Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly ...Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.展开更多
On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyo...On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.展开更多
AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on diseas...AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemot...Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.展开更多
Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By...Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.展开更多
The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and pro...The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and production of deep coal mines.The primary reason for this is that the fracturing of the rock mass induces the formation of a fluid(water)with both kinetic and potential energy.In this paper,a novel water inrush mechanism for deep floor failure due to water hammer effects is proposed based on the Xingdong coal mine in China.The water hammer pressure within rock pore channels has a different impact on the surrounding rock,leading to the degradation of the rock mass channel through repeated conduction and instantaneous cutoff.To further investigate this phenomenon,a progressive corrosion fracture mechanics(PCFM)model induced by a water hammer is established.The results show that the water hammer pressure caused by instantaneous channel truncation increases with increasing water flow velocity.The chemical damage factor(i.e.,stress corrosion fracture)is also incorporated into the Dugdale-Barenblatt(D-B)model to analyze the factors influencing the PCFM.These findings indicate that the greater the degree of damage is,the more likely the concealed fault is to experience water inrush.Finally,methods for controlling water inrush caused by the water hammer effects of deep floors are proposed.The failure mechanisms of the water hammer and the PCFM provide theoretical and practical guidance for controlling water inrush from the deep floor.展开更多
Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the ten...Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk.展开更多
This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the ...This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the phenotypes of bile acid dysregulation in IBS-D patients,and the related pathogenic molecular mechanisms.A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids,specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence,this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D.It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis.展开更多
From lecture halls in Beijing to villages in the mountains of southwest China,a group of young rural innovators from Global South countries recently embarked on a journey that connected policy thinking,technological p...From lecture halls in Beijing to villages in the mountains of southwest China,a group of young rural innovators from Global South countries recently embarked on a journey that connected policy thinking,technological practice and lived rural experience.展开更多
The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a...The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.展开更多
To improve the NO modelling in turbulent flames,the flamelet/progress variable(FPV)model is extended by introducing NO mass fraction into the progress variable and incorporating an additional NO transport equation.Two...To improve the NO modelling in turbulent flames,the flamelet/progress variable(FPV)model is extended by introducing NO mass fraction into the progress variable and incorporating an additional NO transport equation.Two sets of flamelet databases are tabulated with progress variables based on major species and NO mass fraction,respectively.The former is used for the acquisition of the main thermochemical variables,while the latter is employed for NO modelling.Moreover,an additional transport equation is solved to obtain the NO mass fraction,with the source term corrected using the scale similarity method.Model assessments are first conducted on laminar counterflow diffusion flames to identify lookup-related errors and assess the suitability of progress variable definitions.The results show that the progress variables based on major species and NO could correctly describe the main thermochemical quantities and NO-related variables,respectively.Subsequently,the model is applied to the large eddy simulation(LES)of Sandia flames.The results indicate that the extended FPV model improves the NO prediction,with a mean error for NO prediction at 55%,significantly lower than those of existing FPV models(130%and 385%).The LES with the extended FPV model quantitatively captures NO suppression in the mid-range of Reynolds numbers from 22400(Flame D)to 33600(Flame E),but underestimates the NO suppression at higher Reynolds numbers from 33600 to 44800(Flame F).This underprediction is primarily attributed to the underestimation of local extinction levels in flames with high Reynolds numbers.展开更多
An automated method to optimize the definition of the progress variables in the flamelet-based dimension reduction is proposed. The performance of these optimized progress variables in coupling the flamelets and flow ...An automated method to optimize the definition of the progress variables in the flamelet-based dimension reduction is proposed. The performance of these optimized progress variables in coupling the flamelets and flow solver is presented. In the proposed method, the progress variables are defined according to the first two principal components （PCs） from the principal component analysis （PCA） or kernel-density-weighted PCA （KEDPCA） of a set of flamelets. These flamelets can then be mapped to these new progress variables instead of the mixture fraction/conventional progress variables. Thus, a new chemistry look-up table is constructed. A priori validation of these optimized progress variables and the new chemistry table is implemented in a CH4/N2/air lift-off flame. The reconstruction of the lift-off flame shows that the optimized progress variables perform better than the conventional ones, especially in the high temperature area. The coefficient determinations （R2 statistics） show that the KEDPCA performs slightly better than the PCA except for some minor species. The main advantage of the KEDPCA is that it is less sensitive to the database. Meanwhile, the criteria for the optimization are proposed and discussed. The constraint that the progress variables should monotonically evolve from fresh gas to burnt gas is analyzed in detail.展开更多
The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmiss...The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.展开更多
BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gas...BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.展开更多
Liver transplantation,as an effective therapy for patients with liver cancer,plays an important role in improving the quality of life of patients.However,the com-plexity and trauma of liver transplantation can easily ...Liver transplantation,as an effective therapy for patients with liver cancer,plays an important role in improving the quality of life of patients.However,the com-plexity and trauma of liver transplantation can easily lead to the occurrence of malnutrition in patients,and then increase the risk of postoperative complica-tions,which has aroused widespread clinical attention.Reasonable nutritional support can not only maintain the stability of the body’s internal environment,reduce the occurrence of complications,but also promote the recovery of liver and other organ functions.In recent years,with the in-depth understanding of nut-ritional metabolism after liver transplantation,the application of enteral nutrition and parenteral nutrition in nutritional support after liver transplantation has been increasingly extensive and achieved remarkable results.This paper discusses the effect of early postoperative nutritional intervention on patients with liver cancer and liver transplantation,and combined with its mechanism of action,can better understand the effectiveness of intervention,and provide reference for the deve-lopment of scientific and reasonable nutritional support programs in clinical pra-ctice.展开更多
Lipocalin-2(LCN2)is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo.LCN2 is significantly expressed in various tumors...Lipocalin-2(LCN2)is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo.LCN2 is significantly expressed in various tumors and plays an important role in regulating tumor cell proliferation,invasion,and metastasis.The specific actions of LCN2 in tumors may vary depending on the particular type of cancer involved.In this review,we provide an extensive overview of the transcriptional and post-transcriptional regulation of LCN2 in health and disease.Furthermore,we summarize the impact of LCN2 dysregulation in a broad range of tumors.Lastly,we examine the mechanisms of action of LCN2 during tumorigenesis,progression,and metastasis.Understanding the complex relationships between LCN2 and tumor development,progression,and metastasis is vital for advancing our knowledge of cancer biology,developing biomarkers for diagnosis and clinical decision-making,and creating therapeutic strategies to improve the management of patients with cancer.展开更多
BACKGROUND Uncertainty in illness(UI)and fear of progression(FoP)are significant psycho-logical challenges for lung cancer patients.Coping styles and social support are critical mediators,influencing patients'abil...BACKGROUND Uncertainty in illness(UI)and fear of progression(FoP)are significant psycho-logical challenges for lung cancer patients.Coping styles and social support are critical mediators,influencing patients'ability to manage the emotional and psy-chological burden of UI and FoP.However,limited research has explored the chain mediation effect of these factors on the relationship between UI and FoP,particularly among Chinese lung cancer patients.Convenience sampling was used to recruit inpatients diagnosed with lung cancer at a tertiary hospital in Changde City between November and December 2023.A total of 320 participants completed the Mishel Uncertainty in Illness Scale,Simp-lified Coping Style Questionnaire,Mandarin Chinese Version of the Medical Outcomes Study Social Support Survey,and Fear of Progression Questionnaire-Short Form.The chain mediation analysis was performed using the PROCESS macro to examine the relationships between the variables.RESULTS The results revealed that UI had a significant direct effect on FoP(effect=0.224,95%CI:0.136-0.408).Additionally,three indirect pathways were identified:(1)Social support(effect=0.128,95%CI:0.045-0.153);(2)Coping style(effect=0.115,95%CI:0.048-0.157);and(3)Chain mediators involving social support and coping style(effect=0.072,95%CI:0.045-0.120).The total indirect effect of the three mediation paths is 31.5%.These results confirm that social support and coping style significantly mediate the relationship between UI and FoP.CONCLUSION Based on cross-sectional data and a chain mediation model,this study explored the mechanisms between UI,social support,coping style,and FOP.Patients with lung cancer have higher levels of FOP,and the results of this study revealed a correlation between these four factors.Social support and coping style partially mediated the effects of UI on FOP,and there was a chain-mediating effect between UI and FOP.Programs designed to strengthen social support networks should also incorporate training to develop adaptive coping strategies,ultimately reducing FOP and improving overall quality of life.展开更多
The progressive failure characteristics of geomaterial are a remarkable and challenging topic in geotechnical engineering.To study the effect of salt content and temperature on the progressive failure characteristics ...The progressive failure characteristics of geomaterial are a remarkable and challenging topic in geotechnical engineering.To study the effect of salt content and temperature on the progressive failure characteristics of frozen sodium sulfate saline sandy soil,a series of uniaxial compression tests were performed by integrating digital image correlation(DIC)technology into the testing apparatus.The evolution law of the uniaxial compression strength(UCS),the failure strain,and the formation of the shear band of the frozen sodium sulfate saline sandy soil were analyzed.The test results show that within the scope of this study,with the increase of salt content,both the UCS and the shear band angle initially decrease with increasing salt content before showing an increase.In contrast,the failure strain and the width of the shear band exhibit an initial increase followed by a decrease in the samples.In addition,to investigate the brittle failure characteristics of frozen sodium sulfate saline sandy soil,two classic brittleness evaluation methods were employed to quantitatively assess the brittleness level for the soil samples.The findings suggest that the failure characteristics under all test conditions in this study belong to the transition stage between brittle and ductile,indicating that frozen sodium sulfate saline sandy soil exhibits certain brittle behavior under uniaxial compression conditions,and the brittleness index basically decreases and then increases with the rise in salt content.展开更多
Let a_(1),a_(2),a_(3)be nonzero integers with gcd(a_(1),a_(2),a_(3))=1,and let k be any positive integer,K=max[3,|a_(1)|,|a_(2)|,|a_(3)|,k].Suppose that l_(1),l_(2),l_(3)are integers each coprime to k.Suppose further ...Let a_(1),a_(2),a_(3)be nonzero integers with gcd(a_(1),a_(2),a_(3))=1,and let k be any positive integer,K=max[3,|a_(1)|,|a_(2)|,|a_(3)|,k].Suppose that l_(1),l_(2),l_(3)are integers each coprime to k.Suppose further that b is any integer satisfying some necessary congruent conditions.The solvability of linear equation a_(1)p_(1)+a_(2)p_(2)+a_(3)p_(3)=b(p_(j)=l_(j)(mod k),1≤j≤3)with prime variables pi,p_(2),ps is investigated.It is proved that if ai,a_(2),a_(3)are all positive,then the above equation is solvable whenever b≥K^(25);if a,a_(2),a_(3)are not all of the same sign,then the above equation has a solution p_(1),p_(2),p_(3)satisfying max(p_(1),p_(2),p_(3))≤3|b|+K^(25).展开更多
文摘Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.
文摘On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.
基金Supported by The Eye Hospital of Wenzhou Medical University(No.KYQD20220304)The Fifth Batch of Provincial Ten Thousand Personnel Program Outstanding Talents Funding(No.474092204)+1 种基金Innovative Talents and Teams(2024)-The Fifth Batch of Funding Funds for Scientific and Technological Innovation Leading Talents Under the Provincial Ten Thousand Personnel Program(No.4240924003G)The Key R&D Program of Zhejiang(No.2022C03112).
文摘AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
文摘Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.
文摘Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.
基金supported by the National Natural Science Foundation of China(Grant Nos.52225404 and 52404121)the Key Research and Development Program Projects of Xinjiang Uygur Autonomous Region(Grant No.2024B03017).
文摘The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and production of deep coal mines.The primary reason for this is that the fracturing of the rock mass induces the formation of a fluid(water)with both kinetic and potential energy.In this paper,a novel water inrush mechanism for deep floor failure due to water hammer effects is proposed based on the Xingdong coal mine in China.The water hammer pressure within rock pore channels has a different impact on the surrounding rock,leading to the degradation of the rock mass channel through repeated conduction and instantaneous cutoff.To further investigate this phenomenon,a progressive corrosion fracture mechanics(PCFM)model induced by a water hammer is established.The results show that the water hammer pressure caused by instantaneous channel truncation increases with increasing water flow velocity.The chemical damage factor(i.e.,stress corrosion fracture)is also incorporated into the Dugdale-Barenblatt(D-B)model to analyze the factors influencing the PCFM.These findings indicate that the greater the degree of damage is,the more likely the concealed fault is to experience water inrush.Finally,methods for controlling water inrush caused by the water hammer effects of deep floors are proposed.The failure mechanisms of the water hammer and the PCFM provide theoretical and practical guidance for controlling water inrush from the deep floor.
基金supported by the Major Program of National Natural Science Foundation of China(Grant No.42090055)the National Key ScientificInstruments and Equipment Development Projects of China(Grant No.41827808)the National Nature Science Foundation of China(Grant No.42207216).
文摘Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk.
文摘This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the phenotypes of bile acid dysregulation in IBS-D patients,and the related pathogenic molecular mechanisms.A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids,specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence,this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D.It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis.
文摘From lecture halls in Beijing to villages in the mountains of southwest China,a group of young rural innovators from Global South countries recently embarked on a journey that connected policy thinking,technological practice and lived rural experience.
基金supported by the National Key Research and Development Program of China (2021YFB1507401)Qinghai Province Clean Energy Minerals Special Project(2022013004qj004)Geological Survey Project of China Geological Survey (DD20221676, DD20230019)。
文摘The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.
基金supported by the National Natural Science Foundation of China(51906075)the National Key Research and Development Program of China(2019YFE0100100).
文摘To improve the NO modelling in turbulent flames,the flamelet/progress variable(FPV)model is extended by introducing NO mass fraction into the progress variable and incorporating an additional NO transport equation.Two sets of flamelet databases are tabulated with progress variables based on major species and NO mass fraction,respectively.The former is used for the acquisition of the main thermochemical variables,while the latter is employed for NO modelling.Moreover,an additional transport equation is solved to obtain the NO mass fraction,with the source term corrected using the scale similarity method.Model assessments are first conducted on laminar counterflow diffusion flames to identify lookup-related errors and assess the suitability of progress variable definitions.The results show that the progress variables based on major species and NO could correctly describe the main thermochemical quantities and NO-related variables,respectively.Subsequently,the model is applied to the large eddy simulation(LES)of Sandia flames.The results indicate that the extended FPV model improves the NO prediction,with a mean error for NO prediction at 55%,significantly lower than those of existing FPV models(130%and 385%).The LES with the extended FPV model quantitatively captures NO suppression in the mid-range of Reynolds numbers from 22400(Flame D)to 33600(Flame E),but underestimates the NO suppression at higher Reynolds numbers from 33600 to 44800(Flame F).This underprediction is primarily attributed to the underestimation of local extinction levels in flames with high Reynolds numbers.
基金Project supported by the National Natural Science Foundation of China(Nos.50936005,51576182,and 11172296)
文摘An automated method to optimize the definition of the progress variables in the flamelet-based dimension reduction is proposed. The performance of these optimized progress variables in coupling the flamelets and flow solver is presented. In the proposed method, the progress variables are defined according to the first two principal components （PCs） from the principal component analysis （PCA） or kernel-density-weighted PCA （KEDPCA） of a set of flamelets. These flamelets can then be mapped to these new progress variables instead of the mixture fraction/conventional progress variables. Thus, a new chemistry look-up table is constructed. A priori validation of these optimized progress variables and the new chemistry table is implemented in a CH4/N2/air lift-off flame. The reconstruction of the lift-off flame shows that the optimized progress variables perform better than the conventional ones, especially in the high temperature area. The coefficient determinations （R2 statistics） show that the KEDPCA performs slightly better than the PCA except for some minor species. The main advantage of the KEDPCA is that it is less sensitive to the database. Meanwhile, the criteria for the optimization are proposed and discussed. The constraint that the progress variables should monotonically evolve from fresh gas to burnt gas is analyzed in detail.
基金supported by the National Key R&D Program of China(No.2017YFB0304402)。
文摘The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.
基金the Research Project of the Chinese Digestive Early Cancer Physicians’Joint Growth Program,No.GTCZ-2021-AH-34-0012.
文摘BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.
文摘Liver transplantation,as an effective therapy for patients with liver cancer,plays an important role in improving the quality of life of patients.However,the com-plexity and trauma of liver transplantation can easily lead to the occurrence of malnutrition in patients,and then increase the risk of postoperative complica-tions,which has aroused widespread clinical attention.Reasonable nutritional support can not only maintain the stability of the body’s internal environment,reduce the occurrence of complications,but also promote the recovery of liver and other organ functions.In recent years,with the in-depth understanding of nut-ritional metabolism after liver transplantation,the application of enteral nutrition and parenteral nutrition in nutritional support after liver transplantation has been increasingly extensive and achieved remarkable results.This paper discusses the effect of early postoperative nutritional intervention on patients with liver cancer and liver transplantation,and combined with its mechanism of action,can better understand the effectiveness of intervention,and provide reference for the deve-lopment of scientific and reasonable nutritional support programs in clinical pra-ctice.
基金supported by the Program for Science Technology and Innovation Committee of Shenzhen(2021N062-JCYJ20210324115408023)Guangdong High-Level Hospital Construction Fund,Shenzhen High-Level Hospital Construction Fund。
文摘Lipocalin-2(LCN2)is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo.LCN2 is significantly expressed in various tumors and plays an important role in regulating tumor cell proliferation,invasion,and metastasis.The specific actions of LCN2 in tumors may vary depending on the particular type of cancer involved.In this review,we provide an extensive overview of the transcriptional and post-transcriptional regulation of LCN2 in health and disease.Furthermore,we summarize the impact of LCN2 dysregulation in a broad range of tumors.Lastly,we examine the mechanisms of action of LCN2 during tumorigenesis,progression,and metastasis.Understanding the complex relationships between LCN2 and tumor development,progression,and metastasis is vital for advancing our knowledge of cancer biology,developing biomarkers for diagnosis and clinical decision-making,and creating therapeutic strategies to improve the management of patients with cancer.
基金Supported by Hunan Provincial Natural Science Foundation of China,No.2024JJ9579 and No.2025JJ80410The Science and Technology Innovation Program of Changde City,No.2023YD23.
文摘BACKGROUND Uncertainty in illness(UI)and fear of progression(FoP)are significant psycho-logical challenges for lung cancer patients.Coping styles and social support are critical mediators,influencing patients'ability to manage the emotional and psy-chological burden of UI and FoP.However,limited research has explored the chain mediation effect of these factors on the relationship between UI and FoP,particularly among Chinese lung cancer patients.Convenience sampling was used to recruit inpatients diagnosed with lung cancer at a tertiary hospital in Changde City between November and December 2023.A total of 320 participants completed the Mishel Uncertainty in Illness Scale,Simp-lified Coping Style Questionnaire,Mandarin Chinese Version of the Medical Outcomes Study Social Support Survey,and Fear of Progression Questionnaire-Short Form.The chain mediation analysis was performed using the PROCESS macro to examine the relationships between the variables.RESULTS The results revealed that UI had a significant direct effect on FoP(effect=0.224,95%CI:0.136-0.408).Additionally,three indirect pathways were identified:(1)Social support(effect=0.128,95%CI:0.045-0.153);(2)Coping style(effect=0.115,95%CI:0.048-0.157);and(3)Chain mediators involving social support and coping style(effect=0.072,95%CI:0.045-0.120).The total indirect effect of the three mediation paths is 31.5%.These results confirm that social support and coping style significantly mediate the relationship between UI and FoP.CONCLUSION Based on cross-sectional data and a chain mediation model,this study explored the mechanisms between UI,social support,coping style,and FOP.Patients with lung cancer have higher levels of FOP,and the results of this study revealed a correlation between these four factors.Social support and coping style partially mediated the effects of UI on FOP,and there was a chain-mediating effect between UI and FOP.Programs designed to strengthen social support networks should also incorporate training to develop adaptive coping strategies,ultimately reducing FOP and improving overall quality of life.
基金supported by the National Natural Science Foundation of China(Grant Nos.42372312,and 42172299)the Pyramid Talent Training Project of Beijing University of Civil Engineering and Architecture(Grant No.JDYC20220807).
文摘The progressive failure characteristics of geomaterial are a remarkable and challenging topic in geotechnical engineering.To study the effect of salt content and temperature on the progressive failure characteristics of frozen sodium sulfate saline sandy soil,a series of uniaxial compression tests were performed by integrating digital image correlation(DIC)technology into the testing apparatus.The evolution law of the uniaxial compression strength(UCS),the failure strain,and the formation of the shear band of the frozen sodium sulfate saline sandy soil were analyzed.The test results show that within the scope of this study,with the increase of salt content,both the UCS and the shear band angle initially decrease with increasing salt content before showing an increase.In contrast,the failure strain and the width of the shear band exhibit an initial increase followed by a decrease in the samples.In addition,to investigate the brittle failure characteristics of frozen sodium sulfate saline sandy soil,two classic brittleness evaluation methods were employed to quantitatively assess the brittleness level for the soil samples.The findings suggest that the failure characteristics under all test conditions in this study belong to the transition stage between brittle and ductile,indicating that frozen sodium sulfate saline sandy soil exhibits certain brittle behavior under uniaxial compression conditions,and the brittleness index basically decreases and then increases with the rise in salt content.
文摘Let a_(1),a_(2),a_(3)be nonzero integers with gcd(a_(1),a_(2),a_(3))=1,and let k be any positive integer,K=max[3,|a_(1)|,|a_(2)|,|a_(3)|,k].Suppose that l_(1),l_(2),l_(3)are integers each coprime to k.Suppose further that b is any integer satisfying some necessary congruent conditions.The solvability of linear equation a_(1)p_(1)+a_(2)p_(2)+a_(3)p_(3)=b(p_(j)=l_(j)(mod k),1≤j≤3)with prime variables pi,p_(2),ps is investigated.It is proved that if ai,a_(2),a_(3)are all positive,then the above equation is solvable whenever b≥K^(25);if a,a_(2),a_(3)are not all of the same sign,then the above equation has a solution p_(1),p_(2),p_(3)satisfying max(p_(1),p_(2),p_(3))≤3|b|+K^(25).
