The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield...The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield tunneling remains inadequate.The analytical solution for calculating the deformation of the ground and existing tunnel induced by overlapped curved shield tunneling is derived by the Mirror theory,Mindlin solution and Euler-Bernoulli-Pasternak model,subsequently validated through both finite element simulation and field monitoring.It is determined that the overcutting plays a crucial role in the ground settlement resulting from curved shield tunneling compared to straight shield tunneling.The longitudinal settlement distribution can be categorized into five areas,with the area near the tunnel surface experiencing the most dramatic settlement changes.The deformation of the existing tunnel varies most significantly with turning radius compared to tunnel clearance and grouting pressure,especially when the turning radius is less than 30 times the tunnel diameter.The tunnel crown exhibits larger displacement than the tunnel bottom,resulting in a distinctive‘vertical egg'shape.Furthermore,an optimized overcutting mode is proposed,involving precise control of the extension speed and angular velocity of the overcutting cutter,which effectively mitigates ground deformation,ensuring the protection of the existing tunnel during the construction.展开更多
In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded s...In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping sheets.At the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded sheets.In this work,the bulging process of the tailor-welded overlapping sheets was taken as the research object.Aluminum alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental verification.The results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming quality.When increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.展开更多
BACKGROUND Autoimmune liver diseases,including primary biliary cholangitis(PBC),autoi-mmune hepatitis(AIH),and their overlap syndrome(OS),involve immune-mediated liver injury,with OS occurring in 1.2%-25%of PBC patien...BACKGROUND Autoimmune liver diseases,including primary biliary cholangitis(PBC),autoi-mmune hepatitis(AIH),and their overlap syndrome(OS),involve immune-mediated liver injury,with OS occurring in 1.2%-25%of PBC patients.OS carries a higher risk of cirrhosis,hepatocellular carcinoma,and reduced survival.While its pathogenesis remains unclear,gut microbiota dysbiosis and serum metabolite alterations may play key roles.This study uses 16S rRNA sequencing and liquid chromatography-mass spec-trometry(LC-MS)metabolomics to compare gut microbiota and serum metabolites among PBC,AIH,and OS patients,and explores their associations with liver function.AIM To differentiate OS from PBC and AIH based on gut microbiota,serum metabolites,and liver function.METHODS Gut microbiota profiles were analyzed using 16S rRNA sequencing,while untargeted serum metabolomics was conducted via LC-MS.Comparative analyses were performed to identify differences in microbial composition and serum metabolite levels among PBC,AIH,and OS groups.Correlation analyses and network visualization tech-niques were applied to elucidate the interactions among liver function parameters,gut microbiota,and serum metabolites in OS patients.RESULTS Compared to patients with PBC or AIH,OS patients demonstrated significantly reduced microbial diversity and richness.Notable taxonomic shifts included decreased abundances of Firmicutes,Bacteroidetes,and Actinobacteria,alongside increased levels of Proteobacteria and Verrucomicrobia.Distinct serum metabolites,such as pentadecanoic acid and aminoimidazole carboxamide ribonucleotide,were identified in OS patients.Correlation analysis revealed that aspartate aminotransferase(AST)levels were negatively associated with the bacterial genus Fusicatenibacter and the metabolite L-Tyrosine.A microbial-metabolite network diagram further confirmed a strong association between Fusicatenibacter and L-Tyrosine in OS patients.CONCLUSION OS patients show decreased gut microbiota diversity and unique serum metabolites.Multi-omics linked AST,Fusicatenibacter,and L-Tyrosine,revealing OS mechanisms and diagnostic potential.展开更多
K-means uses the sum-of-squared error as the objective function to minimize within-cluster distances.We show that,as a consequence,it also maximizes between-cluster variances.This means that the two measures do not pr...K-means uses the sum-of-squared error as the objective function to minimize within-cluster distances.We show that,as a consequence,it also maximizes between-cluster variances.This means that the two measures do not provide complementary information and that using only one is enough.Based on this property,we propose a new objective function called cluster overlap,which is measured intuitively as the proportion of points shared between the clusters.We adopt the new function within k-means and present an algorithm called overlap k-means.It is an alternative way to design a k-means algorithm.A localized variant is also provided by limiting the overlap calculation to the neighboring points.展开更多
The transformation of natural habitats into human-modified landscapes has far-reaching consequences for species distribution and abundance.As species adapt to these changing environments,shifts in distribution pattern...The transformation of natural habitats into human-modified landscapes has far-reaching consequences for species distribution and abundance.As species adapt to these changing environments,shifts in distribution patterns,niche dynamics,and interspecies interactions may occur,impacting biodiversity at multiple levels and potentially leading to ecosystem imbalances.This study aims to assess the impact of variations in vegetation composition and human disturbance on the distribution of sympatric breeding birds and to determine the extent of niche overlap or differentiation among these species.We conducted field surveys and collected data on bird distribution,vegetation composition,and level of human disturbance in eastern Inner Mongolian grasslands.We focused on the six most frequently co-occurring breeding birds,representing a mix of sparrows,larks,and corvids.Generalized Additive Models revealed varying responses of species occurrence along habitat gradients.Species like the Eurasian Skylark(Alauda arvensis),Mongolian Lark(Melanocorypha mongolica),and Asian Shorttoed Lark(Calandrella cheleensis),increased in larger and more connected habitats,while others,like the Tree Sparrow(Passer montanus),Eurasian Magpie(Pica pica),and Barn Swallow(Hirundo rustica),adapted to more fragmented habitats.Niche analysis indicated habitat generalists tended to occupy larger niches than grassland specialists.Substantial niche overlap was also found among the six co-occurring bird species.Conservation efforts should consider the specific needs of specialist species and strive to maintain or restore critical grassland habitats.Additionally,promoting sustainable agricultural practices that balance the needs of birds and human activities can contribute to the coexistence of generalist and specialist bird species in modified landscapes.展开更多
The hybridization between oxygen 2p and transition-metal 3d states largely determines the electronic structure near the Fermi level and related functionalities of transition-metal oxides(TMOs).Considerable efforts hav...The hybridization between oxygen 2p and transition-metal 3d states largely determines the electronic structure near the Fermi level and related functionalities of transition-metal oxides(TMOs).Considerable efforts have been made to manipulate the p-d hybridization in TMOs by tailoring the spatial orbital overlap via structural engineering.Here,we demonstrate enhanced p-d hybridization in Ba^(2+)-doped LaNiO_(3)epitaxial films by simultaneously modifying both the spatial and energetic overlaps between the O-2p and Ni-3d orbitals.Combining x-ray absorption spectroscopy and firstprinciples calculations,we reveal that the enhanced hybridization stems from the synergistic effects of a reduced chargetransfer energy due to hole injection and an increased spatial orbital overlap due to straightening of Ni-O-Ni bonds.We further show that the enhanced p-d hybridization can be utilized to promote the oxygen evolution activity of LaNiO_(3).This work sheds new insights into the fine-tuning of the electronic structures of TMOs for enhanced functionalities.展开更多
Medical image analysis based on deep learning has become an important technical requirement in the field of smart healthcare.In view of the difficulties in collaborative modeling of local details and global features i...Medical image analysis based on deep learning has become an important technical requirement in the field of smart healthcare.In view of the difficulties in collaborative modeling of local details and global features in multimodal image analysis of ophthalmology,as well as the existence of information redundancy in cross-modal data fusion,this paper proposes amultimodal fusion framework based on cross-modal collaboration and weighted attention mechanism.In terms of feature extraction,the framework collaboratively extracts local fine-grained features and global structural dependencies through a parallel dual-branch architecture,overcoming the limitations of traditional single-modality models in capturing either local or global information;in terms of fusion strategy,the framework innovatively designs a cross-modal dynamic fusion strategy,combining overlappingmulti-head self-attention modules with a bidirectional feature alignment mechanism,addressing the bottlenecks of low feature interaction efficiency and excessive attention fusion computations in traditional parallel fusion,and further introduces cross-domain local integration technology,which enhances the representation ability of the lesion area through pixel-level feature recalibration and optimizes the diagnostic robustness of complex cases.Experiments show that the framework exhibits excellent feature expression and generalization performance in cross-domain scenarios of ophthalmic medical images and natural images,providing a high-precision,low-redundancy fusion paradigm for multimodal medical image analysis,and promoting the upgrade of intelligent diagnosis and treatment fromsingle-modal static analysis to dynamic decision-making.展开更多
BACKGROUND Diabetic foot ulcer(DFU)is a common and serious complication among individuals with diabetes.However,the co-occurrence of DFU with overlap syndrome,particularly involving anti-synthetase syndrome(ASS)and sy...BACKGROUND Diabetic foot ulcer(DFU)is a common and serious complication among individuals with diabetes.However,the co-occurrence of DFU with overlap syndrome,particularly involving anti-synthetase syndrome(ASS)and systemic sclerosis(SSc),is exceptionally rare.CASE SUMMARY We report a case of overlap syndrome(ASS and SSc)with diabetes manifesting as biped gangrene.The patient,a 60-year-old female,presented with painful ulcers on both heels that had persisted for nine months.She was diagnosed with DFU,which was likely attributable to SSc,suboptimal long-term glycemic control,and glucocorticoid therapy.Following four months of treatment,the patient demonstrated significant improvement and was subsequently discharged.At the oneyear follow-up,the patient developed new cyanotic ulcers on the right 4^(th) and 5^(th) toes ten months post-discharge that resolved completely within 3 months following conservative management.The four-year follow-up revealed persistent intermittent cyanosis without ulcer recurrence,although progressive interstitial lung disease necessitated prolonged bed rest.CONCLUSION SSc-related foot ulcers demonstrate favorable outcomes when managed with conventional wound care combined with vasoactive agents.展开更多
Effectively handling imbalanced datasets remains a fundamental challenge in computational modeling and machine learning,particularly when class overlap significantly deteriorates classification performance.Traditional...Effectively handling imbalanced datasets remains a fundamental challenge in computational modeling and machine learning,particularly when class overlap significantly deteriorates classification performance.Traditional oversampling methods often generate synthetic samples without considering density variations,leading to redundant or misleading instances that exacerbate class overlap in high-density regions.To address these limitations,we propose Wasserstein Generative Adversarial Network Variational Density Estimation WGAN-VDE,a computationally efficient density-aware adversarial resampling framework that enhances minority class representation while strategically reducing class overlap.The originality of WGAN-VDE lies in its density-aware sample refinement,ensuring that synthetic samples are positioned in underrepresented regions,thereby improving class distinctiveness.By applying structured feature representation,targeted sample generation,and density-based selection mechanisms strategies,the proposed framework ensures the generation of well-separated and diverse synthetic samples,improving class separability and reducing redundancy.The experimental evaluation on 20 benchmark datasets demonstrates that this approach outperforms 11 state-of-the-art rebalancing techniques,achieving superior results in F1-score,Accuracy,G-Mean,and AUC metrics.These results establish the proposed method as an effective and robust computational approach,suitable for diverse engineering and scientific applications involving imbalanced data classification and computational modeling.展开更多
To meet the intelligent detection needs of underwater defects in large hydropower stations,the hydrodynamic performance of a bionic streamlined remotely operated vehicle containing a thruster protective net structure ...To meet the intelligent detection needs of underwater defects in large hydropower stations,the hydrodynamic performance of a bionic streamlined remotely operated vehicle containing a thruster protective net structure is numerically simulated via computational fluid dynamics and overlapping mesh technology.The results show that the entity model generates greater hydrodynamic force during steady motion,whereas the square net model experiences greater force and moment during unsteady motion.The lateral and vertical force coefficients of the entity model are 4.32 and 3.13 times greater than those of the square net model in the oblique towing test simulation.The square net model also offers better static and dynamic stability,with a 24.5%increase in dynamic stability,achieving the highest lift-to-drag ratio at attack angles of 6°∼8°.This research provides valuable insights for designing and controlling underwater defect detection vehicles for large hydropower stations.展开更多
Sonic Hedgehog Medulloblastoma(SHH-MB)is one of the four primary molecular subgroups of Medulloblastoma.It is estimated to be responsible for nearly one-third of allMB cases.Using transcriptomic and DNA methylation pr...Sonic Hedgehog Medulloblastoma(SHH-MB)is one of the four primary molecular subgroups of Medulloblastoma.It is estimated to be responsible for nearly one-third of allMB cases.Using transcriptomic and DNA methylation profiling techniques,new developments in this field determined four molecular subtypes for SHH-MB.SHH-MB subtypes show distinct DNAmethylation patterns that allow their discrimination fromoverlapping subtypes and predict clinical outcomes.Class overlapping occurs when two or more classes share common features,making it difficult to distinguish them as separate.Using the DNA methylation dataset,a novel classification technique is presented to address the issue of overlapping SHH-MBsubtypes.Penalizedmultinomial regression(PMR),Tomek links(TL),and singular value decomposition(SVD)were all smoothly integrated into a single framework.SVD and group lasso improve computational efficiency,address the problem of high-dimensional datasets,and clarify class distinctions by removing redundant or irrelevant features that might lead to class overlap.As a method to eliminate the issues of decision boundary overlap and class imbalance in the classification task,TL enhances dataset balance and increases the clarity of decision boundaries through the elimination of overlapping samples.Using fivefold cross-validation,our proposed method(TL-SVDPMR)achieved a remarkable overall accuracy of almost 95%in the classification of SHH-MB molecular subtypes.The results demonstrate the strong performance of the proposed classification model among the various SHH-MB subtypes given a high average of the area under the curve(AUC)values.Additionally,the statistical significance test indicates that TL-SVDPMR is more accurate than both SVM and random forest algorithms in classifying the overlapping SHH-MB subtypes,highlighting its importance for precision medicine applications.Our findings emphasized the success of combining SVD,TL,and PMRtechniques to improve the classification performance for biomedical applications with many features and overlapping subtypes.展开更多
Recently,Jayabalan et al published an important study.The authors defined the liver outcome score as a novel biomarker for predicting liver-related mortality in patients with autoimmune hepatitis-primary biliary chola...Recently,Jayabalan et al published an important study.The authors defined the liver outcome score as a novel biomarker for predicting liver-related mortality in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome.After thoroughly reviewing their work,we offer insights that primarily relate to their study design to enhance the medical community’s understanding of this complex disease.展开更多
This letter addresses the study by Jayabalan et al,which underscores the liver outcome score(LOS)and hemoglobin(Hb)as key prognostic markers for patients with autoimmune liver disease overlap syndromes(AILDOS),with pa...This letter addresses the study by Jayabalan et al,which underscores the liver outcome score(LOS)and hemoglobin(Hb)as key prognostic markers for patients with autoimmune liver disease overlap syndromes(AILDOS),with particular relevance to the autoimmune hepatitis-primary biliary cholangitis(AIH-PBC)subgroup.The findings indicate that an LOS threshold of 6 achieves high sensitivity and specificity in predicting liver-related mortality among AIH-PBC patients.Moreover,low Hb levels emerge as a significant mortality predictor across all AILDOS cases.These results contribute valuable perspectives on risk stratification in AILDOS,highlighting the promise of non-invasive prognostic tools.Future studies with larger cohorts are needed to substantiate LOS and Hb as robust markers for clinical application.展开更多
Multi-criteria decision-making(MCDM)is essential for handling complex decision problems under uncertainty,especially in fields such as criminal justice,healthcare,and environmental management.Traditional fuzzy MCDM te...Multi-criteria decision-making(MCDM)is essential for handling complex decision problems under uncertainty,especially in fields such as criminal justice,healthcare,and environmental management.Traditional fuzzy MCDM techniques have failed to deal with problems where uncertainty or vagueness is involved.To address this issue,we propose a novel framework that integrates group and overlap functions with Aczel-Alsina(AA)operational laws in the intuitionistic fuzzy set(IFS)environment.Overlap functions capture the degree to which two inputs share common features and are used to find how closely two values or criteria match in uncertain environments,while the Group functions are used to combine different expert opinions into a single collective result.This study introduces four new aggregation operators:Group Overlap function-based intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Averaging(GOF-IFAAWA)operator,intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Geometric(GOF-IFAAWG),intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)OrderedWeighted Averaging(GOF-IFAAOWA),and intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Ordered Weighted Geometric(GOF-IFAAOWG),which are rigorously defined and mathematically analyzed and offer improved flexibility in managing overlapping,uncertain,and hesitant information.The properties of these operators are discussed in detail.Further,the effectiveness,validity,activeness,and ability to capture the uncertain information,the developed operators are applied to the AI-based Criminal Justice Policy Selection problem.At last,the comparison analysis between prior and proposed studies has been displayed,and then followed by the conclusion of the result.展开更多
The influences of strength coefficient K, work hardening exponent n and thickness t of the overlapping sheet on bulging process are analyzed based on hardening material model. Also, bulging experiments are carried out...The influences of strength coefficient K, work hardening exponent n and thickness t of the overlapping sheet on bulging process are analyzed based on hardening material model. Also, bulging experiments are carried out by taking the aluminum alloy LF21 as formed sheet metal, and selecting overlapping sheet with different thicknesses and material properties, by which accuracy of the above analysis result is verified in the aspects of geometric shape, thickness distribution and limit bulging height. The results show that higher strength coefficient K, larger work hardening exponent n and proper thickness of the overlapping sheet are helpful to improve the formability and forming uniformity of formed sheet metal.展开更多
A resolution method based on Gaussian-like distribution for overlapped linear sweep polarographic peaks was proposed to simultaneously detect the polymetallic components, such as Zn（Ⅱ） and Co（Ⅱ）, coexisting in t...A resolution method based on Gaussian-like distribution for overlapped linear sweep polarographic peaks was proposed to simultaneously detect the polymetallic components, such as Zn（Ⅱ） and Co（Ⅱ）, coexisting in the leaching solution of zinc hydrometallurgy. A Gaussian-like distribution was constructed as the sub-model of overlapped peaks by analyzing the characteristics of linear sweep polarographic curve. Then, the abscissas of each peak and trough were pinpointed through multi-resolution wavelet decomposition, the curve and its derivative curves were fitted by using nonlinear weighted least squares （NWLS）. Finally, overlapped peaks were resolved into independent sub-peaks based on fitted reconstruction parameters. The experimental results show that the relative error of half-wave potential pinpointed by multi-resolution wavelet decomposition is less than 1% and the accuracy of Ip fitted by NWLS is higher than 96%. The proposed resolution method is effective for overlapped linear sweep polarographic peaks of Zn（Ⅱ） and Co（Ⅱ）.展开更多
基金financially supported by the National Natural Science Foundation of China(Grant No.52078334)the National Key Research and Development Program of China(Grant No.2017YFC0805402)the Tianjin Research Innovation Project for Postgraduate Students(Grant No.2021YJSB141).
文摘The deformation caused by tunnel excavation is quite important for safety,especially when it is adjacent to the existing tunnel.Nevertheless,the investigation of deformation characteristics in overlapped curved shield tunneling remains inadequate.The analytical solution for calculating the deformation of the ground and existing tunnel induced by overlapped curved shield tunneling is derived by the Mirror theory,Mindlin solution and Euler-Bernoulli-Pasternak model,subsequently validated through both finite element simulation and field monitoring.It is determined that the overcutting plays a crucial role in the ground settlement resulting from curved shield tunneling compared to straight shield tunneling.The longitudinal settlement distribution can be categorized into five areas,with the area near the tunnel surface experiencing the most dramatic settlement changes.The deformation of the existing tunnel varies most significantly with turning radius compared to tunnel clearance and grouting pressure,especially when the turning radius is less than 30 times the tunnel diameter.The tunnel crown exhibits larger displacement than the tunnel bottom,resulting in a distinctive‘vertical egg'shape.Furthermore,an optimized overcutting mode is proposed,involving precise control of the extension speed and angular velocity of the overcutting cutter,which effectively mitigates ground deformation,ensuring the protection of the existing tunnel during the construction.
基金Funded by the National Natural Science Foundation of China(Nos.52075347,51575364)and the Natural Science Foundation of Liaoning Provincial(No.2022-MS-295)。
文摘In order to solve the problem of poor formability caused by different materials and properties in the process of tailor-welded sheets forming,a forming method was proposed to change the stress state of tailor-welded sheets by covering the tailor-welded sheets with better plastic properties overlapping sheets.At the same time,the interface friction effect between the overlapping and tailor-welded sheets was utilized to control the stress magnitude and further improve the formability and quality of the tailor-welded sheets.In this work,the bulging process of the tailor-welded overlapping sheets was taken as the research object.Aluminum alloy tailor-welded overlapping sheets bulging specimens were studied by a combination of finite element analysis and experimental verification.The results show that the appropriate use of interface friction between tailor-welded and overlapping sheets can improve the formability of tailor-welded sheets and control the flow of weld seam to improve the forming quality.When increasing the interface friction coefficient on the side of tailor-welded sheets with higher strength and decreasing that on the side of tailor-welded sheets with lower strength,the deformation of the tailor-welded sheets are more uniform,the offset of the weld seam is minimal,the limit bulging height is maximal,and the forming quality is optimal.
基金Supported by WBE Liver Foundation,No.WBE20220182022 Young and Middle-aged Talents Incubation Project(Youth Innovation)of Beijing Youan Hospital,Capital Medical University,No.BJYAYY-YN-2022-092023 Young and Middle-aged Talents Incubation Project(Youth Innovation)of Beijing Youan Hospital,Capital Medical University,No.BJYAYYYN2023-14.
文摘BACKGROUND Autoimmune liver diseases,including primary biliary cholangitis(PBC),autoi-mmune hepatitis(AIH),and their overlap syndrome(OS),involve immune-mediated liver injury,with OS occurring in 1.2%-25%of PBC patients.OS carries a higher risk of cirrhosis,hepatocellular carcinoma,and reduced survival.While its pathogenesis remains unclear,gut microbiota dysbiosis and serum metabolite alterations may play key roles.This study uses 16S rRNA sequencing and liquid chromatography-mass spec-trometry(LC-MS)metabolomics to compare gut microbiota and serum metabolites among PBC,AIH,and OS patients,and explores their associations with liver function.AIM To differentiate OS from PBC and AIH based on gut microbiota,serum metabolites,and liver function.METHODS Gut microbiota profiles were analyzed using 16S rRNA sequencing,while untargeted serum metabolomics was conducted via LC-MS.Comparative analyses were performed to identify differences in microbial composition and serum metabolite levels among PBC,AIH,and OS groups.Correlation analyses and network visualization tech-niques were applied to elucidate the interactions among liver function parameters,gut microbiota,and serum metabolites in OS patients.RESULTS Compared to patients with PBC or AIH,OS patients demonstrated significantly reduced microbial diversity and richness.Notable taxonomic shifts included decreased abundances of Firmicutes,Bacteroidetes,and Actinobacteria,alongside increased levels of Proteobacteria and Verrucomicrobia.Distinct serum metabolites,such as pentadecanoic acid and aminoimidazole carboxamide ribonucleotide,were identified in OS patients.Correlation analysis revealed that aspartate aminotransferase(AST)levels were negatively associated with the bacterial genus Fusicatenibacter and the metabolite L-Tyrosine.A microbial-metabolite network diagram further confirmed a strong association between Fusicatenibacter and L-Tyrosine in OS patients.CONCLUSION OS patients show decreased gut microbiota diversity and unique serum metabolites.Multi-omics linked AST,Fusicatenibacter,and L-Tyrosine,revealing OS mechanisms and diagnostic potential.
文摘K-means uses the sum-of-squared error as the objective function to minimize within-cluster distances.We show that,as a consequence,it also maximizes between-cluster variances.This means that the two measures do not provide complementary information and that using only one is enough.Based on this property,we propose a new objective function called cluster overlap,which is measured intuitively as the proportion of points shared between the clusters.We adopt the new function within k-means and present an algorithm called overlap k-means.It is an alternative way to design a k-means algorithm.A localized variant is also provided by limiting the overlap calculation to the neighboring points.
基金supported by the National Natural Science Foundation of China (No.32201304)the Fundamental Research Funds for the Central Universities (No.2412022QD026)。
文摘The transformation of natural habitats into human-modified landscapes has far-reaching consequences for species distribution and abundance.As species adapt to these changing environments,shifts in distribution patterns,niche dynamics,and interspecies interactions may occur,impacting biodiversity at multiple levels and potentially leading to ecosystem imbalances.This study aims to assess the impact of variations in vegetation composition and human disturbance on the distribution of sympatric breeding birds and to determine the extent of niche overlap or differentiation among these species.We conducted field surveys and collected data on bird distribution,vegetation composition,and level of human disturbance in eastern Inner Mongolian grasslands.We focused on the six most frequently co-occurring breeding birds,representing a mix of sparrows,larks,and corvids.Generalized Additive Models revealed varying responses of species occurrence along habitat gradients.Species like the Eurasian Skylark(Alauda arvensis),Mongolian Lark(Melanocorypha mongolica),and Asian Shorttoed Lark(Calandrella cheleensis),increased in larger and more connected habitats,while others,like the Tree Sparrow(Passer montanus),Eurasian Magpie(Pica pica),and Barn Swallow(Hirundo rustica),adapted to more fragmented habitats.Niche analysis indicated habitat generalists tended to occupy larger niches than grassland specialists.Substantial niche overlap was also found among the six co-occurring bird species.Conservation efforts should consider the specific needs of specialist species and strive to maintain or restore critical grassland habitats.Additionally,promoting sustainable agricultural practices that balance the needs of birds and human activities can contribute to the coexistence of generalist and specialist bird species in modified landscapes.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1402902)the National Natural Science Foundation of China(Grant Nos.12374179,12074119,12374145,051B22001,12104157,12134003,and 12304218)the Shanghai Pujiang Program(Grant No.23PJ1402200).
文摘The hybridization between oxygen 2p and transition-metal 3d states largely determines the electronic structure near the Fermi level and related functionalities of transition-metal oxides(TMOs).Considerable efforts have been made to manipulate the p-d hybridization in TMOs by tailoring the spatial orbital overlap via structural engineering.Here,we demonstrate enhanced p-d hybridization in Ba^(2+)-doped LaNiO_(3)epitaxial films by simultaneously modifying both the spatial and energetic overlaps between the O-2p and Ni-3d orbitals.Combining x-ray absorption spectroscopy and firstprinciples calculations,we reveal that the enhanced hybridization stems from the synergistic effects of a reduced chargetransfer energy due to hole injection and an increased spatial orbital overlap due to straightening of Ni-O-Ni bonds.We further show that the enhanced p-d hybridization can be utilized to promote the oxygen evolution activity of LaNiO_(3).This work sheds new insights into the fine-tuning of the electronic structures of TMOs for enhanced functionalities.
基金funded by the Ongoing Research Funding Program(ORF-2025-102),King Saud University,Riyadh,Saudi Arabiaby the Science and Technology Research Programof Chongqing Municipal Education Commission(Grant No.KJQN202400813)by the Graduate Research Innovation Project(Grant Nos.yjscxx2025-269-193 and CYS25618).
文摘Medical image analysis based on deep learning has become an important technical requirement in the field of smart healthcare.In view of the difficulties in collaborative modeling of local details and global features in multimodal image analysis of ophthalmology,as well as the existence of information redundancy in cross-modal data fusion,this paper proposes amultimodal fusion framework based on cross-modal collaboration and weighted attention mechanism.In terms of feature extraction,the framework collaboratively extracts local fine-grained features and global structural dependencies through a parallel dual-branch architecture,overcoming the limitations of traditional single-modality models in capturing either local or global information;in terms of fusion strategy,the framework innovatively designs a cross-modal dynamic fusion strategy,combining overlappingmulti-head self-attention modules with a bidirectional feature alignment mechanism,addressing the bottlenecks of low feature interaction efficiency and excessive attention fusion computations in traditional parallel fusion,and further introduces cross-domain local integration technology,which enhances the representation ability of the lesion area through pixel-level feature recalibration and optimizes the diagnostic robustness of complex cases.Experiments show that the framework exhibits excellent feature expression and generalization performance in cross-domain scenarios of ophthalmic medical images and natural images,providing a high-precision,low-redundancy fusion paradigm for multimodal medical image analysis,and promoting the upgrade of intelligent diagnosis and treatment fromsingle-modal static analysis to dynamic decision-making.
基金Supported by the 1.3.5 Project for Excellence,West China Hospital of Sichuan University,No.ZYGD240051.3.5 Project of Center for High Altitude Medicine,West China Hospital,Sichuan University,No.GYYX24002+2 种基金Sichuan Science and Technology Program,No.2024YFFK0290Health Commission of Sichuan Province,No.23 LCYJ042Science and Technology Department of Sichuan Province,No.2025ZNSFSC1621.
文摘BACKGROUND Diabetic foot ulcer(DFU)is a common and serious complication among individuals with diabetes.However,the co-occurrence of DFU with overlap syndrome,particularly involving anti-synthetase syndrome(ASS)and systemic sclerosis(SSc),is exceptionally rare.CASE SUMMARY We report a case of overlap syndrome(ASS and SSc)with diabetes manifesting as biped gangrene.The patient,a 60-year-old female,presented with painful ulcers on both heels that had persisted for nine months.She was diagnosed with DFU,which was likely attributable to SSc,suboptimal long-term glycemic control,and glucocorticoid therapy.Following four months of treatment,the patient demonstrated significant improvement and was subsequently discharged.At the oneyear follow-up,the patient developed new cyanotic ulcers on the right 4^(th) and 5^(th) toes ten months post-discharge that resolved completely within 3 months following conservative management.The four-year follow-up revealed persistent intermittent cyanosis without ulcer recurrence,although progressive interstitial lung disease necessitated prolonged bed rest.CONCLUSION SSc-related foot ulcers demonstrate favorable outcomes when managed with conventional wound care combined with vasoactive agents.
基金supported by Ongoing Research Funding Program(ORF-2025-488)King Saud University,Riyadh,Saudi Arabia.
文摘Effectively handling imbalanced datasets remains a fundamental challenge in computational modeling and machine learning,particularly when class overlap significantly deteriorates classification performance.Traditional oversampling methods often generate synthetic samples without considering density variations,leading to redundant or misleading instances that exacerbate class overlap in high-density regions.To address these limitations,we propose Wasserstein Generative Adversarial Network Variational Density Estimation WGAN-VDE,a computationally efficient density-aware adversarial resampling framework that enhances minority class representation while strategically reducing class overlap.The originality of WGAN-VDE lies in its density-aware sample refinement,ensuring that synthetic samples are positioned in underrepresented regions,thereby improving class distinctiveness.By applying structured feature representation,targeted sample generation,and density-based selection mechanisms strategies,the proposed framework ensures the generation of well-separated and diverse synthetic samples,improving class separability and reducing redundancy.The experimental evaluation on 20 benchmark datasets demonstrates that this approach outperforms 11 state-of-the-art rebalancing techniques,achieving superior results in F1-score,Accuracy,G-Mean,and AUC metrics.These results establish the proposed method as an effective and robust computational approach,suitable for diverse engineering and scientific applications involving imbalanced data classification and computational modeling.
基金supported by the National Key R&D Program of China(Grant No.2022YFB4703401).
文摘To meet the intelligent detection needs of underwater defects in large hydropower stations,the hydrodynamic performance of a bionic streamlined remotely operated vehicle containing a thruster protective net structure is numerically simulated via computational fluid dynamics and overlapping mesh technology.The results show that the entity model generates greater hydrodynamic force during steady motion,whereas the square net model experiences greater force and moment during unsteady motion.The lateral and vertical force coefficients of the entity model are 4.32 and 3.13 times greater than those of the square net model in the oblique towing test simulation.The square net model also offers better static and dynamic stability,with a 24.5%increase in dynamic stability,achieving the highest lift-to-drag ratio at attack angles of 6°∼8°.This research provides valuable insights for designing and controlling underwater defect detection vehicles for large hydropower stations.
基金funded by the Deanship of Graduate Studies and Scientific Research at Jouf University under grant No.(DGSSR-2024-02-01137).
文摘Sonic Hedgehog Medulloblastoma(SHH-MB)is one of the four primary molecular subgroups of Medulloblastoma.It is estimated to be responsible for nearly one-third of allMB cases.Using transcriptomic and DNA methylation profiling techniques,new developments in this field determined four molecular subtypes for SHH-MB.SHH-MB subtypes show distinct DNAmethylation patterns that allow their discrimination fromoverlapping subtypes and predict clinical outcomes.Class overlapping occurs when two or more classes share common features,making it difficult to distinguish them as separate.Using the DNA methylation dataset,a novel classification technique is presented to address the issue of overlapping SHH-MBsubtypes.Penalizedmultinomial regression(PMR),Tomek links(TL),and singular value decomposition(SVD)were all smoothly integrated into a single framework.SVD and group lasso improve computational efficiency,address the problem of high-dimensional datasets,and clarify class distinctions by removing redundant or irrelevant features that might lead to class overlap.As a method to eliminate the issues of decision boundary overlap and class imbalance in the classification task,TL enhances dataset balance and increases the clarity of decision boundaries through the elimination of overlapping samples.Using fivefold cross-validation,our proposed method(TL-SVDPMR)achieved a remarkable overall accuracy of almost 95%in the classification of SHH-MB molecular subtypes.The results demonstrate the strong performance of the proposed classification model among the various SHH-MB subtypes given a high average of the area under the curve(AUC)values.Additionally,the statistical significance test indicates that TL-SVDPMR is more accurate than both SVM and random forest algorithms in classifying the overlapping SHH-MB subtypes,highlighting its importance for precision medicine applications.Our findings emphasized the success of combining SVD,TL,and PMRtechniques to improve the classification performance for biomedical applications with many features and overlapping subtypes.
基金Supported by The Key Research and Development Project of the Science and Technology Department of Sichuan Province,China,No.2023YFS0280The High-Level Research Initiation Fund of The First Affiliated Hospital of Chengdu Medical College,China,No.CYFY-GQ43.
文摘Recently,Jayabalan et al published an important study.The authors defined the liver outcome score as a novel biomarker for predicting liver-related mortality in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome.After thoroughly reviewing their work,we offer insights that primarily relate to their study design to enhance the medical community’s understanding of this complex disease.
文摘This letter addresses the study by Jayabalan et al,which underscores the liver outcome score(LOS)and hemoglobin(Hb)as key prognostic markers for patients with autoimmune liver disease overlap syndromes(AILDOS),with particular relevance to the autoimmune hepatitis-primary biliary cholangitis(AIH-PBC)subgroup.The findings indicate that an LOS threshold of 6 achieves high sensitivity and specificity in predicting liver-related mortality among AIH-PBC patients.Moreover,low Hb levels emerge as a significant mortality predictor across all AILDOS cases.These results contribute valuable perspectives on risk stratification in AILDOS,highlighting the promise of non-invasive prognostic tools.Future studies with larger cohorts are needed to substantiate LOS and Hb as robust markers for clinical application.
基金supported by“1 Decembrie 1918”University of Alba Iulia,510009 Alba Iuliasupported in part by the HEC-NRPU project,under the grant No.14566.
文摘Multi-criteria decision-making(MCDM)is essential for handling complex decision problems under uncertainty,especially in fields such as criminal justice,healthcare,and environmental management.Traditional fuzzy MCDM techniques have failed to deal with problems where uncertainty or vagueness is involved.To address this issue,we propose a novel framework that integrates group and overlap functions with Aczel-Alsina(AA)operational laws in the intuitionistic fuzzy set(IFS)environment.Overlap functions capture the degree to which two inputs share common features and are used to find how closely two values or criteria match in uncertain environments,while the Group functions are used to combine different expert opinions into a single collective result.This study introduces four new aggregation operators:Group Overlap function-based intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Averaging(GOF-IFAAWA)operator,intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Weighted Geometric(GOF-IFAAWG),intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)OrderedWeighted Averaging(GOF-IFAAOWA),and intuitionistic fuzzy Aczel-Alsina(GOF-IFAA)Ordered Weighted Geometric(GOF-IFAAOWG),which are rigorously defined and mathematically analyzed and offer improved flexibility in managing overlapping,uncertain,and hesitant information.The properties of these operators are discussed in detail.Further,the effectiveness,validity,activeness,and ability to capture the uncertain information,the developed operators are applied to the AI-based Criminal Justice Policy Selection problem.At last,the comparison analysis between prior and proposed studies has been displayed,and then followed by the conclusion of the result.
基金Project(51205260)supported by the National Natural Science Foundation of ChinaProject(L2012046)supported by the Liaoning Provincial Committee of Education,China
文摘The influences of strength coefficient K, work hardening exponent n and thickness t of the overlapping sheet on bulging process are analyzed based on hardening material model. Also, bulging experiments are carried out by taking the aluminum alloy LF21 as formed sheet metal, and selecting overlapping sheet with different thicknesses and material properties, by which accuracy of the above analysis result is verified in the aspects of geometric shape, thickness distribution and limit bulging height. The results show that higher strength coefficient K, larger work hardening exponent n and proper thickness of the overlapping sheet are helpful to improve the formability and forming uniformity of formed sheet metal.
基金Project(2012BAF03B05)supported by the National Key Technology R&D Program of ChinaProject(61025015)supported by the National Natural Science Foundation for Distinguished Young Scholars of China+1 种基金Project(61273185)supported by the National Natural Science Foundation of ChinaProject(2012CK4018)supported by the Science and Technology Project of Hunan Province,China
文摘A resolution method based on Gaussian-like distribution for overlapped linear sweep polarographic peaks was proposed to simultaneously detect the polymetallic components, such as Zn（Ⅱ） and Co（Ⅱ）, coexisting in the leaching solution of zinc hydrometallurgy. A Gaussian-like distribution was constructed as the sub-model of overlapped peaks by analyzing the characteristics of linear sweep polarographic curve. Then, the abscissas of each peak and trough were pinpointed through multi-resolution wavelet decomposition, the curve and its derivative curves were fitted by using nonlinear weighted least squares （NWLS）. Finally, overlapped peaks were resolved into independent sub-peaks based on fitted reconstruction parameters. The experimental results show that the relative error of half-wave potential pinpointed by multi-resolution wavelet decomposition is less than 1% and the accuracy of Ip fitted by NWLS is higher than 96%. The proposed resolution method is effective for overlapped linear sweep polarographic peaks of Zn（Ⅱ） and Co（Ⅱ）.
