This study develops a surrogate super-resolution(SR)framework that accelerates finite element method(FEM)-based computational fluid dynamics(CFD)using deep learning.High-resolution(HR)FEM-based CFDremains computationa...This study develops a surrogate super-resolution(SR)framework that accelerates finite element method(FEM)-based computational fluid dynamics(CFD)using deep learning.High-resolution(HR)FEM-based CFDremains computationally prohibitive for time-sensitive applications,including patient-specific aneurysm hemodynamics where rapid turnaround is valuable.The proposed pipeline learns to reconstruct HR velocity-magnitude fields fromlow-resolution(LR)FEM solutions generated under the same governing equations and boundary conditions.It consistsof three modules:(i)offline pre-training of a residual network on representative vascular geometries;(ii)lightweightfine-tuning to adapt the pretrained model to geometric variability,including patient-specific aneurysm morphologies;and(iii)an unstructured-to-structured sampling strategy with region-of-interest upsampling that concentrates resolution in flow-critical zones(e.g.,the aneurysm sac)rather than the full domain.This targeted reconstruction substantiallyreduces inference and post-processing cost while preserving key HR flow features.Experiments on cerebral aneurysmmodels show that HR velocity-magnitude fields can be recovered with accuracy comparable to direct HR simulationsat less than 1%of the direct HR simulation cost per analysis(LR simulation and SR inference),while adaptation to newgeometries requires only lightweight fine-tuning with limited target-specific HR data.While clinical endpoints andadditional variables(e.g.,pressure or wall-based metrics)are left for future work,the results indicate that the proposedsurrogate SR approach can streamline FEM-based CFD workflows toward near real-time hemodynamic analysis acrossmorphologically similar vascular models.展开更多
Objective:This study presents a mathematical model and finite element simulations to investigate interstitial fluid flow and nanodrug transport in a solid tumor,incorporating transvascular exchange,convection–diffus...Objective:This study presents a mathematical model and finite element simulations to investigate interstitial fluid flow and nanodrug transport in a solid tumor,incorporating transvascular exchange,convection–diffusion–reaction dynamics,and intratumoral injection mechanisms.Impact Statement:Optimizing nanodrug distribution remains a critical challenge in cancer therapy.The proposed model advances nanomedicine by enhancing the mechanistic understanding of nanodrug transport in a solid tumor.Introduction:Cancer,a global threat,often manifests as solid tumors driven by uncontrolled cell growth.The heterogeneous microenvironment,lymphatic drainage,nano-bio interactions,and elevated interstitial fluid pressure(IFP)hinder effective nanodrug delivery.Nanoparticle(NP)-based drug delivery systems offer a promising solution,with FES providing an effective approach to model and simulate the complex delivery process.Methods:The model considered a spherical and symmetrical tumor architecture comprising a central necrosis region,viable tumor,and surrounding healthy tissue with functional lymphatic dynamics.Substantial nanodrug carriers(dextran,liposomal,polyethylene glycol(PEG)-coated gold,and magnetic)and conventional doxorubicin are evaluated in the tumor.The governing fluid flow and solute transport equation along with the specified boundary conditions are solved using the finite element method through the Galerkin approach.Results:Simulations show that IFP peaks in the necrotic core and sharply declines at the viable–healthy tissue interface.Both fluid pressure and velocity are sensitive when fluid flow resistance drops below 5.Necrotic core size influences IFP,and critical necrotic radius(R_(CN))marks pressure stabilization and defines the threshold for effective nanodrug delivery.Vascular normalization and functional lymphatic dynamics show marginal impact.Smaller NPs(~10 nm)diffuse faster but undergo rapid degradation,while larger particles(>30 nm)exhibit prolonged retention at the injection site.Liposomal,PEG-coated gold,and magnetic variants demonstrate superior therapeutic action compared to conventional doxorubicin.Conclusion:The findings of the study highlight its strong potential for optimizing nanodrug delivery and design,as well as hyperthermia treatment,enhancing personalized cancer therapy.展开更多
The Sichuan-Yunnan region,located at the southeastern margin of the Qinghai-Xizang Plateau,serves as a key channel for the southeastward extrusion of plateau material.The characteristics of crustal deformation and the...The Sichuan-Yunnan region,located at the southeastern margin of the Qinghai-Xizang Plateau,serves as a key channel for the southeastward extrusion of plateau material.The characteristics of crustal deformation and the mechanisms of deep material flow have been central topics of interest in geoscience research.In this work,a three-dimensional viscoelastic-plastic finite element model including the upper and mid-lower crust was established,constrained by GNSS horizontal crustal velocity observations and incorporating maj or active faults and geophysical survey data to explore the contribution of mid-lower crustal flow to surface deformation and its coupling with faults.Comparison of modeling experiments shows that relying solely on boundary loading or uniform layering assumptions fails to reproduce the GNSS observed velocities.We introduce a mid-lower crustal low-velocity weak zone,derived from the latest seismic velocity structure models.The new model improves the fit to GNSS observations.Tests of different viscosity coefficients in the low-velocity zone indicate an optimal viscosity range of 7.5×10^(19)-1×10^(20)Pa·s.Vertical profiles reveal that mid-lower crustal material motion is mainly concentrated at depths of 20-40 km,forming localized channelized flow in low-velocity zone with a typical Poiseuille velocity profile which indicates a ductile,fluid-like behavior with the lowvelocity zone serving as primary pathways for deep material transport.The results further show that under the geometric constraints of upper-crustal faults,the mid-lower crustal flow contributes approximately 1-3 mm/a to surface deformation,primarily concentrated along major faults.This indicates that faults play a key role in constraining and modulating the transmission of deep-seated dynamics to shallow surface deformation.However,the contribution of mid-lower crustal flow is also significant;neglecting its influence on surface deformation would lead to an incomplete understanding of the deformation pattern and bias the interpretation of block boundaries and crustal kinematic segmentation.展开更多
This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SE...This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SEM),which is used to simulate low-frequency ground motion(f<1 Hz)by incorporating an innovative efficient discontinuous Galerkin(DG)method for grid division to accurately model basin sedimentary layers at reduced costs.It also introduces a comprehensive hybrid source model for high-frequency random scattering and a nonlinear analysis module for basin sedimentary layers.Deterministic outcomes are combined with modified three-dimensional stochastic finite fault method(3D-EXSIM)simulations of high-frequency ground motion(f>1 Hz).A fourth-order Butterworth filter with zero phase shift is employed for time-domain filtering of low-and high-frequency time series at a crossover frequency of 1 Hz,merging the low and high-frequency ground motions into a broadband time series.Taking an Ms 6.8 Luding earthquake,as an example,this hybrid method was used for a rapid and efficient simulation analysis of broadband ground motion in the region.The accuracy and efficiency of this hybrid method were verified through comparisons with actually observed station data and empirical attenuation curves.Deterministic method simulation results revealed the effects of mountainous topography,basin effects,nonlinear effects within the basin’s sedimentary layers,and a coupling interaction between the basin and the mountains.The findings are consistent with similar studies,showing that near-fault sedimentary basins significantly focus and amplify strong ground motion,and the soil’s nonlinear behavior in the basin influences ground motion to varying extents at different distances from the fault.The mountainous topography impacts the basin’s response to ground motion,leading to barrier effects.This research provides a scientific foundation for seismic zoning,urban planning,and seismic design in nearfault mountain basin regions.展开更多
Two full 3D steady mathematical models are developed by finite element method （FEM） to calcalate coupled physics fields. the electro-magnetic model is built and solved first and so is the fluid motion model with the...Two full 3D steady mathematical models are developed by finite element method （FEM） to calcalate coupled physics fields. the electro-magnetic model is built and solved first and so is the fluid motion model with the acquired electromagnetic force as source body forces in Navier-Stokes equations. Effects caused by the ferromagnetic shell, busbar system around, and open boundary problem as well as inside induced current were considered in terms of the magnetic field. Furthermore, a new modeling method is found to set up solid models and then mesh them entirely with so-called structuralized grids, namely hex-mesh. Examples of 75kA prebaked cell with two kinds of busbar arrangements are presented. Results agree with those disclosed in the literature and confirm that the coupled simulation is valid. It is also concluded that the usage of these models facilitates the consistent analysis of the electric field to magnetic field and then flow motion to the greater extent, local distributions of current density and magnetic flux density are very much dependent on the cell structure, the steel shell is a shield to reduce the magnetic field and flow pattern is two dimensional in the main body of the metal pad.展开更多
Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have be...Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied to the correction of deformities, providing the recovering force-displacement and angle-moment curves that characterize the mechanical behavior of the splint in the overall range of movement.展开更多
The evolution of microstructure in the drawing process of commercially pure aluminum wire （CPAW） does not only depend on the nature of materials, but also on the stress profile. In this study, the effect of stress p...The evolution of microstructure in the drawing process of commercially pure aluminum wire （CPAW） does not only depend on the nature of materials, but also on the stress profile. In this study, the effect of stress profile on the texture evolution of the CPAW was systematically investigated by combining the numerical simulation and the microstructure observation. The results show that the tensile stress at the wire center promotes the formation of 〈111〉 texture, whereas the shear stress nearby the rim makes little contribution to the texture formation. Therefore, the 〈111 〉 texture at the wire center is stronger than that in the surface layer, which also results in a higher microhardness at the center of the CPAW under axial loading.2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.展开更多
A thermo-mechanical coupling.finite element model was built to investigate the inertia friction welding of GH4169 bars. The remeshing and map solution techniques were adopted. Ttle whole welding process was investigat...A thermo-mechanical coupling.finite element model was built to investigate the inertia friction welding of GH4169 bars. The remeshing and map solution techniques were adopted. Ttle whole welding process was investigated by adopting an innovative heat generation model and the flywheel rotational speed measured via the experiment. The simulated evolution of axial shortening shows a good agreement with the experiment. In addition, extensive .strain concentration presents in the interface and flash, and the largest ,strain exists near the flash root. Moreover, an intere.sting thermal reflux phenomenon during the cooling stage was found.展开更多
To investigate the effects of billet geometry on the cold precision forging process of a helical gear, six different billet geometries were designed utilizing the relief-hole principle. And the influences of the bille...To investigate the effects of billet geometry on the cold precision forging process of a helical gear, six different billet geometries were designed utilizing the relief-hole principle. And the influences of the billet geometry on the forming load and the deformation uniformity were analyzed by three-dimensional （3D） finite element method （FEM） under the commercial software DEFORM 3D. The billet geometry was optimized to meet lower forming load and better deformation uniformity requirement. Deformation mechanism was studied through the distribution of flow velocity field and effective strain field. The forging experiments of the helical gear were successfully performed using lead material as a model material under the same process conditions used in the FE simulations. The results show that the forming load decreases as the diameter of relief-hole do increases, but the effect of do on the deformation uniformity is very complicated. The forming load is lower and the deformation is more uniform when do is 10 mm.展开更多
During the process of finite element simulation of precision warm forging, the selection of friction models has a direct effect on the precision accuracy of finite element simulation results. Among all the factors whi...During the process of finite element simulation of precision warm forging, the selection of friction models has a direct effect on the precision accuracy of finite element simulation results. Among all the factors which influence the selection of friction models, the distribution rule of normal stress at the tool-workpiece interface is a key one. To find out the distribution rule of normal stress at the tool-workpiece interface, this paper has made a systematic research on three typical plastic deformation processes: forward extrusion, backward extrusion, and lateral extrusion by a method of finite element simulation. Then on the base of synthesizing and correcting traditional friction models, a new general friction model which is fit for warm extrusion is developed at last.展开更多
Based on CT scanning pictures from a volunteer＇s knee joint, a three-dimensional finite element model of the healthy human knee joint is constructed including complete femur, tibia, fibular, patellar and the main car...Based on CT scanning pictures from a volunteer＇s knee joint, a three-dimensional finite element model of the healthy human knee joint is constructed including complete femur, tibia, fibular, patellar and the main cartilage and ligaments. This model was validated using experimental and numerical results obtained from other authors. The pressure distribution of contact surfaces of knee joint are calculated and analyzed under the load action of ‘heel strike＇, ‘single limb stance＇ and ‘toe-off＇. The results of the gait cycle are that the contact areas of medial cartilage are larger than that of lateral cartilage; the contact force and contact areas would grow larger with the load increasing; the pressure of lateral meniscus is steady, relative to the significant variation of peak pressure in medial meniscus; and the peak value of contact pressure on all components are usually found at about 4570 of the gait cycle.展开更多
Single-point incremental forming （SPIF） is an innovational sheet metal forming method without dedicated dies, which belongs to rapid prototyping technology. In generalizing the SPIF of sheet metal, the deformation a...Single-point incremental forming （SPIF） is an innovational sheet metal forming method without dedicated dies, which belongs to rapid prototyping technology. In generalizing the SPIF of sheet metal, the deformation analysis on forming process becomes an important and useful method for the planning of shell products, the choice of material, the design of the forming process and the planning of the forming tool. Using solid brick elements, the finite element method（FEM） model of truncated pyramid was established. Based on the theory of anisotropy and assumed strain formulation, the SPIF processes with different parameters were simulated. The resulted comparison between the simulations and the experiments shows that the FEM model is feasible and effective. Then, according to the simulated forming process, the deformation pattern of SPIF can be summarized as the combination of plane-stretching deformation and bending deformation. And the study about the process parameters＇ impact on deformation shows that the process parameter of interlayer spacing is a dominant factor on the deformation. Decreasing interlayer spacing, the strain of one step decreases and the formability of blank will be improved. With bigger interlayer spacing, the plastic deformation zone increases and the forming force will be bigger.展开更多
To study the hot deformation behavior of Mg-8.3 Gd-4.4 Y-1.5 Zn-0.8 Mn(wt%) alloy,hot compression tests were conducted using a Gleeble-3500 thermal simulator at temperatures ranging from 653 to773 K,true strain rates ...To study the hot deformation behavior of Mg-8.3 Gd-4.4 Y-1.5 Zn-0.8 Mn(wt%) alloy,hot compression tests were conducted using a Gleeble-3500 thermal simulator at temperatures ranging from 653 to773 K,true strain rates of 0.001-1 s^(-1),and a deformation degree of 60%.Results of hot compression experiments show that the flow stress of the alloy increases with the strain rate.The true stress-true strain curves are corrected by correcting the effect of temperature rise in the deformation process.Activation energy,Q,equal to 287380 J/mol and material constant,n,equal to 4.59 were calculated by fitting the true stress-true strain curves.Then,the constitutive equation was established and verified via finite element simulation.Results of the hot processing map show that the probability of material instability increases with the degree of deformation,which indicates that the material is not suitable for large deformation in a single pass.On the whole,the alloy is appropriate for multipass processing with small deformation and a suitable processing temperature and strain rate are 733 K and 0.01 s-1,respectively.展开更多
Isothermal hot compression experiments were conducted on homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy to investigate hot deformation behavior at the temperature range of 673-773 K and the strain rate range of 0.001-1 s...Isothermal hot compression experiments were conducted on homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy to investigate hot deformation behavior at the temperature range of 673-773 K and the strain rate range of 0.001-1 s^(-1)by using a Gleeble-1500D thermo mechanical simulator.Metallographic characterization on samples deformed to true strain of 0.70 illustrates the occurrence of flow localization and/or microcrack at deformation conditions of 673 K/0.01 s^(-1),673 K/1 s^(-1)and 698 K/1 s^(-1),indicating that these three deformation conditions should be excluded during hot working of homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy.Based on the measured true stress-strain data,the strain-compensated Arrhenius constitutive model was constructed and then incorporated into UHARD subroutine of ABAQUS software to study hot deformation process of homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy.By comparison with measured force-displacement curves,the predicted results can describe well the rheological behavior of homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy,verifying the validity of finite element simulation of hot compression process with this complicated constitutive model.Numerical results demonstrate that the distribution of values of material parameters(α,n,Q and ln A)within deformed sample is inhomogeneous.This issue is directly correlated to the uneven distribution of equivalent plastic strain due to the friction effect.Moreover,at a given temperature the increase of strain rate would result in the decrease of equivalent plastic strain within the central region of deformed sample,which hinders the occurrence of dynamic recrystallization(DRX).展开更多
Materials with the same elastic modulus E and representative stress and strain （σr,εr） present similar indentation-loading curves, whatever the value of strain hardening exponent n. Based on this definition, a goo...Materials with the same elastic modulus E and representative stress and strain （σr,εr） present similar indentation-loading curves, whatever the value of strain hardening exponent n. Based on this definition, a good approach was proposed to extract the plastic properties or constitutive equations of metals from nanoindentation test combining finite element simulation. Firstly, without consideration of strain hardening, the representative stress was determined by varying assumed representative stress over a wide range until a good agreement was reached between the computed and experimental loading curves. Similarly, the corresponding representative strain was determined with different hypothetical values of strain hardening exponent in the range of 0-0.6. Through modulating assumed strain hardening exponent values to make the computed unloading curve coincide with that of the experiment, the real strain hardening exponent was acquired. Once the strain hardening exponent was determined, the initial yield stress ay of metals could be obtained by the power law constitution. The validity of the proposed methodology was verified by three real metals： AISI 304 steel, Fe andA1 alloy.展开更多
Being aimed at the ground subsidence due to underground coal mining,a numerical model of rock was established and an appropriate method of numerical simulation was put forward.Using the measured subsidence data on the...Being aimed at the ground subsidence due to underground coal mining,a numerical model of rock was established and an appropriate method of numerical simulation was put forward.Using the measured subsidence data on the ground,the equivalent mechanical parameters of the rock stratums can be back-calculated by the properly treatment of coal excavation area,then the ground subsidence of other coal mining area can be predicted by FFM.It provided reference for the treatment of the buildings on the ground of this colliery.展开更多
In the process of thin-wall parts assembly for an antenna,the parts assembly deformation deviation is occurring due to the riveting assembly.In view of the riveting assembly deformation problems,it can be analyzed thr...In the process of thin-wall parts assembly for an antenna,the parts assembly deformation deviation is occurring due to the riveting assembly.In view of the riveting assembly deformation problems,it can be analyzed through transient and static simulation.In this work,the theoretical deformation model for riveting assembly is established with round head rivet.The simulation analysis for riveting deformation is carried out with the riveting assembly piece including four rivets,which comparing with the measuring points experiment results of riveting test piece through dealing with the experimental data using the point coordinate transform method and the space line fitting method.Simultaneously,the deformation deviation of the overall thin-wall parts assembly structure is analyzed through finite element simulation;and its results are verified by the measuring experiment for riveting assembly with the deformation deviation of some key points on the thin-wall parts.Through the comparison analysis,it is shown that the simulation results agree well with the experimental results,which proves the correctness and effectiveness of the theoretical analysis,simulation results and the given experiment data processing method.Through the study on the riveting assembly for thin-wall parts,it will provide a theoretical foundation for improving thin-wall parts assembly quality of large antenna in future.展开更多
The rotary forging process of a disc is simulated by 3-D finite element method.The motion of the rotary the is described as the combination of a revolution round the machine axis and a spin round the rotary die axis...The rotary forging process of a disc is simulated by 3-D finite element method.The motion of the rotary the is described as the combination of a revolution round the machine axis and a spin round the rotary die axis. Therefore, the workpiece can be loaded and unloaded partly and cyclically by the cone surface of the rotary the continuously, according with the practical rotary forging process. From the siumulation rasults, the causes of center-thinning during rotary forging of discs are that the locally loading of rotary die made the workpiece center get high radial and tangential tensile stresses, and then the shortening in axial direction and the elongating in tangential and radial direction occur continuous- ly.展开更多
A rate dependent crystal plasticity constitutive model considering self and latent hardening in finite element analysis was developed to simulate rolling textures of pure aluminum. By changing the assignment of orient...A rate dependent crystal plasticity constitutive model considering self and latent hardening in finite element analysis was developed to simulate rolling textures of pure aluminum. By changing the assignment of orientations to finite elements, i.e. assigning the same set of orientations to all elements or different orientations to different elements, the influences of grain interaction on the formation of rolling textures were numerically simulated with this kind of crystal plasticity finite element model. The simulation results reveal that the grains without considering grain interaction rotate faster than those considering grain interaction, and the rotation of grain boundary is slowed down due to the grain interaction. For a good simulation more elements should be assigned to one grain, in which the effects of both the boundary and interior parts of grain contribute to the formation of rolling textures.展开更多
文摘This study develops a surrogate super-resolution(SR)framework that accelerates finite element method(FEM)-based computational fluid dynamics(CFD)using deep learning.High-resolution(HR)FEM-based CFDremains computationally prohibitive for time-sensitive applications,including patient-specific aneurysm hemodynamics where rapid turnaround is valuable.The proposed pipeline learns to reconstruct HR velocity-magnitude fields fromlow-resolution(LR)FEM solutions generated under the same governing equations and boundary conditions.It consistsof three modules:(i)offline pre-training of a residual network on representative vascular geometries;(ii)lightweightfine-tuning to adapt the pretrained model to geometric variability,including patient-specific aneurysm morphologies;and(iii)an unstructured-to-structured sampling strategy with region-of-interest upsampling that concentrates resolution in flow-critical zones(e.g.,the aneurysm sac)rather than the full domain.This targeted reconstruction substantiallyreduces inference and post-processing cost while preserving key HR flow features.Experiments on cerebral aneurysmmodels show that HR velocity-magnitude fields can be recovered with accuracy comparable to direct HR simulationsat less than 1%of the direct HR simulation cost per analysis(LR simulation and SR inference),while adaptation to newgeometries requires only lightweight fine-tuning with limited target-specific HR data.While clinical endpoints andadditional variables(e.g.,pressure or wall-based metrics)are left for future work,the results indicate that the proposedsurrogate SR approach can streamline FEM-based CFD workflows toward near real-time hemodynamic analysis acrossmorphologically similar vascular models.
文摘Objective:This study presents a mathematical model and finite element simulations to investigate interstitial fluid flow and nanodrug transport in a solid tumor,incorporating transvascular exchange,convection–diffusion–reaction dynamics,and intratumoral injection mechanisms.Impact Statement:Optimizing nanodrug distribution remains a critical challenge in cancer therapy.The proposed model advances nanomedicine by enhancing the mechanistic understanding of nanodrug transport in a solid tumor.Introduction:Cancer,a global threat,often manifests as solid tumors driven by uncontrolled cell growth.The heterogeneous microenvironment,lymphatic drainage,nano-bio interactions,and elevated interstitial fluid pressure(IFP)hinder effective nanodrug delivery.Nanoparticle(NP)-based drug delivery systems offer a promising solution,with FES providing an effective approach to model and simulate the complex delivery process.Methods:The model considered a spherical and symmetrical tumor architecture comprising a central necrosis region,viable tumor,and surrounding healthy tissue with functional lymphatic dynamics.Substantial nanodrug carriers(dextran,liposomal,polyethylene glycol(PEG)-coated gold,and magnetic)and conventional doxorubicin are evaluated in the tumor.The governing fluid flow and solute transport equation along with the specified boundary conditions are solved using the finite element method through the Galerkin approach.Results:Simulations show that IFP peaks in the necrotic core and sharply declines at the viable–healthy tissue interface.Both fluid pressure and velocity are sensitive when fluid flow resistance drops below 5.Necrotic core size influences IFP,and critical necrotic radius(R_(CN))marks pressure stabilization and defines the threshold for effective nanodrug delivery.Vascular normalization and functional lymphatic dynamics show marginal impact.Smaller NPs(~10 nm)diffuse faster but undergo rapid degradation,while larger particles(>30 nm)exhibit prolonged retention at the injection site.Liposomal,PEG-coated gold,and magnetic variants demonstrate superior therapeutic action compared to conventional doxorubicin.Conclusion:The findings of the study highlight its strong potential for optimizing nanodrug delivery and design,as well as hyperthermia treatment,enhancing personalized cancer therapy.
基金co-supported by the National Key Research and Development Program of China(2021YFC3000604)the Key Program of the National Natural Science Foundation of China(42130101)。
文摘The Sichuan-Yunnan region,located at the southeastern margin of the Qinghai-Xizang Plateau,serves as a key channel for the southeastward extrusion of plateau material.The characteristics of crustal deformation and the mechanisms of deep material flow have been central topics of interest in geoscience research.In this work,a three-dimensional viscoelastic-plastic finite element model including the upper and mid-lower crust was established,constrained by GNSS horizontal crustal velocity observations and incorporating maj or active faults and geophysical survey data to explore the contribution of mid-lower crustal flow to surface deformation and its coupling with faults.Comparison of modeling experiments shows that relying solely on boundary loading or uniform layering assumptions fails to reproduce the GNSS observed velocities.We introduce a mid-lower crustal low-velocity weak zone,derived from the latest seismic velocity structure models.The new model improves the fit to GNSS observations.Tests of different viscosity coefficients in the low-velocity zone indicate an optimal viscosity range of 7.5×10^(19)-1×10^(20)Pa·s.Vertical profiles reveal that mid-lower crustal material motion is mainly concentrated at depths of 20-40 km,forming localized channelized flow in low-velocity zone with a typical Poiseuille velocity profile which indicates a ductile,fluid-like behavior with the lowvelocity zone serving as primary pathways for deep material transport.The results further show that under the geometric constraints of upper-crustal faults,the mid-lower crustal flow contributes approximately 1-3 mm/a to surface deformation,primarily concentrated along major faults.This indicates that faults play a key role in constraining and modulating the transmission of deep-seated dynamics to shallow surface deformation.However,the contribution of mid-lower crustal flow is also significant;neglecting its influence on surface deformation would lead to an incomplete understanding of the deformation pattern and bias the interpretation of block boundaries and crustal kinematic segmentation.
基金National Natural Science Foundation of China under Grant Nos.U2139208 and 52278516Key Laboratory of Earthquake Engineering and Engineering Vibration,China Earthquake Administration under Grant No.2024D15Key Laboratory of Soft Soil Characteristic and Engineering Environment,Tianjin Chengjian University under Grant No.2022SCEEKL003。
文摘This study presents an effective hybrid simulation approach for simulating broadband ground motion in complex near-fault locations.The approach utilizes a deterministic approach based on the spectral element method(SEM),which is used to simulate low-frequency ground motion(f<1 Hz)by incorporating an innovative efficient discontinuous Galerkin(DG)method for grid division to accurately model basin sedimentary layers at reduced costs.It also introduces a comprehensive hybrid source model for high-frequency random scattering and a nonlinear analysis module for basin sedimentary layers.Deterministic outcomes are combined with modified three-dimensional stochastic finite fault method(3D-EXSIM)simulations of high-frequency ground motion(f>1 Hz).A fourth-order Butterworth filter with zero phase shift is employed for time-domain filtering of low-and high-frequency time series at a crossover frequency of 1 Hz,merging the low and high-frequency ground motions into a broadband time series.Taking an Ms 6.8 Luding earthquake,as an example,this hybrid method was used for a rapid and efficient simulation analysis of broadband ground motion in the region.The accuracy and efficiency of this hybrid method were verified through comparisons with actually observed station data and empirical attenuation curves.Deterministic method simulation results revealed the effects of mountainous topography,basin effects,nonlinear effects within the basin’s sedimentary layers,and a coupling interaction between the basin and the mountains.The findings are consistent with similar studies,showing that near-fault sedimentary basins significantly focus and amplify strong ground motion,and the soil’s nonlinear behavior in the basin influences ground motion to varying extents at different distances from the fault.The mountainous topography impacts the basin’s response to ground motion,leading to barrier effects.This research provides a scientific foundation for seismic zoning,urban planning,and seismic design in nearfault mountain basin regions.
基金the National High Technical Reasearch and Development Programme of China （No. 2003AA327140） the National Natural Science Foundation of China （No. 50374081）.
文摘Two full 3D steady mathematical models are developed by finite element method （FEM） to calcalate coupled physics fields. the electro-magnetic model is built and solved first and so is the fluid motion model with the acquired electromagnetic force as source body forces in Navier-Stokes equations. Effects caused by the ferromagnetic shell, busbar system around, and open boundary problem as well as inside induced current were considered in terms of the magnetic field. Furthermore, a new modeling method is found to set up solid models and then mesh them entirely with so-called structuralized grids, namely hex-mesh. Examples of 75kA prebaked cell with two kinds of busbar arrangements are presented. Results agree with those disclosed in the literature and confirm that the coupled simulation is valid. It is also concluded that the usage of these models facilitates the consistent analysis of the electric field to magnetic field and then flow motion to the greater extent, local distributions of current density and magnetic flux density are very much dependent on the cell structure, the steel shell is a shield to reduce the magnetic field and flow pattern is two dimensional in the main body of the metal pad.
文摘Research in different areas of orthopedic and trauma surgery requires a methodology that allows both a more economic approach and the ability to reproduce different situations in an easy way. Simulation models have been introduced recently in bioengineering and could become an essential tool in the study of any physiological unity, regardless of its complexity. The main problem in modeling with finite elements simulation is to achieve an accurate reproduction of the anatomy and a perfect correlation of the different structures, in any region of the human body. Authors have developed a mixed technique, joining the use of a three-dimensional laser scanner Roland Picza captured together with computed tomography(CT) and 3D CT images, to achieve a perfect reproduction of the anatomy. Finite element(FE) simulation lets us know the biomechanical changes that take place after hipprostheses or osteosynthesis implantation and biological responses of bone to biomechanical changes. The simulation models are able to predict changes in bone stress distribution around the implant, so allowing preventing future pathologies. The development of a FE model of lumbar spine is another interesting application of the simulation. The model allows research on the lumbar spine, not only in physiological conditions but also simulating different load conditions, to assess the impact on biomechanics. Different degrees of disc degeneration can also be simulated to determine the impact on adjacent anatomical elements. Finally, FE models may be useful to test different fixation systems, i.e., pedicular screws, interbody devices or rigid fixations compared with the dynamic ones. We have also developed models of lumbar spine and hip joint to predict the occurrence of osteoporotic fractures, based on densitometric determinations and specific biomechanical models, including approaches from damage and fracture mechanics. FE simulations also allow us to predict the behavior of orthopedic splints applied to the correction of deformities, providing the recovering force-displacement and angle-moment curves that characterize the mechanical behavior of the splint in the overall range of movement.
基金financially supported by the State Grid Corporation of China (No. 52110416001z)the National Natural Science Foundation of China (No. 51331007)
文摘The evolution of microstructure in the drawing process of commercially pure aluminum wire （CPAW） does not only depend on the nature of materials, but also on the stress profile. In this study, the effect of stress profile on the texture evolution of the CPAW was systematically investigated by combining the numerical simulation and the microstructure observation. The results show that the tensile stress at the wire center promotes the formation of 〈111〉 texture, whereas the shear stress nearby the rim makes little contribution to the texture formation. Therefore, the 〈111 〉 texture at the wire center is stronger than that in the surface layer, which also results in a higher microhardness at the center of the CPAW under axial loading.2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science ＆ Technology.
基金The work is supported by the National Natural Science Foundation of＂ China （51005180）.
文摘A thermo-mechanical coupling.finite element model was built to investigate the inertia friction welding of GH4169 bars. The remeshing and map solution techniques were adopted. Ttle whole welding process was investigated by adopting an innovative heat generation model and the flywheel rotational speed measured via the experiment. The simulated evolution of axial shortening shows a good agreement with the experiment. In addition, extensive .strain concentration presents in the interface and flash, and the largest ,strain exists near the flash root. Moreover, an intere.sting thermal reflux phenomenon during the cooling stage was found.
基金Project(51105287)supported by the National Natural Science Foundation of China
文摘To investigate the effects of billet geometry on the cold precision forging process of a helical gear, six different billet geometries were designed utilizing the relief-hole principle. And the influences of the billet geometry on the forming load and the deformation uniformity were analyzed by three-dimensional （3D） finite element method （FEM） under the commercial software DEFORM 3D. The billet geometry was optimized to meet lower forming load and better deformation uniformity requirement. Deformation mechanism was studied through the distribution of flow velocity field and effective strain field. The forging experiments of the helical gear were successfully performed using lead material as a model material under the same process conditions used in the FE simulations. The results show that the forming load decreases as the diameter of relief-hole do increases, but the effect of do on the deformation uniformity is very complicated. The forming load is lower and the deformation is more uniform when do is 10 mm.
文摘During the process of finite element simulation of precision warm forging, the selection of friction models has a direct effect on the precision accuracy of finite element simulation results. Among all the factors which influence the selection of friction models, the distribution rule of normal stress at the tool-workpiece interface is a key one. To find out the distribution rule of normal stress at the tool-workpiece interface, this paper has made a systematic research on three typical plastic deformation processes: forward extrusion, backward extrusion, and lateral extrusion by a method of finite element simulation. Then on the base of synthesizing and correcting traditional friction models, a new general friction model which is fit for warm extrusion is developed at last.
基金supported by the National Natural Science Foundation of China(No.10702048).
文摘Based on CT scanning pictures from a volunteer＇s knee joint, a three-dimensional finite element model of the healthy human knee joint is constructed including complete femur, tibia, fibular, patellar and the main cartilage and ligaments. This model was validated using experimental and numerical results obtained from other authors. The pressure distribution of contact surfaces of knee joint are calculated and analyzed under the load action of ‘heel strike＇, ‘single limb stance＇ and ‘toe-off＇. The results of the gait cycle are that the contact areas of medial cartilage are larger than that of lateral cartilage; the contact force and contact areas would grow larger with the load increasing; the pressure of lateral meniscus is steady, relative to the significant variation of peak pressure in medial meniscus; and the peak value of contact pressure on all components are usually found at about 4570 of the gait cycle.
基金supported by National Natural Science Foundation of China(No. 50175034).
文摘Single-point incremental forming （SPIF） is an innovational sheet metal forming method without dedicated dies, which belongs to rapid prototyping technology. In generalizing the SPIF of sheet metal, the deformation analysis on forming process becomes an important and useful method for the planning of shell products, the choice of material, the design of the forming process and the planning of the forming tool. Using solid brick elements, the finite element method（FEM） model of truncated pyramid was established. Based on the theory of anisotropy and assumed strain formulation, the SPIF processes with different parameters were simulated. The resulted comparison between the simulations and the experiments shows that the FEM model is feasible and effective. Then, according to the simulated forming process, the deformation pattern of SPIF can be summarized as the combination of plane-stretching deformation and bending deformation. And the study about the process parameters＇ impact on deformation shows that the process parameter of interlayer spacing is a dominant factor on the deformation. Decreasing interlayer spacing, the strain of one step decreases and the formability of blank will be improved. With bigger interlayer spacing, the plastic deformation zone increases and the forming force will be bigger.
基金Project supported by the General Program of National Natural Science Foundation of China (51874062)。
文摘To study the hot deformation behavior of Mg-8.3 Gd-4.4 Y-1.5 Zn-0.8 Mn(wt%) alloy,hot compression tests were conducted using a Gleeble-3500 thermal simulator at temperatures ranging from 653 to773 K,true strain rates of 0.001-1 s^(-1),and a deformation degree of 60%.Results of hot compression experiments show that the flow stress of the alloy increases with the strain rate.The true stress-true strain curves are corrected by correcting the effect of temperature rise in the deformation process.Activation energy,Q,equal to 287380 J/mol and material constant,n,equal to 4.59 were calculated by fitting the true stress-true strain curves.Then,the constitutive equation was established and verified via finite element simulation.Results of the hot processing map show that the probability of material instability increases with the degree of deformation,which indicates that the material is not suitable for large deformation in a single pass.On the whole,the alloy is appropriate for multipass processing with small deformation and a suitable processing temperature and strain rate are 733 K and 0.01 s-1,respectively.
基金supported by the National Natural Science Foundation of China(Grant Nos.51805064,51701034)the Scientific and Technological Research Program of Chongqing Municipal Education Commission(Grant Nos.KJQN201801137,KJ1600922)+1 种基金the Basic and Advanced Research Project of Chongqing Science and Technology Commission(Grant Nos.cstc2017jcyj AX0062,cstc2018jcyj AX0035)the Chongqing University Key Laboratory of Micro/Nano Materials Engineering and Technology(Grant Nos.KFJJ2003)
文摘Isothermal hot compression experiments were conducted on homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy to investigate hot deformation behavior at the temperature range of 673-773 K and the strain rate range of 0.001-1 s^(-1)by using a Gleeble-1500D thermo mechanical simulator.Metallographic characterization on samples deformed to true strain of 0.70 illustrates the occurrence of flow localization and/or microcrack at deformation conditions of 673 K/0.01 s^(-1),673 K/1 s^(-1)and 698 K/1 s^(-1),indicating that these three deformation conditions should be excluded during hot working of homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy.Based on the measured true stress-strain data,the strain-compensated Arrhenius constitutive model was constructed and then incorporated into UHARD subroutine of ABAQUS software to study hot deformation process of homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy.By comparison with measured force-displacement curves,the predicted results can describe well the rheological behavior of homogenized Mg-8.5Gd-4.5Y-0.8Zn-0.4Zr alloy,verifying the validity of finite element simulation of hot compression process with this complicated constitutive model.Numerical results demonstrate that the distribution of values of material parameters(α,n,Q and ln A)within deformed sample is inhomogeneous.This issue is directly correlated to the uneven distribution of equivalent plastic strain due to the friction effect.Moreover,at a given temperature the increase of strain rate would result in the decrease of equivalent plastic strain within the central region of deformed sample,which hinders the occurrence of dynamic recrystallization(DRX).
基金Project （51171125） supported by the National Natural Science Foundation of China Project （20110321051 ） supported by the Science and Technology Key Project of Shanxi Province, China
文摘Materials with the same elastic modulus E and representative stress and strain （σr,εr） present similar indentation-loading curves, whatever the value of strain hardening exponent n. Based on this definition, a good approach was proposed to extract the plastic properties or constitutive equations of metals from nanoindentation test combining finite element simulation. Firstly, without consideration of strain hardening, the representative stress was determined by varying assumed representative stress over a wide range until a good agreement was reached between the computed and experimental loading curves. Similarly, the corresponding representative strain was determined with different hypothetical values of strain hardening exponent in the range of 0-0.6. Through modulating assumed strain hardening exponent values to make the computed unloading curve coincide with that of the experiment, the real strain hardening exponent was acquired. Once the strain hardening exponent was determined, the initial yield stress ay of metals could be obtained by the power law constitution. The validity of the proposed methodology was verified by three real metals： AISI 304 steel, Fe andA1 alloy.
文摘Being aimed at the ground subsidence due to underground coal mining,a numerical model of rock was established and an appropriate method of numerical simulation was put forward.Using the measured subsidence data on the ground,the equivalent mechanical parameters of the rock stratums can be back-calculated by the properly treatment of coal excavation area,then the ground subsidence of other coal mining area can be predicted by FFM.It provided reference for the treatment of the buildings on the ground of this colliery.
基金Project(51675100)supported by the National Natural Science Foundation of ChinaProject(2016ZX04004008)supported by the National Numerical Control Equipment Major Project of ChinaProject(6902002116)supported by the Foundation of Certain Ministry of China
文摘In the process of thin-wall parts assembly for an antenna,the parts assembly deformation deviation is occurring due to the riveting assembly.In view of the riveting assembly deformation problems,it can be analyzed through transient and static simulation.In this work,the theoretical deformation model for riveting assembly is established with round head rivet.The simulation analysis for riveting deformation is carried out with the riveting assembly piece including four rivets,which comparing with the measuring points experiment results of riveting test piece through dealing with the experimental data using the point coordinate transform method and the space line fitting method.Simultaneously,the deformation deviation of the overall thin-wall parts assembly structure is analyzed through finite element simulation;and its results are verified by the measuring experiment for riveting assembly with the deformation deviation of some key points on the thin-wall parts.Through the comparison analysis,it is shown that the simulation results agree well with the experimental results,which proves the correctness and effectiveness of the theoretical analysis,simulation results and the given experiment data processing method.Through the study on the riveting assembly for thin-wall parts,it will provide a theoretical foundation for improving thin-wall parts assembly quality of large antenna in future.
文摘The rotary forging process of a disc is simulated by 3-D finite element method.The motion of the rotary the is described as the combination of a revolution round the machine axis and a spin round the rotary die axis. Therefore, the workpiece can be loaded and unloaded partly and cyclically by the cone surface of the rotary the continuously, according with the practical rotary forging process. From the siumulation rasults, the causes of center-thinning during rotary forging of discs are that the locally loading of rotary die made the workpiece center get high radial and tangential tensile stresses, and then the shortening in axial direction and the elongating in tangential and radial direction occur continuous- ly.
基金Projects(50230310 ,50301016) supported by the National Natural Science Foundation of China project(2004053304)supported by the Doctor Program Foundation of the Ministry of Education of China project(2005CB623706) supported by the State KeyFundamental Research and Development Programof China
文摘A rate dependent crystal plasticity constitutive model considering self and latent hardening in finite element analysis was developed to simulate rolling textures of pure aluminum. By changing the assignment of orientations to finite elements, i.e. assigning the same set of orientations to all elements or different orientations to different elements, the influences of grain interaction on the formation of rolling textures were numerically simulated with this kind of crystal plasticity finite element model. The simulation results reveal that the grains without considering grain interaction rotate faster than those considering grain interaction, and the rotation of grain boundary is slowed down due to the grain interaction. For a good simulation more elements should be assigned to one grain, in which the effects of both the boundary and interior parts of grain contribute to the formation of rolling textures.
