A novel flavanol bearing phenylpropionic acid moiety at C-4 through a C-C bonding,named brainin A（1）,was isolated from the rhizomes of Brainea insignis.Its structure was elucidated on the basis of spectral data incl...A novel flavanol bearing phenylpropionic acid moiety at C-4 through a C-C bonding,named brainin A（1）,was isolated from the rhizomes of Brainea insignis.Its structure was elucidated on the basis of spectral data including 2D NMR and HR-ESI-MS.展开更多
Objective The influence of cocoa flavanols(CFs)on cognitive functions in human has been investigated in some clinical trials,but the results are inconclusive.We conduct this systematic review and meta-analysis of rand...Objective The influence of cocoa flavanols(CFs)on cognitive functions in human has been investigated in some clinical trials,but the results are inconclusive.We conduct this systematic review and meta-analysis of randomized controlled trials(RCTs)to figure out whether CFs intervention have a positive effect on cognitive functions.Methods A comprehensive literature search of articles published until June 2019 was performed in PubMed,Cochrane Library,Medline,and Web of Science.Weighted mean difference(WMD)and 95%confidence interval(95%CI)were calculated to reflect the size of the combined effect.Random effect models were used for all analyses.Results A total of 9 RCT studies were finally enrolled in this meta-analysis.CFs has no notable effect on Trail Making Test-A(TMT-A)(WMD:-5.75s,95%CI:-16.71-5.21),which reflects the shifting subdomain of executive function and global executive function.CFs has no significant effect on Trail Making Test-B(TMT-B)(WMD:-11.32s,95%CI:-26.14-3.50),which reflects another specific aspect of the shifting subdomain.Gross cognitive changed as measured by mini mental state examination(MMSE)which consists of a series of items covering cognitive functions except for the executive function domain,but significantly associated with composite z score of several subdomains tests of executive function(WSD:0.40s,95%CI:0.29-0.46).Conclusion This study suggests CFs may have a positive effect on cognitive function,especially executive function.However,large scale and high quality RCTs are needed to further confirm/refute this conclusion.展开更多
α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performe...α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named(–)-epicatechin-3-O-(Z)-coumarate(1), and 16 known analogs(2–17) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro;compound 15 showed moderate inhibitory effect against sucrase with an IC_(50) value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC_(50) value of 1.3 μmol/L. Compounds 8, 10, 11 and15 displayed moderate activity against a lipase with IC_(50) values of 16.0, 13.6, 19.8, and 13.3 μmol/L,respectively.展开更多
Two new flavanol derivatives, bearing phenylpropionic acid moiety at C-4 through a C--C bonding, named brainin B （1） and brainin C （2）, were isolated from Brainea insignis. Their structures were elucidated by NMR ...Two new flavanol derivatives, bearing phenylpropionic acid moiety at C-4 through a C--C bonding, named brainin B （1） and brainin C （2）, were isolated from Brainea insignis. Their structures were elucidated by NMR and MS spectrometry, Brainins B and C were tested for their antioxidant properties in DPPH （2,2-diphenyl-l-picryl- hydrazyl） radical scavenging, and both compounds displayed potent antioxidant activities.展开更多
[Objective]The aim was to identify the composition of pigments from Jujube fruit skin.[Method]Pigments were extracted from＇Lubei Dongzao＇,＇Lajiao Zao＇,＇Chengwu Dongzao＇,＇Dabailing＇and identificated by using hi...[Objective]The aim was to identify the composition of pigments from Jujube fruit skin.[Method]Pigments were extracted from＇Lubei Dongzao＇,＇Lajiao Zao＇,＇Chengwu Dongzao＇,＇Dabailing＇and identificated by using high performance liquid chromatography-mass spectrometry（HPLC-MS）.[Result]The results showed that eight flavanols and four to five flavonols were detected,no anthocyanins was detected.The contents of flavonoids were differnt in four varieties.The contents of flavanols（11 mg/g） and flavonols（1.78 mg/g） in＇Dabailing＇ were one-time higher than other varieties.Quercetin 3 rutinoside was the major flavonol.[Conclusion]The research provided theoretical basis for further study on mechanism of Jujube pigment turnning into the red.展开更多
基金supported by the Natural Science Foundation of China(Nos.30560178 and 20964005)by a program for New Century Excellent Talents in University from MOE(No.NCET-08-0925)a grant from Education Department of Yunnan Province(No.08Y10302)
文摘A novel flavanol bearing phenylpropionic acid moiety at C-4 through a C-C bonding,named brainin A（1）,was isolated from the rhizomes of Brainea insignis.Its structure was elucidated on the basis of spectral data including 2D NMR and HR-ESI-MS.
文摘Objective The influence of cocoa flavanols(CFs)on cognitive functions in human has been investigated in some clinical trials,but the results are inconclusive.We conduct this systematic review and meta-analysis of randomized controlled trials(RCTs)to figure out whether CFs intervention have a positive effect on cognitive functions.Methods A comprehensive literature search of articles published until June 2019 was performed in PubMed,Cochrane Library,Medline,and Web of Science.Weighted mean difference(WMD)and 95%confidence interval(95%CI)were calculated to reflect the size of the combined effect.Random effect models were used for all analyses.Results A total of 9 RCT studies were finally enrolled in this meta-analysis.CFs has no notable effect on Trail Making Test-A(TMT-A)(WMD:-5.75s,95%CI:-16.71-5.21),which reflects the shifting subdomain of executive function and global executive function.CFs has no significant effect on Trail Making Test-B(TMT-B)(WMD:-11.32s,95%CI:-26.14-3.50),which reflects another specific aspect of the shifting subdomain.Gross cognitive changed as measured by mini mental state examination(MMSE)which consists of a series of items covering cognitive functions except for the executive function domain,but significantly associated with composite z score of several subdomains tests of executive function(WSD:0.40s,95%CI:0.29-0.46).Conclusion This study suggests CFs may have a positive effect on cognitive function,especially executive function.However,large scale and high quality RCTs are needed to further confirm/refute this conclusion.
基金supported by grants from National Mega–Project for Innovative Drugs(2012ZX09301002-002)
文摘α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named(–)-epicatechin-3-O-(Z)-coumarate(1), and 16 known analogs(2–17) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro;compound 15 showed moderate inhibitory effect against sucrase with an IC_(50) value of 32.5 μmol/L and significant inhibitory effect against maltase with an IC_(50) value of 1.3 μmol/L. Compounds 8, 10, 11 and15 displayed moderate activity against a lipase with IC_(50) values of 16.0, 13.6, 19.8, and 13.3 μmol/L,respectively.
文摘Two new flavanol derivatives, bearing phenylpropionic acid moiety at C-4 through a C--C bonding, named brainin B （1） and brainin C （2）, were isolated from Brainea insignis. Their structures were elucidated by NMR and MS spectrometry, Brainins B and C were tested for their antioxidant properties in DPPH （2,2-diphenyl-l-picryl- hydrazyl） radical scavenging, and both compounds displayed potent antioxidant activities.
基金Supported by National Key Technology R & D Program 2006BAD01A1701 and 2006BAD18B02Shandong Agriculture Good Cultivar Engineering Project (2008LZ09)~~
文摘[Objective]The aim was to identify the composition of pigments from Jujube fruit skin.[Method]Pigments were extracted from＇Lubei Dongzao＇,＇Lajiao Zao＇,＇Chengwu Dongzao＇,＇Dabailing＇and identificated by using high performance liquid chromatography-mass spectrometry（HPLC-MS）.[Result]The results showed that eight flavanols and four to five flavonols were detected,no anthocyanins was detected.The contents of flavonoids were differnt in four varieties.The contents of flavanols（11 mg/g） and flavonols（1.78 mg/g） in＇Dabailing＇ were one-time higher than other varieties.Quercetin 3 rutinoside was the major flavonol.[Conclusion]The research provided theoretical basis for further study on mechanism of Jujube pigment turnning into the red.
