditional health care workplaces face a serious danger that may threaten their life;it is their exposure to blood and body fluids (BBF). In Lebanon, the introduction of a hospital accreditation system has put a particular emphasis on staff safety, and on the evaluation of professional practice (EPP) programs. Methods: A cross-sectional survey was conducted amongst 277 HCWs working in 4 general hospitals in South Lebanon. Objective: 1) describe the prevalence and the risk factors for occupational exposure to BBF among HCWs;2) evaluate knowledge, attitude, and practices of HCW concerning blood-borne pathogens and adherence to universal safety precautions. Results: The mean age of the respondents was 32.14 years (SD = 10.33), 57.4% were females. 43.3% of HCWs expressed that they use gloves all the time for every activeity of care. 67.1% were aware that needles should not be recapped after use;registered nurses and nursing students were more aware than physicians and nursing assistants (nurse) in this subject. 30% of HCWs declared having had at least one occupational exposure to BBF;62.7% of all accidental exposure was reported to the department responsible for managing exposures. Percutaneous injuries were the most frequently reported. Vaccination coverage was 88.4% for hepatitis B, and 48.4% against influenza. The source patient was tested in 43.4% of reported BBF exposures. Accidental exposure to BBF was more frequent in older people (OR = 3.42;p = 0.03) and the more experienced. Subjects working in intensive care unit ward reported more exposure to BBF (OR = 3;p = 0.04). Participants incurring exposure to BBF resorted to different measures after the injury suggesting a lack of a uniform policy for post-exposure prophylaxis. Conclusion: Exposure to BBF represents an important and frequently preventable occupational hazard for HCWs in Lebanon that requires continuous EPP of HCWs, and a comprehensive approach for prevention and management.
基金Supported by the National Natural Science Foundation of China under Grant No.11272023the Open Fund of State Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications)under GrantNo.IPOC2013B008the Fundamental Research Funds for the Central Universities of China under Grant No.2011BUPTYB02
文摘In this paper, we investigate a(3+1)-dimensional generalized variable-coefficient Kadomtsev–Petviashvili equation, which can describe the nonlinear phenomena in fluids or plasmas. Painlev′e analysis is performed for us to study the integrability, and we find that the equation is not completely integrable. By virtue of the binary Bell polynomials,bilinear form and soliton solutions are obtained, and B¨acklund transformation in the binary-Bell-polynomial form and bilinear form are derived. Soliton collisions are graphically discussed: the solitons keep their original shapes unchanged after the collision except for the phase shifts. Variable coefficients are seen to affect the motion of solitons: when the variable coefficients are chosen as the constants, solitons keep their directions unchanged during the collision; with the variable coefficients as the functions of the temporal coordinate, the one soliton changes its direction.
文摘Tractor hydraulic fluids are tested to maximize their performance levels and to ensure manufacturer′s standards are met.Common tractor hydraulic fluid tests include: Gear Wear Protection,Brake Chatter Reduction,Wet-Clutch Capacity,and Pump Performance tests.These tests are run by Southwest Research Institute,in the U.S.A.,for tractors built by John Deere and Case-New Holland.This paper details current methods for evaluating tractor hydraulic fluids.The tests that are described utilize full size equipment and were developed by the tractor′s original equipment manufacturers(OEMs).
文摘The well preserved eclogitic rocks of the Tso Morari dome in eastern Ladakh, northwest Himalaya, provide information relevant to the exhumation of high pressure/low temperature rocks, and the early stage of the Himalayan orogeny. The Tso Morari unit outcrops south of the Indus suture zone (Fig.1). The eclogitic dome is underlined on its eastern part by the Zildat normal fault where serpentinite lenses and partially hydrated peridotites are abundant. The close association of the high pressure rocks and serpentinites suggests a possible role of serpentinites in the exhumation of ultrahigh\|pressure rocks. To evaluate this possibility, geochemical analyses were carried out on the serpentinites closely associated with the Tso Morari eclogites.
基金This work was financially supported by the National Natural Science Foundation of China(Nos.41372096,41672070)Field work has been supported by colleagues from University of Science and Technology,Beijing,China Non-Ferrous Metals Resources Geological Survey and the relevant geological departments in Xinjiang+2 种基金Teacher Mu Liu from Analytical Testing Research in Center Beijing Research Institute of Uranium Geology(BRIUG)provided assistance for H-O-S isotope testingProfessor Guang Fan and Teacher Xiangkun Ge provided guidance and assistance for the electron probe experimentSynchrotron radiation X-ray fluorescence analysis was supported and helped by Professor Aiguo Li,Lili Zhang and Shuai Yan,Shanghai Institute of Applied Physics,Chinese Academy of Sciences.
文摘The metallogenic environment of the Irtysh gold belt in Xinjiang is studied in detail.The metallogenic geological background,metallogenic conditions and ore-controlling factors of the gold deposits in eastern,central and western regions of the metallogenic belt are compared.The metallogenic structure of the Irtysh tectonic belt has the characteristics of diverging to the west and converging to the east.Composite ore controlling by ductile shearing and magmatic activity in Irtysh gold belt result in zoned and segmented distribution of gold mineralization.Through the fluid inclusion research and H-O-S isotope analysis,the evolution regularity of gold ore-forming fluids in the region was analyzed.Synchrotron radiation X-ray fluorescence was used to analysis the concentration of metal elements in a single fluid inclusion,explaining the occurrence and migration process of Au in hydrothermal fluid.The source of ore forming minerals in western gold deposit is more closely related to magmatic activity,and the structural metamorphism of eastern gold deposit has greater influence on mineralization.Metallogenic fluids of gold deposits are characterized by metamorphic water(and magmatic water)in the early stage and mixed with meteoric water in the late stage.And the metallogenic elements are enriched in CO2 rich fluid.The Au is mainly activated,migrated and enriched with the mixed fluid of magmatic hydrothermal,metamorphic hydrothermal and atmospheric precipitation in the medium-low temperature,shallow to medium-deep environment.
基金Supported by Grants-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology of Japan (to Yamamoto H and Shinomura Y)
文摘AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary cancers.METHODS:DNA was extracted from undiluted pancreatic and biliary fluids.As a surrogate for a genomewide hypomethylation assay,levels of long interspersed nuclear element-1(LINE-1) methylation were analyzed using bisulfite pyrosequencing.CpG island hypermethylation of 10 tumor-associated genes,aryl-hydrocarbon receptor repressor,adenomatous polyposis coli,calcium channel,voltage dependent,T type α1G subunit,insulin-like growth factor 2,O-6-methyl-guanine-DNA methyltransferase,neurogenin 1,CDKN2A,runt-related transcription factor 3(RUNX3),secreted frizzled-related protein 1,and ubiquitin carboxyl-terminal esterase L1(UCHL1),was analyzed using MethyLight.To examine the role of CpG methylation and histone deacetylation in the silencing of UCHL1,human gallbladder carcinoma cell lines and pancreatic carcinoma cell lines were treated with 2 or 5 μmol/L 5-AZA-dC for 72 h or 100 nmol/L Trichostatin A for 24 h.After the treatment,UCHL1 expression was analyzed by real-time reverse transcription-polymerase chain reaction.RESULTS:Pancreatobiliary cancers exhibited significantly lower LINE-1 methylation levels in pancreatic and biliary fluids than did noncancerous pancreatobiliary disease(58.7% ± 4.3% vs 61.7% ± 2.2%,P = 0.027;53.8% ± 6.6% vs 57.5% ± 1.7%,P = 0.007);however,LINE-1 hypomethylation was more evident in pancreatic cancer tissues than in pancreatic fluids(45.4% ± 5.5% vs 58.7% ± 4.3%,P < 0.001).CpG island hypermethylation of tumor-associated genes was detected at various frequencies,but it was not correlated with LINE-1 hypomethylation.Hypermethylation of the UCHL1 gene was cancer-specific and most frequently detected in pancreatic(67%) or biliary(70%) fluids from patients with pancreatobiliary cancer.As a single marker,hypermethylation of the UCHL1 gene in pancreatic and biliary fluids was most useful for the detection of pancreatic and pancreatobiliary cancers,respectively(100% specificity).Hypermethylation of the UCHL1 and RUNX3 genes in pancreatic and biliary fluids was the most useful combined marker for pancreatic(87% sensitivity and 100% specificity) and pancreatobiliary(97% sensitivity and 100% specificity) cancers.Treatment with a demethylating agent,5-AZA-2'-deoxycytidine,restored UCHL1 expression in pancreatobiliary cancer cell lines.CONCLUSION:Our results suggest that hypermethylation of UCHL1 and RUNX3 in pancreatobiliary fluid might be useful for the diagnosis of pancreatobiliary cancers.
文摘These experimental investigations are designed to study shock wave characteristics and spray structure. Supersonic liq- uid jets injected into ambient fields are empirically studied using projectile impacts in a two-stage light gas gun. This study looks primarily at the design of the nozzle assembly, the tip velocity of the high speed jet, the structure of the spray jet and the shock wave generation process. The supersonic liquid jets were visualized using an ultra high-speed camera and the schlieren system for visualization to quantitatively analyze the shock wave angle. The experimental re- sults with straight cone nozzle types and various non-Newtonian fluid viscosities are presented in this paper. The effects of nozzle geometry on the jet behavior are described. The characteristics of the shock wave generation and spray jet structure were found to be significantly related to the nozzle geometry. The expansion gases accelerated the projectile, which had a mass of 6 grams, from 250 m/s. As a result, it was found that the maximum jet velocity appeared in the liquid jet with high viscosity properties. Supersonic liquid jets, which occurred at the leading edge the shock waves and the compression waves in front of the jets, were observed. Also, the shock waves significantly affected the atomization process for each spray droplet.
文摘The present pagination reports both Brownian diffusion and thermophoresis aspects subject to magneto hydrodynamic Williamson fluid model.Assuming the flow is unsteady and blood is treated as Williamson fluid over a wedge with radiation.The governing equations are transformed into ordinary differential equations by using similarity variables.The analytical solutions of the transformed governing equations are obtained by using the RK 4th order method along with shooting technique solver.The effects of various physical parameters such as Hartmann number,local Weissenberg number,radiation parameter,unsteadiness parameter,Prandtl number,Lewis number,Brownian diffusion,thermophoresis,wedge angle parameter,moving wedge parameter,on velocity,temperature,concentration,skin friction,heat transfer rate and mass transfer rate have been discussed in detail.The velocity and temperature profile deprives for larger We and an opposite trend is observed for concentration.The radiation parameter is propositional to temperature and a counter behaviour is observed for Pr.
基金Supported by the National Key Research and Development Program of China(2016YFB0303000)the National Natural Science Foundation of China(51803187)Zhejiang Provincial Natural Science Foundation of China(LQ18E030011)
文摘The flow behavior of gravity-driven falling film of non-conductive high viscosity polymer fluids on an industrial-scale vertical wavy wall was investigated in terms of film thickness and residence time distribution by numerical simulation and experiment.Falling film flow of high viscosity fluids was found to be steady on a vertical wavy wall in the presence of the large film thickness.The comparison between numerical simulation and experiment for the film thickness both in crest and trough of wavy wall showed good agreement.The simulation results of average residence time of falling film flow with different viscous fluids were also consistent with the experimental results.This work provides the initial insights of how to evaluate and optimize the falling film flow system of polymer fluid.
基金Project(20490224) supported by the National Natural Science Foundation of ChinaProject(2003CB615604) supported by the Major State Basic Research and Development Program of ChinaProject supported by Shengli oil field,SINOPEC Petrochemical Co. Ltd.
文摘Modern processing technology is calling the scientific understanding of dynamic processes,where the science of complex fluids plays a central role.We summarize our recent efforts using the generic approaches of multi-scale physics of complex fluids on apparently irrelevant processes,i.e.the mixing of polymer blends,the processing of thermoplastic(TP) toughened thermosetting(TS) composites using phase separation of TP in TS,as well as the enhanced oil recovery using polymer soft gel.It is emphasized that the thorough physical understanding in multi-scales of time and space through the joint efforts of experiment and theory in each scale is the key issue for the modeling of various processes.
基金supported by the National Natural Science Foundation of China(No.51825905).
文摘The reservoir landslide is typically characterized by high-speed movement of a particle-fluid mixture,and its flow and deposit mechanisms are complex.This paper presents the mechanism of submerged granular column collapse under different densities ambient fluids based on coupled computational fluid dynamics and discrete element method(CFD-DEM)analysis.Important fluid-particle interaction forces,such as the drag force and the buoyancy,are considered by exchanging interaction forces between the CFD and DEM computations.We focus on the flow and deposit characteristics of submerged granular column collapse,namely the runout distance,the tail end height,the particle velocity,the energy,and deposit morphology,which are analyzed qualitatively and quantitatively.The change in fluid field caused by submerged granular column collapse and the formation of eddies are also discussed.A relatively dense fluid can significantly hinder the motion of granular flow,but can improve the conversion efficiency of kinetic energy from the vertical to the horizontal direction.Moreover,the eddies caused by fluid turbulence erode the surface of the granular pile,which is especially marked in a high-density fluid.The findings can provide vital theoretical support for the flow and deposit characteristics of granular flow under fluid and offer insights for the study of reservoir landslides.
基金supported by Science,Technology&Innovation Funding Authority(STDF)under grant(No.47062).
文摘Conversion and capture of carbon pollutants based on carbon dioxide to valuable green oil-field chemicals are target all over the world for controlling the global warming.The present article used new room temperature amphiphilic imidazolium ionic liquids with superior surface activity in the aqueous solutions to convert carbon dioxide gas to superior amphiphilic calcium carbonate nanoparticles.In this respect,tetra-cationic ionic liquids 2-(4-dodecyldimethylamino)phenyl)-1,3-bis(3-dodecyldimethylammnonio)propyl)bromide-1-H-imidazol-3-ium acetate and 2-(4-hexyldimethylamino)phenyl)-1,3-bis(3-hexcyldimethylammnonio)propyl)bromide-1 H-imidazol-3-ium acetate were prepared.Their chemical structures,thermal as well as their carbon dioxide absorption/desorption characteristicswere evaluated.Theywere used as solvent and capping agent to synthesize calcium carbonate nanoparticles with controlled crystalline lattice,sizes,thermal properties and spherical surface morphologies.The prepared calcium carbonate nanoparticles were used as additives for the commercial water based drilling mud to improve their filter lose and rheology.The data confirm that the lower concentrations of 2-(4-dodecyldimethylamino)phenyl)-1,3-bis(3-dodecyldimethylammnonio)propyl)bromide-1-H-imidazol-3-ium acetate achieved lower seawater filter lose and improved viscosities.
文摘The purpose of this study is to explore the effects of working fluid on conventional combined cycle integrated with pressurized solid oxide fuel cell (SOFC) and waste heat recovery organic Rankine cycle (ORC) for stationary utility power generation. The mathematical model of a natural gas fueled design configuration is developed in Matlab and Simulink and simulated with 14 working fluids. The effluent gases of SOFC undergo combustion in the combustion chamber and it is utilized in the gas turbine, steam turbine cycle and ORC. The model is compared with those found in literature and the parametric studies of temperature, flow rate, fuel utilization factor and exhaust gas on the system efficiency are examined. Results revealed that working fluids show a closely related behavior in efficiency at low pressure ratio and high flow fraction, fuel utilization, and temperature. R-123 was found to perform the best among 14 working fluids studied, yielding a system energy efficiency of 70% in the combined cycle integrated with SOFC and ORC.
基金financially supported by the National Natural Science Foundation of China(Nos.92355301,42302061)the China Postdoctoral Science Foundation(No.2023M743471)+1 种基金the Key Research Program of the Institute of Geology and Geophysics,Chinese Academy of Sciences(No.IGGCAS-202204)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.Y2021026)。
文摘0 INTRODUCTION Sulfur(S)and carbon(C)are essential volatile elements in both interior and surficial systems of the Earth.The cycling of S and C in subduction zones plays a fundamental role in modulating global S-C fluxes and exerts a significant influence on the climate evolution,mantle's redox budget,and ore deposit formation(Bekaert et al.,2021).
基金Supported by the National Natural Science Foundations of China under Grant No 50476083.
文摘We present a theoretical analysis for fully developed convective beat transfer in a circular tube for power law fluids by assuming that the thermal diffusivity is a function of temperature gradient. The analytical eolution is obtained and the heat transfer behaviour is investigated under a constant heat flux boundary condition. It is shown that the Nusselt number strongly depends on the value of power law index n. The Nusselt number sharply decreases in the range of 0 〈 n 〈 0.1. However, for n 〉 0.5, the Nusselt number decreases monotonically with the increasing n, and for n 〉 20, the values of Nusselt number approach a constant.
基金Project(50476083) supported by the National Natural Science Foundation of China
文摘The hear transfer mechanism and the constitutive models for energy boundary layer in power law fluids were investigated.Two energy transfer constitutive equations models were proposed based on the assumption of similarity of velocity field momentum diffusion and temperature field heat transfer.The governing systems of partial different equations were transformed into ordinary differential equations respectively by using the similarity transformation group.One model was assumed that Prandtl number is a constant,and the other model was assumed that viscosity diffusion is analogous to thermal diffusion.The solutions were presented analytically and numerically by using the Runge-Kutta formulas and shooting technique and the associated transfer characteristics were discussed.
基金funded by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB18030302)the National Key R&D Program of China (2017YFC0602503)the National Natural Science Foundation of China (U1812402, 41430315, 41573011, 41625006)
文摘The Sichuan-Yunnan-Guizhou(SYG)metallogenic province of southwest China is one of the most important Zn-Pb ore zones in China,with^200 Mt ZnPb ores at mean grades of 10 wt.%Zn and 5 wt.%Pb.The source and mechanism of the regional Zn-Pb mineralization remain controversial despite many investigations that have been conducted.The Wusihe Zn-Pb deposit is a representative large-scale Zn-Pb deposit in the northern SYG,which mainly occurs in the Dengying Formation and yields Zn-Pb resources of^3.7 Mt.In this paper,Zn and S isotopes,and Fe and Cd contents of sphalerite from the Wusihe deposit were investigated in an attempt to constrain the controls on Zn and S isotopic variations,the potential sources of ore-forming components,and the possible mineralization mechanisms.Both theδ66Zn andδ34S values in sphalerite from the Wusihe deposit increase systematically from the bottom to the top of the strata-bound orebodies.Such spatial evolution inδ66Zn andδ34S values of sphalerite can be attributed to isotopic Rayleigh fractionation during sphalerite precipitation with temperature variations.The strong correlations between the Zn-S isotopic compositions and Fe-Cd concentrations in sphalerite suggest that their variations were dominated by a similar mechanism.However,the Rayleigh fractionation mechanism cannot explain the spatial variations of Fe and Cd concentrations of sphalerite in this deposit.It is noted that the bottom and top sphalerites from the strata-bound orebodies document contrasting Zn and S isotopic compositions which correspond to the Zn and S isotopic characteristics of basement rocks and host rocks,respectively.Therefore,the mixing of two-source fluids with distinct Zn-S isotopic signatures was responsible for the spatial variations of Zn-S isotopic compositions of sphalerite from the Wusihe deposit.The fluids from basement rocks are characterized by relatively lighter Zn(~0.2‰)and S(~5‰)isotopic compositions while the fluids from host rocks are marked by relatively heavier Zn(~0.6‰)and S(~15‰)isotopic compositions.
文摘On the basis of the free volume theory and activation energy concept,a fundamental equation whichtakes into account the effects of temperature and pressure has been developed.By introducing differentexpressions for the free volume and activation energy,several equations for fluid diffusion coefficients were derivedaccordingly.With the van der Waals free volume and intermal energy formula,a three-parameter model for fluiddiffusion coeffficients at moderate pressure was obtained.The grand average absolute deviation percent of 345data points (44 systems)for self-and infinite dilute inter-diffusivities is 2.32,against the results of the model ofCohen and Turnbull,4.13.In particular,by means of the modified Carnahan-Starling free volume equation,afour-parameter model with average abosolute deviation percent 2.64(30 systems,644 data points)for theestimation of dense fluid inter-and self-diffusivities at high pressures and in supercritical conditions was derived.The derived model is superior to the method of
