Pampus argenteus is a commercially valuable species in many countries.Its artificial cultivation has been impacted by intestinal flatulence,leading to increased mortality.However,the role of gut microbiota in this pro...Pampus argenteus is a commercially valuable species in many countries.Its artificial cultivation has been impacted by intestinal flatulence,leading to increased mortality.However,the role of gut microbiota in this process remains unclear.Therefore,this study utilized high-throughput sequencing of 16S rRNA genes to investigate the gut microbiota in both flatulent and healthy P.argenteus.A total of 227571 high-quality and classifiable reads,representing 312 Amplicon Sequence Variants(ASVs),were obtained.Proteobacteria emerged as the predominant phylum in all samples,with the flatulent group displaying the highest relative abundance(85.3%).Microbial diversity was significantly greater in samples from water than those from tissues.Composition analysis using Bray-Curtis distance via CPCoA revealed distinct gut microbiota compositions between the samples with flatulence and the healthy samples.Co-occurrence network analysis demonstrated that the bacterial community in the flatulent group exhibited disorder due to the high abundance of Vibrio.Functional predictive analysis(PICRUSt2)indicated that flatulence in P.argenteus was associated with impaired methane and lipid metabolism,potentially resulting in excessive methane synthesis utilizing hydrogen and acetic acid as substrates produced by Clostridium sensu stricto 1,Cetobacterium,and Peptoclostridium.This study holds significant implications for early diagnosis and prevention of intestinal flatulence through the regulation of gut microbiota.展开更多
目的探讨中药封包穴位外敷联合西甲硅油对剖宫产患者术后肠胀气的治疗效果。方法选取2020年1月至2023年8月上饶市妇幼保健院收治的80例剖宫产术后肠胀气患者作为研究对象,按照随机数字表法分为对照组与观察组,每组40例。对照组给予西甲...目的探讨中药封包穴位外敷联合西甲硅油对剖宫产患者术后肠胀气的治疗效果。方法选取2020年1月至2023年8月上饶市妇幼保健院收治的80例剖宫产术后肠胀气患者作为研究对象,按照随机数字表法分为对照组与观察组,每组40例。对照组给予西甲硅油治疗,观察组予以中药封包穴位外敷联合西甲硅油治疗。比较两组临床恢复情况、治疗前后视觉模拟评分法(visual analog scale,VAS)及健康调查量表36(36-item short from health survey,SF-36)评分、临床疗效、不良反应发生情况。结果观察组肠鸣音恢复时间、肛门首次排气时间、首次排便时间、肠胀气持续时间均短于对照组,腹胀评分低于对照组,母乳喂养率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能及精神健康评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为92.50%,高于对照组的62.50%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论对于剖宫产术后肠胀气的临床治疗,中药封包穴位外敷联合西甲硅油可缩短患者首次排气时间,降低患者疼痛程度,提高生命质量,在提高疗效的同时具有较高的安全性,社会效益明显,值得临床推广应用。展开更多
Objective:To analyze the factors of flatulence in patients treated with non-invasive ventilator and summarize practical and effective nursing measures.Methods:From July 2020 to June 2021,40 patients who complained of ...Objective:To analyze the factors of flatulence in patients treated with non-invasive ventilator and summarize practical and effective nursing measures.Methods:From July 2020 to June 2021,40 patients who complained of flatulence after using non-invasive ventilator were analyzed.Results:20 cases of abdominal distension were caused by the habit of breathing with their mouth open,10 cases of abdominal distention were caused by liking to eat soup,10 cases of abdominal distention were caused by long-term bed-in-bed activity reduced gastrointestinal peristalsis constipation.Conclusion:We should investigate the causes causing gastrointestinal flatulence with the use of non-invasive ventilators,intervene in advance,boost patient comfort,collaborate with therapy,and improve the therapeutic result.展开更多
Objective: to explore the nursing experience of prevention of intestinal flatulence by acupoint massage and exhaust exercise after cesarean section. Methods: 100 parturients who underwent caesarean section with acupun...Objective: to explore the nursing experience of prevention of intestinal flatulence by acupoint massage and exhaust exercise after cesarean section. Methods: 100 parturients who underwent caesarean section with acupuncture point massage and exhaust exercise were selected and randomly divided into the control group and the observation group. The control group received routine nursing while the observation group received nursing intervention. The nursing quality of the parturients in both groups was counted. Results: the nursing quality of parturients in the observation group was better than that in the control group (P<0.05). Conclusion: abdominal distension will occur after caesarean section. Therefore, post-operative acupuncture point massage exercise should be performed clinically to reduce flatulence of parturients undergoing caesarean section, improve gastrointestinal function of parturients undergoing caesarean section, maintain intestinal peristalsis of parturients undergoing caesarean section, restore normal indexes of the body, and promote anal exhaust. High-quality nursing is indispensable during the implementation of acupuncture point massage exhaust exercise. The exploration of cesarean section parturient exhaust exercise, combined with the basic actual situation of cesarean section parturient, conforms to the cesarean section parturients own condition, formulates effective nursing policy for cesarean section parturient. During the period of acupuncture point nursing for cesarean section parturient, continuous education should be given to enable them to cooperate with the nursing work and improve the details of clinical nursing by combining with the specific opinions of cesarean section parturient on the nursing work, which has high clinical practicality.展开更多
BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and i...BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.展开更多
BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel habits...BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel habits.First-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic gain.GASTRAP^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of action.AIM To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with IBS.METHODS In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 weeks.The primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)4.The analysis was performed using the per-protocol set.Cardinal symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were evaluated.RESULTS Overall,100 patients were evaluated.At W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by W2.No severe adverse event occurred,and tolerability was rated“good”or“very good”by 93%of patients.CONCLUSION GASTRAP^(■)DIRECT is safe and well tolerated,alleviating IBS symptoms rapidly in 2 weeks.This open-label study suggests that the combination of chitin-glucan and simethicone could be beneficial in patients with IBS.展开更多
基金funded by the National Key R&D Program of China(No.2022YFD2400100)the Ningbo 2025 Major Project of Science Technology and Innovation(No.2021Z003)+5 种基金the Public Welfare Program of Ningbo City(Science and Technology Special Commissioner Project)(No.2022S204)the National Natural Science Foundation of China(Nos.31872195,42076118 and 42306114)the China Postdoctoral Science Foundation(No.2022M721729)the General Scientific Research Projects of Zhejiang Provincial Department of Education(No.Y202249062)the Ningbo Public Welfare Science and Technology Project(No.2021S061)the Ningbo Yongjiang Talent Introduction Programme(No.2021B-029-C)。
文摘Pampus argenteus is a commercially valuable species in many countries.Its artificial cultivation has been impacted by intestinal flatulence,leading to increased mortality.However,the role of gut microbiota in this process remains unclear.Therefore,this study utilized high-throughput sequencing of 16S rRNA genes to investigate the gut microbiota in both flatulent and healthy P.argenteus.A total of 227571 high-quality and classifiable reads,representing 312 Amplicon Sequence Variants(ASVs),were obtained.Proteobacteria emerged as the predominant phylum in all samples,with the flatulent group displaying the highest relative abundance(85.3%).Microbial diversity was significantly greater in samples from water than those from tissues.Composition analysis using Bray-Curtis distance via CPCoA revealed distinct gut microbiota compositions between the samples with flatulence and the healthy samples.Co-occurrence network analysis demonstrated that the bacterial community in the flatulent group exhibited disorder due to the high abundance of Vibrio.Functional predictive analysis(PICRUSt2)indicated that flatulence in P.argenteus was associated with impaired methane and lipid metabolism,potentially resulting in excessive methane synthesis utilizing hydrogen and acetic acid as substrates produced by Clostridium sensu stricto 1,Cetobacterium,and Peptoclostridium.This study holds significant implications for early diagnosis and prevention of intestinal flatulence through the regulation of gut microbiota.
文摘目的探讨中药封包穴位外敷联合西甲硅油对剖宫产患者术后肠胀气的治疗效果。方法选取2020年1月至2023年8月上饶市妇幼保健院收治的80例剖宫产术后肠胀气患者作为研究对象,按照随机数字表法分为对照组与观察组,每组40例。对照组给予西甲硅油治疗,观察组予以中药封包穴位外敷联合西甲硅油治疗。比较两组临床恢复情况、治疗前后视觉模拟评分法(visual analog scale,VAS)及健康调查量表36(36-item short from health survey,SF-36)评分、临床疗效、不良反应发生情况。结果观察组肠鸣音恢复时间、肛门首次排气时间、首次排便时间、肠胀气持续时间均短于对照组,腹胀评分低于对照组,母乳喂养率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能及精神健康评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为92.50%,高于对照组的62.50%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论对于剖宫产术后肠胀气的临床治疗,中药封包穴位外敷联合西甲硅油可缩短患者首次排气时间,降低患者疼痛程度,提高生命质量,在提高疗效的同时具有较高的安全性,社会效益明显,值得临床推广应用。
文摘Objective:To analyze the factors of flatulence in patients treated with non-invasive ventilator and summarize practical and effective nursing measures.Methods:From July 2020 to June 2021,40 patients who complained of flatulence after using non-invasive ventilator were analyzed.Results:20 cases of abdominal distension were caused by the habit of breathing with their mouth open,10 cases of abdominal distention were caused by liking to eat soup,10 cases of abdominal distention were caused by long-term bed-in-bed activity reduced gastrointestinal peristalsis constipation.Conclusion:We should investigate the causes causing gastrointestinal flatulence with the use of non-invasive ventilators,intervene in advance,boost patient comfort,collaborate with therapy,and improve the therapeutic result.
文摘Objective: to explore the nursing experience of prevention of intestinal flatulence by acupoint massage and exhaust exercise after cesarean section. Methods: 100 parturients who underwent caesarean section with acupuncture point massage and exhaust exercise were selected and randomly divided into the control group and the observation group. The control group received routine nursing while the observation group received nursing intervention. The nursing quality of the parturients in both groups was counted. Results: the nursing quality of parturients in the observation group was better than that in the control group (P<0.05). Conclusion: abdominal distension will occur after caesarean section. Therefore, post-operative acupuncture point massage exercise should be performed clinically to reduce flatulence of parturients undergoing caesarean section, improve gastrointestinal function of parturients undergoing caesarean section, maintain intestinal peristalsis of parturients undergoing caesarean section, restore normal indexes of the body, and promote anal exhaust. High-quality nursing is indispensable during the implementation of acupuncture point massage exhaust exercise. The exploration of cesarean section parturient exhaust exercise, combined with the basic actual situation of cesarean section parturient, conforms to the cesarean section parturients own condition, formulates effective nursing policy for cesarean section parturient. During the period of acupuncture point nursing for cesarean section parturient, continuous education should be given to enable them to cooperate with the nursing work and improve the details of clinical nursing by combining with the specific opinions of cesarean section parturient on the nursing work, which has high clinical practicality.
基金Supported by National Key R&D Program of China,No.2022YFC25045001.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYGD23012.
文摘BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.
文摘BACKGROUND Irritable bowel syndrome(IBS),defined according to the Rome IV diagnostic criteria,is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel habits.First-line recommended treatments are limited to combining drugs targeting predominant symptoms,particularly pain(antispasmodics),constipation(laxatives),and diarrhea(loperamide),yielding only a limited therapeutic gain.GASTRAP^(■)DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of action.AIM To evaluate the efficacy,tolerability,and safety of 4-week GASTRAP^(■)DIRECT treatment in patients with IBS.METHODS In this prospective,multicenter,open-label trial,120 patients with IBS received three sticks of GASTRAP^(■)DIRECT(1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone)per day for 4 weeks.The primary endpoint was the responder rate,defined as the number of patients whose abdominal pain score decreased by≥30%from baseline to week(W)4.The analysis was performed using the per-protocol set.Cardinal symptoms,impact of global symptoms on daily life,change in stool consistency,and improvement in defecatory disorders were evaluated.RESULTS Overall,100 patients were evaluated.At W4,67%(95%CI:57-75)showed improvement in abdominal pain(score:5.8±2.4 vs 2.9±2.0,P<0.0001).Similar improvements were observed for bloating[8.0±1.7 vs 4.7±2.9,P<0.0001;60%(95%CI:50-70)responders],abdominal distension[7.2±2.1 vs 4.4±3.1,P<0.0001;53%(95%CI:43-63)responders],and impact of global symptoms on daily life[7.1±2.0 vs 4.6±2.9,P<0.0001;54%(95%CI:44-64)responders].Stool consistency improved in most patients(90%and 57%for patients with liquid and hard stools,respectively).Overall,42%of patients with defecatory disorders reported very much/considerable improvements by W2.No severe adverse event occurred,and tolerability was rated“good”or“very good”by 93%of patients.CONCLUSION GASTRAP^(■)DIRECT is safe and well tolerated,alleviating IBS symptoms rapidly in 2 weeks.This open-label study suggests that the combination of chitin-glucan and simethicone could be beneficial in patients with IBS.
